Category: Channels and Arrhythmias


Guo Huang, Ph.D.

Huang

Research Interests:
Comparative study of heart development and regeneration, ischemic heart diseases, stem cell, cardiomyocyte proliferation, regenerative biology

Summary:
The ability to regenerate damaged or lost tissues varies dramatically across organisms and developmental stages. For example, heart regeneration is robust in adult zebrafish and newborn mouse while very limited in adult mouse and human. This presents a particular problem for patients with a heart attack who suffer from a significant loss of heart muscle cells and subsequent life-threatening functional deterioration of the heart.

By taking a comparative approach to study regenerative versus non-regenerative heart repair processes in zebrafish and mouse, we seek to uncover ancestrally conserved injury responses and more importantly, to identify the signals blocking regeneration in the mammalian heart and consequently new treatment strategies for heart diseases.

UCSF Profiles Page

Website


Michael D Grabe, Ph.D.

Grabe

Research Interests:
Membrane channels and transporters, molecular simulation, continuum electrostatics and elasticity theory

Summary:
Our lab uses computational methods to understand biological phenomena. We are primarily interested in the mechanical operation of ion channels and transporters, which move ions and small molecules across membranes. Additionally, we use theoretical approaches to explore how these membrane proteins work together to regulate ion homeostasis in organelles such as the lysosome and Golgi. Lastly, we are developing methodologies for predicting the stability of membrane proteins to understand how mutations give rise to a loss of function, improper trafficking or degradation.

UCSF Profiles Page


William F Degrado, Ph.D.

Degrado

Research Interests:

De novo protein design, drug design, protein structure/function, membrane protein structure, integrins, antivirals, antibiotics.

Summary:
DeGrado’s group works on the design of molecules that inform our understanding of biological processes. They also have developed small molecules drugs for various as potential pharmaceuticals, including antithrombotics, heparin reversal agents, antibacterials, and antiviral agents.

 

UCSF Profiles Page


Benoit G Bruneau, B.Sc., Ph.D.

Bruneau

Research Interests:
Heart development, congenital heart disease, chromatin, embryogenesis, transcription

Summary:
Our laboratory studies the genes that direct a cell to become a heart cell, focusing on the machinery within each cell that turns genes on or off. Many of these factors are implicated in human congenital heart disease, and our studies also focus on understanding the basis of these diseases.

 

UCSF Profiles Page