Research Summary:
The ability to regenerate damaged or lost tissues varies dramatically across organisms and developmental stages. For example, heart regeneration is robust in adult zebrafish and newborn mouse while very limited in adult mouse and human. This presents a particular problem for patients with a heart attack who suffer from a significant loss of heart muscle cells and subsequent life-threatening functional deterioration of the heart. By taking a comparative approach to study regenerative versus non-regenerative heart repair processes in zebrafish and mouse, we seek to uncover ancestrally conserved injury responses and more importantly, to identify the signals blocking regeneration in the mammalian heart and consequently new treatment strategies for heart diseases.
Publications
Ophthalmic acid is a bloodborne metabolite that contributes to age-induced cardiomyocyte hypertrophy.
PD-1-PD-L1 immunomodulatory pathway regulates cardiac regeneration.
Quantitative Three-dimensional Label-free Digital Holographic Imaging of Cardiomyocyte Size, Ploidy, and Cell Division.
Two decades of heart regeneration research: Cardiomyocyte proliferation and beyond.
Unlocking cardiomyocyte renewal potential for myocardial regeneration therapy.
Visualization of regenerating and repairing hearts.
Mending a broken heart with novel cardiogenic small molecules.
Genetic, Epigenetic, and Post-Transcriptional Basis of Divergent Tissue Regenerative Capacities Among Vertebrates.
Vertebrate cardiac regeneration: evolutionary and developmental perspectives.
Hormonal control of cardiac regenerative potential.
The coevolutionary process of restaurant CSR in the time of mega disruption.
In vitro and in vivo roles of glucocorticoid and vitamin D receptors in the control of neonatal cardiomyocyte proliferative potential.
Lamin B2, Guardian of Cardiomyocyte Nuclear Division.
Evidence for hormonal control of heart regenerative capacity during endothermy acquisition.
Unconventional Functions of Muscles in Planarian Regeneration.
Insights into nuclear dynamics using live-cell imaging approaches.
Isolation, Culture and Transduction of Adult Mouse Cardiomyocytes.
C/EBP transcription factors mediate epicardial activation during heart development and injury.
Biotinylation of Cell Surface Proteins.
T Cell Calcium Mobilization Study (Flow Cytometry).
NFAT binding and regulation of T cell activation by the cytoplasmic scaffolding Homer proteins.
STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels.
STIM1 carboxyl-terminus activates native SOC, I(crac) and TRPC1 channels.
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