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Lily Jan, PhD

Professor
Physiology
Address: 
1550 Fourth Street, Rm 484F
UCSF Box 2811
San Francisco, CA 94158
United States
Phone: 
+1 415 476-8748
Email: 
[email protected]
UCSF Profiles

Research Interests: Studies of potassium channels Summary: Ion channels such as potassium channels and calcium-activated chloride channels are important for the function of the heart, lung, and vasculature. Starting with molecular characterizations of the channel proteins, we try to understand how these channels work and how their activities are regulated under various physiological conditions.

Publications: 

Voltage sensors.

Molecular pharmacology

Jan L

TMEM16F exacerbates tau pathology and mediates phosphatidylserine exposure in phospho-tau-burdened neurons.

Proceedings of the National Academy of Sciences of the United States of America

Zubia MV, Yong AJH, Holtz KM, Huang EJ, Jan YN, Jan LY

Nonlinear compliance of NompC gating spring and its implication in mechanotransduction.

bioRxiv : the preprint server for biology

Wang Y, Jin P, Kumar A, Jan L, Cheng Y, Jan YN, Zhang Y

A personal perspective of the voltage-gated potassium channel studies.

Nature structural & molecular biology

Jan LY, Jan YN

Drosophila TMEM63 and mouse TMEM63A are lysosomal mechanosensory ion channels.

Nature cell biology

Li K, Guo Y, Wang Y, Zhu R, Chen W, Cheng T, Zhang X, Jia Y, Liu T, Zhang W, Jan LY, Jan YN

Rare variants in ANO1, encoding a calcium-activated chloride channel, predispose to moyamoya disease.

Brain : a journal of neurology

Pinard A, Ye W, Fraser SM, Rosenfeld JA, Pichurin P, Hickey SE, Guo D, Cecchi AC, Boerio ML, Guey S, Aloui C, Lee K, Kraemer M, Alyemni SO, University of Washington Center for Mendelian Genomics, Bamshad MJ, Nickerson DA, Tournier-Lasserve E, Haider S, Jin SC, Smith ER, Kahle KT, Jan LY, He M, Milewicz DM

Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase.

Nature communications

Feng S, Puchades C, Ko J, Wu H, Chen Y, Figueroa EE, Gu S, Han TW, Ho B, Cheng T, Li J, Shoichet B, Jan YN, Cheng Y, Jan LY

The GARP complex prevents sterol accumulation at the trans-Golgi network during dendrite remodeling.

The Journal of Cell Biology

O'Brien CE, Younger SH, Jan LY, Jan YN

A photo-switchable assay system for dendrite degeneration and repair in Drosophila melanogaster.

Proceedings of the National Academy of Sciences of the United States of America

Liu HH, Hsu CH, Jan LY, Jan YN

Kv1.1 preserves the neural stem cell pool and facilitates neuron maturation during adult hippocampal neurogenesis.

Proceedings of the National Academy of Sciences of the United States of America

Lin King YH, Chen C, Lin King JV, Simms J, Glasscock E, Yang SB, Jan YN, Jan LY

Identification of a conserved drug binding pocket in TMEM16 proteins.

Research square

Cheng Y, Feng S, Puchades C, Ko J, Figueroa E, Chen Y, Wu H, Gu S, Han T, Li J, Ho B, Shoichet B, Jan YN, Jan L

Structure, function and pharmacology of human itch GPCRs.

Nature

Cao C, Kang HJ, Singh I, Chen H, Zhang C, Ye W, Hayes BW, Liu J, Gumpper RH, Bender BJ, Slocum ST, Krumm BE, Lansu K, McCorvy JD, Kroeze WK, English JG, DiBerto JF, Olsen RHJ, Huang XP, Zhang S, Liu Y, Kim K, Karpiak J, Jan LY, Abraham SN, Jin J, Shoichet BK, Fay JF, Roth BL

Kv1.1 channels regulate early postnatal neurogenesis in mouse hippocampus via the TrkB signaling pathway.

eLife

Chou SM, Li KX, Huang MY, Chen C, Lin King YH, Li GG, Zhou W, Teo CF, Jan YN, Jan LY, Yang SB

TMEM16C is involved in thermoregulation and protects rodent pups from febrile seizures.

Proceedings of the National Academy of Sciences of the United States of America

Wang TA, Chen C, Huang F, Feng S, Tien J, Braz JM, Basbaum AI, Jan YN, Jan LY

TMEM16K is an interorganelle regulator of endosomal sorting.

Nature communications

Petkovic M, Oses-Prieto J, Burlingame A, Jan LY, Jan YN

Multi-scale spatial heterogeneity enhances particle clearance in airway ciliary arrays.

Nature physics

Juan GRR, Mathijssen AJTM, He M, Jan L, Marshall W, Prakash M

Chloride channels regulate differentiation and barrier functions of the mammalian airway.

eLife

He M, Wu B, Ye W, Le DD, Sinclair AW, Padovano V, Chen Y, Li KX, Sit R, Tan M, Caplan MJ, Neff N, Jan YN, Darmanis S, Jan LY

Paralytic, the Drosophila voltage-gated sodium channel, regulates proliferation of neural progenitors.

Genes & development

Piggott BJ, Peters CJ, He Y, Huang X, Younger S, Jan LY, Jan YN

Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling.

Cell reports

Feng S, Dang S, Han TW, Ye W, Jin P, Cheng T, Li J, Jan YN, Jan LY, Cheng Y

TMEM16B Calcium-Activated Chloride Channels Regulate Action Potential Firing in Lateral Septum and Aggression in Male Mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Wang L, Simms J, Peters CJ, Tynan-La Fontaine M, Li K, Gill TM, Jan YN, Jan LY

Thermoregulation via Temperature-Dependent PGD2 Production in Mouse Preoptic Area.

Neuron

Wang TA, Teo CF, Åkerblom M, Chen C, Tynan-La Fontaine M, Greiner VJ, Diaz A, McManus MT, Jan YN, Jan LY

Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling.

Cell reports

Feng S, Dang S, Han TW, Ye W, Jin P, Cheng T, Li J, Jan YN, Jan LY, Cheng Y

The multifaceted role of TMEM16A in cancer.

Cell calcium

Crottès D, Jan LY

TMEM16A controls EGF-induced calcium signaling implicated in pancreatic cancer prognosis.

Proceedings of the National Academy of Sciences of the United States of America

Crottès D, Lin YT, Peters CJ, Gilchrist JM, Wiita AP, Jan YN, Jan LY

Thermoregulation via Temperature-Dependent PGD2 Production in Mouse Preoptic Area.

Neuron

Wang TA, Teo CF, Åkerblom M, Chen C, Tynan-La Fontaine M, Greiner VJ, Diaz A, McManus MT, Jan YN, Jan LY

Glial ensheathment of the somatodendritic compartment regulates sensory neuron structure and activity.

Proceedings of the National Academy of Sciences of the United States of America

Yadav S, Younger SH, Zhang L, Thompson-Peer KL, Li T, Jan LY, Jan YN

The Mechanosensitive Ion Channel Piezo Inhibits Axon Regeneration.

