David Pearce, MD

A Novel Function of FOXO4 and mTORC2 for Regulation of Kidney Gluconeogenesis.

Journal of the American Society of Nephrology

John Eric Demko, Bidisha Saha, Enzo Takagi, Robert Weber, David Pearce

Role of mTORC2 in Aldosterone-Independent Potassium Regulation: Resolution of the Aldosterone Paradox.

Journal of the American Society of Nephrology

Bidisha Saha, John Eric Demko, Enzo Takagi, Robert Weber, David Pearce

Salt-sensitive hypertension in GR mutant rats is associated with altered plasma polyunsaturated fatty acid levels and aortic vascular reactivity.

Pflugers Archiv : European journal of physiology

Verouti S, Aeschlimann G, Wang Q, Del Olmo DA, Peyter AC, Menétrey S, Winter DV, Odermatt A, Pearce D, Hummler E, Vanderriele PE

Coordinated Regulation of Renal Glucose Reabsorption and Gluconeogenesis by mTORC2 and Potassium.

bioRxiv : the preprint server for biology

Demko J, Saha B, Takagi E, Mannis A, Weber R, Pearce D

Aldosterone-independent regulation of K+ secretion in the distal nephron.

Current opinion in nephrology and hypertension

Demko J, Weber R, Pearce D, Saha B

Balancing sodium and potassium: Implication of mTORC2-mediated ENaC activation in DCT2 and early CNT for potassium balance in high dietary potassium.

Physiology

Bidisha Saha, Enzo Takagi, John Demko, Robert Weber, Shrutirupa Saha, David Pearce

High Potassium Suppresses Glycosuria and Gluconeogenesis in Tubule-specific mTORC2 Knockout Mice.

Physiology

John Demko, Bidisha Saha, Enzo Takagi, Robert Weber, David Pearce

Chloride-Induced Monomer to Dimer Transition Controls WNK1 Scaffold Activity.

Journal of the American Society of Nephrology

Bidisha Saha, Enzo Takagi, John E. Demko, David Pearce

Critical Role of mTORC2 in Maintaining Sodium and Potassium Balance: Implications for Aldosterone-Independent Regulation of Epithelial Sodium Channel (ENaC) in the Distal Nephron.

Journal of the American Society of Nephrology

Bidisha Saha, John E. Demko, Enzo Takagi, David Pearce

High Potassium Suppresses Glycosuria in Tubule-Specific mTORC2 Knockout Mice.

Journal of the American Society of Nephrology

John E. Demko, Bidisha Saha, Enzo Takagi, David Pearce

mTORC2 Coordinates Renal Gluconeogenesis and Glucose Reabsorption.

Journal of the American Society of Nephrology

John E. Demko, Bidisha Saha, Enzo Takagi, David Pearce

Renal tubule mTORC2 deletion increases gluconeogenesis and urinary glucose excretion.

Physiology

John Demko, Bidisha Saha, Enzo Takagi, Anna Manis, Phillip Richman, David Pearce

Site-specific activity of mTORC2 in regulating renal K+ secretion to maintain ion homeostasis.

Physiology

Bidisha Saha, Enzo Takagi, John Demko, Anna Manis, David Pearce

Potassium Activates mTORC2-dependent SGK1 Phosphorylation to Stimulate Epithelial Sodium Channel: Role in Rapid Renal Responses to Dietary Potassium.

Journal of the American Society of Nephrology : JASN

Saha B, Shabbir W, Takagi E, Duan XP, Leite Dellova DCA, Demko J, Manis A, Loffing-Cueni D, Loffing J, Sørensen MV, Wang WH, Pearce D

WNK1 is a chloride-stimulated scaffold that regulates mTORC2 activity and ion transport.

Journal of cell science

Saha B, Leite-Dellova DCA, Demko J, Sørensen MV, Takagi E, Gleason CE, Shabbir W, Pearce D

Glycosuria in Tubule-Specific mTORC2 Knockout Mice Resolves on a High Potassium Diet.

Journal of the American Society of Nephrology

John E. Demko, Bidisha Saha, Enzo Takagi, Anna D. Manis, David Pearce

Regulation of SGK1 Phosphorylation and Activity by mTORC2.

Journal of the American Society of Nephrology

Enzo Takagi, Junliang Chen, Feng Wang, Bidisha Saha, David Pearce

WNK1 Is a Chloride-Sensing Scaffold That Potently Regulates mTORC2 Activity and ENaC.

