Joanne Engel, MD, PhD

Professor
Engel
UCSF Profiles(link is external)

Research Interests: Bacterial Pathogen-Host Cell Interactions Summary: My laboratory is interested understanding and exploiting the complex interplay of microbial pathogens with eukaryotic cells. To that end, we have investigated the key processes of microbial attachment and entry, intracellular survival, and host cell injury in the context of two important human pathogens, Pseudomonas aeruginosa (PA) and Chlamydia trachomatis (CT). Each of these microorganisms has developed a unique strategy for successful survival that involves subverting and exploiting host cell pathways. Dissecting these processes will allow the development of new diagnostics, therapeutics, and vaccines and will provide a unique window into eukaryotic cell biology. 

Address: 
513 Parnassus Avenue, HSE, Rm 405
UCSF Box 0654
San Francisco, CA 94143
United States
Email: 
joanne.engel@ucsf.edu
Faculty Type: 
Affiliate Faculty
Publications: 

The Chlamydia effector IncE employs two short linear motifs to reprogram host vesicle trafficking.(link is external)

Cell reports

Pha K, Mirrashidi K, Sherry J, Tran CJ, Herrera CM, McMahon E, Elwell CA, Engel JN

Global mapping of the Chlamydia trachomatis conventional secreted effector - host interactome reveals CebN interacts with nucleoporins and Rae1 to impede STAT1 nuclear translocation.(link is external)

bioRxiv : the preprint server for biology

Steiert B, Andersen SE, McCaslin PN, Elwell CA, Faris R, Tijerina X, Smith P, Eldridge Q, Imai BS, Arrington JV, Yau PM, Mirrashidi KM, Johnson JR, Verschueren E, Von Dollen J, Jang GM, Krogan NJ, Engel JN, Weber MM

The Chlamydia effector IncE employs two short linear motifs to reprogram host vesicle trafficking.(link is external)

bioRxiv : the preprint server for biology

Pha K, Mirrashidi K, Sherry J, Tran CJ, Herrera CM, McMahon E, Elwell CA, Engel JN

Spatial control of sensory adaptation modulates mechanosensing in Pseudomonas aeruginosa.(link is external)

bioRxiv : the preprint server for biology

Patino R, Kühn MJ, Macmillan H, Inclan YF, Chavez I, Von Dollen J, Johnson JR, Swaney DL, Krogan NJ, Persat A, Engel JN

Peptidoglycan-Targeted [18F]3,3,3-Trifluoro-d-alanine Tracer for Imaging Bacterial Infection.

JACS Au

Alexandre M. Sorlin, Marina Lo´pez-A´lvarez, Jacob Biboy, Joe Gray, Sarah J. Rabbitt, Junaid Ur Rahim, Sang Hee Lee, Kondapa Naidu Bobba, Joseph Blecha, Mathew F.L. Parker, Robert R. Flavell, Joanne Engel, Michael Ohliger, Waldemar Vollmer, David M. Wilson

Two antagonistic response regulators control Pseudomonas aeruginosa polarization during mechanotaxis.(link is external)

The EMBO journal

Kühn MJ, Macmillan H, Talà L, Inclan Y, Patino R, Pierrat X, Al-Mayyah Z, Engel JN, Persat A

Imaging joint infections using D-methyl-11C-methionine PET/MRI: initial experience in humans.(link is external)

European journal of nuclear medicine and molecular imaging

Polvoy I, Seo Y, Parker M, Stewart M, Siddiqua K, Manacsa HS, Ravanfar V, Blecha J, Hope TA, Vanbrocklin H, Flavell RR, Barry J, Hansen E, Villanueva-Meyer JE, Engel J, Rosenberg OS, Wilson DM, Ohliger MA

Mechanotaxis directs Pseudomonas aeruginosa twitching motility.(link is external)

Proceedings of the National Academy of Sciences of the United States of America

Kühn MJ, Talà L, Inclan YF, Patino R, Pierrat X, Vos I, Al-Mayyah Z, Macmillan H, Negrete J, Engel JN, Persat A

Enabling genetic analysis of diverse bacteria with Mobile-CRISPRi.(link is external)

Nature microbiology

Peters JM, Koo BM, Patino R, Heussler GE, Hearne CC, Qu J, Inclan YF, Hawkins JS, Lu CHS, Silvis MR, Harden MM, Osadnik H, Peters JE, Engel JN, Dutton RJ, Grossman AD, Gross CA, Rosenberg OS

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