
Research Interests: Human endothelial biology, inflammation in cardiovascular diseases, statins, cardiovascular disease in rheumatoid arthritis, cardiovascular disease in HIV, cardiovascular effects of smoking and second hand smoke, cardiovascular effects of air pollutants. Summary: Dr. Ganz' research interests have focused on the role of endothelial dysfunction and inflammation in cardiovascular disease in human subjects. In health, endothelium (the cell lining the inside of arteries), protects against diseases of blood vessels such as atherosclerosis (blockages in arteries). In the presence of damaging risk factors (for example, too much bad cholesterol, not enough good cholesterol, smoking, diabetes or high blood pressure), the endothelium becomes injured and promotes rather than retards cardiovascular disease. The same damaging risk factors also stimulate inflammation in the wall of human arteries. Inflammation and endothelial dysfunction lead to heart attacks and deaths from heart disease; thus, Dr. Ganz is currently focused on finding treatments to reverse endothelial dysfunction and reduce inflammation and their harmful effects and thereby prevent cardiovascular disease in patients.
Publications
Associations of High Attenuation Area-Related Proteomic Biomarkers with Fibrotic or Subpleural Interstitial Lung Abnormalities.
Proteomics-based aging clocks in midlife or late-life and their associated risk of dementia.
Activated GDF11/8 subforms predict cardiovascular events and mortality in humans.
Proteomic discovery analysis of quantitatively assessed emphysema in the general population. The MESA Lung Study.
Circulating Proteins for Prediction of Kidney Disease Progression and Cardiovascular Outcomes: Individual Participant Data Meta-Analysis of Four Cohorts.
Linking Chronic Kidney Disease to Incident Heart Failure and Adverse Cardiac Remodeling Through the Plasma Proteome: The ARIC Study.
Fourteen Biomarkers and Subsequent Disability in Patients with Stroke Recurrence: Results from the SPARCL Trial.
Psychological function in a randomized trial of continuous nitroglycerin for menopausal hot flashes.
Harnessing the Plasma Proteome to Predict Mortality in Heart Failure Subpopulations.
The Association between Proteomic Aging Clocks and the Risk of Cancer in Midlife Individuals.
Human Plasma Proteomic Profile of Clonal Hematopoiesis.
Proteomic Assessment of the Risk of Secondary Cardiovascular Events among Individuals with CKD.
Proceedings of PRINCETON IV: PDE5 inhibitors and cardiac health symposium.
Development, characterization, and replication of proteomic aging clocks: Analysis of 2 population-based cohorts.
Incident heart failure in chronic kidney disease: proteomics informs biology and risk stratification.
The Princeton IV Consensus Recommendations for the Management of Erectile Dysfunction and Cardiovascular Disease.
HOT FLASHES AND SLEEP DISRUPTION IN A RANDOMIZED TRIAL IN MENOPAUSAL WOMEN.
Proteomic Aging Clocks and the Risk of Mortality among Longer-Term Cancer Survivors in the Atherosclerosis Risk in Communities (ARIC) Study.
Association of Integrated Proteomic and Metabolomic Modules with Risk of Kidney Disease Progression.
Princeton IV consensus guidelines: PDE5 inhibitors and cardiac health.
Development and Validation of a Protein Risk Score for Mortality in Heart Failure : A Community Cohort Study.
Circulating Growth Differentiation Factors 11 and 8, Their Antagonists Follistatin and Follistatin-Like-3, and Risk of Heart Failure in Elders.
Evaluation of Associations of Growth Differentiation Factor-11, Growth Differentiation Factor-8, and Their Binding Proteins Follistatin and Follistatin-Like Protein-3 With Dementia and Cognition.
Evaluation of Associations of Growth Differentiation Factor-11, Growth Differentiation Factor-8, and Their Binding Proteins, Follistatin and Follistatin-Like Protein-3, With Measures of Skeletal Muscle Mass, Muscle Strength, and Physical Function in Older
Proteomics of CKD progression in the chronic renal insufficiency cohort.
Development and Characterization of Proteomic Aging Clocks in the Atherosclerosis Risk in Communities (ARIC) Study.
Efficacy of Continuous Transdermal Nitroglycerin for Treating Hot Flashes by Inducing Nitrate Cross-tolerance in Perimenopausal and Postmenopausal Women: A Randomized Clinical Trial.