Journal of the American Society of Nephrology

Bidisha Saha, Deise C. Leite-Dellova, Enzo Takagi, John E. Demko, Waheed Shabbir, David Pearce

Hospitalized Patients With COVID-19 Have Higher Plasma Aldosterone-Renin Ratio and Lower ACE Activity Than Controls.

Journal of the Endocrine Society

Parikh NI, Arowolo F, Durstenfeld MS, Nah G, Njoroge J, Vittinghoff E, Long CS, Ganz P, Pearce D, Hsue P, Wu AHS, Hajizadeh N, Liu KD, Lynch KL

Interactions between mTORC2 core subunits Rictor and mSin1 dictate selective and context-dependent phosphorylation of substrate kinases SGK1 and Akt.

The Journal of biological chemistry

Yu Z, Chen J, Takagi E, Wang F, Saha B, Liu X, Joubert LM, Gleason CE, Jin M, Li C, Nowotny C, Agard D, Cheng Y, Pearce D

Regulation of distal tubule sodium transport: mechanisms and roles in homeostasis and pathophysiology.

Pflugers Archiv : European journal of physiology

Pearce D, Manis AD, Nesterov V, Korbmacher C

Hyperpolarized MRI Detection of Dapagliflozin Effect on Gluconeogenesis in Live Animals: Proof of Principle.

Journal of the American Society of Nephrology

Waheed Shabbir, Enzo Takagi, Michael Ohliger, David Pearce

Role of WNK1 and WNK4 in Sensing Extracellular Potassium in Principal Cells to Modulate mTORC2-Dependent Activation of Epithelial Sodium Channel.

Journal of the American Society of Nephrology

Bidisha Saha, Waheed Shabbir, Enzo Takagi, Mads V. Sorensen, Deise C. Leite-Dellova, David Pearce

Role of mTORC2/SGK1 Signaling in Rapid Response to Acute K Load to Maintain K+ Homeostasis.

Journal of the American Society of Nephrology

Bidisha Saha, Waheed Shabbir, Enzo Takagi, John E. Demko, Mads V. Sorensen, Deise C. Leite-Dellova, David Pearce

Structural Determinants of mTORC2 Substrate Specificity and SGK1 Phosphorylation Revealed by Cryogenic Electron Microscopy.

Journal of the American Society of Nephrology

Junliang Chen, Zanlin Yu, Feng Wang, Xi Liu, Enzo Takagi, Lydia-Marie Joubert, Mingliang Jin, Carlos Nowotny, David Agard, Yifan Cheng, David Pearce

mTORC2 Is Essential for Sodium-Glucose Cotransporter 2.

Journal of the American Society of Nephrology

Waheed Shabbir, John E. Demko, Enzo Takagi, Bidisha Saha, Deise C. Leite-Dellova, Bharathi Sambandam, David Pearce

Role of mTORC2 in biphasic regulation of brown fat metabolism in response to mild and severe cold.

The Journal of biological chemistry

Allu PKR, Paulo E, Bertholet AM, Situ G, Lee SH, Wu Y, Gleason CE, Saha B, Chawla A, Wang B, Pearce D

Hypotheses about sub-optimal hydration in the weeks before coronavirus disease (COVID-19) as a risk factor for dying from COVID-19.

Medical hypotheses

Stookey JD, Allu PKR, Chabas D, Pearce D, Lang F

Regulation of ENaC by aldosterone and potassium.

The FASEB Journal

Deise C. A. Leite Dellova, Bidisha Saha, Enzo Takagi, Waheed Shabbir, David Pearce

mTOR Modulates Sodium and Potassium Conduction in Heterologous Expression System.

The FASEB Journal

Waheed Shabbir, Catherine E. Gleason, Bidisha Saha, Deise C. A. Leite Dellova, David Pearce

Association of Urinary Plasminogen-Plasmin with Edema and Epithelial Sodium Channel Activation in Patients with Nephrotic Syndrome.

American journal of nephrology

Chen JL, Wang L, Yao XM, Zang YJ, Wang Y, Li ZJ, Pearce D, Wang H

Potassium acts through mTOR to regulate its own secretion.

JCI insight

Sørensen MV, Saha B, Jensen IS, Wu P, Ayasse N, Gleason CE, Svendsen SL, Wang WH, Pearce D

Phosphorylation at distinct subcellular locations underlies specificity in mTORC2-mediated activation of SGK1 and Akt.