Neuron

Song Y, Li D, Farrelly O, Miles L, Li F, Kim SE, Lo TY, Wang F, Li T, Thompson-Peer KL, Gong J, Murthy SE, Coste B, Yakubovich N, Patapoutian A, Xiang Y, Rompolas P, Jan LY, Jan YN

Chemically induced vesiculation as a platform for studying TMEM16F activity.

Proceedings of the National Academy of Sciences of the United States of America

Han TW, Ye W, Bethel NP, Zubia M, Kim A, Li KH, Burlingame AL, Grabe M, Jan YN, Jan LY

Far away from the lamppost.

PLoS biology

Oprea TI, Jan L, Johnson GL, Roth BL, Ma'ayan A, Schürer S, Shoichet BK, Sklar LA, McManus MT

Activation of orexin system facilitates anesthesia emergence and pain control.

Proceedings of the National Academy of Sciences of the United States of America

Zhou W, Cheung K, Kyu S, Wang L, Guan Z, Kurien PA, Bickler PE, Jan LY

The Sixth Transmembrane Segment Is a Major Gating Component of the TMEM16A Calcium-Activated Chloride Channel.

Neuron

Peters CJ, Gilchrist JM, Tien J, Bethel NP, Qi L, Chen T, Wang L, Jan YN, Grabe M, Jan LY

Phosphatidylinositol-(4, 5)-bisphosphate regulates calcium gating of small-conductance cation channel TMEM16F.

Proceedings of the National Academy of Sciences of the United States of America

Ye W, Han TW, Nassar LM, Zubia M, Jan YN, Jan LY

Cryo-EM structures of the TMEM16A calcium-activated chloride channel.

Nature

Dang S, Feng S, Tien J, Peters CJ, Bulkley D, Lolicato M, Zhao J, Zuberbühler K, Ye W, Qi L, Chen T, Craik CS, Jan YN, Minor DL, Cheng Y, Jan LY

Cytoplasmic Cl- couples membrane remodeling to epithelial morphogenesis.

Proceedings of the National Academy of Sciences of the United States of America

He M, Ye W, Wang WJ, Sison ES, Jan YN, Jan LY

Phospholipid Homeostasis Regulates Dendrite Morphogenesis in Drosophila Sensory Neurons.

Cell reports

Meltzer S, Bagley JA, Perez GL, O'Brien CE, DeVault L, Guo Y, Jan LY, Jan YN

Inferior Olivary TMEM16B Mediates Cerebellar Motor Learning.

Neuron

Zhang Y, Zhang Z, Xiao S, Tien J, Le S, Le T, Jan LY, Yang H

Composition and Control of a Deg/ENaC Channel during Presynaptic Homeostatic Plasticity.

Cell reports

Orr BO, Gorczyca D, Younger MA, Jan LY, Jan YN, Davis GW

Electron cryo-microscopy structure of the mechanotransduction channel NOMPC.

Nature

Jin P, Bulkley D, Guo Y, Zhang W, Guo Z, Huynh W, Wu S, Meltzer S, Cheng T, Jan LY, Jan YN, Cheng Y

Age-dependent diastolic heart failure in an in vivo Drosophila model.

eLife

Klassen MP, Peters CJ, Zhou S, Williams HH, Jan LY, Jan YN

TAOK2 Kinase Mediates PSD95 Stability and Dendritic Spine Maturation through Septin7 Phosphorylation.

Neuron

Yadav S, Oses-Prieto JA, Peters CJ, Zhou J, Pleasure SJ, Burlingame AL, Jan LY, Jan YN

A Defensive Kicking Behavior in Response to Mechanical Stimuli Mediated by Drosophila Wing Margin Bristles.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Li J, Zhang W, Guo Z, Wu S, Jan LY, Jan YN

In vivo dendrite regeneration after injury is different from dendrite development.

Genes & development

Thompson-Peer KL, DeVault L, Li T, Jan LY, Jan YN

Transmembrane channel-like (tmc) gene regulates Drosophila larval locomotion.

Proceedings of the National Academy of Sciences of the United States of America

Guo Y, Wang Y, Zhang W, Meltzer S, Zanini D, Yu Y, Li J, Cheng T, Guo Z, Wang Q, Jacobs JS, Sharma Y, Eberl DF, Göpfert MC, Jan LY, Jan YN, Wang Z

Phosphorylation of β-Tubulin by the Down Syndrome Kinase, Minibrain/DYRK1a, Regulates Microtubule Dynamics and Dendrite Morphogenesis.

Neuron

Ori-McKenney KM, McKenney RJ, Huang HH, Li T, Meltzer S, Jan LY, Vale RD, Wiita AP, Jan YN

Epidermis-Derived Semaphorin Promotes Dendrite Self-Avoidance by Regulating Dendrite-Substrate Adhesion in Drosophila Sensory Neurons.

Neuron

Meltzer S, Yadav S, Lee J, Soba P, Younger SH, Jin P, Zhang W, Parrish J, Jan LY, Jan YN

Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis.

Science translational medicine

Headland SE, Jones HR, Norling LV, Kim A, Souza PR, Corsiero E, Gil CD, Nerviani A, Dell'Accio F, Pitzalis C, Oliani SM, Jan LY, Perretti M

Dorsal Horn Parvalbumin Neurons Are Gate-Keepers of Touch-Evoked Pain after Nerve Injury.

Cell reports

Petitjean H, Pawlowski SA, Fraine SL, Sharif B, Hamad D, Fatima T, Berg J, Brown CM, Jan LY, Ribeiro-da-Silva A, Braz JM, Basbaum AI, Sharif-Naeini R

Ankyrin Repeats Convey Force to Gate the NOMPC Mechanotransduction Channel.

Cell

Zhang W, Cheng LE, Kittelmann M, Li J, Petkovic M, Cheng T, Jin P, Guo Z, Göpfert MC, Jan LY, Jan YN

EAG2 potassium channel with evolutionarily conserved function as a brain tumor target.

Nature neuroscience

Huang X, He Y, Dubuc AM, Hashizume R, Zhang W, Reimand J, Yang H, Wang TA, Stehbens SJ, Younger S, Barshow S, Zhu S, Cooper MK, Peacock J, Ramaswamy V, Garzia L, Wu X, Remke M, Forester CM, Kim CC, Weiss WA, James CD, Shuman MA, Bader GD, Mueller S, Taylor MD, Jan YN, Jan LY

Regulation of axon regeneration by the RNA repair and splicing pathway.

Nature neuroscience

Song Y, Sretavan D, Salegio EA, Berg J, Huang X, Cheng T, Xiong X, Meltzer S, Han C, Nguyen TT, Bresnahan JC, Beattie MS, Jan LY, Jan YN

The Ret receptor regulates sensory neuron dendrite growth and integrin mediated adhesion.

eLife

Soba P, Han C, Zheng Y, Perea D, Miguel-Aliaga I, Jan LY, Jan YN

Four basic residues critical for the ion selectivity and pore blocker sensitivity of TMEM16A calcium-activated chloride channels.

