Akiko Hata, PhD

Professor

Cardiovascular Research Institute

Research Interests

Roll of growth factor and stress signal in cardiovascular disease

Faculty Type

Core CVRI Faculty

Research Summary:
Research in the Hata lab focuses on the role of the BMP/TGF signaling pathway in the maintenance of vascular homeostasis, control of vascular injury repair, and pathogenesis of vascular diseases, including idiopathic pulmonary arterial hypertension (IPAH), hereditary hemorrhagic telangiectasia (HHT), restenosis, and atherosclerosis. Our approach is to study gene mutations identified among patients with IPAH or HHT and elucidate how these gene products affect the signaling pathway as well as vascular physiology using both cell culture and animal models.

Publications

Reversal of pulmonary veno-occlusive disease phenotypes by inhibition of the integrated stress response

Nature Cardiovasc. Res.

Amit Prabhakar, Rahul Kumar, Meetu Wadhwa, Prajakta Ghatpande, Jingkun Zhang, Ziwen Zhao, Carlos O Lizama, Bhushan N Kharbikar, Stefan Gräf, Carmen M Treacy, Nicholas W Morrell, Brian B Graham, Giorgio Lagna, Akiko Hata

Essential role of the amino-terminal region of Drosha for the Microprocessor function.

iScience

Prabhakar A, Hu S, Tang J, Ghatpande P, Lagna G, Jiang X, Hata A

Development and Characterization of Type I, Type II, and Type III LIM-Kinase Chemical Probes.

Journal of medicinal chemistry

Hanke T, Mathea S, Woortman J, Salah E, Berger BT, Tumber A, Kashima R, Hata A, Kuster B, Müller S, Knapp S

Combination Therapy with STAT3 Inhibitor Enhances SERCA2a-Induced BMPR2 Expression and Inhibits Pulmonary Arterial Hypertension.

International journal of molecular sciences

Bisserier M, Katz MG, Bueno-Beti C, Brojakowska A, Zhang S, Gubara S, Kohlbrenner E, Fazal S, Fargnoli A, Dorfmuller P, Humbert M, Hata A, Goukassian DA, Sassi Y, Hadri L

Structural basis for ALK2/BMPR2 receptor complex signaling through kinase domain oligomerization.

Nature communications

Agnew C, Ayaz P, Kashima R, Loving HS, Ghatpande P, Kung JE, Underbakke ES, Shan Y, Shaw DE, Hata A, Jura N

How do you mend inactive tumor suppressor mutants? You glue them!

Cell chemical biology

Hata A, Lagna G

Control of ribosomal protein synthesis by the Microprocessor complex.

Science signaling

Jiang X, Prabhakar A, Van der Voorn SM, Ghatpande P, Celona B, Venkataramanan S, Calviello L, Lin C, Wang W, Black BL, Floor SN, Lagna G, Hata A

Deletion of Mediator 1 suppresses TGFβ signaling leading to changes in epidermal lineages and regeneration.

PloS one

Oda Y, Nguyen T, Hata A, Meyer MB, Pike JW, Bikle DD

Deregulation of Drosha in the pathogenesis of hereditary hemorrhagic telangiectasia.

Current opinion in hematology

Hata A, Lagna G

Bone morphogenetic protein signaling is required for RAD51-mediated maintenance of genome integrity in vascular endothelial cells.

Communications biology

Vattulainen-Collanus S, Southwood M, Yang XD, Moore S, Ghatpande P, Morrell NW, Lagna G, Hata A

Analysis of the microRNA signature driving adaptive right ventricular hypertrophy in an ovine model of congenital heart disease.

American journal of physiology. Heart and circulatory physiology

Kameny RJ, He Y, Zhu T, Gong W, Raff GW, Chapin CJ, Datar SA, Boehme JT, Hata A, Fineman JR

Inactivating mutations in Drosha mediate vascular abnormalities similar to hereditary hemorrhagic telangiectasia.