Journal of cell science

Gleason CE, Oses-Prieto JA, Li KH, Saha B, Situ G, Burlingame AL, Pearce D

The mTORC2-SGK1 Signaling Module Mediates Local Sensing of Potassium in Kidney Tubule Principal Cells to Activate ENaC and Promote Potassium Secretion.

The FASEB Journal

Bidisha Saha, Catherine Gleason, Peng Wu, Wen-Hui Wang, David Pearce

The SGK3-triggered ubiquitin-proteasome degradation of podocalyxin (PC) and ezrin in podocytes was associated with the stability of the PC/ezrin complex.

Cell death & disease

Yuan YP, Zhao H, Peng LQ, Li ZF, Liu S, Yuan CY, Mwamunyi MJ, Pearce D, Yao LJ

Potassium Can Regulate Its Own Excretion in Collecting Duct Cells: Role of mTORC2, SGK1 and ENaC.

The FASEB Journal

Bidisha Saha, Peng Wu, Catherine E. Gleason, Wenhui Wang, David Pearce

Non-invasive detection of divergent metabolic signals in insulin deficiency vs. insulin resistance in vivo.

Scientific reports

Morze CV, Allu PKR, Chang GY, Marco-Rius I, Milshteyn E, Wang ZJ, Ohliger MA, Gleason CE, Kurhanewicz J, Vigneron DB, Pearce D

Lack of serum- and glucocorticoid-inducible kinase 3 leads to podocyte dysfunction.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Peng LQ, Zhao H, Liu S, Yuan YP, Yuan CY, Mwamunyi MJ, Pearce D, Yao LJ

Direct assessment of renal mitochondrial redox state using hyperpolarized 13 C-acetoacetate.

Magnetic resonance in medicine

von Morze C, Ohliger MA, Marco-Rius I, Wilson DM, Flavell RR, Pearce D, Vigneron DB, Kurhanewicz J, Wang ZJ

Lack of specificity of antibodies raised against CLN3, the lysosomal/endosomal transmembrane protein mutated in juvenile Batten disease.

Bioscience reports

Nelson T, Pearce DA, Kovács AD

Glucocorticoid-induced leucine zipper protein regulates sodium and potassium balance in the distal nephron.

Kidney international

Rashmi P, Colussi G, Ng M, Wu X, Kidwai A, Pearce D

Monitoring acute metabolic changes in the liver and kidneys induced by fructose and glucose using hyperpolarized [2-13 C]dihydroxyacetone.

Magnetic resonance in medicine

Marco-Rius I, von Morze C, Sriram R, Cao P, Chang GY, Milshteyn E, Bok RA, Ohliger MA, Pearce D, Kurhanewicz J, Larson PE, Vigneron DB, Merritt M

Decreased sensitivity of palmitoyl protein thioesterase 1-deficient neurons to chemical anoxia.

Metabolic brain disease

Meyer M, Kovács AD, Pearce DA

Detection of localized changes in the metabolism of hyperpolarized gluconeogenic precursors 13 C-lactate and 13 C-pyruvate in kidney and liver.

Magnetic resonance in medicine

von Morze C, Chang GY, Larson PE, Shang H, Allu PK, Bok RA, Crane JC, Olson MP, Tan CT, Marco-Rius I, Nelson SJ, Kurhanewicz J, Pearce D, Vigneron DB

Detecting Metabolism of Gluconeogenic Precursors Lactate and Pyruvate in Kidney & Liver with Hyperpolarized 13 C MRI.

The FASEB Journal

Cornelius von Morze, Gene-Yuan Chang, Peder E Larson, Hong Shang, Prasanna KR Allu, Robert A Bok, Jason C Crane, Marram P Olson, Chou T Tan, Irene Marco-Rius, Sarah J Nelson, John Kurhanewicz, David Pearce, Daniel B Vigneron

Multiband spectral-spatial RF excitation for hyperpolarized [2-13 C]dihydroxyacetone 13 C-MR metabolism studies.

Magnetic resonance in medicine

Marco-Rius I, Cao P, von Morze C, Merritt M, Moreno KX, Chang GY, Ohliger MA, Pearce D, Kurhanewicz J, Larson PE, Vigneron DB

Regulation of the epithelial Na+ channel by the mTORC2/SGK1 pathway.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

Lang F, Pearce D

mTORC2 regulates renal tubule sodium uptake by promoting ENaC activity.

