Category: Muscle Biology and Heart Failure


Yerem Yeghiazarians, M.D.

Yeghiazarians

Research Interests:
Stem cell (adult or embryonic), Myocardial infarction, Heart failure, Cardiomyopathy

Summary:
The goal of the UCSF Translational Cardiac Stem Cell Program is to bring recent advances in basic science and biology of stem cells to patients with heart disease, heart failure, and cardiomyopathy. There are many different types of stem cells. These can be broadly categorized as adult stem cells (derived from the patient) vs. embryonic type of stem cells. Our group is interested in studying which type of stem cell(s) would be most useful as novel therapy in patients after a heart attack, and exploring the mechanisms by which stem cells can potentially improve the cardiac function.


Brian L. Black, Ph.D.

Research Interests:
Cardiac and skeletal muscle development, differentiation, and function

Summary:
Tissues and organs form during mammalian embryonic development through the integration of numerous signaling and transcriptional pathways. Our major goal is to define pathways controlling organ formation to understand normal development, the molecular basis for congenital defects, and potential mechanisms for organ regeneration and repair.

We use a combination of gene knockouts, transgenic reporter assays, biochemical, computational, and genomic approaches to investigate basic developmental mechanisms. We primarily use the mouse as a model system, but several current projects also use cultured cells or zebrafish as models to understand developmental gene regulation. Current work in the lab is focused primarily on cell autonomous mechanisms underlying gene regulation, tissue specification, organ formation and metabolic control during cardiovascular, craniofacial, and neural crest development.

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