Allen, Christopher D
Ashrafi, Kaveh
Atabai, Kamran
Black, Brian L
Blanc, Paul D
Botvinick, Elias H
Boushey, Homer A
Broaddus, V Courtney
Brown, James K
Bruneau, Benoit G
Calfee, Carolyn S.
Caughey, George H
Chang, Andy
Chapman, Harold A
Charo, Israel F
Chawla, Ajay
Chuang, Pao-Tien
Clyman, Ronald I
Conklin, Bruce R
Connolly, Andrew J
Conte, Michael S
Coughlin, Shaun R
Degrado, William F
Deo, Rahul C
Derynck, Rik M
Dobbs, Leland G
Engel, Joanne N
Erle, David J
Fahy, John Vincent
Fineman, Jeffrey R
Ganz, Peter
Gardner, David G
Gartner, Zev Jordan
Glantz, Stanton A
Gold, Warren M
Grabe, Michael D
Gropper, Michael
Grossman, William
Hart, Daniel O
Hata, Akiko
Hawgood, Samuel
Hoffman, Julien I
Huang, Guo
Ingraham, Holly A
Irannejad, Roshanak
Jan, Lily Y
Julius, David J
Jura, Natalia Z
Kan, Yuet W
Kane, John P
Karliner, Joel S
Kornberg, Thomas B
Koth, Laura L
Krauss, Ronald M
Kurtz, Theodore W
Kwok, Pui-Yan
Lazarus, Stephen C
Lee, Randall J
Lim, Wendell A
Ma, Dengke
Mahley, Robert W
Malloy, Mary J.
Mann, Michael J
Matthay, Michael A
Mcdonald, Donald M
Mikawa, Takashi
Minor, Daniel L
Mostov, Keith E
Oishi, Peter E
Olgin, Jeffrey E
Pearce, David
Peng, Tien
Redberg, Rita F
Reiter, Jeremy F.
Rock, Jason R.
Rowitch, David H
Scheinman, Melvin M
Schiller, Nelson B
Seiple, Ian Bass
Sheppard, Dean
Shokat, Kevan M
Shu, Xiaokun
Shum, Anthony K
Simpson, Paul C
Springer, Matthew L
Srivastava, Deepak
Teitel, David F
Von Zastrow, Mark E
Wang, Rong
Wang, Biao
Wang, Lei
Weiner, Orion D
Weiss, Arthur
Weiss, Ethan J
Werb, Zena
Woodruff, Prescott G
Xu, Allison Wanting
Yeghiazarians, Yerem
Zovein, Ann C

CVRI Scientists

Michael D Grabe, Ph.D.
Associate Professor

Research Interests:
Membrane channels and transporters, molecular simulation, continuum electrostatics and elasticity theory

Summary:
Our lab uses computational methods to understand biological phenomena. We are primarily interested in the mechanical operation of ion channels and transporters, which move ions and small molecules across membranes. Additionally, we use theoretical approaches to explore how these membrane proteins work together to regulate ion homeostasis in organelles such as the lysosome and Golgi. Lastly, we are developing methodologies for predicting the stability of membrane proteins to understand how mutations give rise to a loss of function, improper trafficking or degradation.

CVRIHead