The Journal of clinical investigation

Gleason CE, Frindt G, Cheng CJ, Ng M, Kidwai A, Rashmi P, Lang F, Baum M, Palmer LG, Pearce D

The novel Cln1(R151X) mouse model of infantile neuronal ceroid lipofuscinosis (INCL) for testing nonsense suppression therapy.

Human molecular genetics

Miller JN, Kovács AD, Pearce DA

Collecting duct principal cell transport processes and their regulation.

Clinical journal of the American Society of Nephrology : CJASN

Pearce D, Soundararajan R, Trimpert C, Kashlan OB, Deen PM, Kohan DE

Mineralocorticoid receptor antagonizes Dot1a-Af9 complex to increase αENaC transcription.

American journal of physiology. Renal physiology

Zhang X, Zhou Q, Chen L, Berger S, Wu H, Xiao Z, Pearce D, Zhou X, Zhang W

Osmotic stress changes the expression and subcellular localization of the Batten disease protein CLN3.

PloS one

Getty A, Kovács AD, Lengyel-Nelson T, Cardillo A, Hof C, Chan CH, Pearce DA

The role of nonsense-mediated decay in neuronal ceroid lipofuscinosis.

Human molecular genetics

Miller JN, Chan CH, Pearce DA

Plasma membrane calcium ATPase regulates bone mass by fine-tuning osteoclast differentiation and survival.

The Journal of Cell Biology

Kim HJ, Prasad V, Hyung SW, Lee ZH, Lee SW, Bhargava A, Pearce D, Lee Y, Kim HH

SGK3 regulates Ca(2+) entry and migration of dendritic cells.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Schmid E, Bhandaru M, Nurbaeva MK, Yang W, Szteyn K, Russo A, Leibrock C, Tyan L, Pearce D, Shumilina E, Lang F

Scaffold protein connector enhancer of kinase suppressor of Ras isoform 3 (CNK3) coordinates assembly of a multiprotein epithelial sodium channel (ENaC)-regulatory complex.

The Journal of biological chemistry

Soundararajan R, Ziera T, Koo E, Ling K, Wang J, Borden SA, Pearce D

Age-dependent therapeutic effect of memantine in a mouse model of juvenile Batten disease.

Neuropharmacology

Kovács AD, Saje A, Wong A, Ramji S, Cooper JD, Pearce DA

The Glucocorticoid-induced leucine zipper (GILZ) Is essential for spermatogonial survival and spermatogenesis.

Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation

Romero Y, Vuandaba M, Suarez P, Grey C, Calvel P, Conne B, Pearce D, de Massy B, Hummler E, Nef S

The glucocorticoid-induced leucine zipper (gilz/Tsc22d3-2) gene locus plays a crucial role in male fertility.

Molecular endocrinology (Baltimore, Md.)

Suarez PE, Rodriguez EG, Soundararajan R, Mérillat AM, Stehle JC, Rotman S, Roger T, Voirol MJ, Wang J, Gross O, Pétrilli V, Nadra K, Wilson A, Beermann F, Pralong FP, Maillard M, Pearce D, Chrast R, Rossier BC, Hummler E

Organization of the ENaC-regulatory machinery.

Critical reviews in biochemistry and molecular biology

Soundararajan R, Lu M, Pearce D

Chapter 6 Aldosterone Regulation of Ion Transport.

Brenner and Rector\u0027s The Kidney

David Pearce, Vivek Bhalla, John W. Funder, John B. Stokes

The role of the ENaC-regulatory complex in aldosterone-mediated sodium transport.

Molecular and cellular endocrinology

Soundararajan R, Pearce D, Ziera T

Novel role for SGK3 in glucose homeostasis revealed in SGK3/Akt2 double-null mice.

Molecular endocrinology (Baltimore, Md.)

Yao LJ, McCormick JA, Wang J, Yang KY, Kidwai A, Colussi GL, Boini KM, Birnbaum MJ, Lang F, German MS, Pearce D

Altered glutamate receptor function in the cerebellum of the Ppt1-/- mouse, a murine model of infantile neuronal ceroid lipofuscinosis.

Journal of neuroscience research

Finn R, Kovács AD, Pearce DA

mSIN1 protein mediates SGK1 protein interaction with mTORC2 protein complex and is required for selective activation of the epithelial sodium channel.

