Michael Matthay, MD

Professor, Medicine

Research Interests: Alveolar epithelial transport under normal and pathologic conditions. Resolution of pulmonary edema Mechanisms of Acute Lung Injury Summary: My research program is focused on identifying mechanisms responsible for fluid transport across the alveolar epithelium using cell, molecular, and in vivo models. In addition, our group is focused on understanding the mechanisms responsible for the development and resolution of pulmonary edema and acute lung injury in critically ill patients with acute respiratory failure. The studies include experimental and human-based studies designed to understand the pathogenesis of acute respiratory failure and to test potential new therapies. The work is supported primarily by grants from the National Heart, Lung, and Blood Institute.

Address: 
513 Parnassus Avenue, HSE, Rm 760
UCSF Box 0624
San Francisco, CA 94143
United States
Phone: 
+1 415 819-2807
Faculty Type: 
Parnassus Pulmonary Research Faculty
Publications: 

Agreement Between Sepsis-2 and Sepsis-3 Definitions Among Patients Admitted to the Intensive Care Unit.(link is external)

Annals of the American Thoracic Society

Zalucky AA, Evrard B, Delucchi K, Zhuo H, Wu N, Liu KD, Hendrickson CM, Matthay MA, Kangelaris KN, Calfee CS

Unlocking the Therapeutic Code of Mesenchymal Stromal Cells.(link is external)

American journal of respiratory and critical care medicine

Lingappan K, Matthay MA

Elastance May Determine the Neuromuscular Blockade Effect on Mortality in Acute Respiratory Distress Syndrome.(link is external)

American journal of respiratory and critical care medicine

Zalucky AA, Dianti J, Neyton LPA, Sinha P, Liu KD, Matthay MA, Thompson BT, Goligher EC, Calfee CS

Acute respiratory distress vs healthy lung environments differently affect mesenchymal stromal cell extracellular vesicle miRNAs.(link is external)

Cytotherapy

Rolandsson Enes S, Dzneladze I, Hampton TH, Neff SL, Asarian L, Barua J, Tertel T, Giebel B, Pereyra N, McKenna DH, Hu P, Acton E, Ashare A, Liu KD, Krasnodembskaya AD, English K, Stanton BA, Rocco PRM, Matthay MA, Dos Santos CC, Weiss DJ

Temporal Transitions of the Hyperinflammatory and Hypoinflammatory Phenotypes in Critical Illness.(link is external)

American journal of respiratory and critical care medicine

van Amstel RBE, Bartek B, Vlaar APJ, Gay E, van Vught LA, Cremer OL, Van der Poll T, Shapiro NI, Matthay MA, Calfee CS, Sinha P, Bos LDJ

Pneumothoraces Associated With Vaping Cannabis Concentrate.(link is external)

Pediatrics

Olgin GK, Ludwig C, Matthay MA, Gribben V

Delphi-driven consensus definition for mesenchymal stromal cells and clinical reporting guidelines for mesenchymal stromal cell-based therapeutics.(link is external)

Cytotherapy

Renesme L, Cobey KD, Lalu MM, Bubela T, Chinnadurai R, De Vos J, Dunbar R, Fergusson D, Freund D, Galipeau J, Horwitz E, Lê M, Matthay M, Moher D, Nolta J, Parker G, Phinney DG, Rao M, Rasko JEJ, Rocco PRM, Rossi F, Myles MR, Viswanathan S, Thébaud B

Microbial dynamics and pulmonary immune responses in COVID-19 secondary bacterial pneumonia.(link is external)

Nature communications

Spottiswoode N, Tsitsiklis A, Chu VT, Phan HV, DeVoe C, Love C, Ghale R, Bloomstein J, Zha BS, Maguire CP, Glascock A, Sarma A, Mourani PM, Kalantar KL, Detweiler A, Neff N, Haller SC, COMET Consortium, DeRisi JL, Erle DJ, Hendrickson CM, Kangelaris KN, Krummel MF, Matthay MA, Woodruff PG, Calfee CS, Langelier CR

Acute respiratory distress syndrome.(link is external)

BMJ (Clinical research ed.)

Wick KD, Ware LB, Matthay MA

Endothelial ENaC-α Restrains Oxidative Stress in Lung Capillaries in Murine Pneumococcal Pneumonia-associated Acute Lung Injury.(link is external)

American journal of respiratory cell and molecular biology

Romero MJ, Yue Q, Ahn WM, Hamacher J, Zaidi Y, Haigh S, Sridhar S, Gonzales J, Hudel M, Huo Y, Verin AD, Pace BS, Stansfield BK, Maishan M, Neptune ER, Enkhbaatar P, Su Y, Chakraborty T, Gonsalvez G, Hummler E, Davis WB, Bogdanov VY, Fulton DJR, Csanyi G, Matthay MA, Eaton DC, Lucas R

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