Theodore Kurtz, MD

Peluso MJ, Takahashi S, Hakim J, Kelly JD, Torres L, Iyer NS, Turcios K, Janson O, Munter SE, Thanh C, Donatelli J, Nixon CC, Hoh R, Tai V, Fehrman EA, Hernandez Y, Spinelli MA, Gandhi M, Palafox MA, Vallari A, Rodgers MA, Prostko J, Hackett J, Trinh L, Wrin T, Petropoulos CJ, Chiu CY, Norris PJ, DiGermanio C, Stone M, Busch MP, Elledge SK, Zhou XX, Wells JA, Shu A, Kurtz TW, Pak JE, Wu W, Burbelo PD, Cohen JI, Rutishauser RL, Martin JN, Deeks SG, Henrich TJ, Rodriguez-Barraquer I, Greenhouse B

No evidence of racial disparities in blood pressure salt sensitivity when potassium intake exceeds levels recommended in the US dietary guidelines.

American journal of physiology. Heart and circulatory physiology

Kurtz TW, DiCarlo SE, Pravenec M, Morris RC

SARS-CoV-2 antibody magnitude and detectability are driven by disease severity, timing, and assay.

medRxiv : the preprint server for health sciences

Peluso MJ, Takahashi S, Hakim J, Kelly JD, Torres L, Iyer NS, Turcios K, Janson O, Munter SE, Thanh C, Nixon CC, Hoh R, Tai V, Fehrman EA, Hernandez Y, Spinelli MA, Gandhi M, Palafox MA, Vallari A, Rodgers MA, Prostko J, Hackett J, Trinh L, Wrin T, Petroplolous CJ, Chiu CY, Norris PJ, DiGermanio C, Stone M, Busch MP, Elledge SK, Zhou XX, Wells JA, Shu A, Kurtz TW, Pak JE, Wu W, Burbelo PD, Cohen JI, Rutishauser RL, Martin JN, Deeks SG, Henrich TJ, Rodriguez-Barraquer I, Greenhouse B

Prevalence of SARS-Cov-2 Antibodies in Emergency Medicine Healthcare Workers.

Annals of emergency medicine

Wang RC, Murphy CE, Kornblith AE, Kurtz T, Kohn MA

SARS-CoV-2 seroprevalence and neutralizing activity in donor and patient blood.

Nature communications

Ng DL, Goldgof GM, Shy BR, Levine AG, Balcerek J, Bapat SP, Prostko J, Rodgers M, Coller K, Pearce S, Franz S, Du L, Stone M, Pillai SK, Sotomayor-Gonzalez A, Servellita V, Martin CSS, Granados A, Glasner DR, Han LM, Truong K, Akagi N, Nguyen DN, Neumann NM, Qazi D, Hsu E, Gu W, Santos YA, Custer B, Green V, Williamson P, Hills NK, Lu CM, Whitman JD, Stramer SL, Wang C, Reyes K, Hakim JMC, Sujishi K, Alazzeh F, Pham L, Thornborrow E, Oon CY, Miller S, Kurtz T, Simmons G, Hackett J, Busch MP, Chiu CY

SARS-CoV-2 seroprevalence and neutralizing activity in donor and patient blood from the San Francisco Bay Area.

medRxiv : the preprint server for health sciences

Ng DL, Goldgof GM, Shy BR, Levine AG, Balcerek J, Bapat SP, Prostko J, Rodgers M, Coller K, Pearce S, Franz S, Du L, Stone M, Pillai SK, Sotomayor-Gonzalez A, Servellita V, Martin CSS, Granados A, Glasner DR, Han LM, Truong K, Akagi N, Nguyen DN, Neumann NM, Qazi D, Hsu E, Gu W, Santos YA, Custer B, Green V, Williamson P, Hills NK, Lu CM, Whitman JD, Stramer S, Wang C, Reyes K, Hakim JMC, Sujishi K, Alazzeh F, Pham L, Oon CY, Miller S, Kurtz T, Hackett J, Simmons G, Busch MP, Chiu CY

Strategies Are Needed to Prevent Salt-Induced Hypertension That Do Not Depend on Reducing Salt Intake.

American journal of hypertension

Kurtz TW, Pravenec M, Dicarlo SE

Development of In-Browser Simulators for Medical Education: Introduction of a Novel Software Toolchain.

Journal of medical Internet research

Šilar J, Polák D, Mládek A, Ježek F, Kurtz TW, DiCarlo SE, Živný J, Kofranek J

Animal Models of Hypertension: A Scientific Statement From the American Heart Association.

Hypertension (Dallas, Tex. : 1979)

Lerman LO, Kurtz TW, Touyz RM, Ellison DH, Chade AR, Crowley SD, Mattson DL, Mullins JJ, Osborn J, Eirin A, Reckelhoff JF, Iadecola C, Coffman TM

Small Amounts of Inorganic Nitrate or Beetroot Provide Substantial Protection From Salt-Induced Increases in Blood Pressure.