Proceedings of the National Academy of Sciences of the United States of America

Peters CJ, Yu H, Tien J, Jan YN, Li M, Jan LY

Protein mutated in paroxysmal dyskinesia interacts with the active zone protein RIM and suppresses synaptic vesicle exocytosis.

Proceedings of the National Academy of Sciences of the United States of America

Shen Y, Ge WP, Li Y, Hirano A, Lee HY, Rohlmann A, Missler M, Tsien RW, Jan LY, Fu YH, Ptácek LJ

MST3 kinase phosphorylates TAO1/2 to enable Myosin Va function in promoting spine synapse development.

Neuron

Ultanir SK, Yadav S, Hertz NT, Oses-Prieto JA, Claxton S, Burlingame AL, Shokat KM, Jan LY, Jan YN

Identification of Ppk26, a DEG/ENaC Channel Functioning with Ppk1 in a Mutually Dependent Manner to Guide Locomotion Behavior in Drosophila.

Cell reports

Gorczyca DA, Younger S, Meltzer S, Kim SE, Cheng L, Song W, Lee HY, Jan LY, Jan YN

Common variants associated with general and MMR vaccine-related febrile seizures.

Nature genetics

Feenstra B, Pasternak B, Geller F, Carstensen L, Wang T, Huang F, Eitson JL, Hollegaard MV, Svanström H, Vestergaard M, Hougaard DM, Schoggins JW, Jan LY, Melbye M, Hviid A

Double-bromo and extraterminal (BET) domain proteins regulate dendrite morphology and mechanosensory function.

Genes & development

Bagley JA, Yan Z, Zhang W, Wildonger J, Jan LY, Jan YN

Targeting potassium channels in cancer.

The Journal of Cell Biology

Huang X, Jan LY

Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia.

Nature medicine

Hong T, Yang H, Zhang SS, Cho HC, Kalashnikova M, Sun B, Zhang H, Bhargava A, Grabe M, Olgin J, Gorelik J, Marbán E, Jan LY, Shaw RM

An improved monomeric infrared fluorescent protein for neuronal and tumour brain imaging.

Nature communications

Yu D, Gustafson WC, Han C, Lafaye C, Noirclerc-Savoye M, Ge WP, Thayer DA, Huang H, Kornberg TB, Royant A, Jan LY, Jan YN, Weiss WA, Shu X

Krüppel mediates the selective rebalancing of ion channel expression.

Neuron

Parrish JZ, Kim CC, Tang L, Bergquist S, Wang T, Derisi JL, Jan LY, Jan YN, Davis GW

Drosophila Valosin-Containing Protein is required for dendrite pruning through a regulatory role in mRNA metabolism.

Proceedings of the National Academy of Sciences of the United States of America

Rumpf S, Bagley JA, Thompson-Peer KL, Zhu S, Gorczyca D, Beckstead RB, Jan LY, Jan YN

Lily Jan.

Current biology : CB

Jan L

Imaging-based chemical screening reveals activity-dependent neural differentiation of pluripotent stem cells.

eLife

Sun Y, Dong Z, Jin T, Ang KH, Huang M, Haston KM, Peng J, Zhong TP, Finkbeiner S, Weiss WA, Arkin MR, Jan LY, Guo S

Making antisense of pain.

Nature neuroscience

Han TW, Jan LY

Sound response mediated by the TRP channels NOMPC, NANCHUNG, and INACTIVE in chordotonal organs of Drosophila larvae.

Proceedings of the National Academy of Sciences of the United States of America

Zhang W, Yan Z, Jan LY, Jan YN

TMEM16C facilitates Na(+)-activated K+ currents in rat sensory neurons and regulates pain processing.

Nature neuroscience

Huang F, Wang X, Ostertag EM, Nuwal T, Huang B, Jan YN, Basbaum AI, Jan LY

Identification of a dimerization domain in the TMEM16A calcium-activated chloride channel (CaCC).

Proceedings of the National Academy of Sciences of the United States of America

Tien J, Lee HY, Minor DL, Jan YN, Jan LY

Increased neuronal activity fragments the Golgi complex.

Proceedings of the National Academy of Sciences of the United States of America

Thayer DA, Jan YN, Jan LY

Drosophila NOMPC is a mechanotransduction channel subunit for gentle-touch sensation.

Nature

Yan Z, Zhang W, He Y, Gorczyca D, Xiang Y, Cheng LE, Meltzer S, Jan LY, Jan YN

TMEM16F forms a Ca2+-activated cation channel required for lipid scrambling in platelets during blood coagulation.

Cell

Yang H, Kim A, David T, Palmer D, Jin T, Tien J, Huang F, Cheng T, Coughlin SR, Jan YN, Jan LY

Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction.

Proceedings of the National Academy of Sciences of the United States of America

Huang F, Zhang H, Wu M, Yang H, Kudo M, Peters CJ, Woodruff PG, Solberg OD, Donne ML, Huang X, Sheppard D, Fahy JV, Wolters PJ, Hogan BL, Finkbeiner WE, Li M, Jan YN, Jan LY, Rock JR

Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics.

Genes & development

Huang X, Dubuc AM, Hashizume R, Berg J, He Y, Wang J, Chiang C, Cooper MK, Northcott PA, Taylor MD, Barnes MJ, Tihan T, Chen J, Hackett CS, Weiss WA, James CD, Rowitch DH, Shuman MA, Jan YN, Jan LY

Local generation of glia is a major astrocyte source in postnatal cortex.

Nature

Ge WP, Miyawaki A, Gage FH, Jan YN, Jan LY

Chemical genetic identification of NDR1/2 kinase substrates AAK1 and Rabin8 Uncovers their roles in dendrite arborization and spine development.

Neuron

Ultanir SK, Hertz NT, Li G, Ge WP, Burlingame AL, Pleasure SJ, Shokat KM, Jan LY, Jan YN

Ca2+-activated Cl- channels at a glance.

Journal of cell science

Berg J, Yang H, Jan LY

Kv1.1-dependent control of hippocampal neuron number as revealed by mosaic analysis with double markers.

The Journal of physiology

Yang SB, Mclemore KD, Tasic B, Luo L, Jan YN, Jan LY

Ets transcription factor Pointed promotes the generation of intermediate neural progenitors in Drosophila larval brains.

Proceedings of the National Academy of Sciences of the United States of America

Zhu S, Barshow S, Wildonger J, Jan LY, Jan YN

Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity.

Journal of molecular medicine (Berlin, Germany)

Yang SB, Lee HY, Young DM, Tien AC, Rowson-Baldwin A, Shu YY, Jan YN, Jan LY

Bidirectional regulation of dendritic voltage-gated potassium channels by the fragile X mental retardation protein.

Neuron

Lee HY, Ge WP, Huang W, He Y, Wang GX, Rowson-Baldwin A, Smith SJ, Jan YN, Jan LY

Pathogenic polyglutamine proteins cause dendrite defects associated with specific actin cytoskeletal alterations in Drosophila.

