Category: Advanced technologies


Prescott G Woodruff, M.D., M.P.H.

Woodruff

Research Interests:
Genomics, Asthma, Chronic Obstructive Pulmonary Disease, Stereology, Epidemiology, Clinical Trials, Medical Education

Summary:
My research relates to two common lung diseases, asthma and chronic obstructive pulmonary disease, and falls into three specific categories: 1) the identification of molecular sub-phenotypes of these diseases, 2) the elucidation of mechanisms of inflammation and remodeling in these diseases and 3) clinical trials of novel therapies.


Yerem Yeghiazarians, M.D.

Yeghiazarians

Research Interests:
Stem cell (adult or embryonic), Myocardial infarction, Heart failure, Cardiomyopathy

Summary:
The goal of the UCSF Translational Cardiac Stem Cell Program is to bring recent advances in basic science and biology of stem cells to patients with heart disease, heart failure, and cardiomyopathy. There are many different types of stem cells. These can be broadly categorized as adult stem cells (derived from the patient) vs. embryonic type of stem cells. Our group is interested in studying which type of stem cell(s) would be most useful as novel therapy in patients after a heart attack, and exploring the mechanisms by which stem cells can potentially improve the cardiac function.


Christopher D Allen, Ph.D.

Allen

Research Interests:
Cellular dynamics of allergic immune responses underlying asthma

Summary:
Asthma is a chronic lung disease that afflicts tens of millions of people in the US and is particularly prevalent in children. In the majority of individuals with asthma, underlying allergic inflammation in the lung makes a significant contribution to the disease etiology. In order to understand the cellular and molecular events driving this allergic inflammation, we use advanced technologies, including two-photon microscopy and flow cytometry, to directly visualize and characterize inflammatory cells in the lungs as well as in lymphoid organs that ‘prime’ cells for immune responses in the respiratory tract. A particular emphasis of our research is on the generation and function of the IgE class of antibodies that contribute to allergic responses.

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