Takashi Mikawa, PhD

Bilateral cellular flows display asymmetry prior to left-right organizer formation in amniote gastrulation.

Proceedings of the National Academy of Sciences of the United States of America

Asai R, Sinha S, Prakash VN, Mikawa T

Ipsilateral restriction of chromosome movement along a centrosome, and apical-basal axis during the cell cycle.

Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology

Cai P, Casas CJ, Quintero Plancarte G, Mikawa T, Hua LL

Cellular flows initiate left-right patterning prior to laterality gene expression in amniotes.

bioRxiv : the preprint server for biology

Asai R, Sinha S, Prakash VN, Mikawa T

Differential Sensitivity of Midline Patterning to Mitosis during and after Primitive Streak Extension.

bioRxiv : the preprint server for biology

Zhao Z, Asai R, Mikawa T

Coupling and uncoupling of midline morphogenesis and cell flow in amniote gastrulation.

eLife

Asai R, Prakash VN, Sinha S, Prakash M, Mikawa T

Ipsilateral restriction of chromosome movement along a centrosome, and apical-basal axis during the cell cycle.

Research square

Cai P, Casas CJ, Plancarte GQ, Mikawa T, Hua LL

Ipsilateral restriction of chromosome movement along a centrosome, and apical-basal axis during the cell cycle.

bioRxiv : the preprint server for biology

Cai P, Casas CJ, Hua LL, Mikawa T

Coupling and uncoupling of midline morphogenesis and cell flow in amniote gastrulation.

bioRxiv : the preprint server for biology

Asai R, Prakash VN, Sinha S, Prakash M, Mikawa T

Population Analysis of Daptomycin-non-Susceptible Methicillin-Resistant Staphylococcus aureus Reveals the Presence of Variants That Contribute to Daptomycin Resistance.

Current microbiology

Kanesaka I, Yabuta J, Jitsukawa T, Fujisaki S, Morita M, Mikawa T, Kanayama Katsuse A, Takahashi H, Ohno A, Kobayashi I

Mitotic Antipairing of Homologous Chromosomes.

Results and problems in cell differentiation

Hua LL, Casas CJ, Mikawa T

Avians as a Model System of Vascular Development.

Methods in molecular biology (Clifton, N.J.)

Asai R, Bressan M, Mikawa T

Programmed cell death along the midline axis patterns ipsilaterality in gastrulation.

Science (New York, N.Y.)

Maya-Ramos L, Mikawa T

Mitotic antipairing of homologous and sex chromosomes via spatial restriction of two haploid sets.

Proceedings of the National Academy of Sciences of the United States of America

Hua LL, Mikawa T

Body Cavity Development Is Guided by Morphogen Transfer between Germ Layers.

Cell reports

Schlueter J, Mikawa T

Dynamic Cellular Integration Drives Functional Assembly of the Heart's Pacemaker Complex.

Cell reports

Bressan M, Henley T, Louie JD, Liu G, Christodoulou D, Bai X, Taylor J, Seidman CE, Seidman JG, Mikawa T

Chick cranial neural crest cells use progressive polarity refinement, not contact inhibition of locomotion, to guide their migration.

Developmental biology

Genuth MA, Allen CDC, Mikawa T, Weiner OD

Chromosome Painting of Mouse Chromosomes.

Methods in molecular biology (Clifton, N.J.)

Hua LL, Mikawa T

Avians as a model system of vascular development.

Methods in molecular biology (Clifton, N.J.)

Bressan M, Mikawa T

Hemodynamic forces regulate developmental patterning of atrial conduction.

PloS one

Bressan MC, Louie JD, Mikawa T

Early divergence of central and peripheral neural retina precursors during vertebrate eye development.

Developmental dynamics : an official publication of the American Association of Anatomists

Venters SJ, Mikawa T, Hyer J

Reciprocal myocardial-endocardial interactions pattern the delay in atrioventricular junction conduction.

Development (Cambridge, England)

Bressan M, Yang PB, Louie JD, Navetta AM, Garriock RJ, Mikawa T

Microtubules coordinate VEGFR2 signaling and sorting.

PloS one

Czeisler C, Mikawa T

Induction of the Proepicardium.

Journal of developmental biology

Maya-Ramos L, Cleland J, Bressan M, Mikawa T

Isolation and culture of mouse proepicardium using serum-free conditions.

Methods (San Diego, Calif.)

Garriock RJ, Mikawa T, Yamaguchi TP

Central and peripheral retina arise through distinct developmental paths.

PloS one

Venters SJ, Mikawa T, Hyer J

Early mesodermal cues assign avian cardiac pacemaker fate potential in a tertiary heart field.

Science (New York, N.Y.)