Hypertension (Dallas, Tex. : 1979)

Morris RC, Pravenec M, Šilhavý J, DiCarlo SE, Kurtz TW

Testing Computer Models Predicting Human Responses to a High-Salt Diet.

Hypertension (Dallas, Tex. : 1979)

Kurtz TW, DiCarlo SE, Pravenec M, Ježek F, Šilar J, Kofránek J, Morris RC

Changing views on the common physiologic abnormality that mediates salt sensitivity and initiation of salt-induced hypertension: Japanese research underpinning the vasodysfunction theory of salt sensitivity.

Hypertension research : official journal of the Japanese Society of Hypertension

Kurtz TW, DiCarlo SE, Pravenec M, Morris RC

Functional foods for augmenting nitric oxide activity and reducing the risk for salt-induced hypertension and cardiovascular disease in Japan.

Journal of cardiology

Kurtz TW, DiCarlo SE, Pravenec M, Morris RC

Reply.

Journal of hypertension

Kurtz TW, DiCarlo SE, Pravenec M, Morris RC

The pivotal role of renal vasodysfunction in salt sensitivity and the initiation of salt-induced hypertension.

Current opinion in nephrology and hypertension

Kurtz TW, DiCarlo SE, Pravenec M, Morris RC

The American Heart Association Scientific Statement on salt sensitivity of blood pressure: Prompting consideration of alternative conceptual frameworks for the pathogenesis of salt sensitivity?

Journal of hypertension

Kurtz TW, DiCarlo SE, Pravenec M, Morris RC

What abnormalities initiate salt-induced increases in blood pressure according to the autoregulation and vasodysfunction theories for salt sensitivity?

Kidney international

Kurtz TW, Morris RC

Response to Tautological Nature of Guyton's Theory of Blood Pressure Control.

American journal of hypertension

Kurtz TW, DiCarlo SE, Morris RC

An Appraisal of Methods Recently Recommended for Testing Salt Sensitivity of Blood Pressure.

Journal of the American Heart Association

Kurtz TW, DiCarlo SE, Pravenec M, Morris RC

Effects of transgenic expression of dopamine beta hydroxylase (Dbh) gene on blood pressure in spontaneously hypertensive rats.

Physiological research

Pravenec M, Landa V, Zídek V, Mlejnek P, Šilhavý J, Mir SA, Vaingankar SM, Wang J, Kurtz TW

Logical Issues With the Pressure Natriuresis Theory of Chronic Hypertension.

American journal of hypertension

Kurtz TW, DiCarlo SE, Morris RC

An alternative hypothesis to the widely held view that renal excretion of sodium accounts for resistance to salt-induced hypertension.

Kidney international

Kurtz TW, DiCarlo SE, Pravenec M, Schmidlin O, Tanaka M, Morris RC

Response to Hall.

Circulation

Morris RC, Schmidlin O, Sebastian A, Tanaka M, Kurtz TW

Vasodysfunction That Involves Renal Vasodysfunction, Not Abnormally Increased Renal Retention of Sodium, Accounts for the Initiation of Salt-Induced Hypertension.

Circulation

Morris RC, Schmidlin O, Sebastian A, Tanaka M, Kurtz TW

Increased Energy Expenditure, Ucp1 Expression, and Resistance to Diet-induced Obesity in Mice Lacking Nuclear Factor-Erythroid-2-related Transcription Factor-2 (Nrf2).

The Journal of biological chemistry

Schneider K, Valdez J, Nguyen J, Vawter M, Galke B, Kurtz TW, Chan JY

Genetic Variation in Renal Expression of Folate Receptor 1 (Folr1) Gene Predisposes Spontaneously Hypertensive Rats to Metabolic Syndrome.

Hypertension (Dallas, Tex. : 1979)

Pravenec M, Kožich V, Krijt J, Sokolová J, Zídek V, Landa V, Mlejnek P, Šilhavý J, Šimáková M, Škop V, Trnovská J, Kazdová L, Kajiya T, Wang J, Kurtz TW

Oxidized LDL (oxLDL) activates the angiotensin II type 1 receptor by binding to the lectin-like oxLDL receptor.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Yamamoto K, Kakino A, Takeshita H, Hayashi N, Li L, Nakano A, Hanasaki-Yamamoto H, Fujita Y, Imaizumi Y, Toyama-Yokoyama S, Nakama C, Kawai T, Takeda M, Hongyo K, Oguro R, Maekawa Y, Itoh N, Takami Y, Onishi M, Takeya Y, Sugimoto K, Kamide K, Nakagami H, Ohishi M, Kurtz TW, Sawamura T, Rakugi H

Molecular-based mechanisms of Mendelian forms of salt-dependent hypertension: questioning the prevailing theory.

