In major cardiovascular diseases, including stroke and heart attack, loss of blood flow causes loss of oxygen (ischemia), leading to tissue damage and cell deaths. A species of ground squirrels from the Arctic can tolerate such ischemic attack, but the underlying biological basis has been unknown. The study from this paper identified an unusual protein variant ATP5G1 from cells of Arctic ground squirrels that contributes to the protection from ischemic stress. This basic science discovery may lay the groundwork to develop potential therapeutic strategies to treat human ischemic disorders.
In a clinical collaboration with Melvin Scheinman from the UCSF Comprehensive Genetic Arrythmia Program, CVRI investigators Rahul Deo and Natalia Jura, along with MD/PhD trainee Erron Titus, set out to explain how mutations in the calcium-storage protein, calsequestrin, cause lethal arrhthymias. The team solved a new X-ray crystal structure of human cardiac calsequestrin, revealing the biochemical basis of calsequestrin’s assembly into filaments. Using the new structure, the team was able to map disease-associated mutations to the filament surfaces and explain how the location of the mutation in the structure determines the severity of disease.
The global burden of diabetes is rapidly increasing, from 451 million people in 2019 to 693 million by 20451. The insidious onset of type 2 diabetes delays diagnosis and increases morbidity2. Given the multifactorial vascular effects of diabetes, we hypothesized that smartphone-based photoplethysmography could provide a widely accessible digital biomarker for diabetes. y 20451.
CVRI FACULTY POSITIONS AT THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
The Cardiovascular Research Instituteand its partner departments at UCSF seek new faculty members at the rank of Assistant, Associate, or Full Professor. We seek individuals working on topics directly relatedto cardiovascular biology and disease. Areas of interest include hypoxia and ischemia, vascular biology, inflammation and atherogenesis, cardiomyocyte biology and heart failure, stroke, neurovascular and small vessel disease, cardiovascular genetics and congenital disease, and studies of the conduction system and arrhythmias. Laboratories will be located in the Smith Cardiovascular Research Building on UCSF’s vibrant Mission Bay Campus. Primary academic appointments in an appropriate basic science or clinical department, membership in graduate programs, ongoing partial salary support and generous start-up funding will be provided. A Ph.D. and/or M.D. degree, at least 4-5 years research background, and a robust independent research program are required.
Please visit http://www.cvri.ucsf.edu to learn more. Please apply online at https://aprecruit.ucsf.edu/JPF03011and include a Cover Letter, CV, summaries of research accomplishments (1 page) and future research plans (up to 2 pages), a Statement of Contributions to Diversity (See link in recruitment plan) and contact information for three references. New investigators should arrange for three letters of recommendation to be submitted to the same site. Review of applications will begin on December 1, 2020 and should be submitted prior to that date for full consideration. Contact email@example.com questions.
UC San Francisco seeks candidates whose experience, teaching, research, or community service has prepared them to contribute to our commitment to diversity and excellence. The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status.
When Dr. Ethan Weiss arrived in New York in late April, he started his first shift almost immediately.
Ethan Weiss, MD is part of the twenty-four UC San Francisco health care workers on voluntary assignment in New York City providing urgently needed health care support for patients.
Pui-Yan Kwok, MD, PhD
This award is to celebrate the achievement of a biomedical scientist:
- who has performed extraordinary work in biomedical sciences which has changed the thinking in the human genomics field; and/or
- who has uncovered new insights which brought forth new therapies; and/or
- whose lifetime contribution has significantly impacted the Asia-Pacific region
It is with great sadness that we share the news that John F. Murray, Professor of Medicine emeritus, has passed away.Dr. Murray was tirelessly dedicated to what was then called San Francisco General Hospital (now, Zuckerberg San Francisco General Hospital & Trauma Center), where he was chief of pulmonology from 1966 until 1989.
Natalia Jura, PhD, is focused on how cells transmit signals via protein molecules on their surface to elucidate what goes wrong in cellular communication with cancer. “We are using cryogenic electron microscopy to tackle the structure of a class of these proteins called Receptor Tyrosine Kinases. These are the first studies that will allow us to look at these molecules as a whole piece, understand their architecture, and see how mutations change them.”
Read the Interview.
The genome of human cells looks a lot like a tangled ball of yarn, with tightly wound clumps from which myriad loose strands escape and loop out. But there is order to this tangle, and growing evidence that the genome’s 3D architecture influences the activity of its genes.
Understanding the rules that control gene activity has been the object of a long collaboration between Gladstone Investigators Deepak Srivastava, Benoit Bruneau, Katherine Pollard, Bruce Conklin, and Nevan Krogan, and their UC San Francisco (UCSF) partner Brian Black. Together, they have already found many key regulators of gene activity in the heart.