Proceedings of the National Academy of Sciences of the United States of America

Lee SB, Bagley JA, Lee HY, Jan LY, Jan YN

Light-induced structural and functional plasticity in Drosophila larval visual system.

Science (New York, N.Y.)

Yuan Q, Xiang Y, Yan Z, Han C, Jan LY, Jan YN

Isolation and Expression Profile of the Ca-Activated Chloride Channel-like Membrane Protein 6 Gene in Xenopus laevis.

Laboratory animal research

Lee RM, Ryu RH, Jeong SW, Oh SJ, Huang H, Han JS, Lee CH, Lee CJ, Jan LY, Jeong SM

Dronc caspase exerts a non-apoptotic function to restrain phospho-Numb-induced ectopic neuroblast formation in Drosophila.

Development (Cambridge, England)

Ouyang Y, Petritsch C, Wen H, Jan L, Jan YN, Lu B

Enhancer-driven membrane markers for analysis of nonautonomous mechanisms reveal neuron-glia interactions in Drosophila.

Proceedings of the National Academy of Sciences of the United States of America

Han C, Jan LY, Jan YN

Cloning and heterologous expression of new xANO2 from Xenopus laevis.

Biochemical and biophysical research communications

Ryu RH, Oh SJ, Lee RM, Jeong SW, Jan LY, Lee CH, Lee CJ, Jeong SM

Differential regulation of dendritic and axonal development by the novel Krüppel-like factor Dar1.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Ye B, Kim JH, Yang L, McLachlan I, Younger S, Jan LY, Jan YN

Light-avoidance-mediating photoreceptors tile the Drosophila larval body wall.

Nature

Xiang Y, Yuan Q, Vogt N, Looger LL, Jan LY, Jan YN

Mechanisms of distribution and targeting of neuronal ion channels.

Current opinion in drug discovery & development

Thayer DA, Jan LY

The role of the TRP channel NompC in Drosophila larval and adult locomotion.

Neuron

Cheng LE, Song W, Looger LL, Jan LY, Jan YN

Altered ultrasonic vocalizations in a tuberous sclerosis mouse model of autism.

Proceedings of the National Academy of Sciences of the United States of America

Young DM, Schenk AK, Yang SB, Jan YN, Jan LY

Branching out: mechanisms of dendritic arborization.

Nature reviews. Neuroscience

Jan YN, Jan LY

Studies on expression and function of the TMEM16A calcium-activated chloride channel.

Proceedings of the National Academy of Sciences of the United States of America

Huang F, Rock JR, Harfe BD, Cheng T, Huang X, Jan YN, Jan LY

Mammalian Par3 regulates progenitor cell asymmetric division via notch signaling in the developing neocortex.

Neuron

Bultje RS, Castaneda-Castellanos DR, Jan LY, Jan YN, Kriegstein AR, Shi SH

Drosophila IKK-related kinase Ik2 and Katanin p60-like 1 regulate dendrite pruning of sensory neuron during metamorphosis.

Proceedings of the National Academy of Sciences of the United States of America

Lee HH, Jan LY, Jan YN

Control of the postmating behavioral switch in Drosophila females by internal sensory neurons.

Neuron

Yang CH, Rumpf S, Xiang Y, Gordon MD, Song W, Jan LY, Jan YN

G protein-activated inwardly rectifying potassium channels mediate depotentiation of long-term potentiation.

Proceedings of the National Academy of Sciences of the United States of America

Chung HJ, Ge WP, Qian X, Wiser O, Jan YN, Jan LY

Neuronal activity regulates phosphorylation-dependent surface delivery of G protein-activated inwardly rectifying potassium channels.

Proceedings of the National Academy of Sciences of the United States of America

Chung HJ, Qian X, Ehlers M, Jan YN, Jan LY

Dividing glial cells maintain differentiated properties including complex morphology and functional synapses.

Proceedings of the National Academy of Sciences of the United States of America

Ge WP, Zhou W, Luo Q, Jan LY, Jan YN

Dynein is required for polarized dendritic transport and uniform microtubule orientation in axons.

Nature cell biology

Zheng Y, Wildonger J, Ye B, Zhang Y, Kita A, Younger SH, Zimmerman S, Jan LY, Jan YN

Genetic and physiologic dissection of the vertebrate cardiac conduction system.

PLoS biology

Chi NC, Shaw RM, Jungblut B, Huisken J, Ferrer T, Arnaout R, Scott I, Beis D, Xiao T, Baier H, Jan LY, Tristani-Firouzi M, Stainier DY

Drosophila egg-laying site selection as a system to study simple decision-making processes.

Science (New York, N.Y.)

Yang CH, Belawat P, Hafen E, Jan LY, Jan YN

Stoichiometry of Kir channels with phosphatidylinositol bisphosphate.

Channels (Austin, Tex.)

Jin T, Sui JL, Rosenhouse-Dantsker A, Chan KW, Jan LY, Logothetis DE

Foxn4 directly regulates tbx2b expression and atrioventricular canal formation.

Genes & development

Chi NC, Shaw RM, De Val S, Kang G, Jan LY, Black BL, Stainier DY

Retrospective: Seymour Benzer (1921-2007).

Science (New York, N.Y.)

Jan YN, Jan L

Identification of yeast proteins necessary for cell-surface function of a potassium channel.

Proceedings of the National Academy of Sciences of the United States of America

Haass FA, Jonikas M, Walter P, Weissman JS, Jan YN, Jan LY, Schuldiner M

Growing dendrites and axons differ in their reliance on the secretory pathway.

Cell

Ye B, Zhang Y, Song W, Younger SH, Jan LY, Jan YN

Complex formation with the Type B gamma-aminobutyric acid receptor affects the expression and signal transduction of the extracellular calcium-sensing receptor. Studies with HEK-293 cells and neurons.

The Journal of biological chemistry

Chang W, Tu C, Cheng Z, Rodriguez L, Chen TH, Gassmann M, Bettler B, Margeta M, Jan LY, Shoback D

Numb and Numbl are required for maintenance of cadherin-based adhesion and polarity of neural progenitors.

Nature neuroscience

Rasin MR, Gazula VR, Breunig JJ, Kwan KY, Johnson MB, Liu-Chen S, Li HS, Jan LY, Jan YN, Rakic P, Sestan N

Drosophila sensory neurons require Dscam for dendritic self-avoidance and proper dendritic field organization.

Neuron

Soba P, Zhu S, Emoto K, Younger S, Yang SJ, Yu HH, Lee T, Jan LY, Jan YN

Peripheral multidendritic sensory neurons are necessary for rhythmic locomotion behavior in Drosophila larvae.

Proceedings of the National Academy of Sciences of the United States of America

Song W, Onishi M, Jan LY, Jan YN

HLA, NFKB1 and NFKBIA gene polymorphism profile in autoimmune diabetes mellitus patients.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association

Katarina K, Daniela P, Peter N, Marianna R, Pavlina C, Stepanka P, Jan L, Ludmila T, Michal A, Marie C

Projections of Drosophila multidendritic neurons in the central nervous system: links with peripheral dendrite morphology.

