Category: Site Parnassus

Harold A Chapman, M.D.

Chapman

Research Interests:
Antigen presentation by MHC class II molecules important to immunity and autoimmunity and extracellular matrix remodeling important to cell migration and tissue repair

Summary:
The Chapman lab is focused on basic and biomedical aspects of lung injury and tissue remodeling. Currently the lab is exploring the process of epithelial to mesenchymal transition (EMT) in the lung, a process whereby epithelial lining cells of the lung become reprogrammed to migrate and activate a fibrotic program. The process is also implicated in progression of lung cancer and the lab is exploring the mechanisms by which EMT contributes to lung fibrosis and cancer metastasis.

 

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Carolyn S. Calfee, M.D., MAS

Calfee

Research Interests:
Acute lung injury, acute respiratory distress syndrome, cigarette smoking, molecular epidemiology, biomarkers

Summary:
Dr. Calfee’s primary academic focus is the prevention, diagnosis, prognosis, and treatment of acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS). Current research projects include: (1) the role of biomarkers in investigating ALI/ARDS pathogenesis, early diagnosis, treatment, and prognosis; (2) the role of cigarette smoke exposure in susceptibility to lung injury; and (3) novel treatments for acute lung injury.

 

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Elias H Botvinick, M.D.

Botvinick

Research Interests:
Nuclear medicine, nuclear cardiology, PET/CT, MRI, CT, cardiac cardiology, echocardiology, nuclear magnetic resonance, cardiovascular imaging, stress testimg, heart, myocardial perfusion, scintigraphy, coronary, sychrony, sychronization

Summary:
My research centers on a collaborative effort to develop noninvasive imaging methods for the identification and evaluation of cardiac anatomy and pathophysiology, and apply them to the diagnosis, risk stratification and monitoring of clinical disease. The work is centered on nuclear medicine methods, PET and SPECT, as well as echocardiography, MRI, and CT.

 

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Paul D Blanc, M.D., MSPH

Blanc

Research Interests:

Epidemiology of occupational lung disease, Asthma outcomes and Occupational toxicology

Summary:
Dr. Blanc’s research addresses the impact of work-related and environmental exposures on human health, in particular respiratory diseases such as asthma, and COPD. His work focuses on the role that such exposures can play in causing disease and also how ongoing stressors can aggravate pre-existing disease and lead to disability

Prescott G Woodruff, M.D., M.P.H.

Woodruff

Research Interests:
Genomics, Asthma, Chronic Obstructive Pulmonary Disease, Stereology, Epidemiology, Clinical Trials, Medical Education

Summary:
My research relates to two common lung diseases, asthma and chronic obstructive pulmonary disease, and falls into three specific categories: 1) the identification of molecular sub-phenotypes of these diseases, 2) the elucidation of mechanisms of inflammation and remodeling in these diseases and 3) clinical trials of novel therapies.

Allison Wanting Xu, M.Sc., Ph.D.

Xu

Research Interests:
Hypothalamic regulation of energy balance, obesity and type 2 diabetes

Summary:
Our lab’s major research focus is to understand the mechanisms by which energy balance is regulated. We use a combination of mouse genetics, whole body physiology and real time imaging approaches to elucidate the function of specific hypothalamic neurons and how they integrate peripheral metabolic signals under distinct physiologic conditions.

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