Kevan Shokat, PhD

Professor, Cellular Molecular Pharmacology

Research Interests: Design of drugs to treat cardiovascular disease, cancer, and autoimmune diseases. Summary:

Address: 
600 16th Street, Rm N512D
UCSF Box 2280
San Francisco, CA 94158
United States
Phone: 
+1 415 514-0472
Faculty Type: 
Affiliate Faculty
Publications: 

Deazaguanylation is a nucleobase-protein conjugation required for type IV CBASS immunity.(link is external)

bioRxiv : the preprint server for biology

Wassarman DR, Pfaff P, Paulo JA, Gygi SP, Shokat KM, Kranzusch PJ

HBV Remodels PP2A Complexes to Rewire Kinase Signaling in Hepatocellular Carcinoma.(link is external)

Cancer research

Turnham RE, Pitea A, Jang GM, Xu Z, Lim HC, Choi AL, Von Dollen J, Levin RS, Webber JT, McCarthy E, Hu J, Li X, Che L, Singh A, Yoon A, Chan G, Kelley RK, Swaney DL, Zhang W, Bandyopadhyay S, Theis FJ, Eckhardt M, Chen X, Shokat KM, Ideker T, Krogan NJ, Gordan JD

Direct RAS inhibitors turn 10.(link is external)

Nature chemical biology

Ostrem JML, Peters U, Shokat KM

Subcellular activation of β-adrenergic receptors using a spatially restricted antagonist.(link is external)

Proceedings of the National Academy of Sciences of the United States of America

Liccardo F, Morstein J, Lin TY, Pampel J, Lang D, Shokat KM, Irannejad R

Targeting Ras-, Rho-, and Rab-family GTPases via a conserved cryptic pocket.(link is external)

Cell

Morstein J, Bowcut V, Fernando M, Yang Y, Zhu L, Jenkins ML, Evans JT, Guiley KZ, Peacock DM, Krahnke S, Lin Z, Taran KA, Huang BJ, Stephen AG, Burke JE, Lightstone FC, Shokat KM

IL-13 and IL-17A activate ß1 integrin through an NF-kB/Rho kinase/PIP5K1? pathway to enhance force transmission in airway smooth muscle.(link is external)

Proceedings of the National Academy of Sciences of the United States of America

Ngo U, Shi Y, Woodruff P, Shokat K, DeGrado W, Jo H, Sheppard D, Sundaram AB

Absence of ABL1 exon 2-encoded SH3 residues in BCR::ABL1 destabilizes the autoinhibited kinase conformation and confers resistance to asciminib.(link is external)

Leukemia

Leyte-Vidal A, DeFilippis R, Outhwaite IR, Kwan I, Lee JY, Leavitt C, Miller KB, Rea D, Rangwala AM, Lou K, Patel S, Alvarez A, Shokat KM, Bahar I, Seeliger MA, Shah NP

Acute rapamycin treatment reveals novel mechanisms of behavioral, physiological, and functional dysfunction in a maternal inflammation mouse model of autism and sensory over-responsivity.(link is external)

bioRxiv : the preprint server for biology

Le Belle JE, Condro M, Cepeda C, Oikonomou KD, Tessema K, Dudley L, Schoenfield J, Kawaguchi R, Geschwind D, Silva AJ, Zhang Z, Shokat K, Harris NG, Kornblum HI

IL-13 and IL-17A Activate β1 Integrin through an NF-kB/Rho kinase/PIP5K1γ pathway to Enhance Force Transmission in Airway Smooth Muscle.(link is external)

bioRxiv : the preprint server for biology

Ngo U, Shi Y, Woodruff P, Shokat K, DeGrado W, Jo H, Sheppard D, Sundaram AB

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