
Research Interests: Development of a novel T cell therapy to induce beige adipogenesis Summary: Type 2 diabetes is a leading cause of mortality in the United States, and its prevalence continues to rise in concert with the rising prevalence of obesity, the predominant risk factor for developing insulin resistance and diabetes. Obesity can result from a multitude of different complex physiological and socioeconomic conditions that individuals are often unable to overcome. Simply stated however, obesity is a manifestation of excessive storage of energy. Consequently, it could potentially be mitigated by turning on the body's dormant systems for burning, not storing, that energy. In this proposal, we will develop regulatory T (Treg) cells as a powerful class of engineered, non-destructive cellular immunotherapies to tackle obesity and its co-associated metabolic disease type 2 diabetes. We will engineer fat-localizing Treg cells to deliver signals to convert energy-storing adipose tissue (AT) into energy-burning AT, thereby reversing or preventing obesity and insulin resistance in mice (and eventually humans.) https://diabetes.ucsf.edu/lab/bapat-lab
Publications
TAMing immunity through an unexpected source.
Immune Dysregulation in Obesity.
Tissue-resident regulatory T cells as transient, tissue-agnostic immunomodulatory populations.
Immunometabolism at the crossroads of obesity and cancer-a Keystone Symposia report.
Estrogen-Related Receptor γ Maintains Pancreatic Acinar Cell Function and Identity by Regulating Cellular Metabolism.
Surface Proteomics Reveals CD72 as a Target for In Vitro-Evolved Nanobody-Based CAR-T Cells in KMT2A/MLL1-Rearranged B-ALL.
A diagnostic host response biosignature for COVID-19 from RNA profiling of nasal swabs and blood.
Magnitude and Kinetics of Anti-Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Responses and Their Relationship to Disease Severity.
SARS-CoV-2 seroprevalence and neutralizing activity in donor and patient blood.
Evaluation of SARS-CoV-2 serology assays reveals a range of test performance.
Magnitude and kinetics of anti-SARS-CoV-2 antibody responses and their relationship to disease severity.
SARS-CoV-2 seroprevalence and neutralizing activity in donor and patient blood from the San Francisco Bay Area.
Test performance evaluation of SARS-CoV-2 serological assays.
Characterization of Immune Cells from Adipose Tissue.
The nuclear receptor REV-ERBα modulates Th17 cell-mediated autoimmune disease.
Electronic cigarette inhalation alters innate immunity and airway cytokines while increasing the virulence of colonizing bacteria.
Innate immunity. Dermal adipocytes protect against invasive Staphylococcus aureus skin infection.
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