Hypertension (Dallas, Tex. : 1979)

Kurtz TW, Dominiczak AF, DiCarlo SE, Pravenec M, Morris RC

The 24 h pattern of arterial pressure in mice is determined mainly by heart rate-driven variation in cardiac output.

Physiological reports

Kurtz TW, Lujan HL, DiCarlo SE

John Laragh: scientific pioneer.

American journal of hypertension

Kurtz TW

Effects of mtDNA in SHR-mtF344 versus SHR conplastic strains on reduced OXPHOS enzyme levels, insulin resistance, cardiac hypertrophy, and systolic dysfunction.

Physiological genomics

Houštek J, Vrbacký M, Hejzlarová K, Zídek V, Landa V, Šilhavý J, Šimáková M, Mlejnek P, Kazdová L, Mikšík I, Neckár J, Papoušek F, Kolár F, Kurtz TW, Pravenec M

Fumaric acid esters can block pro-inflammatory actions of human CRP and ameliorate metabolic disturbances in transgenic spontaneously hypertensive rats.

PloS one

Šilhavý J, Zídek V, Mlejnek P, Landa V, Šimáková M, Strnad H, Oliyarnyk O, Škop V, Kazdová L, Kurtz T, Pravenec M

Rosuvastatin can block pro-inflammatory actions of transgenic human C-reactive protein without reducing its circulating levels.

Cardiovascular therapeutics

Šilhavý J, Zídek V, Landa V, Šimáková M, Mlejnek P, Škop V, Oliyarnyk O, Kazdová L, Mancini M, Saar K, Schulz H, Hübner N, Kurtz TW, Pravenec M

Recurrent pituitary macroadenoma with increased plasma ACTH precursors that cross-react in a commonly used ACTH immunoassay.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

Woeber KA, White A, Kurtz TW

When blockade of the renin-angiotensin system becomes a two-edged sword.

American journal of hypertension

Kurtz TW

Tissue-specific peroxisome proliferator activated receptor gamma expression and metabolic effects of telmisartan.

American journal of hypertension

Zídek V, Mlejnek P, Simáková M, Silhavy J, Landa V, Kazdová L, Pravenec M, Kurtz TW

Folate deficiency is associated with oxidative stress, increased blood pressure, and insulin resistance in spontaneously hypertensive rats.

American journal of hypertension

Pravenec M, Kozich V, Krijt J, Sokolová J, Zídek V, Landa V, Simáková M, Mlejnek P, Silhavy J, Oliyarnyk O, Kazdová L, Kurtz TW

Telmisartan modulates mitochondrial function in vascular smooth muscle cells.

Hypertension research : official journal of the Japanese Society of Hypertension

Takeuchi K, Yamamoto K, Ohishi M, Takeshita H, Hongyo K, Kawai T, Takeda M, Kamide K, Kurtz TW, Rakugi H

Experimental models of type-2 diabetic nephropathy.

Experimental diabetes research

Tomino Y, Cooper ME, Kurtz TW, Shimizu Y

Nonsynonymous variants in mt-Nd2, mt-Nd4, and mt-Nd5 are linked to effects on oxidative phosphorylation and insulin sensitivity in rat conplastic strains.

Physiological genomics

Houštek J, Hejzlarová K, Vrbacký M, Drahota Z, Landa V, Zídek V, Mlejnek P, Šimáková M, Šilhavy J, Mikšík I, Kazdová L, Oliyarnyk O, Kurtz T, Pravenec M

Differential pharmacology and benefit/risk of azilsartan compared to other sartans.

Vascular health and risk management

Kurtz TW, Kajiya T

Molecular and cellular effects of azilsartan: a new generation angiotensin II receptor blocker.

Journal of hypertension

Kajiya T, Ho C, Wang J, Vilardi R, Kurtz TW

CD36 overexpression predisposes to arrhythmias but reduces infarct size in spontaneously hypertensive rats: gene expression profile analysis.

Physiological genomics

Neckár J, Šilhavy J, Zídek V, Landa V, Mlejnek P, Šimáková M, Seidman JG, Seidman C, Kazdová L, Klevstig M, Novák F, Vecka M, Papoušek F, Houštek J, Drahota Z, Kurtz TW, Kolár F, Pravenec M

Effects of human C-reactive protein on pathogenesis of features of the metabolic syndrome.

Hypertension (Dallas, Tex. : 1979)

Pravenec M, Kajiya T, Zídek V, Landa V, Mlejnek P, Simáková M, Silhavý J, Malínská H, Oliyarnyk O, Kazdová L, Fan J, Wang J, Kurtz TW

Angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers and diabetes: a meta-analysis of placebo-controlled clinical trials.

American journal of hypertension

Tocci G, Paneni F, Palano F, Sciarretta S, Ferrucci A, Kurtz T, Mancia G, Volpe M

Age-related autocrine diabetogenic effects of transgenic resistin in spontaneously hypertensive rats: gene expression profile analysis.

