The Cardiovascular Research Institute (CVRI) performs cutting edge research illuminating causes, treatment and prevention of cardiovascular and pulmonary biology and disease and trains clinicians and scientists to become future leaders of these fields.
The CVRI provides a home for a wide spectrum of investigation ranging from the most basic science to disease-focused through patient-based research to public policy. It links faculty interested in cardiovascular biology and disease across UCSF programs, departments and campuses and is the administrative home for UCSF’s Center for Tobacco Control Research and Education. The diversity of CVRI’s faculty and its collaborative culture fosters a multidisciplinary approach to research problems and provides an important bridge between UCSF’s outstanding clinical and basic science departments.
UCSF’ s Cardiovascular Research Institute and its partner basic science and clinical departments seek to recruit new faculty to develop exciting and impactful research programs in areas of major scientific opportunity and unmet medical need. Please apply here.
Nature – Pump, rest, leak, repeat by Dr. Michael Grabe The cover illustration shows vacuolar-type adenosine triphosphatases (V-ATPases, large blue structures) on a synaptic vesicle from a nerve cell in the mammalian brain. V-ATPases pump… Continue Reading
Adrenergic-Thyroid Hormone Interactions Drive Postnatal Thermogenesis and Loss of Mammalian Heart Regenerative Capacity Why can't adult human hearts regenerate after injury like a heart attack? The Huang lab recently presented findings in Circulation to support that loss of… Continue Reading
Poison Frogs, Birds, Hold Clues to Antidotes for Deadly Toxins A team of researchers at UC San Francisco, the California Academy of Sciences and Stanford University have uncovered some intriguing clues in the mystery… Continue Reading
Binding of SARS-CoV-2 spike protein to ACE2 is disabled by thiol-based drugs; evidence from in vitro SARS-CoV-2 infection studies Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and the SARS-CoV-2 spike protein is an envelope glycoprotein that… Continue Reading
Cytoprotection by a naturally occurring variant of ATP5G1 in Arctic ground squirrel neural progenitor cell photo credit to: https://innovativegenomics.org/ news/dengke-ma-extreme-hibernation In major cardiovascular diseases, including stroke and heart attack, loss of blood flow causes loss of oxygen (ischemia), leading to… Continue Reading
The structure of a calsequestrin filament reveals mechanisms of familial arrhythmia In a clinical collaboration with Melvin Scheinman from the UCSF Comprehensive Genetic Arrythmia Program, CVRI investigators Rahul Deo and Natalia Jura, along with MD/PhD trainee Erron… Continue Reading