
Professor
Medicine
Email
Faculty Type
Affiliate Faculty
Research Interests: Asthma, allergy and inflammation; functional genomics Summary: Asthma is an increasingly common disease that affects about 20 million American children and adults. We are working to understand how proteins made by the immune system act within the lungs to cause some of the most important problems experienced by people with asthma. We also work on understanding newly discovered ways in which genes are turned on and off during health and disease.
Publications
A multi-omics recovery factor predicts long COVID in the IMPACC study.
The Journal of clinical investigation
Mucus Plugs Correlate with Small Airway Remodelling in Asthma: A Case-Control Study.
American journal of respiratory and critical care medicine
Baseline predictors for 28-day COVID-19 severity and mortality among hospitalized patients: results from the IMPACC study.
Frontiers in medicine
MICBG406A polymorphism reduces risk of mechanical ventilation and death during viral acute lung injury.
JCI insight
Empiric Azithromycin in COVID-19 Impacts the Respiratory Microbiome and Antimicrobial Resistome without Anti-inflammatory Benefit.
Research square
Type 2 immune responses are associated with less severe COVID-19 in a hospitalized cohort.
The journal of allergy and clinical immunology. Global
Minimalistic Transcriptomic Signatures Permit Accurate Early Prediction of COVID-19 Mortality.
medRxiv : the preprint server for health sciences
Peripheral blood mononuclear cell transcriptomic trajectories reveal dynamic regulation of inflammatory actors in delirium.
medRxiv : the preprint server for health sciences
Identification of a multi-omics factor predictive of long COVID in the IMPACC study.
bioRxiv : the preprint server for biology
Machine learning models predict long COVID outcomes based on baseline clinical and immunologic factors.
medRxiv : the preprint server for health sciences
Unraveling SARS-CoV-2 Host-Response Heterogeneity through Longitudinal Molecular Subtyping.
bioRxiv : the preprint server for biology
Chronic Viral Reactivation and Associated Host Immune Response and Clinical Outcomes in Acute COVID-19 and Post-Acute Sequelae of COVID-19.
bioRxiv : the preprint server for biology
Microbial dynamics and pulmonary immune responses in COVID-19 secondary bacterial pneumonia.
Nature communications
Immediate myeloid depot for SARS-CoV-2 in the human lung.
Science advances
Distinct pulmonary and systemic effects of dexamethasone in severe COVID-19.
Nature communications
Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study.
Nature communications
GCLiPP: global crosslinking and protein purification method for constructing high-resolution occupancy maps for RNA binding proteins.
Genome biology
SARS-CoV-2 infection of airway organoids reveals conserved use of Tetraspanin-8 by Ancestral, Delta, and Omicron variants.
Stem cell reports
Fluorogenic reporter enables identification of compounds that inhibit SARS-CoV-2.
Nature microbiology
Genomic characterization and therapeutic utilization of IL-13-responsive sequences in asthma.
Cell genomics
COVID-19-associated Lung Microvascular Endotheliopathy: A "From the Bench" Perspective.
American journal of respiratory and critical care medicine
Plasma SARS-CoV-2 nucleocapsid antigen levels are associated with progression to severe disease in hospitalized COVID-19.
Critical care (London, England)
Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: Results from the IMPACC study.
EBioMedicine
Mass cytometry reveals a conserved immune trajectory of recovery in hospitalized COVID-19 patients.
Immunity
Immediate myeloid depot for SARS-CoV-2 in the human lung.
Research square
Immediate myeloid depot for SARS-CoV-2 in the human lung.
bioRxiv : the preprint server for biology
The Type 2 Asthma Mediator IL-13 Inhibits Severe Acute Respiratory Syndrome Coronavirus 2 Infection of Bronchial Epithelium.
American journal of respiratory cell and molecular biology
A conserved immune trajectory of recovery in hospitalized COVID-19 patients.
bioRxiv : the preprint server for biology
Massively parallel analysis of human 3' UTRs reveals that AU-rich element length and registration predict mRNA destabilization.
G3 (Bethesda, Md.)
Impaired immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19.
medRxiv : the preprint server for health sciences
Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS.
Nature communications
Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19.
Science translational medicine
Publisher Correction: Global absence and targeting of protective immune states in severe COVID-19.
Nature
SARS-CoV-2 infection studies in lung organoids identify TSPAN8 as novel mediator.
bioRxiv : the preprint server for biology
Impaired immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19.
