Professor
Medicine
Email
Faculty Type
Affiliate Faculty
Research Interests: Acute lung injury, acute respiratory distress syndrome, cigarette smoking, molecular epidemiology, biomarkers Summary: Dr. Calfee's primary academic focus is the prevention, diagnosis, prognosis, and treatment of acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS). Current research projects include: (1) the role of biomarkers in investigating ALI/ARDS pathogenesis, early diagnosis, treatment, and prognosis; (2) the role of cigarette smoke exposure in susceptibility to lung injury; and (3) novel treatments for acute lung injury.
Publications
Longitudinal multi-omic signatures of ARDS and sepsis inflammatory phenotypes identify key pathways associated with mortality.
medRxiv : the preprint server for health sciences
A multi-omics recovery factor predicts long COVID in the IMPACC study.
The Journal of clinical investigation
Acute Respiratory Distress Syndrome Phenotypes After Stem Cell Transplantation: A Latent Class Analysis.
Critical care explorations
Heterogeneity in association of myocardial injury and mortality in sepsis or acute respiratory distress syndrome by subphenotype: a retrospective study.
Critical care (London, England)
Host-Microbe Multiomic Profiling Predicts Mortality in Sepsis.
American journal of respiratory and critical care medicine
Research Priorities for Noninvasive Sampling of the Lower Respiratory Tract during Acute Respiratory Failure: An Official American Thoracic Society Workshop Report.
Annals of the American Thoracic Society
Treatment with Allogenic Mesenchymal Stromal Cells for Moderate to Severe Acute Respiratory Distress Syndrome: A Double-Blind, Placebo-controlled, Multi-Center, Phase 2b Clinical Trial (STAT).
American journal of respiratory and critical care medicine
Reply to Sun et al.: Neuromuscular Blockade Efficacy in High Elastance ARDS: Signal or Statistical Noise?
American journal of respiratory and critical care medicine
Evaluating the generalisability of formulas used to set tidal volumes in mechanically ventilated patients: an observational, multicohort, retrospective study.
The Lancet. Respiratory medicine
Baseline predictors for 28-day COVID-19 severity and mortality among hospitalized patients: results from the IMPACC study.
Frontiers in medicine
MICBG406A polymorphism reduces risk of mechanical ventilation and death during viral acute lung injury.
JCI insight
Empiric Azithromycin in COVID-19 Impacts the Respiratory Microbiome and Antimicrobial Resistome without Anti-inflammatory Benefit.
Research square
Type 2 immune responses are associated with less severe COVID-19 in a hospitalized cohort.
The journal of allergy and clinical immunology. Global
Elastance May Determine the Neuromuscular Blockade Effect on Mortality in Acute Respiratory Distress Syndrome.
American journal of respiratory and critical care medicine
Minimalistic Transcriptomic Signatures Permit Accurate Early Prediction of COVID-19 Mortality.
medRxiv : the preprint server for health sciences
Evidence-based personalised medicine in critical care: a framework for quantifying and applying individualised treatment effects in patients who are critically ill.
The Lancet. Respiratory medicine
Integrating a host transcriptomic biomarker with a large language model for diagnosis of lower respiratory tract infection.
medRxiv : the preprint server for health sciences
Gut bacterial lactate stimulates lung epithelial mitochondria and exacerbates acute lung injury.
bioRxiv : the preprint server for biology
Agreement Between Sepsis-2 and Sepsis-3 Definitions Among Patients Admitted to the Intensive Care Unit.
Annals of the American Thoracic Society
Temporal Transitions of the Hyperinflammatory and Hypoinflammatory Phenotypes in Critical Illness.
American journal of respiratory and critical care medicine
Peripheral blood mononuclear cell transcriptomic trajectories reveal dynamic regulation of inflammatory actors in delirium.
medRxiv : the preprint server for health sciences
Identification of a multi-omics factor predictive of long COVID in the IMPACC study.
bioRxiv : the preprint server for biology
Machine learning models predict long COVID outcomes based on baseline clinical and immunologic factors.
medRxiv : the preprint server for health sciences
Pulmonary FABP4 Is an Inverse Biomarker of Pneumonia in Critically Ill Children and Adults.
American journal of respiratory and critical care medicine
Anti-CD14 treatment in patients with severe COVID-19: Clinical and biological effects in a Phase 2 randomized open-label adaptive platform clinical trial.
