Trevor Fidler, PhD

Assistant Professor, Cardiovascular Research Institute

UCSF Profiles(link is external)

Research Interests:

Inflammatory Mechanisms in Atherosclerosis

Address:

555 & 535 Mission Bay Blvd Sou, Rm 452J

UCSF Box 3122

San Francisco, CA 94158

United States

Phone:

+1 415 514-8082

Email:

trevor.fidler@ucsf.edu

Websites:

https://trevorfidler.ucsf.edu/fidler-lab(link is external)

Faculty Type:

Core CVRI Faculty

Publications:

An epigenetic switch in macrophages promotes fibrosis in the failing heart.(link is external)

Nature Cardiovascular Research

Tall AR, Fidler TP

Suppression of IL-1β promotes beneficial accumulation of fibroblast-like cells in atherosclerotic plaques in clonal hematopoiesis.(link is external)

Nature Cardiovascular Research

Fidler TP, Dunbar A, Kim E, Hardaway B, Pauli J, Xue C, Abramowicz S, Xiao T, O'Connor K, Sachs N, Wang N, Maegdefessel L, Levine R, Reilly M, Tall AR

Genetic modification of inflammation- and clonal hematopoiesis-associated cardiovascular risk.(link is external)

The Journal of clinical investigation

Yu Z, Fidler TP, Ruan Y, Vlasschaert C, Nakao T, Uddin MM, Mack T, Niroula A, Heimlich JB, Zekavat SM, Gibson CJ, Griffin GK, Wang Y, Peloso GM, Heard-Costa N, Levy D, Vasan RS, Aguet F, Ardlie KG, Taylor KD, Rich SS, Rotter JI, Libby P, Jaiswal S, Ebert BL, Bick AG, Tall AR, Natarajan P

Hematopoietic NLRP3 and AIM2 Inflammasomes Promote Diabetes-Accelerated Atherosclerosis, but Increased Necrosis Is Independent of Pyroptosis.(link is external)

Diabetes

Hsu CC, Fidler TP, Kanter JE, Kothari V, Kramer F, Tang J, Tall AR, Bornfeldt KE

Endogenous SOD2 (Superoxide Dismutase) Regulates Platelet-Dependent Thrombin Generation and Thrombosis During Aging.(link is external)

Arteriosclerosis, thrombosis, and vascular biology

Sonkar VK, Eustes AS, Ahmed A, Jensen M, Solanki MV, Swamy J, Kumar R, Fidler TP, Houtman JCD, Allen BG, Spitz DR, Abel ED, Dayal S

Erythroid lineage Jak2V617F expression promotes atherosclerosis through erythrophagocytosis and macrophage ferroptosis.(link is external)

The Journal of clinical investigation

Liu W, Östberg N, Yalcinkaya M, Dou H, Endo-Umeda K, Tang Y, Hou X, Xiao T, Fidler TP, Abramowicz S, Yang YG, Soehnlein O, Tall AR, Wang N

Modulation of the NLRP3 inflammasome by Sars-CoV-2 Envelope protein.(link is external)

Scientific reports

Yalcinkaya M, Liu W, Islam MN, Kotini AG, Gusarova GA, Fidler TP, Papapetrou EP, Bhattacharya J, Wang N, Tall AR

Oxidized Phospholipids Promote NETosis and Arterial Thrombosis in LNK(SH2B3) Deficiency.(link is external)

Circulation

Dou H, Kotini A, Liu W, Fidler T, Endo-Umeda K, Sun X, Olszewska M, Xiao T, Abramowicz S, Yalcinkaya M, Hardaway B, Tsimikas S, Que X, Bick A, Emdin C, Natarajan P, Papapetrou EP, Witztum JL, Wang N, Tall AR

The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis.(link is external)

Nature

Fidler TP, Xue C, Yalcinkaya M, Hardaway B, Abramowicz S, Xiao T, Liu W, Thomas DG, Hajebrahimi MA, Pircher J, Silvestre-Roig C, Kotini AG, Luchsinger LL, Wei Y, Westerterp M, Snoeck HW, Papapetrou EP, Schulz C, Massberg S, Soehnlein O, Ebert B, Levine RL, Reilly MP, Libby P, Wang N, Tall AR

Inhibition of JAK2 Suppresses Myelopoiesis and Atherosclerosis in Apoe-/- Mice.(link is external)

Cardiovascular drugs and therapy

Tang Y, Liu W, Wang W, Fidler T, Woods B, Levine RL, Tall AR, Wang N

Loss of MCU prevents mitochondrial fusion in G1-S phase and blocks cell cycle progression and proliferation.(link is external)

Science signaling

Koval OM, Nguyen EK, Santhana V, Fidler TP, Sebag SC, Rasmussen TP, Mittauer DJ, Strack S, Goswami PC, Abel ED, Grumbach IM

