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| Ashrafi, Kaveh |
| Bernstein, Harold S. |
| Black, Brian L |
| Blanc, Paul D |
| Botvinick, Elias H |
| Boushey, Homer A |
| Broaddus, V Courtney |
| Brodsky, Frances M |
| Brown, James K |
| Bruneau, Benoit G |
| Caughey, George H |
| Chapman, Harold A |
| Charo, Israel F |
| Chatterjee, Kanu |
| Chuang, Pao-Tien |
| Clyman, Ronald I |
| Conklin, Bruce R |
| Conte, Michael S |
| Coughlin, Shaun R |
| Derynck, Rik M |
| Dobbs, Leland G |
| Eisner, Mark D |
| Engel, Joanne N |
| Erle, David J |
| Fahy, John Vincent |
| Farese, Robert V |
| Fielding, Christopher J |
| Fineman, Jeffrey R |
| Gardner, David G |
| Gartner, Zev Jordan |
| Glantz, Stanton A |
| Gold, Warren M |
| Gropper, Michael |
| Grossman, William |
| Hawgood, Samuel |
| Hill, Arthur C |
| Hoffman, Julien I |
| Ingraham, Holly A |
| Jan, Lily Y |
| Julius, David J |
| Kan, Yuet W |
| Kane, John P |
| Karliner, Joel S |
| Kornberg, Thomas B |
| Kurtz, Theodore W |
| Kwok, Pui-Yan |
| Lazarus, Stephen C |
| Lee, Randall J |
| Lim, Wendell A |
| Mahley, Robert W |
| Malloy, Mary J. |
| Mann, Michael J |
| Martin, Gail R |
| Matthay, Michael A |
| Mcdonald, Donald M |
| Mikawa, Takashi |
| Minor, Daniel L |
| Mostov, Keith E |
| Nadel, Jay A |
| Olgin, Jeffrey E |
| Pearce, David |
| Pittet, Jean-Francois |
| Redberg, Rita F |
| Reiter, Jeremy F. |
| Rosen, Steven D |
| Rowitch, David H |
| Scheinman, Melvin M |
| Schiller, Nelson B |
| Shaw, Robin M. |
| Sheppard, Dean |
| Shokat, Kevan M |
| Simpson, Paul C |
| Springer, Matthew L |
| Srivastava, Deepak |
| Stainier, Didier Y. R. |
| Teitel, David F |
| Von Zastrow, Mark E |
| Wang, Rong |
| Weiner, Orion D |
| Weiss, Arthur |
| Weiss, Ethan J |
| Werb, Zena |
| Woodruff, Prescott G |
| Xu, Allison Wanting |
| Young, William L |
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CVRI Scientists
Harold S. Bernstein, M.D., Ph.D.
Professor in Residence, Pediatrics
Research Interests:
Stem cells, cardiac muscle, skeletal muscle, cell cycle regulation
Summary:
Each year, more than 900,000 people in the U.S. experience a heart attack, and about 500,000 die from complications of heart failure. Heart failure occurs when heart muscle cells are damaged and the heart is unable to meet the demands placed on it by the body. Unlike other organs, the heart is unable to repair itself. We seek to develop new ways of stimulating heart muscle repair or producing replacement heart muscle cells to be used for repair, thereby treating or avoiding heart failure.
Specifically, our laboratory studies the mechanisms regulating cell division, and how such processes play a role in cardiovascular biology and disease. To this end our work has focused on three main areas of basic investigation: 1) mechanisms of cell cycle withdrawal during muscle differentiation; 2) cardiac fate determination in myogenic stem cells, and; 3) the role of cell cycle machinery in cellular hypertrophy. In addition, we recently have initiated two new areas of translational and clinical research that apply their understanding of how muscle cells behave to the development of new diagnostic and therapeutic approaches to heart failure: 4) human embryonic stem cell-based therapies for heart failure; and 5) identification of biomarkers of heart failure in patients with congenital heart disease.
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