Lily Jan, PhD

Professor, Physiology

Research Interests: Studies of potassium channels Summary: Ion channels such as potassium channels and calcium-activated chloride channels are important for the function of the heart, lung, and vasculature. Starting with molecular characterizations of the channel proteins, we try to understand how these channels work and how their activities are regulated under various physiological conditions.

Address: 
1550 Fourth Street, Rm 484F
UCSF Box 2811
San Francisco, CA 94158
United States
Phone: 
+1 415 476-8748
Faculty Type: 
Affiliate Faculty
Publications: 

Voltage sensors.(link is external)

Molecular pharmacology

Jan L

TMEM16F exacerbates tau pathology and mediates phosphatidylserine exposure in phospho-tau-burdened neurons.(link is external)

Proceedings of the National Academy of Sciences of the United States of America

Zubia MV, Yong AJH, Holtz KM, Huang EJ, Jan YN, Jan LY

Nonlinear compliance of NompC gating spring and its implication in mechanotransduction.(link is external)

bioRxiv : the preprint server for biology

Wang Y, Jin P, Kumar A, Jan L, Cheng Y, Jan YN, Zhang Y

Drosophila TMEM63 and mouse TMEM63A are lysosomal mechanosensory ion channels.(link is external)

Nature cell biology

Li K, Guo Y, Wang Y, Zhu R, Chen W, Cheng T, Zhang X, Jia Y, Liu T, Zhang W, Jan LY, Jan YN

Rare variants in ANO1, encoding a calcium-activated chloride channel, predispose to moyamoya disease.(link is external)

Brain : a journal of neurology

Pinard A, Ye W, Fraser SM, Rosenfeld JA, Pichurin P, Hickey SE, Guo D, Cecchi AC, Boerio ML, Guey S, Aloui C, Lee K, Kraemer M, Alyemni SO, University of Washington Center for Mendelian Genomics, Bamshad MJ, Nickerson DA, Tournier-Lasserve E, Haider S, Jin SC, Smith ER, Kahle KT, Jan LY, He M, Milewicz DM

Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase.(link is external)

Nature communications

Feng S, Puchades C, Ko J, Wu H, Chen Y, Figueroa EE, Gu S, Han TW, Ho B, Cheng T, Li J, Shoichet B, Jan YN, Cheng Y, Jan LY

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