Associate Professor
M_MED-CORE-PULM
Email
Websites
Faculty Type
Parnassus Pulmonary Research Faculty
Developmental pathways in the maintenance of adult tissue homeostasis Our laboratory is interested in studying how key developmental pathways continue to persist in adulthood to maintain normal homeostatic organ function. We are particularly focused on the mesenchymal cell types (e.g. fibroblasts, pericytes, and etc.) that are poorly understood and lack precise anatomical definition, but are integral to the structural integrity and function of adult organs such as the lung.
Publications
Hedgehog-interacting protein orchestrates alveologenesis and protects against bronchopulmonary dysplasia and emphysema.
Science advances
Identification of Meibomian gland stem cell populations and mechanisms of aging.
Nature communications
Convergent evolution of senescent fibroblasts in fibrosis and cancer with aging.
Seminars in cancer biology
Identification of Meibomian gland stem cell populations and mechanisms of aging.
bioRxiv : the preprint server for biology
Senescent fibroblasts in the tumor stroma rewire lung cancer metabolism and plasticity.
bioRxiv : the preprint server for biology
An in vivo screening platform identifies senolytic compounds that target p16INK4a+ fibroblasts in lung fibrosis.
The Journal of clinical investigation
In vivo protein turnover rates in varying oxygen tensions nominate MYBBP1A as a mediator of the hyperoxia response.
Science advances
Bad Neighbors or Bad Neighborhoods: Pathogenic Residency of T Cells in Chronic Obstructive Pulmonary Disease.
American journal of respiratory and critical care medicine
Group 2 innate lymphoid cells constrain type 3/17 lymphocytes in shared stromal niches to restrict liver fibrosis.
bioRxiv : the preprint server for biology
Sentinel p16INK4a+ cells in the basement membrane form a reparative niche in the lung.
Science (New York, N.Y.)
Intersection of Inflammation and Senescence in the Aging Lung Stem Cell Niche.
Frontiers in cell and developmental biology
Human alveolar type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells.
Nature cell biology
An inflammatory switch for stem cell plasticity.
Nature cell biology
Gli1+ mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung.
Nature cell biology
The Role of Hedgehog Signaling in Adult Lung Regeneration and Maintenance.
Journal of developmental biology
Endothelial toll-like receptor 4 maintains lung integrity via epigenetic suppression of p16INK4a.
Aging cell
Expansion of hedgehog disrupts mesenchymal identity and induces emphysema phenotype.
The Journal of clinical investigation
Long noncoding RNAs are spatially correlated with transcription factors and regulate lung development.
Genes & development
Distinct functions for Wnt/β-catenin in hair follicle stem cell proliferation and survival and interfollicular epidermal homeostasis.
Cell stem cell
Development of the pulmonary vasculature: Current understanding and concepts for the future.
Pulmonary circulation
Plasma levels of S100A4 in portopulmonary hypertension.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
Herpes simplex encephalitis in a patient with recurrent pituitary adenoma receiving radiation therapy.
American journal of clinical oncology
The 1p-encoded protein stathmin and resistance of malignant gliomas to nitrosoureas.
Journal of the National Cancer Institute
Lentiviral vectors with two independent internal promoters transfer high-level expression of multiple transgenes to human hematopoietic stem-progenitor cells.
Molecular therapy : the journal of the American Society of Gene Therapy
Address
513 Parnassus Avenue, HSE, Rm 1312
UCSF Box 0130
San Francisco, CA 94143
United States