Other models for cellular
decision-making
We use a wide
range of model systems to investigate cellular
decision-making. We study cell polarity and motility in
single cells in culture (neutrophils, yeast, Dictyostelium) as
well as cell motility in a multicellular context (zebrafish
and chick development). Other projects in the lab focus
on proliferation, differentiation, and survival of single
cells (fibroblasts, T-cells), the relation between genome
organization and transcription (embryonic stem cells), as well
as the development of multicellular organisms (zebrafish and
chick) . We feel that analysis of divergent systems that are
linked more in logic than specific molecules is the surest
route to discovering the fundamental principles of cell
signaling.
(Jeff Alexander, Miriam Genuth, Shuaixin He, Zairan, Liu, Justin McLaurin, Suvrajit Saha, Doug Tischer, Stephanie Woo)