Proteomics analysis of plasma from middle-aged adults identifies protein markers of dementia risk in later life.
Associations of circulating proteins with lipoprotein profiles: proteomic analyses from the OmniHeart randomized trial and the Atherosclerosis Risk in Communities (ARIC) Study.
Proteomic cardiovascular risk assessment in chronic kidney disease.
Analytical and Biological Variability of a Commercial Modified Aptamer Assay in Plasma Samples of Patients with Chronic Kidney Disease.
Identification of Protein Biomarkers of the Dietary Approaches to Stop Hypertension Diet in Randomized Feeding Studies and Validation in an Observational Study.
Alterations in the Circulating Proteome Associated with Albuminuria.
Plasma Protein Biomarkers of Healthy Dietary Patterns: Results from the Atherosclerosis Risk in Communities Study and the Framingham Heart Study.
Chronic E-Cigarette Use Impairs Endothelial Function on the Physiological and Cellular Levels.
Testican-2 Is Associated with Reduced Risk of Incident ESKD.
Response to comment on "A proteomic surrogate for cardiovascular outcomes that is sensitive to multiple mechanisms of change in risk".
Hospitalized Patients With COVID-19 Have Higher Plasma Aldosterone-Renin Ratio and Lower ACE Activity Than Controls.
A proteomic surrogate for cardiovascular outcomes that is sensitive to multiple mechanisms of change in risk.
Effect of HIV-1 Infection on Angiopoietin 1 and 2 Levels and Measures of Microvascular and Macrovascular Endothelial Dysfunction.
Proteins Associated with Risk of Kidney Function Decline in the General Population.
Comparison of proteomic methods in evaluating biomarker-AKI associations in cardiac surgery patients.
Large-scale plasma proteomic analysis identifies proteins and pathways associated with dementia risk.
Proteomics for personalized cardiovascular risk assessment: in pursuit of the Holy Grail.
Impact of Kidney Function on the Blood Proteome and on Protein Cardiovascular Risk Biomarkers in Patients With Stable Coronary Heart Disease.
Mechanisms of Sodium-Glucose Cotransporter 2 Inhibition: Insights From Large-Scale Proteomics.
Do Ambient Ozone or Other Pollutants Modify Effects of Controlled Ozone Exposure on Pulmonary Function?
Nonsurgical Periodontal Therapy in CKD: Findings of the Kidney and Periodontal Disease (KAPD) Pilot Randomized Controlled Trial.
Plasma protein patterns as comprehensive indicators of health.
William Ganz and His Legacy.
Echocardiographic determination of pulmonary arterial capacitance.
Vascular Aging Is Accelerated in Flight Attendants With Occupational Secondhand Smoke Exposure.
Associations of microvascular dysfunction with cardiovascular outcomes: The cardiac, endothelial function and arterial stiffness in ESRD (CERES) cohort.
Cardiovascular injury induced by tobacco products: assessment of risk factors and biomarkers of harm. A Tobacco Centers of Regulatory Science compilation.
Reproducibility and Variability of Protein Analytes Measured Using a Multiplexed Modified Aptamer Assay.
Unique Circulating MicroRNA Profiles in HIV Infection.
IL-1β Inhibition Reduces Atherosclerotic Inflammation in HIV Infection.
Higher incidence of vasodilator-induced left ventricular cavity dilation by PET when compared to treadmill exercise-ECHO in hypertrophic cardiomyopathy.
Cardiovascular function and ozone exposure: The Multicenter Ozone Study in oldEr Subjects (MOSES).
Sex differences in vascular dysfunction and cardiovascular outcomes: The cardiac, endothelial function, and arterial stiffness in ESRD (CERES) study.
Association of Arterial and Lymph Node Inflammation With Distinct Inflammatory Pathways in Human Immunodeficiency Virus Infection.
In Reply.
Role of T-Cell Dysfunction, Inflammation, and Coagulation in Microvascular Disease in HIV.
The Kidney and Periodontal Disease (KAPD) study: A pilot randomized controlled trial testing the effect of non-surgical periodontal therapy on chronic kidney disease.
Associations of Macro- and Microvascular Endothelial Dysfunction With Subclinical Ventricular Dysfunction in End-Stage Renal Disease.
HIV and Hepatitis C-Coinfected Patients Have Lower Low-Density Lipoprotein Cholesterol Despite Higher Proprotein Convertase Subtilisin Kexin 9 (PCSK9): An Apparent "PCSK9-Lipid Paradox".
