
Associate Professor
Medicine
Email
Faculty Type
Affiliate Faculty
My lab’s research has focused on mitral valve prolapse or “floppy” mitral valve, and the combined use of echocardiography, cardiac magnetic resonance (CMR), and molecular genetics to better understand disease mechanisms and progression to either severe mitral regurgitation or life-threatening ventricular arrhythmias.
Publications
Sex-based Differences in Mitral Annular Disjunction Severity and Arrhythmic Risk in Mitral Valve Prolapse.
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography
Phenotyping of Mitral Valve Prolapse Without Severe Mitral Regurgitation Using Electrocardiographic and Echocardiographic Data.
JACC. Clinical electrophysiology
Countywide burden, pathology, and genetics of lethal hypertrophic cardiomyopathy: from the POST SCD study.
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology
Multimodality Imaging of Arrhythmic Risk in Mitral Valve Prolapse.
Circulation. Cardiovascular imaging
Characteristics of Patients With the Arrhythmogenic Mitral Valve Prolapse Syndrome and Sudden Cardiac Arrest and Sustained Ventricular Arrhythmias.
Circulation. Arrhythmia and electrophysiology
Inheritance of Imaging Parameters of Arrhythmic Risk in Mitral Valve Prolapse: A Pedigree Study.
Circulation. Cardiovascular imaging
Interstitial Fibrosis and Arrhythmic Mitral Valve Prolapse: Unravelling Sex-Based Differences.
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
Smoking Cessation and Incident Atrial Fibrillation in a Longitudinal Cohort.
JACC. Clinical electrophysiology
Primary Atriopathy in Mitral Valve Prolapse: Echocardiographic Evidence and Clinical Implications.
Circulation. Cardiovascular imaging
Mitral Annular Disjunction: An Under-Recognized Entity in Pediatrics.
JACC. Case reports
Clinical Improvement With Transcatheter Edge-to-Edge Tricuspid Repair Irrespective of Right Atrial Pressure.
JACC. Advances
Mechanical Dispersion Discriminates Between Arrhythmic and Nonarrhythmic Sudden Death: From the POST SCD Study.
JACC. Clinical electrophysiology
Left ventricular fibrosis in arrhythmic mitral valve prolapse: quantification and comparison of semi-automated techniques assessed by cardiac magnetic resonance.
The international journal of cardiovascular imaging
Identifying Mitral Valve Prolapse at Risk for Arrhythmias and Fibrosis From Electrocardiograms Using Deep Learning.
JACC. Advances
Stroke in mitral valve prolapse: risk factors and left atrial function in cryptogenic versus non-cryptogenic ischemic subtypes.
Frontiers in neurology
Abnormal Mechanics Relate to Myocardial Fibrosis and Ventricular Arrhythmias in Patients With Mitral Valve Prolapse.
Circulation. Cardiovascular imaging
Research Opportunities in the Treatment of Mitral Valve Prolapse: JACC Expert Panel.
Journal of the American College of Cardiology
Genome-wide association study reveals novel genetic loci: a new polygenic risk score for mitral valve prolapse.
European heart journal
Sex Differences and Similarities in Valvular Heart Disease.
Circulation research
Coffee Consumption and Incident Tachyarrhythmias: Reported Behavior, Mendelian Randomization, and Their Interactions.
JAMA internal medicine
Antemortem and Post-Mortem Characteristics of Lethal Mitral Valve Prolapse Among All Countywide Sudden Deaths.
JACC. Clinical electrophysiology
Cardiac Imaging for Risk Assessment of Malignant Ventricular Arrhythmias in Patients With Mitral Valve Prolapse.
Frontiers in cardiovascular medicine
Heart Disease and Stroke Statistics-2021 Update: A Report From the American Heart Association.
Circulation
Characteristics and Significance of Tricuspid Valve Prolapse in a Large Multidecade Echocardiographic Study.
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography
Long-term outcomes of ablation for ventricular arrhythmias in mitral valve prolapse.
Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing
Artificial Intelligence in Cardiovascular Imaging.
Methodist DeBakey cardiovascular journal
Heart Disease and Stroke Statistics-2020 Update: A Report From the American Heart Association.
Circulation
Automated and Interpretable Patient ECG Profiles for Disease Detection, Tracking, and Discovery.