Research square
Longitudinal single-cell epitope and RNA-sequencing reveals the immunological impact of type 1 interferon autoantibodies in critical COVID-19: Anti-IFN antibodies in critical COVID-19 correlate with poor ISG response and upregulation of LAIR1 surface prot
bioRxiv : the preprint server for biology
Flow-Cytometric Analysis and Purification of Airway Epithelial-Cell Subsets.
American journal of respiratory cell and molecular biology
The type 2 asthma mediator IL-13 inhibits SARS-CoV-2 infection of bronchial epithelium.
bioRxiv : the preprint server for biology
Mapping the 17q12-21.1 Locus for Variants Associated with Early-Onset Asthma in African Americans.
American journal of respiratory and critical care medicine
COVID-19 ARDS is characterized by a dysregulated host response that differs from cytokine storm and is modified by dexamethasone.
Research square
Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men.
Cell stem cell
Global Absence and Targeting of Protective Immune States in Severe COVID-19.
bioRxiv : the preprint server for biology
Whole-Genome Sequencing Identifies Novel Functional Loci Associated with Lung Function in Puerto Rican Youth.
American journal of respiratory and critical care medicine
Steps toward Cell Therapy for Cystic Fibrosis.
American journal of respiratory cell and molecular biology
Development of allergic airway immunity depends on MARCH1-mediated ubiquitination of MHCII and CD86 in dendritic cells.
The Journal of Immunology
Efficient RNP-directed Human Gene Targeting Reveals SPDEF Is Required for IL-13-induced Mucostasis.
American journal of respiratory cell and molecular biology
Comparison of Reproducibility, Accuracy, Sensitivity, and Specificity of miRNA Quantification Platforms.
Cell reports
The airway epithelium in asthma.
Advances in immunology
The epigenetic regulator ATF7ip inhibits Il2 expression, regulating Th17 responses.
The Journal of experimental medicine
A massively parallel 3' UTR reporter assay reveals relationships between nucleotide content, sequence conservation, and mRNA destabilization.
Genome research
Singling out Th2 cells in eosinophilic esophagitis.
The Journal of clinical investigation
Putting Mucins on the Map.
American journal of respiratory and critical care medicine
An airway epithelial IL-17A response signature identifies a steroid-unresponsive COPD patient subgroup.
The Journal of clinical investigation
Integrative approach identifies corticosteroid response variant in diverse populations with asthma.
The Journal of allergy and clinical immunology
Tissue signals imprint ILC2 identity with anticipatory function.
Nature immunology
Erratum: Comprehensive multi-center assessment of small RNA-seq methods for quantitative miRNA profiling.
Nature biotechnology
Comprehensive multi-center assessment of small RNA-seq methods for quantitative miRNA profiling.
Nature biotechnology
Widespread Effects of Chemokine 3' Untranslated Regions on mRNA Degradation and Protein Production in Human Cells.
Journal of immunology (Baltimore, Md. : 1950)
IFN-stimulated Gene Expression, Type 2 Inflammation, and Endoplasmic Reticulum Stress in Asthma.
American journal of respiratory and critical care medicine
CD40 Mediates Maturation of Thymic Dendritic Cells Driven by Self-Reactive CD4+ Thymocytes and Supports Development of Natural Regulatory T Cells.
Journal of immunology (Baltimore, Md. : 1950)
Airway Mucus and Asthma: The Role of MUC5AC and MUC5B.
Journal of clinical medicine
CRISPR-Cas9-mediated functional dissection of 3'-UTRs.
Nucleic Acids Research
Metabolomics analysis identifies sex-associated metabotypes of oxidative stress and the autotaxin-lysoPA axis in COPD.
The European respiratory journal
Intelectin contributes to allergen-induced IL-25, IL-33, and TSLP expression and type 2 response in asthma and atopic dermatitis.
Mucosal immunology
A tissue checkpoint regulates type 2 immunity.
Nature immunology
Chitin-Induced Airway Epithelial Cell Innate Immune Responses Are Inhibited by Carvacrol/Thymol.
PloS one
Epithelial tethering of MUC5AC-rich mucus impairs mucociliary transport in asthma.
The Journal of clinical investigation
Linoleic acid-derived lipid mediators increase in a female-dominated subphenotype of COPD.
The European respiratory journal
Massively Parallel Identification of Regulatory Variants in Asthma.
Annals of the American Thoracic Society
Abstract B65: Dissecting the tumor myeloid compartment reveals rare activating antigen presenting cells, critical for T cell immunity.
Tumor Microenvironment
The Endoplasmic Reticulum Resident Protein AGR3. Required for Regulation of Ciliary Beat Frequency in the Airway.
American journal of respiratory cell and molecular biology
Increased expression of neutrophil-related genes in patients with early sepsis-induced ARDS.
