Graziano BR, Gong D, Anderson KE, Pipathsouk A, Goldberg AR, Weiner OD.

A module for Rac temporal signal integration revealed with optogenetics.

J. Cell Biol., 216: 2515-2531 (2017). PDF

Diz-Muñoz A, Thurley K, Chintamen S, Altschuler SJ, Wu LF, Fletcher DA, Weiner OD.

Membrane tension acts through PLD2 and mTORC2 to constrain actin assembly during neutrophil migration.

PLoS Biology, 14: e1002474 (2016). PDF

Hoeller O, Toettcher JE, Cai H, Sun Y, Huang CH, Freyre M, Zhao M, Devreotes PN, Weiner OD.

GB regulates coupling between actin oscillators for cell polarity and directed migration.

PLoS Biology, 14: e1002381 (2016). PDF

Buckley CE, Moore RE, Reade A, Goldberg A, Weiner OD#, Clarke JDW#

Reversible optogenetic control of subcellular protein localization in a live vertebrate embryo.

Developmental Cell, 36: 117-26 (2016). PDF (#corresponding author)

Liu Z, Weiner OD.

Positioning the cleavage furrow: all you need is Rho.

Journal of Cell Biology, 6: 605-607 (2016). PDF

Genuth MA, Weiner OD.

Cell migration: recoiling from an embrace.

Current Biology, 25: R566-568 (2015). PDF

Jost AP, Weiner OD.

Probing yeast polarity with acute, reversible, optogenetic inhibition of protein function.

ACS Synthetic Biology, 4: 1077-85 (2015). PDF

Wu J, Pipathsouk A, Kizer-Gunnink A, Fusetti F, Alkema W, Liu S, ALtschuler SJ, Wu L, Kortholt A, Weiner OD.

Homer3 regulates the establishment of neutrophil polarity.

Molecular Biology of the Cell, 26: 1629-39 (2015). PDF

Tischer D, Weiner OD.

Illuminating cell signaling with optogenetic tools.

Nature Reviews Molecular and Cellular Biology, 15: 551-8 (2014). PDF

Graziano BR, Weiner OD.

Self-organization of protrusions and polarity during eukaryotic chemotaxis.

Current Opinion in Cell Biology, 30: 60-67 (2014). PDF

Hoeller O, Gong D, Weiner OD.

How to understand and outwit adaptation.

Developmental Cell, 28: 607-616 (2014). PDF

Weiner OD.

How should we be selecting our graduate students?

Molecular Biology of the Cell, 25:429-30 (2014). PDF

Motta-Mena LB, Reade AR, Mallory MJ, Glantz S, Weiner OD, Lynch KW, Gardner KH.
A versatile optogenetic gene expression system with rapid activation/deactivation kinetics.

Nature Chemical Biology, 10:196-202 (2014). PDF

Toettcher JE, Weiner OD#, Lim WA#.

Using optogenetics to interrogate the dynamic control of signal transmission by the Ras/Erk module.

Cell, 155: 1422-1434 (2013). (#corresponding author) PDF

Editor's Choice, Science Signaling
Recommended by Faculty of 1000

Parent A, Weiner OD.

The symphony of cell movement:  how cells orchestrate diverse signals and forces to control migration.

Current Opinion in Cell Biology, 25: 523-5 (2013). PDF

Dandekar SN, Park J, Peng GE, Onuffer J, Lim WA, Weiner OD.

Actin dynamics rapidly reset chemoattractant receptor sensitivity following adaptation in neutrophils.

Philosophical Transactions of the Royal Society B, 368: 20130008 (2013). PDF

Hoeller O, Bolourani P, Stephens LR, Hawkins PT, Weiner OD, Kay RR, Weeks G.

Different PI3K isoforms orchestrate different phases of macropinocytosis in Dictyostelium.

Journal of Cell Science, 126: 4296-307 (2013). PDF

Yang X, Jost AP, Weiner OD#, Tang C#.

A light-inducible organelle-targeting system for dynamically activating and inactivating signaling in budding yeast.

Molecular Biology of the Cell, 24: 2419-30 (2013). (#corresponding author)  PDF

Houk A, Jilkine S, Mejean CO, Boltyanskiy R, Dufresne ER, Agenent S, Altschuler SJ, Wu LF, Weiner OD.

Membrane tension maintains cell polarity by confining signals to the leading edge during neutrophil migration.

Cell, 148: 175-188 (2012). PDF
Video Abstract
Preview in Developmental Cell
Dispatch in Current Biology
Featured Article in Cell Migration Gateway
Recommended by Faculty of 1000


Ku CJ, Wang Y, Weiner OD, Altschuler SJ, Wu LF.

Network crosstalk dynamically changes during neutrophil polarization.