Bressan M, Liu G, Mikawa T

Early arterial differentiation and patterning in the avian embryo model.

Seminars in cell & developmental biology

Garriock RJ, Mikawa T

A dual role for ErbB2 signaling in cardiac trabeculation.

Development (Cambridge, England)

Liu J, Bressan M, Hassel D, Huisken J, Staudt D, Kikuchi K, Poss KD, Mikawa T, Stainier DY

An anteroposterior wave of vascular inhibitor downregulation signals aortae fusion along the embryonic midline axis.

Development (Cambridge, England)

Garriock RJ, Czeisler C, Ishii Y, Navetta AM, Mikawa T

Eph regulates dorsoventral asymmetry of the notochord plate and convergent extension-mediated notochord formation.

PloS one

Oda-Ishii I, Ishii Y, Mikawa T

BMP signals promote proepicardial protrusion necessary for recruitment of coronary vessel and epicardial progenitors to the heart.

Developmental cell

Ishii Y, Garriock RJ, Navetta AM, Coughlin LE, Mikawa T

Morphogenesis and cytodifferentiation of the avian retinal pigmented epithelium require downregulation of Group B1 Sox genes.

Development (Cambridge, England)

Ishii Y, Weinberg K, Oda-Ishii I, Coughlin L, Mikawa T

FGFR-1 is required by epicardium-derived cells for myocardial invasion and correct coronary vascular lineage differentiation.

Developmental biology

Pennisi DJ, Mikawa T

Notochord-derived BMP antagonists inhibit endothelial cell generation and network formation.

Developmental biology

Bressan M, Davis P, Timmer J, Herzlinger D, Mikawa T

Endothelial cell lineages of the heart.

Cell and tissue research

Ishii Y, Langberg J, Rosborough K, Mikawa T

Induction of proepicardial marker gene expression by the liver bud.

Development (Cambridge, England)

Ishii Y, Langberg JD, Hurtado R, Lee S, Mikawa T

Development of the cardiac conduction system.

Seminars in cell & developmental biology

Mikawa T, Hurtado R

FGF-mediated induction of ciliary body tissue in the chick eye.

Developmental biology

Dias da Silva MR, Tiffin N, Mima T, Mikawa T, Hyer J

Bone marrow Oct3/4+ cells differentiate into cardiac myocytes via age-dependent paracrine mechanisms.

Circulation research

Pallante BA, Duignan I, Okin D, Chin A, Bressan MC, Mikawa T, Edelberg JM

Enhanced sensitivity and stability in two-color in situ hybridization by means of a novel chromagenic substrate combination.

Developmental dynamics : an official publication of the American Association of Anatomists

Hurtado R, Mikawa T

TrkB/BDNF signaling regulates photoreceptor progenitor cell fate decisions.

Developmental biology

Turner BA, Sparrow J, Cai B, Monroe J, Mikawa T, Hempstead BL

VEGF family members regulate myocardial tubulogenesis and coronary artery formation in the embryo.

Circulation research

Tomanek RJ, Ishii Y, Holifield JS, Sjogren CL, Hansen HK, Mikawa T

Normal patterning of the coronary capillary plexus is dependent on the correct transmural gradient of FGF expression in the myocardium.

Developmental biology

Pennisi DJ, Mikawa T

Somatic transgenesis in the avian model system.

Birth defects research. Part C, Embryo today : reviews

Ishii Y, Mikawa T

Developmental transitions in electrical activation patterns in chick embryonic heart.

The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology

Sedmera D, Reckova M, Bigelow MR, Dealmeida A, Stanley CP, Mikawa T, Gourdie RG, Thompson RP

A role for Tbx5 in proepicardial cell migration during cardiogenesis.

Physiological genomics

Hatcher CJ, Diman NY, Kim MS, Pennisi D, Song Y, Goldstein MM, Mikawa T, Basson CT

Negative regulation of midline vascular development by the notochord.

Developmental cell

Reese DE, Hall CE, Mikawa T

Folding of the tectal cortex by local remodeling of neural differentiation.

Developmental dynamics : an official publication of the American Association of Anatomists

Mima T, Mikawa T

Induction and patterning of the primitive streak, an organizing center of gastrulation in the amniote.

Developmental dynamics : an official publication of the American Association of Anatomists

Mikawa T, Poh AM, Kelly KA, Ishii Y, Reese DE

Somatic transgenesis using retroviral vectors in the chicken embryo.

Developmental dynamics : an official publication of the American Association of Anatomists

Ishii Y, Reese DE, Mikawa T

Platelet-derived growth factor-AB promotes the generation of adult bone marrow-derived cardiac myocytes.