The Journal of biological chemistry

Lu M, Wang J, Ives HE, Pearce D

Identification of CNK3 in the Aldosterone-regulated ENaC Regulatory Complex.

The FASEB Journal

Tim Ziera, Eric Koo, Rama Soundararajan, David Pearce

Decreased bone density and increased phosphaturia in gene-targeted mice lacking functional serum- and glucocorticoid-inducible kinase 3.

Kidney international

Bhandaru M, Kempe DS, Rotte A, Capuano P, Pathare G, Sopjani M, Alesutan I, Tyan L, Huang DY, Siraskar B, Judenhofer MS, Stange G, Pichler BJ, Biber J, Quintanilla-Martinez L, Wagner CA, Pearce D, Föller M, Lang F

Altered sensitivity of cerebellar granule cells to glutamate receptor overactivation in the Cln3(Δex7/8)-knock-in mouse model of juvenile neuronal ceroid lipofuscinosis.

Neurochemistry international

Finn R, Kovács AD, Pearce DA

Cardiovascular effects of melanocortins.

European journal of pharmacology

Humphreys MH, Ni XP, Pearce D

Regulation of gastric acid secretion by the serum and glucocorticoid inducible kinase isoform SGK3.

Journal of gastroenterology

Pasham V, Rotte A, Bhandaru M, Eichenmüller M, Fröhlich H, Mack AF, Bobbala D, Yang W, Pearce D, Lang F

Temporary inhibition of AMPA receptors induces a prolonged improvement of motor performance in a mouse model of juvenile Batten disease.

Neuropharmacology

Kovács AD, Saje A, Wong A, Szénási G, Kiricsi P, Szabó E, Cooper JD, Pearce DA

Glucocorticoid-induced Leucine zipper 1 stimulates the epithelial sodium channel by regulating serum- and glucocorticoid-induced kinase 1 stability and subcellular localization.

The Journal of biological chemistry

Soundararajan R, Wang J, Melters D, Pearce D

Expression and role of serum and glucocorticoid-regulated kinase 2 in the regulation of Na+/H+ exchanger 3 in the mammalian kidney.

American journal of physiology. Renal physiology

Pao AC, Bhargava A, Di Sole F, Quigley R, Shao X, Wang J, Thomas S, Zhang J, Shi M, Funder JW, Moe OW, Pearce D

Blunted IgE-mediated activation of mast cells in mice lacking the serum- and glucocorticoid-inducible kinase SGK3.

American journal of physiology. Cell physiology

Zemtsova IM, Heise N, Fröhlich H, Qadri SM, Kucherenko Y, Boini KM, Pearce D, Shumilina E, Lang F

Role of epithelial sodium channels and their regulators in hypertension.

The Journal of biological chemistry

Soundararajan R, Pearce D, Hughey RP, Kleyman TR

Regulation of gastric acid secretion by PKB/Akt2.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Rotte A, Pasham V, Bhandaru M, Eichenmüller M, Yang W, Qadri SM, Kempe DS, Puchchakayala G, Pearce D, Birnbaum MJ, Lang F

Phosphopeptide screen uncovers novel phosphorylation sites of Nedd4-2 that potentiate its inhibition of the epithelial Na+ channel.

The Journal of biological chemistry

Hallows KR, Bhalla V, Oyster NM, Wijngaarden MA, Lee JK, Li H, Chandran S, Xia X, Huang Z, Chalkley RJ, Burlingame AL, Pearce D

Akt/PKB-sensitive proximal tubular glucose and phosphate transport.

The FASEB Journal

Michael Föller, Daniela S. Kempe, Gulab Siraskar, Henning Fröhlich, Teresa F. Ackermann, Balasaheb Siraskar, Harald Völkl, Martin Judenhofer, Bernd Pichler, Karla F. Leavens, Morris J. Birnbaum, David Pearce, Florian Lang

GILZ1: a key molecular determinant of intracellular signaling specificity governing epithelial sodium transport.

The FASEB Journal

Rama Soundararajan, Jian Wang, Daniel Melters, I-Chia Shih, David Pearce

Phosphopeptide Screen Uncovers JNK1 as a Potentiator of Nedd4-2-Mediated Epithelial Na+ Channel Inhibition.

The FASEB Journal

Vivek Bhalla, Nicholas M Oyster, Marjolein Wijngaarden, Jeffrey Lee, Hui Li, Xiaoyu Xia, Zhirong Huang, Robert Chalkley, Alma Burlingame, David Pearce, Ken Hallows

mTOR complex-2 activates ENaC by phosphorylating SGK1.

