Christopher Allen, PhD

Associate Professor, Cardiovascular Research Institute
Research Interests: 
Cellular dynamics of allergic immune responses underlying asthma

Research Summary:
Asthma is a chronic lung disease that afflicts tens of millions of people in the US and is particularly prevalent in children. In the majority of individuals with asthma, underlying allergic inflammation in the lung makes a significant contribution to the disease etiology. In order to understand the cellular and molecular events driving this allergic inflammation, we use advanced technologies, including two-photon microscopy and flow cytometry, to directly visualize and characterize inflammatory cells in the lungs as well as in lymphoid organs that 'prime' cells for immune responses in the respiratory tract. A particular emphasis of our research is on the generation and function of the IgE class of antibodies that contribute to allergic responses.

Address: 
555 Mission Bay Blvd South, Rm 452R
UCSF Box 3122
San Francisco, CA 94158
United States
Phone: 
+1 415 476-5178
Faculty Type: 
Core CVRI Faculty
Publications: 

BCR ligation selectively inhibits IgE class switch recombination.(link is external)

bioRxiv : the preprint server for biology

Wade-Vallance AK, Yang Z, Libang JB, Krishnapura AR, Jung JB, Matcham EW, Robinson MJ, Allen CDC

B cell receptor ligation induces IgE plasma cell elimination.(link is external)

The Journal of experimental medicine

Wade-Vallance AK, Yang Z, Libang JB, Robinson MJ, Tarlinton DM, Allen CDC

Macrophage Cx43 Is Necessary for Fibroblast Cytosolic Calcium and Lung Fibrosis After Injury.(link is external)

Frontiers in immunology

Bhattacharyya A, Torre P, Yadav P, Boostanpour K, Chen TY, Tsukui T, Sheppard D, Muramatsu R, Seed RI, Nishimura SL, Jung JB, Tang XZ, Allen CDC, Bhattacharya M

CD97 promotes spleen dendritic cell homeostasis through the mechanosensing of red blood cells.(link is external)

Science (New York, N.Y.)

Liu D, Duan L, Rodda LB, Lu E, Xu Y, An J, Qiu L, Liu F, Looney MR, Yang Z, Allen CDC, Li Z, Marson A, Cyster JG

Features of B Cell Responses Relevant to Allergic Disease.(link is external)

Journal of immunology (Baltimore, Md. : 1950)

Allen CDC

MicroRNA-directed pathway discovery elucidates an miR-221/222-mediated regulatory circuit in class switch recombination.(link is external)

The Journal of experimental medicine

Wigton EJ, Mikami Y, McMonigle RJ, Castellanos CA, Wade-Vallance AK, Zhou SK, Kageyama R, Litterman A, Roy S, Kitamura D, Dykhuizen EC, Allen CDC, Hu H, O'Shea JJ, Ansel KM

Intrinsic and extrinsic regulation of IgE B cell responses.(link is external)

Current opinion in immunology

Wade-Vallance AK, Allen CDC

Show more