Guo Huang, PhD

Associate Professor, Cardiovascular Research Institute
Research Interests: 
Organ regeneration and extreme physiology in development and evolution

Research Summary:
The ability to regenerate damaged or lost tissues varies dramatically across organisms and developmental stages. For example, heart regeneration is robust in adult zebrafish and newborn mouse while very limited in adult mouse and human. This presents a particular problem for patients with a heart attack who suffer from a significant loss of heart muscle cells and subsequent life-threatening functional deterioration of the heart. By taking a comparative approach to study regenerative versus non-regenerative heart repair processes in zebrafish and mouse, we seek to uncover ancestrally conserved injury responses and more importantly, to identify the signals blocking regeneration in the mammalian heart and consequently new treatment strategies for heart diseases.

Address: 
555 & 535 Mission Bay Blvd Sou, Rm 352V
UCSF Box 3120
San Francisco, CA 94158
United States
Phone: 
+1 415 502-2873
Faculty Type: 
Core CVRI Faculty
Publications: 

Ophthalmic acid is a bloodborne metabolite that contributes to age-induced cardiomyocyte hypertrophy.(link is external)

bioRxiv : the preprint server for biology

Mehdipour M, Park S, Wei W, Long JZ, Huang GN

PD-1-PD-L1 immunomodulatory pathway regulates cardiac regeneration.(link is external)

Nature Cardiovascular Research

Qin J, Huang GN, Moslehi J

An injury-responsive mmp14b enhancer is required for heart regeneration.(link is external)

Science advances

Zlatanova I, Sun F, Wu RS, Chen X, Lau BH, Colombier P, Sinha T, Celona B, Xu SM, Materna SC, Huang GN, Black BL

Quantitative Three-dimensional Label-free Digital Holographic Imaging of Cardiomyocyte Size, Ploidy, and Cell Division.(link is external)

bioRxiv : the preprint server for biology

Park S, Huang H, Ross I, Moreno J, Khyeam S, Simmons J, Huang GN, Payumo AY

Unlocking cardiomyocyte renewal potential for myocardial regeneration therapy.(link is external)

Journal of molecular and cellular cardiology

Mehdipour M, Park S, Huang GN

Visualization of regenerating and repairing hearts.(link is external)

Clinical science (London, England : 1979)

Powers N, Huang GN

Mending a broken heart with novel cardiogenic small molecules.(link is external)

Cell regeneration (London, England)

Powers N, Huang GN

Adrenergic-Thyroid Hormone Interactions Drive Postnatal Thermogenesis and Loss of Mammalian Heart Regenerative Capacity.(link is external)

Circulation

Payumo AY, Chen X, Hirose K, Chen X, Hoang A, Khyeam S, Yu H, Wang J, Chen Q, Powers N, Chen L, Bigley RB, Lovas J, Hu G, Huang GN

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