Development (Cambridge, England)

Grueber WB, Ye B, Yang CH, Younger S, Borden K, Jan LY, Jan YN

Channeling to the nucleus.

Neuron

Chung HJ, Jan LY

Postnatal deletion of Numb/Numblike reveals repair and remodeling capacity in the subventricular neurogenic niche.

Cell

Kuo CT, Mirzadeh Z, Soriano-Navarro M, Rasin M, Wang D, Shen J, Sestan N, Garcia-Verdugo J, Alvarez-Buylla A, Jan LY, Jan YN

SK channels mediate NADPH oxidase-independent reactive oxygen species production and apoptosis in granulocytes.

Proceedings of the National Academy of Sciences of the United States of America

Fay AJ, Qian X, Jan YN, Jan LY

Turning G proteins on and off using peptide ligands.

ACS chemical biology

Ja WW, Wiser O, Austin RJ, Jan LY, Roberts RW

The secretory pathway and neuron polarization.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Ye B, Zhang YW, Jan LY, Jan YN

Activity- and mTOR-dependent suppression of Kv1.1 channel mRNA translation in dendrites.

Science (New York, N.Y.)

Raab-Graham KF, Haddick PC, Jan YN, Jan LY

Electrostatic interactions in the channel cavity as an important determinant of potassium channel selectivity.

Proceedings of the National Academy of Sciences of the United States of America

Bichet D, Grabe M, Jan YN, Jan LY

K+ channel selectivity depends on kinetic as well as thermodynamic factors.

Proceedings of the National Academy of Sciences of the United States of America

Grabe M, Bichet D, Qian X, Jan YN, Jan LY

Polarized axonal surface expression of neuronal KCNQ channels is mediated by multiple signals in the KCNQ2 and KCNQ3 C-terminal domains.

Proceedings of the National Academy of Sciences of the United States of America

Chung HJ, Jan YN, Jan LY

International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels.

Pharmacological reviews

Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, Lazdunski M, Nichols CG, Seino S, Vandenberg CA

Identification by mass spectrometry and functional characterization of two phosphorylation sites of KCNQ2/KCNQ3 channels.

Proceedings of the National Academy of Sciences of the United States of America

Surti TS, Huang L, Jan YN, Jan LY, Cooper EC

Common molecular pathways mediate long-term potentiation of synaptic excitation and slow synaptic inhibition.

Cell

Huang CS, Shi SH, Ule J, Ruggiu M, Barker LA, Darnell RB, Jan YN, Jan LY

Dendrite-specific remodeling of Drosophila sensory neurons requires matrix metalloproteases, ubiquitin-proteasome, and ecdysone signaling.

Proceedings of the National Academy of Sciences of the United States of America

Kuo CT, Jan LY, Jan YN

A potassium channel, the M-channel, as a therapeutic target.

Current opinion in investigational drugs (London, England : 2000)

Surti TS, Jan LY

Mammalian electrophysiology on a microfluidic platform.

Proceedings of the National Academy of Sciences of the United States of America

Ionescu-Zanetti C, Shaw RM, Seo J, Jan YN, Jan LY, Lee LP

A fluorescent probe designed for studying protein conformational change.

Proceedings of the National Academy of Sciences of the United States of America

Cohen BE, Pralle A, Yao X, Swaminath G, Gandhi CS, Jan YN, Kobilka BK, Isacoff EY, Jan LY

Targeted deletion of numb and numblike in sensory neurons reveals their essential functions in axon arborization.

Genes & development

Huang EJ, Li H, Tang AA, Wiggins AK, Neve RL, Zhong W, Jan LY, Jan YN

A quantitative assessment of models for voltage-dependent gating of ion channels.

Proceedings of the National Academy of Sciences of the United States of America

Grabe M, Lecar H, Jan YN, Jan LY

Control of dendrite arborization by an Ig family member, dendrite arborization and synapse maturation 1 (Dasm1).

Proceedings of the National Academy of Sciences of the United States of America

Shi SH, Cox DN, Wang D, Jan LY, Jan YN

The immunoglobulin family member dendrite arborization and synapse maturation 1 (Dasm1) controls excitatory synapse maturation.

Proceedings of the National Academy of Sciences of the United States of America

Shi SH, Cheng T, Jan LY, Jan YN

NO stimulation of ATP-sensitive potassium channels: Involvement of Ras/mitogen-activated protein kinase pathway and contribution to neuroprotection.

Proceedings of the National Academy of Sciences of the United States of America

Lin YF, Raab-Graham K, Jan YN, Jan LY

Evolving potassium channels by means of yeast selection reveals structural elements important for selectivity.

Proceedings of the National Academy of Sciences of the United States of America

Bichet D, Lin YF, Ibarra CA, Huang CS, Yi BA, Jan YN, Jan LY

Nanos and Pumilio are essential for dendrite morphogenesis in Drosophila peripheral neurons.

Current biology : CB

Ye B, Petritsch C, Clark IE, Gavis ER, Jan LY, Jan YN

Inactivation of Numb and Numblike in embryonic dorsal forebrain impairs neurogenesis and disrupts cortical morphogenesis.

Neuron

Li HS, Wang D, Shen Q, Schonemann MD, Gorski JA, Jones KR, Temple S, Jan LY, Jan YN

International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels.

Pharmacological reviews

Gutman GA, Chandy KG, Adelman JP, Aiyar J, Bayliss DA, Clapham DE, Covarriubias M, Desir GV, Furuichi K, Ganetzky B, Garcia ML, Grissmer S, Jan LY, Karschin A, Kim D, Kuperschmidt S, Kurachi Y, Lazdunski M, Lesage F, Lester HA, McKinnon D, Nichols CG, O'Kelly I, Robbins J, Robertson GA, Rudy B, Sanguinetti M, Seino S, Stuehmer W, Tamkun MM, Vandenberg CA, Wei A, Wulff H, Wymore RS, International Union of Pharmacology

Merging functional studies with structures of inward-rectifier K(+) channels.

Nature reviews. Neuroscience

Bichet D, Haass FA, Jan LY

Distinct roles of Bazooka and Stardust in the specification of Drosophila photoreceptor membrane architecture.

Proceedings of the National Academy of Sciences of the United States of America

Hong Y, Ackerman L, Jan LY, Jan YN

Answers and questions from the KvAP structures.

Neuron

Cohen BE, Grabe M, Jan LY

Oncogenic potential of TASK3 (Kcnk9) depends on K+ channel function.

Proceedings of the National Academy of Sciences of the United States of America

Pei L, Wiser O, Slavin A, Mu D, Powers S, Jan LY, Hoey T

Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene.

Cancer cell

Mu D, Chen L, Zhang X, See LH, Koch CM, Yen C, Tong JJ, Spiegel L, Nguyen KC, Servoss A, Peng Y, Pei L, Marks JR, Lowe S, Hoey T, Jan LY, McCombie WR, Wigler MH, Powers S

Contribution of GIRK2-mediated postsynaptic signaling to opiate and alpha 2-adrenergic analgesia and analgesic sex differences.