Cell, 149: 1073-1083 (2012). PDF


Diz-Muñoz A, Fletcher DA, Weiner OD

Use the force: membrane tension as an organizer of cell shape and movement.

Trends in Cell Biology, 23: 47-53 (2012). PDF


Millius A, Watanabe N, Weiner OD.

Diffusion, capture, and recycling of SCAR/WAVE and Arp2/3 complexes observed in cells with single-molecule imaging.

Journal of Cell Science, 125: 1165-1176 (2012). PDF


Woo S, Housley MP, Weiner OD, Stainier DY.

Nodal signaling regulates endodermal cell motlity and actin dynamics via Rac1 and Prex1.

Journal of Cell Biology, 198: 941-952 (2012). PDF


Toettcher JE, Gong D, Lim WA, Weiner OD.

Light-based feedback for controlling intracellular signaling dynamics.

Nature Methods, 8: 837-9 (2011). PDF


Peng GE, Wilson SR, Weiner OD.

A pharmacological cocktail for arresting actin dynamics in living cells. 

Molecular Biology of the Cell, 22: 3986-94 (2011). PDF


Toettcher JE, Gong D, Lim WA, Weiner OD.

Light control of plasma membrane recruitment using the Phy--PIF system.

Methods in Enzymology, 497: 409-23 (2011). PDF


Toettcher JE, Voigt CA, Weiner OD, Lim WA.

The promise of optogenetics in cell biology: interrogating molecular circuits in space and time.

Nature Methods, 8: 35-8 (2011). PDF


Puthenveedu MA, Lauffer B, Temkin P, Carlton P, Thorn K, Sedat J, Taunton J, Weiner OD, Parton RG, von Zastrow M.

Sequence-dependent sorting of recycling proteins by actin- stabilized endosomal microdomains.

Cell, 143: 761-773 (2010). PDF


Houk AR, Millius A, Weiner OD.

Compete globally, bud locally.

Cell, 139: 656-658 (2009). PDF


Levskaya A, Weiner OD, Lim WA, Voigt CA.

Spatiotemporal control of cell signaling using a light-switchable protein interaction.

Nature, 461: 997-1001 (2009). PDF

Scientist Top 10 Innovation for 2009
Science Signaling Breakthrough of the Year 2009
Recommended by Faculty of 1000

Kress H, Park JG, Mejean CO, Forster JD, Park J, Walse SS, Zhang Y, Wu D, Weiner OD, Fahmy TM, Dufresne ER.

Cell stimulation with optically manipulated microsources.

Nature Methods, 6: 905-909 (2009). PDF


Millius A*, Dandekar SN*, Houk AR*, Weiner OD.

Neutrophils establish rapid and robust Scar/WAVE complex polarity in an actin-dependent fashion.

Current Biology, 19(3): 253-259 (2009). (*equal contribution) PDF


Millius A, Weiner OD.

Manipulation of neutrophil-like HL-60 cells for the study of directed migration.

Methods in Molecular Biology, 591: 147-58 (2009). PDF


Weiner OD#, Marganski WA, Wu LF, Altschuler SJ, Kirschner MW#.

An actin-based wave generator organizes cell motility.

PLoS Biology, 5(9): e221 (2007). (#corresponding author) PDF


Weiner OD* , Rentel MC*, Ott A, Brown GE, Jedrychowski M, Yaffe MB, Gygi SP, Cantley LC, Bourne HR, Kirschner MW.

Hem-1 complexes regulate multiple polarity effectors at the leading edge of migrating neutrophils.

PLoS Biology, 4(2): e38 (2006). (*equal contribution) PDF


Weiner OD, Neilsen PO, Prestwich GD, Kirschner MW, Cantley LC, Bourne HR.

A PI(3,4,5)P3/ Rho GTPase positive feedback loop regulates neutrophil polarity.

Nature Cell Biology, 4: 509-513 (2002). PDF


Bourne HR, Weiner OD.

Cell polarity: a chemical compass.

Nature, 419: 21 (2002). PDF


Weiner OD.

Regulation of cell polarity during eukaryotic chemotaxis: the chemotactic compass.

Current Opinion in Cell Biology, 14: 196-202 (2002). PDF


Servant, G*, Weiner OD*, Herzmark P, Bhalla T, Sedat JW, Bourne HR.

Polarization of chemoattractant receptor signaling during neutrophil chemotaxis.

Science, 287: 1037-1040 (2000). (*equal contribution) PDF


Weiner OD, Servant G, Welch MD, Mitchison TJ, Sedat JW, Bourne HR.

Spatial control of actin polymerization during neutrophil chemotaxis.

Nature Cell Biology, 1: 75-81 (1999). PDF


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