Science signaling

Jiang X, Wooderchak-Donahue WL, McDonald J, Ghatpande P, Baalbaki M, Sandoval M, Hart D, Clay H, Coughlin S, Lagna G, Bayrak-Toydemir P, Hata A

The role of TGF-β superfamily signaling in neurological disorders.

Acta biochimica et biophysica Sinica

Kashima R, Hata A

Identification of MicroRNA-124 as a Major Regulator of Enhanced Endothelial Cell Glycolysis in Pulmonary Arterial Hypertension via PTBP1 (Polypyrimidine Tract Binding Protein) and Pyruvate Kinase M2.

Circulation

Caruso P, Dunmore BJ, Schlosser K, Schoors S, Dos Santos C, Perez-Iratxeta C, Lavoie JR, Zhang H, Long L, Flockton AR, Frid MG, Upton PD, D'Alessandro A, Hadinnapola C, Kiskin FN, Taha M, Hurst LA, Ormiston ML, Hata A, Stenmark KR, Carmeliet P, Stewart DJ, Morrell NW

Let-7 microRNA-dependent control of leukotriene signaling regulates the transition of hematopoietic niche in mice.

Nature communications

Jiang X, Hawkins JS, Lee J, Lizama CO, Bos FL, Zape JP, Ghatpande P, Peng Y, Louie J, Lagna G, Zovein AC, Hata A

Hyperactive locomotion in a Drosophila model is a functional readout for the synaptic abnormalities underlying fragile X syndrome.

Science signaling

Kashima R, Redmond PL, Ghatpande P, Roy S, Kornberg TB, Hanke T, Knapp S, Lagna G, Hata A

Suppression of C9orf72 RNA repeat-induced neurotoxicity by the ALS-associated RNA-binding protein Zfp106.

eLife

Celona B, Dollen JV, Vatsavayai SC, Kashima R, Johnson JR, Tang AA, Hata A, Miller BL, Huang EJ, Krogan NJ, Seeley WW, Black BL

TGF-β Signaling from Receptors to Smads.

Cold Spring Harbor perspectives in biology

Hata A, Chen YG

Augmented noncanonical BMP type II receptor signaling mediates the synaptic abnormality of fragile X syndrome.

Science signaling

Kashima R, Roy S, Ascano M, Martinez-Cerdeno V, Ariza-Torres J, Kim S, Louie J, Lu Y, Leyton P, Bloch KD, Kornberg TB, Hagerman PJ, Hagerman R, Lagna G, Hata A

Quantitative Real-Time PCR Analysis of MicroRNAs and Their Precursors Regulated by TGF-β Signaling.

Methods in molecular biology (Clifton, N.J.)

Kang H, Hata A

Dysregulation of microRNA biogenesis machinery in cancer.

Critical reviews in biochemistry and molecular biology

Hata A, Kashima R

Targeting BMP signalling in cardiovascular disease and anaemia.

Nature reviews. Cardiology

Morrell NW, Bloch DB, ten Dijke P, Goumans MJ, Hata A, Smith J, Yu PB, Bloch KD

Therapeutic Ultrasound Promotes Reperfusion and Angiogenesis in a Rat Model of Peripheral Arterial Disease.

Circulation journal : official journal of the Japanese Circulation Society

Nazer B, Ghahghaie F, Kashima R, Khokhlova T, Perez C, Crum L, Matula T, Hata A

The role of microRNAs in cell fate determination of mesenchymal stem cells: balancing adipogenesis and osteogenesis.

BMB reports

Kang H, Hata A

Disruption of miR-29 Leads to Aberrant Differentiation of Smooth Muscle Cells Selectively Associated with Distal Lung Vasculature.

PLoS genetics

Cushing L, Costinean S, Xu W, Jiang Z, Madden L, Kuang P, Huang J, Weisman A, Hata A, Croce CM, Lü J

Dysregulation of microRNA biogenesis and gene silencing in cancer.

Science signaling

Hata A, Lieberman J

Functions of the bone morphogenetic protein signaling pathway through microRNAs (review).

International journal of molecular medicine

Hata A, Kang H

Down-regulation of miR-96 by bone morphogenetic protein signaling is critical for vascular smooth muscle cell phenotype modulation.