Physiological genomics

Pravenec M, Zídek V, Landa V, Simáková M, Mlejnek P, Silhavy J, Maxová M, Kazdová L, Seidman JG, Seidman CE, Eminaga S, Gorham J, Wang J, Kurtz TW

Genome-wide association studies will unlock the genetic basis of hypertension.: con side of the argument.

Hypertension (Dallas, Tex. : 1979)

Kurtz TW

Chlorthalidone: don't call it "thiazide-like" anymore.

Hypertension (Dallas, Tex. : 1979)

Kurtz TW

Design, synthesis, and docking studies of novel benzimidazoles for the treatment of metabolic syndrome.

Journal of medicinal chemistry

Mizuno CS, Chittiboyina AG, Shah FH, Patny A, Kurtz TW, Pershadsingh HA, Speth RC, Karamyan VT, Carvalho PB, Avery MA

Recent advances in genetics of the spontaneously hypertensive rat.

Current hypertension reports

Pravenec M, Kurtz TW

Deficiency in the nuclear factor E2-related factor-2 transcription factor results in impaired adipogenesis and protects against diet-induced obesity.

The Journal of biological chemistry

Pi J, Leung L, Xue P, Wang W, Hou Y, Liu D, Yehuda-Shnaidman E, Lee C, Lau J, Kurtz TW, Chan JY

Telmisartan-induced inhibition of vascular cell proliferation beyond angiotensin receptor blockade and peroxisome proliferator-activated receptor-gamma activation.

Hypertension (Dallas, Tex. : 1979)

Yamamoto K, Ohishi M, Ho C, Kurtz TW, Rakugi H

Increased liver oxidative stress and altered PUFA metabolism precede development of non-alcoholic steatohepatitis in SREBP-1a transgenic spontaneously hypertensive rats with genetic predisposition to hepatic steatosis.

Molecular and cellular biochemistry

Malínská H, Oliyarnyk O, Hubová M, Zídek V, Landa V, Simáková M, Mlejnek P, Kazdová L, Kurtz TW, Pravenec M

Next generation multifunctional angiotensin receptor blockers.

Hypertension research : official journal of the Japanese Society of Hypertension

Kurtz TW, Klein U

Dissection of chromosome 18 blood pressure and salt-sensitivity quantitative trait loci in the spontaneously hypertensive rat.

Hypertension (Dallas, Tex. : 1979)

Johnson MD, He L, Herman D, Wakimoto H, Wallace CA, Zidek V, Mlejnek P, Musilova A, Simakova M, Vorlicek J, Kren V, Viklicky O, Qi NR, Wang J, Seidman CE, Seidman J, Kurtz TW, Aitman TJ, Pravenec M

Long-term pioglitazone treatment enhances lipolysis in rat adipose tissue.

International journal of obesity (2005)

Pravenec M, Kazdová L, Maxová M, Zídek V, Mlejnek P, Simáková M, Kurtz TW

Beyond the classic angiotensin-receptor-blocker profile.

Nature clinical practice. Cardiovascular medicine

Kurtz TW

Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension.

Nature genetics

Pravenec M, Churchill PC, Churchill MC, Viklicky O, Kazdova L, Aitman TJ, Petretto E, Hubner N, Wallace CA, Zimdahl H, Zidek V, Landa V, Dunbar J, Bidani A, Griffin K, Qi N, Maxova M, Kren V, Mlejnek P, Wang J, Kurtz TW

Molecule-specific effects of angiotensin II-receptor blockers independent of the renin-angiotensin system.

American journal of hypertension

Kurtz TW, Pravenec M

Telmisartan increases fatty acid oxidation in skeletal muscle through a peroxisome proliferator-activated receptor-gamma dependent pathway.

Journal of hypertension

Sugimoto K, Kazdová L, Qi NR, Hyakukoku M, Kren V, Simáková M, Zídek V, Kurtz TW, Pravenec M

Inhibition of cardiovascular cell proliferation by angiotensin receptor blockers: are all molecules the same?

Journal of hypertension

Benson SC, Iguchi R, Ho CI, Yamamoto K, Kurtz TW

Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass.

Nature genetics

Petretto E, Sarwar R, Grieve I, Lu H, Kumaran MK, Muckett PJ, Mangion J, Schroen B, Benson M, Punjabi PP, Prasad SK, Pennell DJ, Kiesewetter C, Tasheva ES, Corpuz LM, Webb MD, Conrad GW, Kurtz TW, Kren V, Fischer J, Hubner N, Pinto YM, Pravenec M, Aitman TJ, Cook SA

Type 2 diabetes and oral antihyperglycemic drugs.

Current medicinal chemistry

Mizuno CS, Chittiboyina AG, Kurtz TW, Pershadsingh HA, Avery MA

Identification of mutated Srebf1 as a QTL influencing risk for hepatic steatosis in the spontaneously hypertensive rat.