Circulation research

Xaymardan M, Tang L, Zagreda L, Pallante B, Zheng J, Chazen JL, Chin A, Duignan I, Nahirney P, Rafii S, Mikawa T, Edelberg JM

Hemodynamic-dependent patterning of endothelin converting enzyme 1 expression and differentiation of impulse-conducting Purkinje fibers in the embryonic heart.

Development (Cambridge, England)

Hall CE, Hurtado R, Hewett KW, Shulimovich M, Poma CP, Reckova M, Justus C, Pennisi DJ, Tobita K, Sedmera D, Gourdie RG, Mikawa T

Epicardium is required for the full rate of myocyte proliferation and levels of expression of myocyte mitogenic factors FGF2 and its receptor, FGFR-1, but not for transmural myocardial patterning in the embryonic chick heart.

Developmental dynamics : an official publication of the American Association of Anatomists

Pennisi DJ, Ballard VL, Mikawa T

Evidence for an extracellular matrix bridge guiding proepicardial cell migration to the myocardium of chick embryos.

Developmental dynamics : an official publication of the American Association of Anatomists

Nahirney PC, Mikawa T, Fischman DA

Optic cup morphogenesis requires pre-lens ectoderm but not lens differentiation.

Developmental biology

Hyer J, Kuhlman J, Afif E, Mikawa T

Fibroblast growth factor (FGF)-4 can induce proliferation of cardiac cushion mesenchymal cells during early valve leaflet formation.

Developmental biology

Sugi Y, Ito N, Szebenyi G, Myers K, Fallon JF, Mikawa T, Markwald RR

His-Purkinje lineages and development.

Novartis Foundation symposium

Gourdie RG, Harris BS, Bond J, Edmondson AM, Cheng G, Sedmera D, O'Brien TX, Mikawa T, Thompson RP

Induction and patterning of the Purkinje fibre network.

Novartis Foundation symposium

Mikawa T, Gourdie RG, Takebayashi-Suzuki K, Kanzawa N, Hyer J, Pennisi DJ, Poma CP, Shulimovich M, Diaz KG, Layliev J, Prasad A

Constitutive expression of preproendothelin in the cardiac neural crest selectively promotes expansion of the adventitia of the great vessels in vivo.

Developmental biology

Ballard VL, Mikawa T

Development of the coronary vessel system.

Circulation research

Reese DE, Mikawa T, Bader DM

Induction and patterning of the cardiac conduction system.

The International journal of developmental biology

Pennisi DJ, Rentschler S, Gourdie RG, Fishman GI, Mikawa T

Competency of embryonic cardiomyocytes to undergo Purkinje fiber differentiation is regulated by endothelin receptor expression.

Development (Cambridge, England)

Kanzawa N, Poma CP, Takebayashi-Suzuki K, Diaz KG, Layliev J, Mikawa T

Cell death along the embryo midline regulates left-right sidedness.

Developmental dynamics : an official publication of the American Association of Anatomists

Kelly KA, Wei Y, Mikawa T

Purkinje fibers of the avian heart express a myogenic transcription factor program distinct from cardiac and skeletal muscle.

Developmental biology

Takebayashi-Suzuki K, Pauliks LB, Eltsefon Y, Mikawa T

TBX5 transcription factor regulates cell proliferation during cardiogenesis.

Developmental biology

Hatcher CJ, Kim MS, Mah CS, Goldstein MM, Wong B, Mikawa T, Basson CT

Fate diversity of primitive streak cells during heart field formation in ovo.

Developmental dynamics : an official publication of the American Association of Anatomists

Wei Y, Mikawa T

Trk C receptor signaling regulates cardiac myocyte proliferation during early heart development in vivo.

Developmental biology

Lin MI, Das I, Schwartz GM, Tsoulfas P, Mikawa T, Hempstead BL

Axonal growth of the spinal cord interneurons expressing a homophilic adhesion molecule SC1 ectopically.

Neuroscience research

Fujii T, Funahashi J, Matsuura R, Izaki T, Nakamura H, Mikawa T, Tanaka H

In vivo induction of cardiac Purkinje fiber differentiation by coexpression of preproendothelin-1 and endothelin converting enzyme-1.

Development (Cambridge, England)

Takebayashi-Suzuki K, Yanagisawa M, Gourdie RG, Kanzawa N, Mikawa T

Trk C signaling is required for retinal progenitor cell proliferation.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Das I, Sparrow JR, Lin MI, Shih E, Mikawa T, Hempstead BL

Stable transfectants of smooth muscle cell line lacking the expression of myosin light chain kinase and their characterization with respect to the actomyosin system.