Proceedings of the National Academy of Sciences of the United States of America

Mitrovic I, Margeta-Mitrovic M, Bader S, Stoffel M, Jan LY, Basbaum AI

Tiling of the Drosophila epidermis by multidendritic sensory neurons.

Development (Cambridge, England)

Grueber WB, Jan LY, Jan YN

Probing protein electrostatics with a synthetic fluorescent amino acid.

Science (New York, N.Y.)

Cohen BE, McAnaney TB, Park ES, Jan YN, Boxer SG, Jan LY

M channel KCNQ2 subunits are localized to key sites for control of neuronal network oscillations and synchronization in mouse brain.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Cooper EC, Harrington E, Jan YN, Jan LY

Bazooka and atypical protein kinase C are required to regulate oocyte differentiation in the Drosophila ovary.

Proceedings of the National Academy of Sciences of the United States of America

Cox DN, Seyfried SA, Jan LY, Jan YN

Bazooka is required for localization of determinants and controlling proliferation in the sensory organ precursor cell lineage in Drosophila.

Proceedings of the National Academy of Sciences of the United States of America

Roegiers F, Younger-Shepherd S, Jan LY, Jan YN

Function of GB1 and GB2 subunits in G protein coupling of GABA(B) receptors.

Proceedings of the National Academy of Sciences of the United States of America

Margeta-Mitrovic M, Jan YN, Jan LY

Ligand-induced signal transduction within heterodimeric GABA(B) receptor.

Proceedings of the National Academy of Sciences of the United States of America

Margeta-Mitrovic M, Jan YN, Jan LY

Asymmetric cell division in the Drosophila nervous system.

Nature reviews. Neuroscience

Jan YN, Jan LY

Dendrites.

Genes & development

Jan YN, Jan LY

Expression Profile of Aging and Oxidative Stress Response in Drosophila melanogaster.

TheScientificWorldJournal

Zou S, Meadows S, Sharp L, Jan LY, Jan YN

Controlling potassium channel activities: Interplay between the membrane and intracellular factors.

Proceedings of the National Academy of Sciences of the United States of America

Yi BA, Minor DL, Lin YF, Jan YN, Jan LY

Ethanol hypersensitivity and olfactory discrimination defect in mice lacking a homolog of Drosophila neuralized.

Proceedings of the National Academy of Sciences of the United States of America

Ruan Y, Tecott L, Jiang MM, Jan LY, Jan YN

Probing ion permeation and gating in a K+ channel with backbone mutations in the selectivity filter.

Nature neuroscience

Lu T, Ting AY, Mainland J, Jan LY, Schultz PG, Yang J

Analysis of endoplasmic reticulum trafficking signals by combinatorial screening in mammalian cells.

Proceedings of the National Academy of Sciences of the United States of America

Zerangue N, Malan MJ, Fried SR, Dazin PF, Jan YN, Jan LY, Schwappach B

Role of ER export signals in controlling surface potassium channel numbers.

Science (New York, N.Y.)

Ma D, Zerangue N, Lin YF, Collins A, Yu M, Jan YN, Jan LY

Two types of asymmetric divisions in the Drosophila sensory organ precursor cell lineage.

Nature cell biology

Roegiers F, Younger-Shepherd S, Jan LY, Jan YN

Genome-wide study of aging and oxidative stress response in Drosophila melanogaster.

Proceedings of the National Academy of Sciences of the United States of America

Zou S, Meadows S, Sharp L, Jan LY, Jan YN

Signalling mechanisms: a decade of signalling.

Current opinion in neurobiology

Jan LY, Stevens CF

A genomewide survey of basic helix-loop-helix factors in Drosophila.

Proceedings of the National Academy of Sciences of the United States of America

Moore AW, Barbel S, Jan LY, Jan YN

The polar T1 interface is linked to conformational changes that open the voltage-gated potassium channel.

Cell

Minor DL, Lin YF, Mobley BC, Avelar A, Jan YN, Jan LY, Berger JM

Ectopic scute induces Drosophila ommatidia development without R8 founder photoreceptors.

Proceedings of the National Academy of Sciences of the United States of America

Sun Y, Jan LY, Jan YN

Mouse numb is an essential gene involved in cortical neurogenesis.

Proceedings of the National Academy of Sciences of the United States of America

Zhong W, Jiang MM, Schonemann MD, Meneses JJ, Pedersen RA, Jan LY, Jan YN

A gain-of-function screen for genes that affect the development of the Drosophila adult external sensory organ.

Genetics

Abdelilah-Seyfried S, Chan YM, Zeng C, Justice NJ, Younger-Shepherd S, Sharp LE, Barbel S, Meadows SA, Jan LY, Jan YN

Colocalization and coassembly of two human brain M-type potassium channel subunits that are mutated in epilepsy.

Proceedings of the National Academy of Sciences of the United States of America

Cooper EC, Aldape KD, Abosch A, Barbaro NM, Berger MS, Peacock WS, Jan YN, Jan LY

An artificial tetramerization domain restores efficient assembly of functional Shaker channels lacking T1.

Proceedings of the National Academy of Sciences of the United States of America

Zerangue N, Jan YN, Jan LY

Control of cell divisions in the nervous system: symmetry and asymmetry.

Annual review of neuroscience

Lu B, Jan L, Jan YN

Genes regulating dendritic outgrowth, branching, and routing in Drosophila.

Genes & development

Gao FB, Brenman JE, Jan LY, Jan YN

Asymmetry across species.

Nature cell biology

Jan YN, Jan LY

Ion channel genes and human neurological disease: recent progress, prospects, and challenges.

Proceedings of the National Academy of Sciences of the United States of America

Cooper EC, Jan LY

Immunohistochemical localization of GABA(B) receptors in the rat central nervous system.

The Journal of comparative neurology

Margeta-Mitrovic M, Mitrovic I, Riley RC, Jan LY, Basbaum AI

Evidence that the nucleotide exchange and hydrolysis cycle of G proteins causes acute desensitization of G-protein gated inward rectifier K+ channels.

Proceedings of the National Academy of Sciences of the United States of America

Chuang HH, Yu M, Jan YN, Jan LY

The Drosophila LIM-only gene, dLMO, is mutated in Beadex alleles and might represent an evolutionarily conserved function in appendage development.

Proceedings of the National Academy of Sciences of the United States of America

Zeng C, Justice NJ, Abdelilah S, Chan YM, Jan LY, Jan YN

Asymmetric cell division: lessons from flies and worms.

Current opinion in genetics & development

Lu B, Jan LY, Jan YN

Molecular basis for interactions of G protein betagamma subunits with effectors.

Science (New York, N.Y.)

Ford CE, Skiba NP, Bae H, Daaka Y, Reuveny E, Shekter LR, Rosal R, Weng G, Yang CS, Iyengar R, Miller RJ, Jan LY, Lefkowitz RJ, Hamm HE

Asymmetric cell division.

Nature

Jan YN, Jan LY

G-protein signaling: fine-tuning signaling kinetics.