Hypertension (Dallas, Tex. : 1979)

Pravenec M, Kazdova L, Landa V, Zidek V, Mlejnek P, Simakova M, Jansa P, Forejt J, Kren V, Krenova D, Qi N, Wang JM, Chan D, Aitman TJ, Kurtz TW

Direct linkage of mitochondrial genome variation to risk factors for type 2 diabetes in conplastic strains.

Genome research

Pravenec M, Hyakukoku M, Houstek J, Zidek V, Landa V, Mlejnek P, Miksik I, Dudová-Mothejzikova K, Pecina P, Vrbacky M, Drahota Z, Vojtiskova A, Mracek T, Kazdova L, Oliyarnyk O, Wang J, Ho C, Qi N, Sugimoto K, Kurtz T

Molecular genetics of experimental hypertension and the metabolic syndrome: from gene pathways to new therapies.

Hypertension (Dallas, Tex. : 1979)

Pravenec M, Kurtz TW

Design and synthesis of the first generation of dithiolane thiazolidinedione- and phenylacetic acid-based PPARgamma agonists.

Journal of medicinal chemistry

Chittiboyina AG, Venkatraman MS, Mizuno CS, Desai PV, Patny A, Benson SC, Ho CI, Kurtz TW, Pershadsingh HA, Avery MA

New treatment strategies for patients with hypertension and insulin resistance.

The American journal of medicine

Kurtz TW

Telmisartan but not valsartan increases caloric expenditure and protects against weight gain and hepatic steatosis.

Hypertension (Dallas, Tex. : 1979)

Sugimoto K, Qi NR, Kazdová L, Pravenec M, Ogihara T, Kurtz TW

Fat-specific transgenic expression of resistin in the spontaneously hypertensive rat impairs fatty acid re-esterification.

International journal of obesity (2005)

Pravenec M, Kazdová L, Cahová M, Landa V, Zídek V, Mlejnek P, Simáková M, Wang J, Qi N, Kurtz TW

BP-1107 [{2-[4-(2,4-dioxo-thiazolidin-5-ylmethyl)-phenoxy]-ethyl}-methyl-amide]: a novel synthetic thiazolidinedione that inhibits epidermal hyperplasia in psoriatic skin-severe-combined immunodeficient mouse transplants after topical application.

The Journal of pharmacology and experimental therapeutics

Bhagavathula N, Nerusu KC, Reddy M, Ellis CN, Chittiboyina A, Avery M, Pershadsingh HA, Kurtz TW, Varani J

A new transgenic rat model of hepatic steatosis and the metabolic syndrome.

Hypertension (Dallas, Tex. : 1979)

Qi NR, Wang J, Zidek V, Landa V, Mlejnek P, Kazdová L, Pravenec M, Kurtz TW

Treating the metabolic syndrome: telmisartan as a peroxisome proliferator-activated receptor-gamma activator.

Acta diabetologica

Kurtz TW

Recommendations for blood pressure measurement in animals: summary of an AHA scientific statement from the Council on High Blood Pressure Research, Professional and Public Education Subcommittee.

Arteriosclerosis, thrombosis, and vascular biology

Kurtz TW, Griffin KA, Bidani AK, Davisson RL, Hall JE, AHA Council on High Blood Pressure Research, Professional and Public Education Subcommittee

Recommendations for blood pressure measurement in humans and experimental animals: part 2: blood pressure measurement in experimental animals: a statement for professionals from the Subcommittee of Professional and Public Education of the American Heart A

Arteriosclerosis, thrombosis, and vascular biology

Kurtz TW, Griffin KA, Bidani AK, Davisson RL, Hall JE, Subcommittee of Professional and Public Education of the American Heart Association Council on High

Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease.

Nature genetics

Hubner N, Wallace CA, Zimdahl H, Petretto E, Schulz H, Maciver F, Mueller M, Hummel O, Monti J, Zidek V, Musilova A, Kren V, Causton H, Game L, Born G, Schmidt S, Müller A, Cook SA, Kurtz TW, Whittaker J, Pravenec M, Aitman TJ

Recommendations for blood pressure measurement in humans and experimental animals: part 1: blood pressure measurement in humans: a statement for professionals from the Subcommittee of Professional and Public Education of the American Heart Association Cou

Circulation

Pickering TG, Hall JE, Appel LJ, Falkner BE, Graves J, Hill MN, Jones DW, Kurtz T, Sheps SG, Roccella EJ

Recommendations for blood pressure measurement in humans: an AHA scientific statement from the Council on High Blood Pressure Research Professional and Public Education Subcommittee.

Journal of clinical hypertension (Greenwich, Conn.)