Journal of cellular biochemistry

Kim S, Hata A, Kang H

Cardiovascular applications of therapeutic ultrasound.

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing

Nazer B, Gerstenfeld EP, Hata A, Crum LA, Matula TJ

Acetylation of p53 stimulates miRNA processing and determines cell survival following genotoxic stress.

The EMBO journal

Chang J, Davis-Dusenbery BN, Kashima R, Jiang X, Marathe N, Sessa R, Louie J, Gu W, Lagna G, Hata A

Atrial natriuretic peptide is negatively regulated by microRNA-425.

The Journal of clinical investigation

Arora P, Wu C, Khan AM, Bloch DB, Davis-Dusenbery BN, Ghorbani A, Spagnolli E, Martinez A, Ryan A, Tainsh LT, Kim S, Rong J, Huan T, Freedman JE, Levy D, Miller KK, Hata A, Del Monte F, Vandenwijngaert S, Swinnen M, Janssens S, Holmes TM, Buys ES, Bloch KD, Newton-Cheh C, Wang TJ

Role of microRNAs in lung development and pulmonary diseases.

Pulmonary circulation

Sessa R, Hata A

Regulation of miRNA biogenesis as an integrated component of growth factor signaling.

Current opinion in cell biology

Blahna MT, Hata A

Functions of microRNAs in cardiovascular biology and disease.

Annual review of physiology

Hata A

Targeting the TGFβ signalling pathway in disease.

Nature reviews. Drug discovery

Akhurst RJ, Hata A

Inhibition of microRNA-302 (miR-302) by bone morphogenetic protein 4 (BMP4) facilitates the BMP signaling pathway.

The Journal of biological chemistry

Kang H, Louie J, Weisman A, Sheu-Gruttadauria J, Davis-Dusenbery BN, Lagna G, Hata A

Bone morphogenetic protein signaling in vascular disease: anti-inflammatory action through myocardin-related transcription factor A.

The Journal of biological chemistry

Wang D, Prakash J, Nguyen P, Davis-Dusenbery BN, Hill NS, Layne MD, Hata A, Lagna G

MicroRNA regulation of smooth muscle gene expression and phenotype.

Current opinion in hematology

Kang H, Hata A

A taste of TGFβ in Tuscany.

Development (Cambridge, England)

Hata A, Brivanlou AH

Smad-mediated regulation of microRNA biosynthesis.

FEBS letters

Blahna MT, Hata A

Bone morphogenetic protein 4 promotes vascular smooth muscle contractility by activating microRNA-21 (miR-21), which down-regulates expression of family of dedicator of cytokinesis (DOCK) proteins.

The Journal of biological chemistry

Kang H, Davis-Dusenbery BN, Nguyen PH, Lal A, Lieberman J, Van Aelst L, Lagna G, Hata A

MicroRNA and vascular remodelling in acute vascular injury and pulmonary vascular remodelling.

Cardiovascular research

McDonald RA, Hata A, MacLean MR, Morrell NW, Baker AH

Micromanaging vascular smooth muscle cell differentiation and phenotypic modulation.

Arteriosclerosis, thrombosis, and vascular biology

Davis-Dusenbery BN, Wu C, Hata A

Hypoxia potentiates microRNA-mediated gene silencing through posttranslational modification of Argonaute2.

Molecular and Cellular Biology

Wu C, So J, Davis-Dusenbery BN, Qi HH, Bloch DB, Shi Y, Lagna G, Hata A

down-regulation of Kruppel-like factor-4 (KLF4) by microRNA-143/145 is critical for modulation of vascular smooth muscle cell phenotype by transforming growth factor-beta and bone morphogenetic protein 4.

The Journal of biological chemistry

Davis-Dusenbery BN, Chan MC, Reno KE, Weisman AS, Layne MD, Lagna G, Hata A

Regulation of pri-miRNA Processing Through Smads.

Advances in experimental medicine and biology

Hata A, Davis BN

Smad-mediated miRNA processing: a critical role for a conserved RNA sequence.