Glucose Metabolism Is Required for Platelet Hyperactivation in a Murine Model of Type 1 Diabetes.(link is external)

Diabetes

Fidler TP, Marti A, Gerth K, Middleton EA, Campbell RA, Rondina MT, Weyrich AS, Abel ED

Macrophage Inflammation, Erythrophagocytosis, and Accelerated Atherosclerosis in Jak2 V617F Mice.(link is external)

Circulation research

Wang W, Liu W, Fidler T, Wang Y, Tang Y, Woods B, Welch C, Cai B, Silvestre-Roig C, Ai D, Yang YG, Hidalgo A, Soehnlein O, Tabas I, Levine RL, Tall AR, Wang N

Deletion of GLUT1 and GLUT3 Reveals Multiple Roles for Glucose Metabolism in Platelet and Megakaryocyte Function.(link is external)

Cell reports

Fidler TP, Campbell RA, Funari T, Dunne N, Balderas Angeles E, Middleton EA, Chaudhuri D, Weyrich AS, Abel ED

Deletion of GLUT1 and GLUT3 Reveals Multiple Roles for Glucose Metabolism in Platelet and Megakaryocyte Function.(link is external)

Cell reports

Fidler TP, Campbell RA, Funari T, Dunne N, Balderas Angeles E, Middleton EA, Chaudhuri D, Weyrch AS, Abel ED

Superoxide Dismutase 2 is dispensable for platelet function.(link is external)

Thrombosis and haemostasis

Fidler TP, Rowley JW, Araujo C, Boudreau LH, Marti A, Souvenir R, Dale K, Boilard E, Weyrich AS, Abel ED

Deletion of GLUT1 and GLUT3 Reveals Multiple Roles for Glucose Metabolism in Platelet and Megakaryocyte Function.(link is external)

Cell reports

Fidler TP, Campbell RA, Funari T, Dunne N, Balderas Angeles E, Middleton EA, Chaudhuri D, Weyrich AS, Abel ED

Erratum: SWELL1 is a regulator of adipocyte size, insulin signalling and glucose homeostasis.(link is external)

Nature cell biology

Zhang Y, Xie L, Gunasekar SK, Tong D, Mishra A, Gibson WJ, Wang C, Fidler T, Marthaler B, Klingelhutz A, Abel ED, Samuel I, Smith JK, Cao L, Sah R

Glucose Transporter 3 Potentiates Degranulation and Is Required for Platelet Activation.(link is external)

Arteriosclerosis, thrombosis, and vascular biology

Fidler TP, Middleton EA, Rowley JW, Boudreau LH, Campbell RA, Souvenir R, Funari T, Tessandier N, Boilard E, Weyrich AS, Abel ED

Erratum: SWELL1 is a regulator of adipocyte size, insulin signalling and glucose homeostasis.(link is external)

Nature cell biology

Zhang Y, Xie L, Gunasekar SK, Tong D, Mishra A, Gibson WJ, Wang C, Fidler T, Marthaler B, Klingelhutz A, Abel ED, Samuel I, Smith JK, Cao L, Sah R

SWELL1 is a regulator of adipocyte size, insulin signalling and glucose homeostasis.(link is external)

Nature cell biology

Zhang Y, Xie L, Gunasekar SK, Tong D, Mishra A, Gibson WJ, Wang C, Fidler T, Marthaler B, Klingelhutz A, Abel ED, Samuel I, Smith JK, Cao L, Sah R

Metabolic pathways of inhaled glucocorticoids by the CYP3A enzymes.(link is external)

Drug metabolism and disposition: the biological fate of chemicals

Moore CD, Roberts JK, Orton CR, Murai T, Fidler TP, Reilly CA, Ward RM, Yost GS

Cytochrome P450 2S1 depletion enhances cell proliferation and migration in bronchial epithelial cells, in part, through modulation of prostaglandin E(2) synthesis.(link is external)

Drug metabolism and disposition: the biological fate of chemicals

Madanayake TW, Fidler TP, Fresquez TM, Bajaj N, Rowland AM

Correction to "improved coiled-coil design enhances interaction with bcr-abl and induces apoptosis".(link is external)

Molecular pharmaceutics

Dixon AS, Miller GD, Bruno BJ, Constance JE, Woessner DW, Fidler TP, Robertson JC, Cheatham TE, Lim CS

Improved coiled-coil design enhances interaction with Bcr-Abl and induces apoptosis.(link is external)

Molecular pharmaceutics

Dixon AS, Miller GD, Bruno BJ, Constance JE, Woessner DW, Fidler TP, Robertson JC, Cheatham TE, Lim CS

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Trevor Fidler, PhD