Pickering TG, Hall JE, Appel LJ, Falkner BE, Graves JW, Hill MN, Jones DH, Kurtz T, Sheps SG, Roccella EJ, Council on High Blood Pressure Research Professional and Public Education Subcommittee, American Hea

Recommendations for blood pressure measurement in humans and experimental animals. Part 2: Blood pressure measurement in experimental animals: a statement for professionals from the subcommittee of professional and public education of the American Heart A

Hypertension (Dallas, Tex. : 1979)

Kurtz TW, Griffin KA, Bidani AK, Davisson RL, Hall JE, Subcommittee of Professional and Public Education of the American Heart Association

Recommendations for blood pressure measurement in humans and experimental animals: Part 1: blood pressure measurement in humans: a statement for professionals from the Subcommittee of Professional and Public Education of the American Heart Association Cou

Hypertension (Dallas, Tex. : 1979)

Pickering TG, Hall JE, Appel LJ, Falkner BE, Graves J, Hill MN, Jones DW, Kurtz T, Sheps SG, Roccella EJ, Subcommittee of Professional and Public Education of the American Heart Association Council on High

A spontaneous mutation in the desmoglein 4 gene underlies hypotrichosis in a new lanceolate hair rat model.

Differentiation; research in biological diversity

Meyer B, Bazzi H, Zidek V, Musilova A, Pravenec M, Kurtz TW, Nurnberg P, Christiano AM

Antidiabetic mechanisms of angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonists: beyond the renin-angiotensin system.

Journal of hypertension

Kurtz TW, Pravenec M

Alpha-Lipoic acid-based PPARgamma agonists for treating inflammatory skin diseases.

Archives of dermatological research

Venkatraman MS, Chittiboyina A, Meingassner J, Ho CI, Varani J, Ellis CN, Avery MA, Pershadsingh HA, Kurtz TW, Benson SC

Insulin-sensitizing effects of telmisartan: implications for treating insulin-resistant hypertension and cardiovascular disease.

Diabetes care

Pershadsingh HA, Kurtz TW

Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARgamma-modulating activity.

Hypertension (Dallas, Tex. : 1979)

Benson SC, Pershadsingh HA, Ho CI, Chittiboyina A, Desai P, Pravenec M, Qi N, Wang J, Avery MA, Kurtz TW

CD36 mediates the phagocytosis of Plasmodium falciparum-infected erythrocytes by rodent macrophages.

The Journal of infectious diseases

Patel SN, Serghides L, Smith TG, Febbraio M, Silverstein RL, Kurtz TW, Pravenec M, Kain KC

Rosiglitazone inhibits proliferation, motility, and matrix metalloproteinase production in keratinocytes.

The Journal of investigative dermatology

Bhagavathula N, Nerusu KC, Lal A, Ellis CN, Chittiboyina A, Avery MA, Ho CI, Benson SC, Pershadsingh HA, Kurtz TW, Varani J

The CD36 protein functions as an immunogenic domain of the RT8 alloantigen.

European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics

Mlejnek P, Kren V, Liska F, Zídek V, Landa V, Kurtz TW, Pravenec M

Transgenic and recombinant resistin impair skeletal muscle glucose metabolism in the spontaneously hypertensive rat.

The Journal of biological chemistry

Pravenec M, Kazdová L, Landa V, Zidek V, Mlejnek P, Jansa P, Wang J, Qi N, Kurtz TW

False claims of blood pressure-independent protection by blockade of the renin angiotensin aldosterone system?

Hypertension (Dallas, Tex. : 1979)

Kurtz TW

Insulin mediated hemodynamic responses in spontaneous hypertensive rats (SHRs): effect of chromosome 4 gene transfer.

Clinical and experimental hypertension (New York, N.Y. : 1993)

Rao SP, McRae C, Lapanowski K, Churchill M, Kurtz TW, Dunbar JC

Gene expression profiling in hypertension research: a critical perspective.

Hypertension (Dallas, Tex. : 1979)

Pravenec M, Wallace C, Aitman TJ, Kurtz TW

Genetic isolation of quantitative trait loci for blood pressure development and renal mass on chromosome 5 in the spontaneously hypertensive rat.

Physiological research

Pravenec M, Kren V, Krenová D, Zídek V, Simáková M, Musilová A, Vorlícek J, Lezin ES, Kurtz TW

Transgenic expression of CD36 in the spontaneously hypertensive rat is associated with amelioration of metabolic disturbances but has no effect on hypertension.

Physiological research

Pravenec M, Landa V, Zídek V, Musilová A, Kazdová L, Qi N, Wang J, St Lezin E, Kurtz TW

Target organ damage in hypertension: mechanisms, prevention, and management.

American journal of hypertension

Catanzaro DF, Kurtz TW

Pharmacogenetic evidence that cd36 is a key determinant of the metabolic effects of pioglitazone.

The Journal of biological chemistry

Qi N, Kazdova L, Zidek V, Landa V, Kren V, Pershadsingh HA, Lezin ES, Abumrad NA, Pravenec M, Kurtz TW

Genetic analysis of metabolic defects in the spontaneously hypertensive rat.