Circulation. Cardiovascular quality and outcomes
Primary cilia defects causing mitral valve prolapse.
Science translational medicine
Genome-Wide Association Study-Driven Gene-Set Analyses, Genetic, and Functional Follow-Up Suggest GLIS1 as a Susceptibility Gene for Mitral Valve Prolapse.
Circulation. Genomic and precision medicine
Heart Disease and Stroke Statistics-2019 Update: A Report From the American Heart Association.
Circulation
Left ventricular mechanical dispersion predicts arrhythmic risk in mitral valve prolapse.
Heart (British Cardiac Society)
New insights into mitral valve dystrophy: a Filamin-A genotype-phenotype and outcome study.
European heart journal
Heart Disease and Stroke Statistics-2018 Update: A Report From the American Heart Association.
Circulation
Incidental Statin Use and the Risk of Stroke or Transient Ischemic Attack after Radiotherapy for Head and Neck Cancer.
Journal of stroke
Mitral Valve Prolapse: Multimodality Imaging and Genetic Insights.
Progress in cardiovascular diseases
Heritability of Mitral Regurgitation: Observations From the Framingham Heart Study and Swedish Population.
Circulation. Cardiovascular genetics
Clinical performance of high-resolution late gadolinium enhancement imaging with compressed sensing.
Journal of magnetic resonance imaging : JMRI
Relationship between native papillary muscle T1 time and severity of functional mitral regurgitation in patients with non-ischemic dilated cardiomyopathy.
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
Diffuse myocardial fibrosis in patients with mitral valve prolapse and ventricular arrhythmia.
Heart (British Cardiac Society)
Tricuspid Regurgitation and Mortality in Patients With Transvenous Permanent Pacemaker Leads.
The American journal of cardiology
Mitral valve disease--morphology and mechanisms.
Nature reviews. Cardiology
Response to Letter Regarding Article, "Familial Clustering of Mitral Valve Prolapse in the Community".
Circulation
Left Ventricular Ejection Index as a Marker of Early Myocardial Dysfunction in Primary Mitral Regurgitation: Novel or Old in Disguise?
Circulation. Cardiovascular imaging
Genetic association analyses highlight biological pathways underlying mitral valve prolapse.
Nature genetics
Assessment of mitral valve disease: a review of imaging modalities.
Current treatment options in cardiovascular medicine
Mitral valve prolapse and glaucoma: a 'floppy' perception?
Heart (British Cardiac Society)
Mild expression of mitral valve prolapse in the Framingham offspring: expanding the phenotypic spectrum.
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography
Intermediate-signal-intensity late gadolinium enhancement predicts ventricular tachyarrhythmias in patients with hypertrophic cardiomyopathy.
Circulation. Cardiovascular imaging
CMR predictors of mitral regurgitation in mitral valve prolapse.
JACC. Cardiovascular imaging
Mitral regurgitation augments post-myocardial infarction remodeling failure of hypertrophic compensation.
Journal of the American College of Cardiology
Frequency and mechanism of persistent systolic anterior motion and mitral regurgitation after septal ablation in obstructive hypertrophic cardiomyopathy.
The American journal of cardiology
A framework for the analysis of acoustical cardiac signals.
IEEE transactions on bio-medical engineering
Software enhanced learning of cardiac auscultation.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
Usefulness of three-dimensionally guided assessment of mitral stenosis using matrix-array ultrasound.
The American journal of cardiology
Case records of the Massachusetts General Hospital. Case 15-2005. An 80-year-old man with shortness of breath, edema, and proteinuria.
The New England journal of medicine
Leaflet concavity: a rapid visual clue to the presence and mechanism of functional mitral regurgitation.
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography
A locus for autosomal dominant mitral valve prolapse on chromosome 11p15.4.
American journal of human genetics
Impact of tissue harmonic imaging in patients with distorted left ventricles: improvement in accuracy and reproducibility of visual, manual and automated echocardiographic assessment of left ventricular ejection fraction.
European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology
A semiautomated objective technique for applying the proximal isovelocity surface area method to quantitate mitral regurgitation: Clinical studies with the digital flow map.
American heart journal
Endothelial dysfunction during heart failure: effects of Carvedilol
Heart Failure Reviews
Metabolic derangement in ischemic heart disease and its therapeutic control.
The American journal of cardiology
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