Douglas Gould, PhD

Professor
Ophthalmology
Research Interests
Vascular and systemic diseases of the extracellular matrix
Websites
https://ophthalmology.ucsf.edu/gouldlab/
Faculty Type
Core CVRI Faculty

The Gould Lab studies the biological functions of basement membranes—specialized extracellular matrix structures that are essential for the development, function, and maintenance of every organ. Our research focuses on type IV collagen, particularly the COL4A1 and COL4A2 genes, whose mutations cause a multisystem disorder affecting the brain, eye, kidney, skeletal muscle, and other tissues. By combining human genetics, mouse models, cell biology, and physiology, we investigate how defects in a ubiquitous extracellular matrix protein produce tissue-specific disease and identify the molecular mechanisms that underlie cerebrovascular disease, glaucoma, kidney disease, myopathy, and other manifestations.

A central goal of the lab is to translate fundamental biological discoveries into new therapeutic strategies. We develop and use experimental models to define disease mechanisms, understand why patients with similar mutations can have very different clinical outcomes, and identify genetic and environmental factors that modify disease severity. These studies have helped establish the clinical and biological framework for what is now known as Gould syndrome and continue to guide efforts toward mechanism-based therapies and precision medicine. More broadly, our work seeks to advance understanding of how basement membranes regulate development, vascular integrity, tissue homeostasis, and aging, with implications that extend well beyond rare genetic disorders.

Publications

Greater recovery after critical illness (GRACE): a call to action to create a new roadmap for critical illness research.

Thorax

Flaws D, Stewart JD, Haines KJ, Fraser JF, McAuley DF, Patterson SE, Hodgson CL, Andersen SK, Bagshaw SM, Bourne RS, Connolly B, Cove M, Dhesi J, Duncan S, Gould D, Hartley P, Higgins L, Hough CL, Kwizera A, Leggett N, Ni Lochlainn M, Lone NI, MacTavish P, Manthorpe J, Mocellin D, Mikkelsen ME, Parekh D, Rosa RG, Rowan K, Summers C, Sutt AL, Taylor SP, Teixeira C, Tronstad O, Wilcox ME, Wilson E, Winearls J, McPeake J

COL4A1 and COL4A2-related disorders: Clinical features, diagnostic guidelines, and management.

Genetics in medicine : official journal of the American College of Medical Genetics

Tambala D, Vassar R, Snow J, Balestrini S, Bersano A, Guey S, Bonaventura E, Signorini S, Sartori S, Bertini E, Tonduti D, Parazzini C, Macchiaiolo M, Pelizza MF, Pichiecchio A, Massella L, Coste T, Orcesi S, Politano D, Bacci G, Marziali E, Dollfus H, Mandelli A, Chinali M, Plaisier E, Simioni P, Colombatti R, Guerrini R, Tournier-Lasserve E, Gould DB, Musolino PL

Long-term effects of restriction of intravenous fluid in adult ICU patients with septic shock.

Intensive care medicine

Kjær MN, Meyhoff TS, Sivapalan P, Granholm A, Hjortrup PB, Madsen MB, Møller MH, Egerod I, Wetterslev J, Lange T, Cronhjort M, Laake JH, Jakob SM, Nalos M, Ostermann M, Gould D, Cecconi M, Malbrain MLNG, Ahlstedt C, Kiel LB, Bestle MH, Nebrich L, Hildebrandt T, Russell L, Vang M, Rasmussen ML, Sølling C, Brøchner AC, Krag M, Pfortmueller C, Kriz M, Siegemund M, Albano G, Aagaard SR, Bundgaard H, Crone V, Wichmann S, Johnstad B, Martin YK, Seidel P, Mårtensson J, Hollenberg J, Wistrand M, Donati A, Barbara E, Karvunidis T, Hollinger A, Carsetti A, Lumlertgul N, Joelsson-Alm E, Lambiris N, Aslam TN, Friberg FF, Vesterlund GK, Mortensen CB, Vestergaard SR, Caspersen SF, Jensen DB, Borup M, Rasmussen BS, Perner A

https://profiles.ucsf.edu/douglas.gould
Address

555 & 535 Mission Bay Blvd South
UCSF Box 3118
San Francisco, CA 94158
United States