Mammalian genome : official journal of the International Mammalian Genome Society

Pravenec M, Zídek V, Musilová A, Simáková M, Kostka V, Mlejnek P, Kren V, Krenova D, Bílá V, Míková B, Jáchymová M, Horký K, Kazdová L, St Lezin E, Kurtz TW

Increased genetic susceptibility to renal damage in the stroke-prone spontaneously hypertensive rat.

Kidney international

Churchill PC, Churchill MC, Griffin KA, Picken M, Webb RC, Kurtz TW, Bidani AK

Genetics of Cd36 and the hypertension metabolic syndrome.

Seminars in nephrology

Pravenec M, Kurtz TW

New frontiers in aldosterone/mineralocorticoid biology: a reemerging force in target organ damage and hypertension.

American journal of hypertension

Kurtz TW, Catanzaro DF

Kidney-specific chromosome transfer in genetic hypertension: the Dahl hypothesis revisited.

Kidney international

Churchill PC, Churchill MC, Bidani AK, Kurtz TW

Genetic isolation of a blood pressure quantitative trait locus on chromosome 2 in the spontaneously hypertensive rat.

Journal of hypertension

Pravenec M, Zídek V, Musilová A, Vorlícek J, Kren V, St Lezin E, Kurtz TW

Defective fatty acid uptake in the spontaneously hypertensive rat is a primary determinant of altered glucose metabolism, hyperinsulinemia, and myocardial hypertrophy.

The Journal of biological chemistry

Hajri T, Ibrahimi A, Coburn CT, Knapp FF, Kurtz T, Pravenec M, Abumrad NA

Differential salt-sensitivity in the pathogenesis of renal damage in SHR and stroke prone SHR.

American journal of hypertension

Griffin KA, Churchill PC, Picken M, Webb RC, Kurtz TW, Bidani AK

Identification of a mutation in ADD1/SREBP-1 in the spontaneously hypertensive rat.

Mammalian genome : official journal of the International Mammalian Genome Society

Pravenec M, Jansa P, Kostka V, Zídek V, Kren V, Forejt J, Kurtz TW

Transgenic rescue of defective Cd36 ameliorates insulin resistance in spontaneously hypertensive rats.

Nature genetics

Pravenec M, Landa V, Zidek V, Musilova A, Kren V, Kazdova L, Aitman TJ, Glazier AM, Ibrahimi A, Abumrad NA, Qi N, Wang JM, St Lezin EM, Kurtz TW

Genetic susceptibility to renal injury in hypertension.

Experimental nephrology

Bidani AK, Griffin KA, Churchill PC, Churchill MC, St Lezin E, Kurtz TW

Troglitazone improves psoriasis and normalizes models of proliferative skin disease: ligands for peroxisome proliferator-activated receptor-gamma inhibit keratinocyte proliferation.

Archives of dermatology

Ellis CN, Varani J, Fisher GJ, Zeigler ME, Pershadsingh HA, Benson SC, Chi Y, Kurtz TW

Ligands for the peroxisome proliferator-activated receptor-gamma and the retinoid X receptor-alpha exert synergistic antiproliferative effects on human coronary artery smooth muscle cells.

Molecular cell biology research communications : MCBRC

Benson S, Padmanabhan S, Kurtz TW, Pershadsingh HA

Genetic analysis of rat chromosome 1 and the Sa gene in spontaneous hypertension.

Hypertension (Dallas, Tex. : 1979)

St Lezin E, Liu W, Wang JM, Yang Y, Qi N, Kren V, Zidek V, Kurtz TW, Pravenec M

Peroxisome proliferator-activated receptor (PPAR)-gamma expression in human vascular smooth muscle cells: inhibition of growth, migration, and c-fos expression by the peroxisome proliferator-activated receptor (PPAR)-gamma activator troglitazone.

American journal of hypertension

Benson S, Wu J, Padmanabhan S, Kurtz TW, Pershadsingh HA

Genetic isolation of a chromosome 1 region affecting susceptibility to hypertension-induced renal damage in the spontaneously hypertensive rat.

Hypertension (Dallas, Tex. : 1979)

St Lezin E, Griffin KA, Picken M, Churchill MC, Churchill PC, Kurtz TW, Liu W, Wang N, Kren V, Zidek V, Pravenec M, Bidani AK

Genetics of Cd36 and the clustering of multiple cardiovascular risk factors in spontaneous hypertension.

The Journal of clinical investigation

Pravenec M, Zidek V, Simakova M, Kren V, Krenova D, Horky K, Jachymova M, Mikova B, Kazdova L, Aitman TJ, Churchill PC, Webb RC, Hingarh NH, Yang Y, Wang JM, Lezin EM, Kurtz TW

Congenic strains for genetic analysis of hypertension and dyslipidemia in the spontaneously hypertensive rat.

Transplantation proceedings

Pravenec M, Krenová D, Kren V, Zídek V, Simáková M, Musilová A, Bottger A, van Zutphen BF, St Lezin E, Kurtz TW

Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats.