RNA biology

Davis-Dusenbery BN, Hata A

The amiloride derivative phenamil attenuates pulmonary vascular remodeling by activating NFAT and the bone morphogenetic protein signaling pathway.

Molecular and Cellular Biology

Chan MC, Weisman AS, Kang H, Nguyen PH, Hickman T, Mecker SV, Hill NS, Lagna G, Hata A

MicroRNA in Cancer: The Involvement of Aberrant MicroRNA Biogenesis Regulatory Pathways.

Genes & cancer

Davis-Dusenbery BN, Hata A

Mechanisms of control of microRNA biogenesis.

Journal of biochemistry

Davis-Dusenbery BN, Hata A

Smad proteins bind a conserved RNA sequence to promote microRNA maturation by Drosha.

Molecular cell

Davis BN, Hilyard AC, Nguyen PH, Lagna G, Hata A

Regulation of pri-miRNA processing through Smads.

Advances in experimental medicine and biology

Hata A, Davis BN

Molecular basis for antagonism between PDGF and the TGFbeta family of signalling pathways by control of miR-24 expression.

The EMBO journal

Chan MC, Hilyard AC, Wu C, Davis BN, Hill NS, Lal A, Lieberman J, Lagna G, Hata A

Induction of microRNA-221 by platelet-derived growth factor signaling is critical for modulation of vascular smooth muscle phenotype.

The Journal of biological chemistry

Davis BN, Hilyard AC, Nguyen PH, Lagna G, Hata A

SMAD proteins control DROSHA-mediated microRNA maturation.

Nature

Davis BN, Hilyard AC, Lagna G, Hata A

Control of phenotypic plasticity of smooth muscle cells by bone morphogenetic protein signaling through the myocardin-related transcription factors.

The Journal of biological chemistry

Lagna G, Ku MM, Nguyen PH, Neuman NA, Davis BN, Hata A

A novel regulatory mechanism of the bone morphogenetic protein (BMP) signaling pathway involving the carboxyl-terminal tail domain of BMP type II receptor.

Molecular and Cellular Biology

Chan MC, Nguyen PH, Davis BN, Ohoka N, Hayashi H, Du K, Lagna G, Hata A

BMP-dependent activation of caspase-9 and caspase-8 mediates apoptosis in pulmonary artery smooth muscle cells.

American journal of physiology. Lung cellular and molecular physiology

Lagna G, Nguyen PH, Ni W, Hata A

OAZ regulates bone morphogenetic protein signaling through Smad6 activation.

The Journal of biological chemistry

Ku M, Howard S, Ni W, Lagna G, Hata A

Positive and negative regulation of the transforming growth factor beta/activin target gene goosecoid by the TFII-I family of transcription factors.

Molecular and Cellular Biology

Ku M, Sokol SY, Wu J, Tussie-Luna MI, Roy AL, Hata A

Indian hedgehog gene is a target of the bone morphogenetic protein signaling pathway.

The Journal of biological chemistry

Seki K, Hata A

Poly(ADP-ribose) polymerase 1 interacts with OAZ and regulates BMP-target genes.

Biochemical and biophysical research communications

Ku MC, Stewart S, Hata A

Early hematopoietic zinc finger protein (EHZF), the human homolog to mouse Evi3, is highly expressed in primitive human hematopoietic cells.

Blood

Bond HM, Mesuraca M, Carbone E, Bonelli P, Agosti V, Amodio N, De Rosa G, Di Nicola M, Gianni AM, Moore MA, Hata A, Grieco M, Morrone G, Venuta S

Mouse Snail family transcription repressors regulate chondrocyte, extracellular matrix, type II collagen, and aggrecan.

The Journal of biological chemistry

Seki K, Fujimori T, Savagner P, Hata A, Aikawa T, Ogata N, Nabeshima Y, Kaechoong L

https://profiles.ucsf.edu/akiko.hata

Address

555 & 535 Mission Bay Blvd Sou, Rm 001
UCSF Box 3118
San Francisco, CA 94158
United States