American journal of physiology. Lung cellular and molecular physiology
Epithelial interleukin-25 is a key mediator in Th2-high, corticosteroid-responsive asthma.
American journal of respiratory and critical care medicine
Erratum: Corrigendum: The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance.
Nature immunology
IL-17 and "TH2-high" asthma: Adding fuel to the fire?
The Journal of allergy and clinical immunology
Selective targeting of TGF-β activation to treat fibroinflammatory airway disease.
Science translational medicine
The cell biology of asthma.
The Journal of Cell Biology
Massively parallel functional annotation of 3' untranslated regions.
Nature biotechnology
The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance.
Nature immunology
Asthmatics with exacerbation during acute respiratory illness exhibit unique transcriptional signatures within the nasal mucosa.
Genome medicine
Hands-on workshops as an effective means of learning advanced technologies including genomics, proteomics and bioinformatics.
Genomics, proteomics & bioinformatics
Age-dependent hepatic lymphoid organization directs successful immunity to hepatitis B.
The Journal of clinical investigation
Apolipoprotein A1 potentiates lipoxin A4 synthesis and recovery of allergen-induced disrupted tight junctions in the airway epithelium.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Molecular basis of selective atrial fibrosis due to overexpression of transforming growth factor-β1.
Cardiovascular research
T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire.
The Journal of Cell Biology
T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire.
The Journal of experimental medicine
Altered microRNA profiles in bronchoalveolar lavage fluid exosomes in asthmatic patients.
The Journal of allergy and clinical immunology
An integrated nano-scale approach to profile miRNAs in limited clinical samples.
American journal of clinical and experimental immunology
Airway epithelial miRNA expression is altered in asthma.
American journal of respiratory and critical care medicine
Network analysis identifies a putative role for the PPAR and type 1 interferon pathways in glucocorticoid actions in asthmatics.
BMC medical genomics
AGR2 is induced in asthma and promotes allergen-induced mucin overproduction.
American journal of respiratory cell and molecular biology
The αvβ6 integrin modulates airway hyperresponsiveness in mice by regulating intraepithelial mast cells.
The Journal of clinical investigation
The mammalian target of rapamycin regulates cholesterol biosynthetic gene expression and exhibits a rapamycin-resistant transcriptional profile.
Proceedings of the National Academy of Sciences of the United States of America
Toward a systematic understanding of mRNA 3' untranslated regions.
Proceedings of the American Thoracic Society
Expression of IL-4 receptor alpha on smooth muscle cells is not necessary for development of experimental allergic asthma.
The Journal of allergy and clinical immunology
Systemically dispersed innate IL-13-expressing cells in type 2 immunity.
Proceedings of the National Academy of Sciences of the United States of America
Intelectin is required for IL-13-induced monocyte chemotactic protein-1 and -3 expression in lung epithelial cells and promotes allergic airway inflammation.
American journal of physiology. Lung cellular and molecular physiology
Distinct roles of FOXA2 and FOXA3 in allergic airway disease and asthma.
American journal of respiratory and critical care medicine
Thymic OX40 expression discriminates cells undergoing strong responses to selection ligands.
Journal of immunology (Baltimore, Md. : 1950)
The protein disulfide isomerase AGR2 is essential for production of intestinal mucus.
Proceedings of the National Academy of Sciences of the United States of America
CD11b+ myeloid cells are the key mediators of Th2 cell homing into the airway in allergic inflammation.
Journal of immunology (Baltimore, Md. : 1950)
The epithelial anion transporter pendrin is induced by allergy and rhinovirus infection, regulates airway surface liquid, and increases airway reactivity and inflammation in an asthma model.
Journal of immunology (Baltimore, Md. : 1950)
Disease-specific gene expression profiling in multiple models of lung disease.
American journal of respiratory and critical care medicine
Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients.
The Journal of clinical investigation
Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids.
Proceedings of the National Academy of Sciences of the United States of America
Integrin beta6 mediates phospholipid and collectin homeostasis by activation of latent TGF-beta1.
American journal of respiratory cell and molecular biology
Progress toward a systems biology approach to acute lung injury.
American journal of physiology. Lung cellular and molecular physiology
Genomics and proteomics of lung disease: conference summary.
American journal of physiology. Lung cellular and molecular physiology
Influenza virus infection causes global respiratory tract B cell response modulation via innate immune signals.
Journal of immunology (Baltimore, Md. : 1950)
Delayed goblet cell hyperplasia, acetylcholine receptor expression, and worm expulsion in SMC-specific IL-4Ralpha-deficient mice.