Biochemistry and Biology of GDF11 and Myostatin: Similarities, Differences, and Questions for Future Investigation.
Continuous transdermal nitroglycerin therapy for menopausal hot flashes: a single-arm, dose-escalation trial.
Endothelin-1 Predicts Hemodynamically Assessed Pulmonary Arterial Hypertension in HIV Infection.
Behavioral Cardiovascular Risk Factors - Effect of Physical Activity and Cardiorespiratory Fitness on Cardiovascular Outcomes.
Association of growth differentiation factor 11/8, putative anti-ageing factor, with cardiovascular outcomes and overall mortality in humans: analysis of the Heart and Soul and HUNT3 cohorts.
Novel Biomarkers of Cardiac Stress, Cardiovascular Dysfunction, and Outcomes in HIV-Infected Individuals.
Traditional Risk Factors Versus Biomarkers for Prediction of Secondary Events in Patients With Stable Coronary Heart Disease: From the Heart and Soul Study.
Utility of both carotid intima-media thickness and endothelial function for cardiovascular risk stratification in patients with angina-like symptoms.
A novel minimally-invasive method to sample human endothelial cells for molecular profiling.
Depletion of B-cells with rituximab improves endothelial function and reduces inflammation among individuals with rheumatoid arthritis.
Changes in erectile dysfunction over time in relation to Framingham cardiovascular risk in the Boston Area Community Health (BACH) Survey.
Association of peripheral microvascular dysfunction and erectile dysfunction.
Increased levels of asymmetric dimethylarginine are associated with pulmonary arterial hypertension in HIV infection.
Reperfusion times and in-hospital outcomes among patients with an isolated posterior myocardial infarction: insights from the National Cardiovascular Data Registry (NCDR).
All men with vasculogenic erectile dysfunction require a cardiovascular workup.
Role of soluble endothelial cell-selective adhesion molecule biomarker in albuminuria and kidney function changes in patients with coronary artery disease: the Heart and Soul Study.
Physician accuracy in interpreting potential ST-segment elevation myocardial infarction electrocardiograms.
Long-term outcomes of patients sent emergently to the catheterization laboratory for possible primary percutaneous coronary intervention.
Clinical characteristics and reperfusion times among patients with an isolated posterior myocardial infarction.
Emergency medical service utilization and door-to-balloon time for HIV-infected individuals with ST-elevation myocardial infarction.
Endothelial dysfunction in coronary heart disease is more than a systemic process.
Elevated levels of asymmetric dimethylarginine are associated with lower CD4+ count and higher viral load in HIV-infected individuals.
Glycemic associations with endothelial function and biomarkers among 5 ethnic groups: the Multi-Ethnic Study of Atherosclerosis and the Mediators of Atherosclerosis in South Asians Living in America studies.
Comparison of clinical characteristics and outcomes of cardiac arrest survivors having versus not having coronary angiography.
Inflammatory biomarkers, death, and recurrent nonfatal coronary events after an acute coronary syndrome in the MIRACL study.
Impact of door-to-activation time on door-to-balloon time in primary percutaneous coronary intervention for ST-segment elevation myocardial infarctions: a report from the Activate-SF registry.
The Princeton III Consensus recommendations for the management of erectile dysfunction and cardiovascular disease.
Electrocardiographic criteria for ST-elevation myocardial infarction in patients with left ventricular hypertrophy.
Prevalence and factors associated with false-positive ST-segment elevation myocardial infarction diagnoses at primary percutaneous coronary intervention–capable centers: a report from the Activate-SF registry.
Prognostic utility of erectile dysfunction for cardiovascular disease in younger men and those with diabetes.
The association of CD4+ T-cell counts and cardiovascular risk in treated HIV disease.
The exposure-dependent effects of aged secondhand smoke on endothelial function.
Carotid Intima-Media Thickness Progression in HIV-Infected Adults Occurs Preferentially at the Carotid Bifurcation and Is Predicted by Inflammation.
Delaying primary percutaneous coronary intervention for computed tomographic scans in the emergency department.
Relationship of antihypertensive treatment to plasma markers of vascular inflammation and remodeling in the Comparison of Amlodipine versus Enalapril to Limit Occurrences of Thrombosis study.
Carotid intima-media thickness among human immunodeficiency virus-infected patients without coronary calcium.
