Category: News and Events

Electronic Cigarette Use and Myocardial Infarction Among Adults in the US Population Assessment of Tobacco and Health

E-cigarettes are widely promoted as safer alternatives to cigarettes. But a new study by CVRI Center for Tobacco Control Research and Education’s Dharma Bhatta, PhD, and Stanton Glantz, PhD shows just the opposite. Using data from a large national survey, they found that both e-cigarettes and combustible cigarettes are independently associated with increased risk of myocardial infarction (heart attack). Significantly, they found that people who continued to smoke will using e-cigarettes (so-called “dual use,” the most common use pattern, was riskier than using either product alone and switching from combustible cigarettes to e-cigarettes is not associated with
lower risk of myocardial infarction than continuing to smoke. Complete cessation is the only way to reduce risk of myocardial infarction.

The conclude that e-cigarettes should not be promoted or prescribed as a less risky alternative to combustible cigarettes and should not be recommended for smoking cessation among people with or at risk of myocardial infarction.


JAHA Paper

Brian Black – Director of the Cardiovascular Research Institute Appointment

From the Dean



Dear School of Medicine Community,

I am pleased to announce the appointment of Brian L. Black, PhD as the new Director of the Cardiovascular Research Institute (CVRI), effective March 1, 2019.

Since joining UCSF in 1998, Dr. Black has led an internationally recognized basic research laboratory focused on developmental biology, with a primary emphasis on transcriptional control mechanisms. His research group has made several seminal contributions to the understanding of cardiovascular biology. Dr. Black has been part of CVRI leadership for the past 12 years and has served as Interim Director for the last 17 months.

Dr. Black earned his PhD in Microbiology and Immunology from Wake Forest University and conducted his postdoctoral training in Molecular Biology at the University of Texas Southwestern Medical Center in Dallas. Over the past decade, Dr. Black has served in leadership roles in the American Heart Association, the North American Vascular Biology Organization, and as a member the Weinstein Cardiovascular Development Steering Committee. He currently serves on the Editorial Board of the journal Development.

Dr. Black is a highly dedicated teacher and mentor at UCSF. He received the 2014 Haile T. Debas Excellence in Teaching Award for his efforts in medical student teaching. He has served as the CVRI mentoring program coordinator for the past 11 years and is the Principal Investigator of the CVRI’s postdoctoral training grant. Dr. Black is a member of the Biomedical Sciences and Developmental and Stem Cell Biology Graduate Program Executive Committees and currently serves on the Medical Scientist Training Program (MSTP) Council.

As a first-generation college graduate, Dr. Black brings an understanding that the path to higher education and to success in science may not be straightforward and that individuals, particularly those from underrepresented groups, often face obstacles along the way to success in science and medicine. He is committed to promoting the careers of women and individuals from groups that are underrepresented in science and medicine (UIM) and increasing the pipeline of female and UIM scientists as a source of future faculty members.

I am confident that Dr. Black’s vision and leadership will help maintain and expand the excellence of the science at the CVRI, while working to preserve the collegial and cohesive spirit that has made the Institute such a great place to teach, learn, and conduct research.

I would like to thank the search committee, chaired by Dr. Jeff Olgin, for its work in considering an exceptional pool of candidates from across the country for this position.

Talmadge E. King, Jr., MD
Dean, School of Medicine

2018 Packard Fellow Ian Seiple

Packard Fellowships in Science and Engineering Announces New Class of Fellows and Celebrates 30th Anniversary – The David and Lucile Packard Foundation

Ian Seiple
Department of Pharmaceutical Chemistry, University of California, San Francisco
Discipline: Chemistry

Despite significant advances in drug discovery over the past century, many disease-associated biomolecules remain challenging to target with “drug-like” small molecules. The Seiple group develops methods for the design, synthesis, and optimization of molecules that are larger and more structurally complex than traditional therapeutics.

Daniel Minor : A Universal CaM Switch Changes the Kv7 Channel

Kv7 channels are central to the control of excitation in the heart and brain, and harbor  disease mutations associated with arrhythmias, epilepsy, and deafness. The calcium sensor protein calmodulin controls the action of Kv7 channels and provides a key link between channel activity and cellular signaling pathways. In this video, members from the Minor Lab describe their recent studies published in Neuron that uncover a universal mechanism by which calmodulin controls Kv7 channels through an Apo/CaM clamp and a C-lobe-driven switch mechanism.

Video link

Pui-Yan Kwok – Director of the Institute of Biomedical Sciences at the Academia Sinica

Dear IHG Colleagues,

“I am writing to let you know that our esteemed colleague, Pui Kwok, will be assuming the directorship of the Institute for Biomedical Sciences at the Academia Sinica in Taipei, Taiwan, effective October 1. This is a tremendous honor, but also a great new opportunity for Pui to help build a large precision medicine program in Taiwan . . . he will maintain his lab and his significant roles in the IHG, namely as Director of the Genomics Core Facility, member of the Executive Committee, and co-Director of the Genomic Medicine Initiative. He will continue as co-PI on both the NBSeq study and the newly funded CSER2 program. He will also maintain roles within the CVRI and Department of Dermatology.
With his focus on precision medicine in Taiwan, we anticipate that there may be many opportunities for new collaborations between scientists there and here. . .
Let us all congratulate Pui on this recognition, and on the exciting opportunity ahead for him to build a new program to advance precision medicine and human genetics in Asia.”

