Zebrafish; development; transcription; stem cells
The development of a multi-cellular organism from a single cell is a complex process that is regulated at many stages. One important level of regulation is the control of gene expression, that is, how and when genes are switched on or off to produce RNA and proteins. This process, transcriptional regulation, is critical for proper development. Disturbing this important step can have consequences for development and is often a hallmark of disease. It is therefore very important to understand the mechanisms underlying the transcriptional control of gene expression, and this is the broad aim of my lab.
We are particularly interested in understanding how general transcription factors can be used in specific ways to control genes. How they recognize where to bind in the genome, and what other factors (e.g. interacting proteins) may affect how they function to control development and differentiation.