CHEST critical care
Unraveling SARS-CoV-2 Host-Response Heterogeneity through Longitudinal Molecular Subtyping.
bioRxiv : the preprint server for biology
Chronic Viral Reactivation and Associated Host Immune Response and Clinical Outcomes in Acute COVID-19 and Post-Acute Sequelae of COVID-19.
bioRxiv : the preprint server for biology
Cytometry masked autoencoder: An accurate and interpretable automated immunophenotyper.
Cell reports. Medicine
Microbial dynamics and pulmonary immune responses in COVID-19 secondary bacterial pneumonia.
Nature communications
Causal inference can lead us to modifiable mechanisms and informative archetypes in sepsis.
Intensive care medicine
Phenotyping COVID-19 respiratory failure in spontaneously breathing patients with AI on lung CT-scan.
Critical care (London, England)
Immediate myeloid depot for SARS-CoV-2 in the human lung.
Science advances
From ICU Syndromes to ICU Subphenotypes: Consensus Report and Recommendations For Developing Precision Medicine in ICU.
American journal of respiratory and critical care medicine
Long-term air pollution exposure and the risk of primary graft dysfunction after lung transplantation.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
Distinct pulmonary and systemic effects of dexamethasone in severe COVID-19.
Nature communications
Biological effects of corticosteroids on pneumococcal pneumonia in Mice-translational significance.
Critical care (London, England)
Neutrophil Reduction Attenuates the Severity of Lung Injury in the Early Phase of Pneumococcal Pneumonia in Mice.
American journal of physiology. Lung cellular and molecular physiology
Elevated Hemoglobin A1c and the Risk of Developing ARDS in Two Cohort Studies.
CHEST critical care
Causes and attributable fraction of death from ARDS in inflammatory phenotypes of sepsis.
Critical care (London, England)
Acute respiratory distress syndrome guidelines: oceans apart or rivers that merge?
Intensive care medicine
Smoking-Attributable Health Care Expenditures for US Adults With Chronic Lower Respiratory Disease.
JAMA network open
Rapidly improving ARDS differs clinically and biologically from persistent ARDS.
Critical care (London, England)
Host-microbe multiomic profiling reveals age-dependent immune dysregulation associated with COVID-19 immunopathology.
Science translational medicine
The Plasma Lipidomic Landscape in Patients with Sepsis due to Community-acquired Pneumonia.
American journal of respiratory and critical care medicine
Critical Care: A Second Special Issue of the Blue Journal.
American journal of respiratory and critical care medicine
Host and Microbe Blood Metagenomics Reveals Key Pathways Characterizing Critical Illness Phenotypes.
American journal of respiratory and critical care medicine
Molecular Phenotypes of ARDS in the ROSE Trial have Differential Outcomes and Gene Expression Patterns That Differ at Baseline and Longitudinally Over Time.
American journal of respiratory and critical care medicine
Smoking Primes the Metabolomic Response in Trauma.
The journal of trauma and acute care surgery
Clustering COVID-19 ARDS patients through the first days of ICU admission. An analysis of the CIBERESUCICOVID Cohort.
Critical care (London, England)
Identification of a hyperinflammatory sepsis phenotype using protein biomarker and clinical data in the ProCESS randomized trial.
Scientific reports
Critical Care: A Special Issue of the Blue Journal.
American journal of respiratory and critical care medicine
The Translational Value of Rodent Models of Sepsis.
American journal of respiratory and critical care medicine
Novel subtypes of severe COVID-19 respiratory failure based on biological heterogeneity: a secondary analysis of a randomized controlled trial.
Critical care (London, England)
Host-Microbe Multiomic Profiling Reveals Age-Dependent COVID-19 Immunopathology.
medRxiv : the preprint server for health sciences
Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study.
Nature communications
The antibiotic resistance reservoir of the lung microbiome expands with age in a population of critically ill patients.
Nature communications
A New Global Definition of Acute Respiratory Distress Syndrome.
American journal of respiratory and critical care medicine
From Berlin to Global: The Need for Syndromic Definitions of ARDS.
American journal of respiratory and critical care medicine
The Impact of Donor Smoking on Primary Graft Dysfunction and Mortality after Lung Transplantation.
American journal of respiratory and critical care medicine
Functional recovery in a cohort of ECMO and non-ECMO acute respiratory distress syndrome survivors.