Current biology : CB

Zerangue N, Jan LY

Presynaptic localization of Kv1.4-containing A-type potassium channels near excitatory synapses in the hippocampus.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Cooper EC, Milroy A, Jan YN, Jan LY, Lowenstein DH

Serendipity, the principle of limited sloppiness, and neural development.

The International journal of developmental biology

Jan YN, Jan LY

Probing the G-protein regulation of GIRK1 and GIRK4, the two subunits of the KACh channel, using functional homomeric mutants.

The Journal of biological chemistry

Vivaudou M, Chan KW, Sui JL, Jan LY, Reuveny E, Logothetis DE

Ways and means for left shifts in the MaxiK channel.

Proceedings of the National Academy of Sciences of the United States of America

Jan LY, Jan YN

Voltage-gated and inwardly rectifying potassium channels.

The Journal of physiology

Jan LY, Jan YN

Genghis Khan (Gek) as a putative effector for Drosophila Cdc42 and regulator of actin polymerization.

Proceedings of the National Academy of Sciences of the United States of America

Luo L, Lee T, Tsai L, Tang G, Jan LY, Jan YN

The N terminus of the Drosophila Numb protein directs membrane association and actin-dependent asymmetric localization.

Proceedings of the National Academy of Sciences of the United States of America

Knoblich JA, Jan LY, Jan YN

Breaking symmetry in the CNS.

Trends in cell biology

Li P, Yang X, Wasser M, Cai Y, Chia W, Shen CP, Jan LY, Jan YN

Xath5 participates in a network of bHLH genes in the developing Xenopus retina.

Neuron

Kanekar S, Perron M, Dorsky R, Harris WA, Jan LY, Jan YN, Vetter ML

Defective gamma-aminobutyric acid type B receptor-activated inwardly rectifying K+ currents in cerebellar granule cells isolated from weaver and Girk2 null mutant mice.

Proceedings of the National Academy of Sciences of the United States of America

Slesinger PA, Stoffel M, Jan YN, Jan LY

Scanning mutagenesis of the putative transmembrane segments of Kir2.1, an inward rectifier potassium channel.

Proceedings of the National Academy of Sciences of the United States of America

Collins A, Chuang H, Jan YN, Jan LY

Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis.

Development (Cambridge, England)

Zhong W, Jiang MM, Weinmaster G, Jan LY, Jan YN

Receptor-regulated ion channels.

Current opinion in cell biology

Jan LY, Jan YN

Stabilization of ion selectivity filter by pore loop ion pairs in an inwardly rectifying potassium channel.

Proceedings of the National Academy of Sciences of the United States of America

Yang J, Yu M, Jan YN, Jan LY

Normal cerebellar development but susceptibility to seizures in mice lacking G protein-coupled, inwardly rectifying K+ channel GIRK2.

Proceedings of the National Academy of Sciences of the United States of America

Signorini S, Liao YJ, Duncan SA, Jan LY, Stoffel M

Rho family GTP-binding proteins in growth cone signalling.

Current opinion in neurobiology

Luo L, Jan LY, Jan YN

Asymmetric segregation of the Drosophila numb protein during mitosis: facts and speculations.

Cold Spring Harbor symposia on quantitative biology

Knoblich JA, Jan LY, Jan YN

Cloned potassium channels from eukaryotes and prokaryotes.

Annual review of neuroscience

Jan LY, Jan YN

Heteromultimerization of G-protein-gated inwardly rectifying K+ channel proteins GIRK1 and GIRK2 and their altered expression in weaver brain.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Liao YJ, Jan YN, Jan LY

Neuronal type information encoded in the basic-helix-loop-helix domain of proneural genes.

Proceedings of the National Academy of Sciences of the United States of America

Chien CT, Hsiao CD, Jan LY, Jan YN

The Drosophila Numb protein inhibits signaling of the Notch receptor during cell-cell interaction in sensory organ lineage.

Proceedings of the National Academy of Sciences of the United States of America

Frise E, Knoblich JA, Younger-Shepherd S, Jan LY, Jan YN

Role of inscuteable in orienting asymmetric cell divisions in Drosophila.

Nature

Kraut R, Chia W, Jan LY, Jan YN, Knoblich JA

Identification of a titratable lysine residue that determines sensitivity of kidney potassium channels (ROMK) to intracellular pH.

The EMBO journal

Fakler B, Schultz JH, Yang J, Schulte U, Brandle U, Zenner HP, Jan LY, Ruppersberg JP

Membrane permeability.

Current opinion in cell biology

Jan LY, Jan YN

Differential effects of the Rac GTPase on Purkinje cell axons and dendritic trunks and spines.

Nature

Luo L, Hensch TK, Ackerman L, Barbel S, Jan LY, Jan YN

Delta is a ventral to dorsal signal complementary to Serrate, another Notch ligand, in Drosophila wing formation.

Genes & development

Doherty D, Feger G, Younger-Shepherd S, Jan LY, Jan YN

A strongly inwardly rectifying K+ channel that is sensitive to ATP.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Collins A, German MS, Jan YN, Jan LY, Zhao B

Small GTPases in axon outgrowth.

Perspectives on developmental neurobiology

Luo L, Jan L, Jan YN

Cloning of rat KATP-2 channel and decreased expression in pancreatic islets of male Zucker diabetic fatty rats.

Biochemical and biophysical research communications

Stoffel M, Tokuyama Y, Trabb JB, German MS, Tsaar ML, Jan LY, Polonsky KS, Bell GI

The Shaker-like potassium channels of the mouse rod bipolar cell and their contributions to the membrane current.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Klumpp DJ, Song EJ, Ito S, Sheng MH, Jan LY, Pinto LH

The molecular organization of voltage-dependent K+ channels in vivo.

Progress in brain research

Sheng M, Jan YN, Jan L

Evidence for presynaptic N-methyl-D-aspartate autoreceptors in the spinal cord dorsal horn.

Proceedings of the National Academy of Sciences of the United States of America

Liu H, Wang H, Sheng M, Jan LY, Jan YN, Basbaum AI

Activation of the cloned muscarinic potassium channel by G protein beta gamma subunits.

Nature

Reuveny E, Slesinger PA, Inglese J, Morales JM, Iñiguez-Lluhi JA, Lefkowitz RJ, Bourne HR, Jan YN, Jan LY

Atonal is the proneural gene for Drosophila photoreceptors.

Nature

Jarman AP, Grell EH, Ackerman L, Jan LY, Jan YN

lola encodes a putative transcription factor required for axon growth and guidance in Drosophila.

Development (Cambridge, England)

Giniger E, Tietje K, Jan LY, Jan YN

Contrasting subcellular localization of the Kv1.2 K+ channel subunit in different neurons of rat brain.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Sheng M, Tsaur ML, Jan YN, Jan LY

The role of gene cassettes in axis formation during Drosophila oogenesis.

Trends in genetics : TIG

Ruohola-Baker H, Jan LY, Jan YN

Images of purified Shaker potassium channels.