The Journal of biological chemistry

Kishi H, Mikawa T, Seto M, Sasaki Y, Kanayasu-Toyoda T, Yamaguchi T, Imamura M, Ito M, Karaki H, Bao J, Nakamura A, Ishikawa R, Kohama K

Formation of the avian primitive streak from spatially restricted blastoderm: evidence for polarized cell division in the elongating streak.

Development (Cambridge, England)

Wei Y, Mikawa T

Adenovirus-mediated gene transfer of a truncated form of fibroblast growth factor receptor inhibits growth of glioma cells both in vitro and in vivo.

Journal of neuro-oncology

Saiki M, Mima T, Takahashi JC, Tani S, Yukawa H, Ueno H, Mikawa T, Itoh N, Kikuchi H, Hashimoto N, Miyatake S

Isoform-specific interaction of the myosin-binding proteins (MyBPs) with skeletal and cardiac myosin is a property of the C-terminal immunoglobulin domain.

The Journal of biological chemistry

Alyonycheva TN, Mikawa T, Reinach FC, Fischman DA

Ependymal/subependymal zone cells of postnatal and adult songbird brain generate both neurons and nonneuronal siblings in vitro and in vivo.

Journal of neurobiology

Goldman SA, Zukhar A, Barami K, Mikawa T, Niedzwiecki D

The fate diversity of mesodermal cells within the heart field during chicken early embryogenesis.

Developmental biology

Cohen-Gould L, Mikawa T

Smooth muscle alpha-actin downregulation in cultured chick aortic smooth muscle and neural crest cells is associated with altered cell shape.

Experimental cell research

Mishima N, Mikawa T, Kirby ML

Retroviral vectors to study cardiovascular development.

Trends in cardiovascular medicine

Mikawa T, Hyer J, Itoh N, Wei Y

Pericardial mesoderm generates a population of coronary smooth muscle cells migrating into the heart along with ingrowth of the epicardial organ.

Developmental biology

Mikawa T, Gourdie RG

Loss of fibroblast growth factor receptors is necessary for terminal differentiation of embryonic limb muscle.

Development (Cambridge, England)

Itoh N, Mima T, Mikawa T

The carboxyl terminus of myosin binding protein C (MyBP-C, C-protein) specifies incorporation into the A-band of striated muscle.

Journal of cell science

Gilbert R, Kelly MG, Mikawa T, Fischman DA

Antisense suppression of skeletal muscle myosin light chain-1 biosynthesis impairs myofibrillogenesis in cultured myotubes.

Journal of muscle research and cell motility

Nawrotzki R, Fischman DA, Mikawa T

FGF can induce outgrowth of somatic mesoderm both inside and outside of limb-forming regions.

Developmental biology

Mima T, Ohuchi H, Noji S, Mikawa T

Fibroblast growth factor receptor is required for in vivo cardiac myocyte proliferation at early embryonic stages of heart development.

Proceedings of the National Academy of Sciences of the United States of America

Mima T, Ueno H, Fischman DA, Williams LT, Mikawa T

Mapping the origin of the avian enteric nervous system with a retroviral marker.

Developmental dynamics : an official publication of the American Association of Anatomists

Epstein ML, Mikawa T, Brown AM, McFarlin DR

The major myosin-binding domain of skeletal muscle MyBP-C (C protein) resides in the COOH-terminal, immunoglobulin C2 motif.

The Journal of Cell Biology

Okagaki T, Weber FE, Fischman DA, Vaughan KT, Mikawa T, Reinach FC

Retroviral analysis of cardiac morphogenesis: discontinuous formation of coronary vessels.

Proceedings of the National Academy of Sciences of the United States of America

Mikawa T, Fischman DA

Clonal analysis of cardiac morphogenesis in the chicken embryo using a replication-defective retrovirus. III: Polyclonal origin of adjacent ventricular myocytes.

Developmental dynamics : an official publication of the American Association of Anatomists

Mikawa T, Cohen-Gould L, Fischman DA

Metanephric mesenchyme contains multipotent stem cells whose fate is restricted after induction.

Development (Cambridge, England)

Herzlinger D, Koseki C, Mikawa T, al-Awqati Q

Clonal analysis of cardiac morphogenesis in the chicken embryo using a replication-defective retrovirus: I. Formation of the ventricular myocardium.

Developmental dynamics : an official publication of the American Association of Anatomists

Mikawa T, Borisov A, Brown AM, Fischman DA

In vivo analysis of a new lacZ retrovirus vector suitable for cell lineage marking in avian and other species.

Experimental cell research

Mikawa T, Fischman DA, Dougherty JP, Brown AM

Changes in myosin isozymes during development of chicken breast muscle.

Journal of biochemistry

Takano-Ohmuro H, Obinata T, Masaki T, Mikawa T

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Takashi Mikawa, PhD