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A trimeric form of the Kv7.1 A domain Tail
 

PDB ID: 3HFE and 3HFC

Xu, Q., Minor, Jr., D.L., Crystal structure of a trimeric form of the KV7.1 (KCNQ1) A-domain tail coiled-coil reveals structural plasticity and context dependent changes in a putative coiled-coil trimerization motif. Protein Science 18:2100—2114 (2009)

 
TRPM7 Assembly Domain
 

PDB ID: 3E7K

Fujiwara, Y., Minor, Jr., D.L. X-ray Crystal Structure of a TRPM Assembly Domain Reveals an Antiparallel Four-stranded Coiled-coil. J. Mol. Biol. 383, 854-870 (2008).

 

 

 
CaV 2.1 IQ domain-Ca2+/Calmodulin Complex
 

PDB ID: 3DVM

Kim, E.Y., Rumpf, C.H., Fujiwara, Y., Cooley, E.S., Van Petegem, F., and Minor, Jr., D.L. Structures of CaV2 Ca2+/CaM-IQ Domain Complexes Reveal Binding Modes that Underlie Calcium-Dependent Inactivation and Facilitation. Structure 16, 1455-1467 (2008).

 

 

 
CaV 2.2 IQ domain-Ca2+/Calmodulin Complex
 

PDB ID: 3DVE, 3DVJ

Kim, E.Y., Rumpf, C.H., Fujiwara, Y., Cooley, E.S., Van Petegem, F., and Minor, Jr., D.L. Structures of CaV2 Ca2+/CaM-IQ Domain Complexes Reveal Binding Modes that Underlie Calcium-Dependent Inactivation and Facilitation. Structure 16, 1455-1467 (2008).

 

 

 
CaV 2.3 IQ domain-Ca2+/Calmodulin Complex
 

PDB ID: 3DVK

Kim, E.Y., Rumpf, C.H., Fujiwara, Y., Cooley, E.S., Van Petegem, F., and Minor, Jr., D.L. Structures of CaV2 Ca2+/CaM-IQ Domain Complexes Reveal Binding Modes that Underlie Calcium-Dependent Inactivation and Facilitation. Structure 16, 1455-1467 (2008).

 

 

 
Kv7.4 (KCNQ4) assembly specificity domain
 

2OVC Kv7.4 (KCNQ4) assembly specificity domain
PDB ID: 2OVC

Structural insight into KCNQ (Kv7) channel assembly and channelopathy. Howard, R.J., Clark, K.A., Holton, J.M., and Minor, Jr., D.L., Neuron 53 663-675 (2007)

 

 
KChIP1/Kv4.3 T1 domain complex
 

2I2R KChIP1/Kv4.3 T1 Domain complex
PDB ID: 212R

Three-dimensional structure of the KChIP/Kv4.3 T1 domain complex reveals a cross-shaped octamer. Pioletti, M., Findeisen, F., Hura, G.L., and Minor, Jr., D.L., Nature Structural & Molecular Biology 13 987 995 (2006)

 

 
Voltage-gated Potassium Channel T1 assembly domain
 

1QDW Kv1.2 T1 domain 33-119
PDB ID: 1QDW

1QDV Kv1.2 T1 domain 33-131
PDB ID: 1QDV

1DSX KV1.2 T1 domain33-131 T46V mutant
PDB ID: 1DSX

The polar T1 interface is linked to conformational changes that open the voltage-gated potassium channel. Minor, Jr., D.L., Lin, Y.F, Mobley, B.C., Avelar, A., Jan, Y.N., Jan, L.Y. and Berger, J.M. Cell 102 657-670 (2000)

 

 
Voltage-gated Calcium Channel β-subunit
 

1T0H CaVβ2a
PDB ID: 1TOH

1T0J CaVβ2a - CaV1.2 AID complex
PDB ID: 1TOJ

Structure of a complex between a voltage gated calcium channel beta-subunit and an alpha-subunit domain.
Van Petegem, F., Clark, K.A., Chatelain, F.C., and Minor, Jr., D.L. Nature 429 671-675 (2004)

 
CaV1.2 IQ domain-Ca2+/Calmodulin Complex
 

2BE6 CaV1.2 IQ domain-Ca2+/CaM complex
PDB ID: 2BE6

Insights into voltage-gated calcium channel regulation from the structure of the CaV1.2 IQ domain-Ca2+/calmodulin complex. Van Petegem, F, Chatelain, F.C., Minor, Jr., D.L., Nature Structural & Molecular Biology 12 1108-1115 (2005)

 
 
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