PLoS pathogens
Microarray analysis of a mouse model of transfusion-related acute lung injury (TRALI) reveals prominent increased expression of neutrophil-derived chemokines.
The FASEB Journal
IL-13 and epidermal growth factor receptor have critical but distinct roles in epithelial cell mucin production.
American journal of respiratory cell and molecular biology
The asthma channel? Stay tuned . . .
American journal of respiratory and critical care medicine
A distinctive alveolar macrophage activation state induced by cigarette smoking.
American journal of respiratory and critical care medicine
IL-4 receptor signaling in Clara cells is required for allergen-induced mucus production.
Journal of immunology (Baltimore, Md. : 1950)
Dissecting asthma using focused transgenic modeling and functional genomics.
The Journal of allergy and clinical immunology
Tissue-selective mast cell reconstitution and differential lung gene expression in mast cell-deficient Kit(W-sh)/Kit(W-sh) sash mice.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Aspergillus antigen induces robust Th2 cytokine production, inflammation, airway hyperreactivity and fibrosis in the absence of MCP-1 or CCR2.
Respiratory research
Asthma investigators begin to reap the fruits of genomics.
Genome biology
Abnormal alveolar development associated with elevated adenine nucleosides.
American journal of respiratory cell and molecular biology
Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma.
Nature medicine
Activated alpha4 integrins are preferentially expressed on immature thymocytes and activated T cells.
Developmental immunology
The Th2 lymphocyte products IL-4 and IL-13 rapidly induce airway hyperresponsiveness through direct effects on resident airway cells.
American journal of respiratory cell and molecular biology
Interleukin-13 induces dramatically different transcriptional programs in three human airway cell types.
American journal of respiratory cell and molecular biology
Effect of serial-day exposure to nitrogen dioxide on airway and blood leukocytes and lymphocyte subsets.
The European respiratory journal
Intraepithelial lymphocytes in the lung: a neglected lymphocyte population.
American journal of respiratory cell and molecular biology
Recent advances in molecular biological techniques and their relevance to pulmonary research.
Thorax
Secondary lymphoid-tissue chemokine (SLC) stimulates integrin alpha 4 beta 7-mediated adhesion of lymphocytes to mucosal addressin cell adhesion molecule-1 (MAdCAM-1) under flow.
Journal of immunology (Baltimore, Md. : 1950)
Integrin beta cytoplasmic domains differentially bind to cytoskeletal proteins.
The Journal of biological chemistry
Presentation of integrins on leukocyte microvilli: a role for the extracellular domain in determining membrane localization.
The Journal of Cell Biology
Structure-function analysis of the integrin beta 7 subunit: identification of domains involved in adhesion to MAdCAM-1.
Journal of immunology (Baltimore, Md. : 1950)
Differential expression of homing molecules on recirculating lymphocytes from sheep gut, peripheral, and lung lymph.
Journal of immunology (Baltimore, Md. : 1950)
Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin.
The Journal of Cell Biology
Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity.
The Journal of experimental medicine
Intraepithelial lymphocytes. Scratching the surface.
Current biology : CB
Expression and function of the MAdCAM-1 receptor, integrin alpha 4 beta 7, on human leukocytes.
Journal of immunology (Baltimore, Md. : 1950)
Lung epithelial lining fluid T cell subsets defined by distinct patterns of beta 7 and beta 1 integrin expression.
American journal of respiratory cell and molecular biology
Polymerase chain reaction cloning with degenerate primers: homology-based identification of adhesion molecules.
Methods in enzymology
Selective expression of integrin alpha 4 beta 7 on a subset of human CD4+ memory T cells with Hallmarks of gut-trophism.
Journal of immunology (Baltimore, Md. : 1950)
How do integrins integrate? The role of cell adhesion receptors in differentiation and development.
American journal of respiratory cell and molecular biology
Role of integrin alpha 4 beta 7/alpha 4 beta P in lymphocyte adherence to fibronectin and VCAM-1 and in homotypic cell clustering.
The Journal of Cell Biology
Novel integrin alpha and beta subunit cDNAs identified in airway epithelial cells and lung leukocytes using the polymerase chain reaction.
American journal of respiratory cell and molecular biology
Complete amino acid sequence of an integrin beta subunit (beta 7) identified in leukocytes.
The Journal of biological chemistry
Complete amino acid sequence of a novel integrin beta subunit (beta 6) identified in epithelial cells using the polymerase chain reaction.
The Journal of biological chemistry
Effect of exercise rate and route of inhalation on sulfur-dioxide-induced bronchoconstriction in asthmatic subjects.
The American review of respiratory disease
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