Improvement in revascularization time after creation of a coronary catheterization laboratory at a public hospital.
Predictors of depressed left ventricular function in patients presenting with ST-elevation myocardial infarction.
Coronary circulatory function in patients with the metabolic syndrome.
The CHADS2 score predicts ischemic stroke in the absence of atrial fibrillation among subjects with coronary heart disease: data from the Heart and Soul Study.
Associations of endothelial dysfunction and arterial stiffness with intradialytic hypotension and hypertension.
AJC editor's consensus: rheumatoid arthritis and atherosclerotic cardiovascular disease.
Initiation of antiretroviral therapy at higher nadir CD4+ T-cell counts is associated with reduced arterial stiffness in HIV-infected individuals.
Does erectile dysfunction contribute to cardiovascular disease risk prediction beyond the Framingham risk score?
Association of abacavir and impaired endothelial function in treated and suppressed HIV-infected patients.
Endothelin-1 is a key mediator of coronary vasoconstriction in patients with transplant coronary arteriosclerosis.
Erectile dysfunction and mortality.
Relationship of oxidized phospholipids and biomarkers of oxidized low-density lipoprotein with cardiovascular risk factors, inflammatory biomarkers, and effect of statin therapy in patients with acute coronary syndromes: Results from the MIRACL (Myocardia
Structural and functional manifestations of human atherosclerosis: do they run in parallel?
Role of viral replication, antiretroviral therapy, and immunodeficiency in HIV-associated atherosclerosis.
Rheumatoid arthritis: model of systemic inflammation driving atherosclerosis.
Endogenous tissue plasminogen activator and risk of recurrent cardiac events after an acute coronary syndrome in the MIRACL study.
Is hyperlipidemia or its treatment associated with erectile dysfunction?: Results from the Boston Area Community Health (BACH) Survey.
Individualized approach to the management of coronary heart disease: identifying the nonresponders before it is too late.
Comparison of effects of rosuvastatin (10 mg) versus atorvastatin (40 mg) on rho kinase activity in caucasian men with a previous atherosclerotic event.
Inflammation, statin therapy, and risk of stroke after an acute coronary syndrome in the MIRACL study.
Improved characterization of atherosclerotic plaques by gadolinium contrast during intravascular magnetic resonance imaging of human arteries.
Right ventricular dysfunction assessed by cardiovascular magnetic resonance imaging predicts poor prognosis late after myocardial infarction.
Rho kinase inhibition improves endothelial function in human subjects with coronary artery disease.
Beyond lipid lowering: What have we learned about the benefits of statins from the acute coronary syndromes trials?
Role of nitric oxide in the regulation of digital pulse volume amplitude in humans.
Impact of coronary endothelial function on the progression of cardiac transplant-associated arteriosclerosis: effect of anti-oxidant vitamins C and E.
Effect of ACAT inhibition on the progression of coronary atherosclerosis.
Sexual dysfunction and cardiac risk (the Second Princeton Consensus Conference).
Characterization of human atherosclerotic plaques by intravascular magnetic resonance imaging.
Erectile dysfunction: pathophysiologic mechanisms pointing to underlying cardiovascular disease.
Sexual dysfunction and cardiac risk (the Second Princeton Consensus Conference).
High-density lipoprotein, but not low-density lipoprotein cholesterol levels influence short-term prognosis after acute coronary syndrome: results from the MIRACL trial.
Statin therapy, LDL cholesterol, C-reactive protein, and coronary artery disease.
Statins and endothelial dysfunction.
Comparison of endothelial function in young men and women with a family history of premature coronary artery disease.
Long-term effect of combined vitamins E and C on coronary and peripheral endothelial function.
Early statin therapy in acute coronary syndromes.
Pharmacoeconomic evaluation of the effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes.
Expression patterns of vascular endothelial growth factor in human cardiac allografts: association with rejection.
Endothelin-1 and vascular tone in subjects with atherogenic risk factors.
Circulating autoantibodies to oxidized LDL correlate with impaired coronary endothelial function after cardiac transplantation.
Endothelial function. From vascular biology to clinical applications.
Contribution of endothelin to pulmonary vascular tone under normoxic and hypoxic conditions.
Coronary flow velocity and disturbed flow predict adverse clinical outcome after coronary angioplasty.
Vasomotor and vascular effects of hormone replacement therapy.
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