Current biology : CB

Li M, Unwin N, Stauffer KA, Jan YN, Jan LY

Neuronal cell fate specification in Drosophila.

Current opinion in neurobiology

Jan YN, Jan LY

Assembly of potassium channels.

Annals of the New York Academy of Sciences

Li M, Isacoff E, Jan YN, Jan LY

Functional gene cassettes in development.

Proceedings of the National Academy of Sciences of the United States of America

Jan YN, Jan LY

The regulation and function of the helix-loop-helix gene, asense, in Drosophila neural precursors.

Development (Cambridge, England)

Jarman AP, Brand M, Jan LY, Jan YN

asense is a Drosophila neural precursor gene and is capable of initiating sense organ formation.

Development (Cambridge, England)

Brand M, Jarman AP, Jan LY, Jan YN

A late role for a subset of neurogenic genes to limit sensory precursor recruitments in Drosophila embryos.

Roux's archives of developmental biology : the official organ of the EDBO

Bodmer R, Jan LY, Jan YN

Cell interactions and gene interactions in peripheral neurogenesis.

Genes & development

Ghysen A, Dambly-Chaudière C, Jan LY, Jan YN

Tracing neurons with a kinesin-β-galactosidase fusion protein.

Roux's archives of developmental biology : the official organ of the EDBO

Giniger E, Wells W, Jan LY, Jan YN

Neuronal specification.

Current opinion in genetics & development

Jan YN, Jan LY

Elucidation of biophysical and biological properties of voltage-gated potassium channels.

Cold Spring Harbor symposia on quantitative biology

Baldwin TJ, Isacoff E, Li M, Lopez GA, Sheng M, Tsaur ML, Yan YN, Jan LY

Structural elements involved in specific K+ channel functions.

Annual review of physiology

Jan LY, Jan YN

How might the diversity of potassium channels be generated?

Trends in neurosciences

Jan LY, Jan YN

Functional expression of Shaker K+ channels in a baculovirus-infected insect cell line.

Neuron

Klaiber K, Williams N, Roberts TM, Papazian DM, Jan LY, Miller C

A superfamily of ion channels.

Nature

Jan LY, Jan YN

Molecular studies of voltage-gated potassium channels.

Cold Spring Harbor symposia on quantitative biology

Isacoff E, Papazian D, Timpe L, Jan YN, Jan LY

Role of helix-loop-helix proteins in Drosophila neurogenesis.

Cold Spring Harbor symposia on quantitative biology

Vaessin H, Caudy M, Bier E, Jan LY, Jan YN

Spider toxins selectively block calcium currents in Drosophila.

Neuron

Leung HT, Branton WD, Phillips HS, Jan L, Byerly L

Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence.

Cell

Murre C, McCaw PS, Vaessin H, Caudy M, Jan LY, Jan YN, Cabrera CV, Buskin JN, Hauschka SD, Lassar AB

Voltage-sensitive ion channels.

Cell

Jan LY, Jan YN

Identification of a component of Drosophila polar granules.

Development (Cambridge, England)

Hay B, Ackerman L, Barbel S, Jan LY, Jan YN

Identification and characterization of a neuron-specific nuclear antigen in Drosophila.

Science (New York, N.Y.)

Bier E, Ackerman L, Barbel S, Jan L, Jan YN

Expression of functional potassium channels from Shaker cDNA in Xenopus oocytes.

Nature

Timpe LC, Schwarz TL, Tempel BL, Papazian DM, Jan YN, Jan LY

Ion channels in Drosophila.

Annual review of physiology

Papazian DM, Schwarz TL, Tempel BL, Timpe LC, Jan LY

Neurotoxins from Plectreurys spider venom are potent presynaptic blockers in Drosophila.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Branton WD, Kolton L, Jan YN, Jan LY

Transformation of sensory organs by mutations of the cut locus of D. melanogaster.

Cell

Bodmer R, Barbel S, Sheperd S, Jack JW, Jan LY, Jan YN

Cloning of genomic and complementary DNA from Shaker, a putative potassium channel gene from Drosophila.

Science (New York, N.Y.)

Papazian DM, Schwarz TL, Tempel BL, Jan YN, Jan LY

Sequence of a probable potassium channel component encoded at Shaker locus of Drosophila.

Science (New York, N.Y.)

Tempel BL, Papazian DM, Schwarz TL, Jan YN, Jan LY

Gene dosage and complementation analysis of the Shaker locus in Drosophila.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Timpe LC, Jan LY

Identification and purification of an irreversible presynaptic neurotoxin from the venom of the spider Hololena curta.

Proceedings of the National Academy of Sciences of the United States of America

Bowers CW, Phillips HS, Lee P, Jan YN, Jan LY

Muscle connections between imaginal discs in Drosophila.

Developmental biology

Dambly-Chaudière C, Ghysen A, Jan YN, Jan LY

Formation of neuronal pathways in the imaginal discs of Drosophila melanogaster.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Jan YN, Ghysen A, Christoph I, Barbel S, Jan LY

Mutating a gene for a potassium channel by hybrid dysgenesis: an approach to the cloning of the Shaker locus in Drosophila.

Cold Spring Harbor symposia on quantitative biology

Jan LY, Barbel S, Timpe L, Laffer C, Salkoff L, O'Farrell P, Jan YN

Peptides in neuronal function: studies using frog autonomic ganglia.

Cold Spring Harbor symposia on quantitative biology

Jan YN, Bowers CW, Branton D, Evans L, Jan LY

Some features of peptidergic transmission.

Progress in brain research

Jan YN, Jan LY

Peptidergic transmission in sympathetic ganglia of the frog.

The Journal of physiology

Jan LY, Jan YN

Antibodies to horseradish peroxidase as specific neuronal markers in Drosophila and in grasshopper embryos.

Proceedings of the National Academy of Sciences of the United States of America

Jan LY, Jan YN

Segmental differences in the protein content of Drosophila imaginal discs.

The EMBO journal

Ghysen A, Dambly-Chaudière C, Jan LY, Jan YN

Further evidence for peptidergic transmission in sympathetic ganglia.

Proceedings of the National Academy of Sciences of the United States of America

Jan YN, Jan LY, Kuffler SW

Synaptic vesicle exocytosis captured by quick freezing and correlated with quantal transmitter release.

The Journal of Cell Biology

Heuser JE, Reese TS, Dennis MJ, Jan Y, Jan L, Evans L

A Drosophila mutant with a temperature-sensitive block in nerve conduction.

Proceedings of the National Academy of Sciences of the United States of America

Wu CF, Ganetzky B, Jan LY, Jan YN, Benzer S

Genetic dissection of short-term and long-term facilitation at the Drosophila neuromuscular junction.

Proceedings of the National Academy of Sciences of the United States of America

Jan YN, Jan LY

Two mutations of synaptic transmission in Drosophila.

Proceedings of the Royal Society of London. Series B, Biological sciences

Jan YN, Jan LY, Dennis MJ

Ultrastructural localization of rhodopsin in the vertebrate retina.

The Journal of Cell Biology

Jan LY, Revel JP

Websites: 
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Affiliate Faculty