Unique transmembrane domain interactions differentially modulate integrin αvβ3 and αIIbβ3 function

CVRI investigators decipher the mechanism by which platelets are activated to form clots, a key step in both normal and thrombotic processes. The researchers reveal how interactions between transmembrane helices of key proteins found in the membranes of platelets and many other cells help orchestrate the process. Their work is also informs our understanding of the assembly of many other proteins involved in transmembrane signal transduction.

Rustem I. Litvinov, Marco Mravic, Hua Zhu, John W. Weisel, William F. DeGrado, and Joel S. Bennett

PNAS paper