Journal of the American Society of Nephrology : JASN

Lu M, Wang J, Jones KT, Ives HE, Feldman ME, Yao LJ, Shokat KM, Ashrafi K, Pearce D

Akt2/PKBbeta-sensitive regulation of renal phosphate transport.

Acta physiologica (Oxford, England)

Kempe DS, Ackermann TF, Boini KM, Klaus F, Umbach AT, Dërmaku-Sopjani M, Judenhofer MS, Pichler BJ, Capuano P, Stange G, Wagner CA, Birnbaum MJ, Pearce D, Föller M, Lang F

Regulation of renal tubular glucose reabsorption by Akt2/PKBβ.

American journal of physiology. Renal physiology

Kempe DS, Siraskar G, Fröhlich H, Umbach AT, Stübs M, Weiss F, Ackermann TF, Völkl H, Birnbaum MJ, Pearce D, Föller M, Lang F

Akt2 and SGK3 are both determinants of postnatal hair follicle development.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Mauro TM, McCormick JA, Wang J, Boini KM, Ray L, Monks B, Birnbaum MJ, Lang F, Pearce D

Evidence for a noradrenergic mechanism causing hypertension and abnormal glucose metabolism in rats with relative deficiency of gamma-melanocyte-stimulating hormone.

Experimental physiology

Ni XP, van Dijk C, Pearce D, Humphreys MH

Epithelial sodium channel regulated by differential composition of a signaling complex.

Proceedings of the National Academy of Sciences of the United States of America

Soundararajan R, Melters D, Shih IC, Wang J, Pearce D

Rictor/TORC2 regulates Caenorhabditis elegans fat storage, body size, and development through sgk-1.

PLoS biology

Jones KT, Greer ER, Pearce D, Ashrafi K

Activity of the p110-alpha subunit of phosphatidylinositol-3-kinase is required for activation of epithelial sodium transport.

American journal of physiology. Renal physiology

Wang J, Knight ZA, Fiedler D, Williams O, Shokat KM, Pearce D

Differential activities of glucocorticoid-induced leucine zipper protein isoforms.

The Journal of biological chemistry

Soundararajan R, Wang J, Melters D, Pearce D

NH2 terminus of serum and glucocorticoid-regulated kinase 1 binds to phosphoinositides and is essential for isoform-specific physiological functions.

American journal of physiology. Renal physiology

Pao AC, McCormick JA, Li H, Siu J, Govaerts C, Bhalla V, Soundararajan R, Pearce D

Salt, sodium channels, and SGK1.

The Journal of clinical investigation

Pearce D, Kleyman TR

AMP-activated kinase inhibits the epithelial Na+ channel through functional regulation of the ubiquitin ligase Nedd4-2.

The Journal of biological chemistry

Bhalla V, Oyster NM, Fitch AC, Wijngaarden MA, Neumann D, Schlattner U, Pearce D, Hallows KR

Disinhibitory pathways for control of sodium transport: regulation of ENaC by SGK1 and GILZ.

American journal of physiology. Renal physiology

Bhalla V, Soundararajan R, Pao AC, Li H, Pearce D

Renal function of gene-targeted mice lacking both SGK1 and SGK3.

American journal of physiology. Regulatory, integrative and comparative physiology

Grahammer F, Artunc F, Sandulache D, Rexhepaj R, Friedrich B, Risler T, McCormick JA, Dawson K, Wang J, Pearce D, Wulff P, Kuhl D, Lang F

Inhibition of the Epithelial Sodium Channel by AMP-Activated Kinase Involves Modulation of Nedd4-2 Activity.

The FASEB Journal

Kenneth R Hallows, Nicholas M Oyster, Vivek Bhalla, David Pearce

Reduced locomotion in the serum and glucocorticoid inducible kinase 3 knock out mouse.

Behavioural brain research

Lang UE, Wolfer DP, Grahammer F, Strutz-Seebohm N, Seebohm G, Lipp HP, McCormick JA, Hellweg R, Dawson K, Wang J, Pearce D, Lang F

A novel role for glucocorticoid-induced leucine zipper protein in epithelial sodium channel-mediated sodium transport.

The Journal of biological chemistry

Soundararajan R, Zhang TT, Wang J, Vandewalle A, Pearce D

Modulation by dietary sodium intake of melanocortin 3 receptor mRNA and protein abundance in the rat kidney.