Nature genetics

Aitman TJ, Glazier AM, Wallace CA, Cooper LD, Norsworthy PJ, Wahid FN, Al-Majali KM, Trembling PM, Mann CJ, Shoulders CC, Graf D, St Lezin E, Kurtz TW, Kren V, Pravenec M, Ibrahimi A, Abumrad NA, Stanton LW, Scott J

The spontaneously hypertensive rat: a model to dissect cellular defects in glucose and fatty acid metabolism.

Pathologie-biologie

Aitman TJ, Pravenec M, Kurtz TW, Scott J

Transcription-modulating drugs: a new frontier in the treatment of essential hypertension.

Hypertension (Dallas, Tex. : 1979)

Kurtz TW, Gardner DG

Blood pressure and survival of a chromosome 7 congenic strain bred from Dahl rats.

Mammalian genome : official journal of the International Mammalian Genome Society

Cicila GT, Dukhanina OI, Kurtz TW, Walder R, Garrett MR, Dene H, Rapp JP

Genetic susceptibility to hypertension-induced renal damage in the rat. Evidence based on kidney-specific genome transfer.

The Journal of clinical investigation

Churchill PC, Churchill MC, Bidani AK, Griffin KA, Picken M, Pravenec M, Kren V, St Lezin E, Wang JM, Wang N, Kurtz TW

Rat chromosome 1: regional localization of seven genes (Slc9a3, Srd5a1, Esr, Tcp1, Grik5, Tnnt3, Jak2) and anchoring of the genetic linkage map to the cytogenetic map.

Mammalian genome : official journal of the International Mammalian Genome Society

Szpirer C, Szpirer J, Tissir F, Stephanova E, Vanvooren P, Kurtz TW, Iwai N, Inagami T, Pravenec M, Kren V, Klinga-Levan K, Levan G

Linkage mapping of the cellular retinoic acid-binding protein 1 (Crabp1) gene to rat chromosome 8.

Mammalian genome : official journal of the International Mammalian Genome Society

Pravenec M, Kren V, Wang J, Kurtz TW

Quantitative trait loci for cellular defects in glucose and fatty acid metabolism in hypertensive rats.

Nature genetics

Aitman TJ, Gotoda T, Evans AL, Imrie H, Heath KE, Trembling PM, Truman H, Wallace CA, Rahman A, Doré C, Flint J, Kren V, Zidek V, Kurtz TW, Pravenec M, Scott J

Linkage mapping of the Na-K-2Cl cotransporter gene (Slc12a1) to rat chromosome 3.

Mammalian genome : official journal of the International Mammalian Genome Society

Wang J, Pravenec M, Kren V, Kurtz TW

Map of the differential segment of rat chromosome 8 in the SHR-Lx congenic strain.

Transplantation proceedings

Krenová D, Kurtz TW, Wang JM, Pravenec M, Kren V

Rat genome mapping using recombinant inbred strains.

Transplantation proceedings

Kren V, Kurtz TW, Krenova D, Bila V, Printz M, Pravenec M

Effects of thiazolidinediones on growth and differentiation of human aorta and coronary myocytes.

American journal of hypertension

Morikang E, Benson SC, Kurtz TW, Pershadsingh HA

Genetic isolation of a region of chromosome 8 that exerts major effects on blood pressure and cardiac mass in the spontaneously hypertensive rat.

The Journal of clinical investigation

Kren V, Pravenec M, Lu S, Krenova D, Wang JM, Wang N, Merriouns T, Wong A, St Lezin E, Lau D, Szpirer C, Szpirer J, Kurtz TW

Use of AFLP markers for gene mapping and QTL detection in the rat.

Genomics

Otsen M, den Bieman M, Kuiper MT, Pravenec M, Kren V, Kurtz TW, Jacob HJ, Lankhorst A, van Zutphen BF

Quantitative trait loci influencing cholesterol and phospholipid phenotypes map to chromosomes that contain genes regulating blood pressure in the spontaneously hypertensive rat.

The Journal of clinical investigation

Bottger A, van Lith HA, Kren V, Krenová D, Bílá V, Vorlícek J, Zídek V, Musilová A, Zdobinská M, Wang JM, van Zutphen BF, Kurtz TW, Pravenec M

Linkage mapping of the carboxyl ester lipase gene (Cel) to rat chromosome 3.

Mammalian genome : official journal of the International Mammalian Genome Society

Pravenec M, Kren V, Wang J, Bottger A, van Zutphen LF, Kurtz TW

A genetic linkage map of the rat derived from recombinant inbred strains.

Mammalian genome : official journal of the International Mammalian Genome Society

Pravenec M, Gauguier D, Schott JJ, Buard J, Kren V, Bílá V, Szpirer C, Szpirer J, Wang JM, Huang H, St Lezin E, Spence MA, Flodman P, Printz M, Lathrop GM, Vergnaud G, Kurtz TW