Peter Ganz, MD

Professor, Medicine

Research Interests: Human endothelial biology, inflammation in cardiovascular diseases, statins, cardiovascular disease in rheumatoid arthritis, cardiovascular disease in HIV, cardiovascular effects of smoking and second hand smoke, cardiovascular effects of air pollutants. Summary: Dr. Ganz' research interests have focused on the role of endothelial dysfunction and inflammation in cardiovascular disease in human subjects. In health, endothelium (the cell lining the inside of arteries), protects against diseases of blood vessels such as atherosclerosis (blockages in arteries). In the presence of damaging risk factors (for example, too much bad cholesterol, not enough good cholesterol, smoking, diabetes or high blood pressure), the endothelium becomes injured and promotes rather than retards cardiovascular disease. The same damaging risk factors also stimulate inflammation in the wall of human arteries. Inflammation and endothelial dysfunction lead to heart attacks and deaths from heart disease; thus, Dr. Ganz is currently focused on finding treatments to reverse endothelial dysfunction and reduce inflammation and their harmful effects and thereby prevent cardiovascular disease in patients.

Address: 
2540 23rd Street, Rm 4204
San Francisco, CA 94110
United States
Faculty Type: 
Affiliate Faculty
Publications: 

Psychological function in a randomized trial of continuous nitroglycerin for menopausal hot flashes.(link is external)

Menopause (New York, N.Y.)

Zhao EL, Gibson CJ, Raghunathan H, Schembri M, Ganz P, Huang AJ

Harnessing the Plasma Proteome to Predict Mortality in Heart Failure Subpopulations.(link is external)

Circulation. Heart failure

Chadwick J, Hinterberg MA, Asselbergs FW, Biegel H, Boersma E, Cappola TP, Chirinos JA, Coresh J, Ganz P, Gordon DA, Kureshi N, Loupey KM, Orlenko A, Ostroff R, Sampson L, Shrestha S, Sweitzer NK, Williams SA, Zhao L, Kardys I, Lanfear DE

Cross-Ancestry Comparison of Aptamer and Antibody Proteomics Measures.(link is external)

Research square

Raffield L, Nicholas J, Katz D, Tahir U, Debban C, Aguet F, Blackwell T, Bowler R, Broadaway K, Chen J, Clish C, Coresh J, Cornell E, Cruz D, Deo R, Doyle M, Durda P, Ekunwe L, Floyd J, Gill D, Guo X, Hoogeveen R, Johnson WC, Lange L, Li Y, Manning A, Meigs J, Mi M, Mychaleckyj J, Olson N, Pratte K, Psaty B, Reiner A, Ruan P, Sevilla-Gonzalez M, Shah A, Sun Q, Tracy R, Wen J, Wood A, Wilson J, Young K, Yu B, Rooney M, Manichaikul A, Dubin R, Mohlke K, Rich S, Rotter J, Ganz P, Gerszten R, Taylor K

Proteomics-based aging clocks in midlife and late-life and risk of dementia.(link is external)

Research square

Sedaghat S, Park S, Walker R, Wang S, Liu J, Hughes T, Sabayan B, Tang W, Coresh J, Pankow J, Walker K, Casanova R, Dubin R, Deo R, Rotter J, Wood A, Ganz P, Lutsey P, Guan W, Prizment A

The Association between Proteomic Aging Clocks and the Risk of Cancer in Midlife Individuals.(link is external)

medRxiv : the preprint server for health sciences

Wang S, Rao Z, Li A, Blaes AH, Blaha MJ, Coresh J, Dubin R, Deo R, Joshu CE, Marshall CH, Pankow JS, Rotter JI, Thyagarajan B, Whelton SP, Ganz P, Guan W, Platz EA, Prizment A

Association of Coagulation Factor XI Level With Cardiovascular Events and Cardiac Function in Community-Dwelling Adults: From ARIC and CHS.(link is external)

Circulation

Ji Y, Zhang MJ, Wang W, Norby FL, Eaton AA, Inciardi RM, Alonso A, Sedaghat S, Ganz P, Van't Hof J, Solomon SD, Chaves PHM, Heckbert SR, Shah AM, Chen LY

Human Plasma Proteomic Profile of Clonal Hematopoiesis.(link is external)

bioRxiv : the preprint server for biology

Yu Z, Vromman A, Nguyen NQH, Schuermans A, Rentz T, Vellarikkal SK, Uddin MM, Niroula A, Griffin G, Honigberg MC, Lin AE, Gibson CJ, Katz DH, Tahir U, Fang S, Haidermota S, Ganesh S, Antoine T, Weinstock J, Austin TR, Ramachandran VS, Peloso GM, Hornsby W, Ganz P, Manson JE, Haring B, Kooperberg CL, Reiner AP, Bis JC, Psaty BM, Min YI, Correa A, Lange LA, Post WS, Rotter JI, Rich SS, Wilson JG, Ebert BL, Yu B, Ballantyne CM, Coresh J, Sankaran VG, Bick AG, Jaiswal S, Gerszten RE, NHLBI Trans-Omics for Precision Medicine, Libby P, Gupta RM, Natarajan P

Proteomic Assessment of the Risk of Secondary Cardiovascular Events among Individuals with CKD.(link is external)

Journal of the American Society of Nephrology : JASN

Deo R, Dubin RF, Ren Y, Wang J, Feldman H, Shou H, Coresh J, Grams ME, Surapaneni AL, Cohen JB, Kansal M, Rahman M, Dobre M, He J, Kelly T, Go AS, Kimmel PL, Vasan RS, Segal MR, Li H, Ganz P

Proceedings of PRINCETON IV: PDE5 inhibitors and cardiac health symposium.(link is external)

Sexual medicine reviews

Rosen RC, Miner M, Burnett AL, Blaha MJ, Ganz P, Goldstein I, Kim N, Kohler T, Lue T, McVary K, Mulhall J, Parish SJ, Sadeghi-Nejad H, Sadovsky R, Sharlip I, Kloner RA

Development, characterization, and replication of proteomic aging clocks: Analysis of 2 population-based cohorts.(link is external)

PLoS medicine

Wang S, Rao Z, Cao R, Blaes AH, Coresh J, Deo R, Dubin R, Joshu CE, Lehallier B, Lutsey PL, Pankow JS, Post WS, Rotter JI, Sedaghat S, Tang W, Thyagarajan B, Walker KA, Ganz P, Platz EA, Guan W, Prizment A

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