American journal of physiology. Regulatory, integrative and comparative physiology

Ni XP, Bhargava A, Pearce D, Humphreys MH

Serum- and glucocorticoid-regulated kinase 1 regulates ubiquitin ligase neural precursor cell-expressed, developmentally down-regulated protein 4-2 by inducing interaction with 14-3-3.

Molecular endocrinology (Baltimore, Md.)

Bhalla V, Daidié D, Li H, Pao AC, LaGrange LP, Wang J, Vandewalle A, Stockand JD, Staub O, Pearce D

Decreased intestinal glucose transport in the sgk3-knockout mouse.

Pflugers Archiv : European journal of physiology

Sandu C, Rexhepaj R, Grahammer F, McCormick JA, Henke G, Palmada M, Nammi S, Lang U, Metzger M, Just L, Skutella T, Dawson K, Wang J, Pearce D, Lang F

SGK1: a rapid aldosterone-induced regulator of renal sodium reabsorption.

Physiology (Bethesda, Md.)

McCormick JA, Bhalla V, Pao AC, Pearce D

Regulation of GluR1 abundance in murine hippocampal neurones by serum- and glucocorticoid-inducible kinase 3.

The Journal of physiology

Strutz-Seebohm N, Seebohm G, Mack AF, Wagner HJ, Just L, Skutella T, Lang UE, Henke G, Striegel M, Hollmann M, Rouach N, Nicoll RA, McCormick JA, Wang J, Pearce D, Lang F

Enhanced mitochondrial degradation of yeast cytochrome c with amphipathic structures.

Current genetics

Chen X, Moerschell RP, Pearce DA, Ramanan DD, Sherman F

Steroid receptor coactivator-1 splice variants differentially affect corticosteroid receptor signaling.

Endocrinology

Meijer OC, Kalkhoven E, van der Laan S, Steenbergen PJ, Houtman SH, Dijkmans TF, Pearce D, de Kloet ER

Targeted disruption of the protein kinase SGK3/CISK impairs postnatal hair follicle development.

Molecular biology of the cell

McCormick JA, Feng Y, Dawson K, Behne MJ, Yu B, Wang J, Wyatt AW, Henke G, Grahammer F, Mauro TM, Lang F, Pearce D

Long double-stranded RNA-mediated RNA interference as a tool to achieve site-specific silencing of hypothalamic neuropeptides.

Brain research. Brain research protocols

Bhargava A, Dallman MF, Pearce D, Choi S

Mechanisms of mineralocorticoid action: determinants of receptor specificity and actions of regulated gene products.

Trends in endocrinology and metabolism: TEM

Bhargava A, Pearce D

Regulation of epithelial ion transport by aldosterone through changes in gene expression.

Molecular and cellular endocrinology

Bhargava A, Wang J, Pearce D

Sgk1 mediates osmotic induction of NPR-A gene in rat inner medullary collecting duct cells.

Hypertension (Dallas, Tex. : 1979)

Chen S, McCormick JA, Prabaker K, Wang J, Pearce D, Gardner DG

Homodimerization of the glucocorticoid receptor is not essential for response element binding: activation of the phenylethanolamine N-methyltransferase gene by dimerization-defective mutants.

Molecular endocrinology (Baltimore, Md.)

Adams M, Meijer OC, Wang J, Bhargava A, Pearce D

Multiple corticosteroid receptors in a teleost fish: distinct sequences, expression patterns, and transcriptional activities.

Endocrinology

Greenwood AK, Butler PC, White RB, DeMarco U, Pearce D, Fernald RD

Genetic disruption of gamma-melanocyte-stimulating hormone signaling leads to salt-sensitive hypertension in the mouse.

The Journal of clinical investigation

Ni XP, Pearce D, Butler AA, Cone RD, Humphreys MH

The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha,beta,gamma-ENaC.

Pflugers Archiv : European journal of physiology

Friedrich B, Feng Y, Cohen P, Risler T, Vandewalle A, Bröer S, Wang J, Pearce D, Lang F

Aldosterone: its receptor, target genes, and actions.

Vitamins and hormones

Pearce D, Bhargava A, Cole TJ

SGK1 regulation of epithelial sodium transport.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Pearce D

The serum and glucocorticoid-inducible kinase SGK1 and the Na+/H+ exchange regulating factor NHERF2 synergize to stimulate the renal outer medullary K+ channel ROMK1.

