Binding of SARS-CoV-2 spike protein to ACE2 is disabled by thiol-based drugs; evidence from in vitro SARS-CoV-2 infection studies Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and the SARS-CoV-2 spike protein is an envelope glycoprotein that binds angiotensin converting enzyme 2 as an entry receptor. Read… Continue Reading
Cytoprotection by a naturally occurring variant of ATP5G1 in Arctic ground squirrel neural progenitor cell photo credit to: https://innovativegenomics.org/ news/dengke-ma-extreme-hibernation In major cardiovascular diseases, including stroke and heart attack, loss of blood flow causes loss of oxygen (ischemia), leading to tissue damage and cell deaths. A species of ground squirrels… Continue Reading
The structure of a calsequestrin filament reveals mechanisms of familial arrhythmia In a clinical collaboration with Melvin Scheinman from the UCSF Comprehensive Genetic Arrythmia Program, CVRI investigators Rahul Deo and Natalia Jura, along with MD/PhD trainee Erron Titus, set out to explain how mutations in the calcium-storage protein,… Continue Reading
A digital biomarker of diabetes from smartphone-based vascular signals The global burden of diabetes is rapidly increasing, from 451 million people in 2019 to 693 million by 20451. The insidious onset of type 2 diabetes delays diagnosis and increases morbidity2. Given the multifactorial vascular… Continue Reading
These San Francisco doctors flew to New York to fight the coronavirus — and they have a warning for us When Dr. Ethan Weiss arrived in New York in late April, he started his first shift almost immediately. Read More Continue Reading
UCSF studying stem cells as possible coronavirus treatment UCSF’s Dr. Michael Matthay wasn’t thinking about a pandemic in January when he launched a clinical trial to investigate whether certain stem cells could effectively treat a serious form of respiratory failure. Read more. Continue Reading
Ethan Weiss Answers the Call to New York Ethan Weiss, MD is part of the twenty-four UC San Francisco health care workers on voluntary assignment in New York City providing urgently needed health care support for patients. Ethan's story on his decision to go. Continue Reading
2020 Chen Award for Distinguished Academic Achievement in Human Genetic and Genomic Research Pui-Yan Kwok, MD, PhD This award is to celebrate the achievement of a biomedical scientist: who has performed extraordinary work in biomedical sciences which has changed the thinking in the human genomics field; and/or who… Continue Reading
Remembering John F. Murray, MD It is with great sadness that we share the news that John F. Murray, Professor of Medicine emeritus, has passed away.Dr. Murray was tirelessly dedicated to what was then called San Francisco General Hospital (now,… Continue Reading