Congratulatory message excerpts from Neil Risch, Ph.D., Director of the Institute of Human Genetics at UCSF.

Shaun Coughlin – Global Head of Cardiovascular and Metabolism at Novartis

Dear Colleagues,

As is being announced today at Novartis, Shaun Coughlin, MD, PhD, will be joining the biotech giant to become Global Head of Cardiovascular and Metabolism at Novartis Institute for Biomedical Research in Cambridge, Massachusetts. He will start his new position on November 1.

We are sad to lose one of our most respected leaders, yet profoundly grateful for his decades of service and immeasurable contributions to our mission. Dr. Coughlin is an outstanding example of the personal qualities that collectively have propelled UCSF to the top: a relentless drive to push the boundaries of our knowledge, a deep commitment to improve health for our patients, and steadfast devotion in teaching and mentoring the next generation of physician-scientists.

Dr. Coughlin received undergraduate and graduate training at Massachusetts Institute of Technology and an MD from Harvard Medical School. After an internal medicine residency at Massachusetts General Hospital, he joined UCSF for a cardiology fellowship and postdoc in 1984. He became a faculty member here in 1986, director of the Cardiovascular Research Institute at UCSF in 1997, and Distinguished Professor of Cardiovascular Biology and Medicine in 2006.

His research discoveries revealed a mechanism by which proteases regulate cellular behaviors including a key mechanism that controls blood platelet activation and clot formation. This work led to a new medical therapy for preventing heart attacks and strokes and has been honored by the American Heart Association’s Basic Science Award in 2003 and its Research Achievement Award in 2014. Among his numerous other awards are the Bristol-Myers Squibb Cardiovascular Research Award and the Distinguished Career Award from the International Society on Thrombosis and Haemostasis.

He is a member of the National Academy of Sciences, the National Academy of Medicine, and the American Academy of Arts & Sciences.

CVRI Professor and Associate Director Brian Black, PhD, will be serving as interim director. A national search for a permanent new director will be initiated soon.

Shaun Coughlin’s impact on our institution has been invaluable. Please join me in thanking him for his service and wishing him the very best for his new career.


Talmadge E. King, Jr., MD
Dean, School of Medicine

Dean Sheppard – American Academy of Arts and Sciences

Dean Sheppard, MD, has been elected to the American Academy of Arts and Sciences


American Academy of Arts and Sciences

The Academy membership encompasses over 4,600 Fellows and 600 Foreign Honorary Members and reflects the full range of disciplines and professions: mathematics, the physical and biological sciences, medicine, the social sciences and humanities, business, government, public affairs, and the arts. Among the Academy’s Fellows are more than 250 Nobel laureates and 60 Pulitzer Prize winners.


Pui-Yan Kwok – MBSAA Distinguished Service Award

The Distinguished Service Award recognizes alumni who have brought honor and distinction to the Division of the Biological Sciences and to the University of Chicago by demonstrating outstanding leadership in-and making significant contributions to-the biological sciences or medicine through research, clinical care, health service administration, public and professional service, or civic duties. The Distinguished Service Award for Early Achievement requirements includes the criteria above and alumni who graduated within the past fifteen years are eligible.


John Fahy – Elected to the Association of American Physicians

The Association of American Physicians is a nonprofit, professional organization founded in 1885 by seven physicians, including Dr. William Osler, for “the advancement of scientific and practical medicine.” Now the Association is composed of over 1300 active members and approximately 600 emeritus and honorary members from the United States, Canada and other countries. The goals of its members include the pursuit of medical knowledge, and the advancement through experimentation and discovery of basic and clinical science and their application to clinical medicine. Each year, individuals having attained excellence in achieving these goals, are recognized by nomination for membership by the Council of the Association. Their election gives them the opportunity to share their scientific discoveries and contributions with their colleagues at the annual meeting.

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Pamela Ling – Elected to American Society for Clinical Investigation

Five UC San Francisco faculty members have been elected to the American Society for Clinical Investigation (ASCI) after a highly competitive nomination process.

The ASCI, which is one of the oldest medical honor societies in the United States, received 160 membership nominations for 2016 and recommended 74 nominees for election.

The five faculty members elected are:
Pamela M. Ling, MD, MPH, a professor in the Department of Internal Medicine, studies tobacco industry marketing strategies targeting young adults, women, and other high-risk population, and new smokeless and novel tobacco product marketing strategies the UCSF Center for Tobacco Control Research and Education.

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Kamran Atabai – Elected to American Society for Clinical Investigation

Five UC San Francisco faculty members have been elected to the American Society for Clinical Investigation (ASCI) after a highly competitive nomination process.

The ASCI, which is one of the oldest medical honor societies in the United States, received 160 membership nominations for 2016 and recommended 74 nominees for election.

The five faculty members elected are:

Kamran Atabai, MD, an investigator in the Cardiovascular Research Institute at UCSF, where his research interests include apoptotic cell and collagen clearance in health and disease. The work of his laboratory includes examining the role of the extracellular matrix in regulating metabolism, tissue remodeling and smooth muscle function as these processes relate to cardiovascular disease.

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