Journal of the American Society of Nephrology : JASN

Yun CC, Palmada M, Embark HM, Fedorenko O, Feng Y, Henke G, Setiawan I, Boehmer C, Weinman EJ, Sandrasagra S, Korbmacher C, Cohen P, Pearce D, Lang F

Effect of immunosuppressive agents on glucocorticoid receptor function in A6 cells.

American journal of physiology. Renal physiology

Edinger RS, Watkins SC, Pearce D, Johnson JP

Glucocorticoids prolong Ca(2+) transients in hippocampal-derived H19-7 neurons by repressing the plasma membrane Ca(2+)-ATPase-1.

Molecular endocrinology (Baltimore, Md.)

Bhargava A, Mathias RS, McCormick JA, Dallman MF, Pearce D

Hypotonic induction of SGK1 and Na+ transport in A6 cells.

American journal of physiology. Renal physiology

Rozansky DJ, Wang J, Doan N, Purdy T, Faulk T, Bhargava A, Dawson K, Pearce D

Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na(+) channel cell surface expression.

The EMBO journal

Debonneville C, Flores SY, Kamynina E, Plant PJ, Tauxe C, Thomas MA, Münster C, Chraïbi A, Pratt JH, Horisberger JD, Pearce D, Loffing J, Staub O

Determinants of subnuclear organization of mineralocorticoid receptor characterized through analysis of wild type and mutant receptors.

The Journal of biological chemistry

Pearce D, Náray-Fejes-Tóth A, Fejes-Tóth G

The role of SGK1 in hormone-regulated sodium transport.

Trends in endocrinology and metabolism: TEM

Pearce D

Aldosterone induces rapid apical translocation of ENaC in early portion of renal collecting system: possible role of SGK.

American journal of physiology. Renal physiology

Loffing J, Zecevic M, Féraille E, Kaissling B, Asher C, Rossier BC, Firestone GL, Pearce D, Verrey F

Human immunodeficiency virus type 1 Vpr contains two leucine-rich helices that mediate glucocorticoid receptor coactivation independently of its effects on G(2) cell cycle arrest.

Journal of virology

Sherman MP, de Noronha CM, Pearce D, Greene WC

Transcriptional repression of the 5-HT1A receptor promoter by corticosterone via mineralocorticoid receptors depends on the cellular context.

Journal of neuroendocrinology

Meijer OC, Williamson A, Dallman MF, Pearce D

Regulation of the rat serotonin-1A receptor gene by corticosteroids.

The Journal of biological chemistry

Wissink S, Meijer O, Pearce D, van Der Burg B, van Der Saag PT

Toxicity of copper, cobalt, and nickel salts is dependent on histidine metabolism in the yeast Saccharomyces cerevisiae.

Journal of bacteriology

Pearce DA, Sherman F

Distinct glucocorticoid receptor transcriptional regulatory surfaces mediate the cytotoxic and cytostatic effects of glucocorticoids.

Molecular and Cellular Biology

Rogatsky I, Hittelman AB, Pearce D, Garabedian MJ

Androgen and glucocorticoid receptor heterodimer formation. A possible mechanism for mutual inhibition of transcriptional activity.

The Journal of biological chemistry

Chen Sy, Wang J, Yu Gq, Liu W, Pearce D

The Paracoccus denitrificans ccmA, B and C genes: cloning and sequencing, and analysis of the potential of their products to form a haem or apo- c-type cytochrome transporter.

Microbiology (Reading, England)

Page MD, Pearce DA, Norris HAC, Ferguson SJ

Mineralocorticoid and glucocorticoid receptor activities distinguished by nonreceptor factors at a composite response element.

Science (New York, N.Y.)

Pearce D, Yamamoto KR

Expression of rat renal Na/H antiporter mRNA levels in response to respiratory and metabolic acidosis.

The Journal of clinical investigation

Krapf R, Pearce D, Lynch C, Xi XP, Reudelhuber TL, Pouysségur J, Rector FC

NaCl reflection coefficients in proximal tubule apical and basolateral membrane vesicles. Measurement by induced osmosis and solvent drag.

Biophysical Journal

Pearce D, Verkman AS

Membrane water and solute permeability determined quantitatively by self-quenching of an entrapped fluorophore.

Biochemistry

Chen PY, Pearce D, Verkman AS

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David Pearce, MD