News

Congratulations to CVRI 2025 Catalyst Awardees, Roshanak Irannejad and Arun Padmanabhan!

Congratulations to CVRI investigators Roshanak Irranejad and Arun Padmanabhan on being recipients of the 2025 Catalyst Awards! UCSF principal investigators with promising translational projects designed for patient benefit and with commercial potential spanning therapeutics, diagnostics, medical...

Dan Minor receives Kenneth S. Cole Award!

Congratulations to Dan Minor for being the recipient of the Kenneth S. Cole Award for his work in Ion Channel Biophysics.

Chromatin remodelling drives immune cell-fibroblast communication in heart failure.

Chronic inflammation and tissue fibrosis are common responses that worsen organ function, yet the molecular mechanisms governing their cross-talk are poorly understood. In diseased organs, stress-induced gene expression changes fuel maladaptive cell state transitions1 and pathological interaction...

Self-extinguishing relay waves enable homeostatic control of human neutrophil swarming.

Neutrophils collectively migrate to sites of injury and infection. How these swarms are coordinated to ensure the proper level of recruitment is unknown. Using an ex vivomodel of infection, we show that human neutrophil swarming is organized by multiple pulsatile chemoattractant waves. These waves...

John Clements, Whose Science Transformed Newborn Care, Dies at 101

John Clements, MD, whose scientific discoveries helped save millions of newborns around the world from respiratory distress syndrome and whose boundless appetite for learning helped create the interdisciplinary culture at UC San Francisco, has died at the age of 101.

Variants in tubule epithelial regulatory elements mediate most heritable differences in human kidney function

Kidney failure, the decrease of kidney function below a threshold necessary to support life, is a major cause of morbidity and mortality. We performed a genome-wide association study (GWAS) of 406,504 individuals in the UK Biobank, identifying 430 loci affecting kidney function in middle-aged...

Rare coding variant analysis for human diseases across biobanks and ancestries.

Large-scale sequencing has enabled unparalleled opportunities to investigate the role of rare coding variation in human phenotypic variability. Here, we present a pan-ancestry analysis of sequencing data from three large biobanks, including the All of Us research program. Using mixed-effects models...

Clonal hematopoiesis, cardiovascular events and treatment benefit in 63,700 individuals from five TIMI randomized trials.

Clonal hematopoiesis of indeterminate potential (CHIP) has been associated with an increased risk of cardiovascular (CV) disease in the general population. Currently, it is unclear whether this association is observed in large clinical trial cohorts with a high burden of existing CV disease or...

Opposing GPCR signaling programs protein intake setpoint in Drosophila.

Animals defend a target level for their fundamental needs, including food, water, and sleep. Deviation from the target range, or “setpoint,” triggers motivated behaviors to eliminate that difference. Whether and how the setpoint itself is encoded remains enigmatic for all motivated behaviors.

Remodelling of the translatome controls diet and its impact on tumorigenesis.

Fasting is associated with a range of health benefits. How fasting signals elicit changes in the proteome to establish metabolic programmes remains poorly understood. Here we show that hepatocytes selectively remodel the translatome while global translation is paradoxically downregulated during...