Critical care (London, England)
Robust airway microbiome signatures in acute respiratory failure and hospital-acquired pneumonia.
Nature medicine
Simvastatin in Critically Ill Patients with Covid-19.
The New England journal of medicine
Acute respiratory distress syndrome phenotypes with distinct clinical outcomes in PHARLAP trial cohort.
Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine
Subphenotypes of Acute Respiratory Distress Syndrome: Advancing Towards Precision Medicine.
Tuberculosis and respiratory diseases
Identifying molecular phenotypes in sepsis: an analysis of two prospective observational cohorts and secondary analysis of two randomised controlled trials.
The Lancet. Respiratory medicine
Subphenotypes Assigned to Pediatric Acute Respiratory Failure Patients Show Differing Outcomes.
American journal of respiratory and critical care medicine
Exposure to ambient air pollutants and acute respiratory distress syndrome risk in sepsis.
Intensive care medicine
Clinical and biological heterogeneity of multisystem inflammatory syndrome in adults following SARS-CoV-2 infection: a case series.
Frontiers in medicine
ESICM guidelines on acute respiratory distress syndrome: definition, phenotyping and respiratory support strategies.
Intensive care medicine
Early plasma angiopoietin-2 is prognostic for ARDS and mortality among critically ill patients with sepsis.
Critical care (London, England)
Metagenomic Sequencing in the ICU for Precision Diagnosis of Critical Infectious Illnesses.
Critical care (London, England)
Aerosolized nicotine from e-cigarettes alters gene expression, increases lung protein permeability, and impairs viral clearance in murine influenza infection.
Frontiers in immunology
Subphenotypes of frailty in lung transplant candidates.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Plasma metabolic profiling implicates dysregulated lipid metabolism and glycolytic shift in hyperinflammatory ARDS.
American journal of physiology. Lung cellular and molecular physiology
NKG2D receptor activation drives primary graft dysfunction severity and poor lung transplantation outcomes.
JCI insight
Prevalence of type-1 interferon autoantibodies in adults with non-COVID-19 acute respiratory failure.
Respiratory research
Biological Phenotyping in Sepsis and Acute Respiratory Distress Syndrome.
Annual review of medicine
Immune Modulation in Sepsis, ARDS, and Covid-19 - The Road Traveled and the Road Ahead.
NEJM evidence
Integrated host-microbe plasma metagenomics for sepsis diagnosis in a prospective cohort of critically ill adults.
Nature microbiology
COVID-19-associated Lung Microvascular Endotheliopathy: A "From the Bench" Perspective.
American journal of respiratory and critical care medicine
Hospital trajectories and early predictors of clinical outcomes differ between SARS-CoV-2 and influenza pneumonia.
EBioMedicine
Informed consent process in the ISPY COVID trial is ethically acceptable.
European journal of internal medicine
Plasma SARS-CoV-2 nucleocapsid antigen levels are associated with progression to severe disease in hospitalized COVID-19.
Critical care (London, England)
The relationship between plasma cystatin C, mortality and acute respiratory distress syndrome subphenotype in the HARP-2 trial.
Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine
New Insights into Clinical and Mechanistic Heterogeneity of the Acute Respiratory Distress Syndrome: Summary of the Aspen Lung Conference 2021.
American journal of respiratory cell and molecular biology
Contemporary trends in PGD incidence, outcomes, and therapies.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: Results from the IMPACC study.
EBioMedicine
Metagenomic prediction of antimicrobial resistance in critically ill patients with lower respiratory tract infections.
Genome medicine
Redefining critical illness.
Nature medicine
Extracorporeal Membrane Oxygenation during Respiratory Pandemics: Past, Present, and Future.
American journal of respiratory and critical care medicine
Impact of e-cigarette aerosol on primary human alveolar epithelial type 2 cells.
American journal of physiology. Lung cellular and molecular physiology
Mass cytometry reveals a conserved immune trajectory of recovery in hospitalized COVID-19 patients.
Immunity
Ventilatory Ratio Is a Valuable Prognostic Indicator in an Observational Cohort of Patients With ARDS.
Respiratory care
Immediate myeloid depot for SARS-CoV-2 in the human lung.
Research square
Immediate myeloid depot for SARS-CoV-2 in the human lung.
bioRxiv : the preprint server for biology
Cigarette Smoke Exposure and Acute Respiratory Distress Syndrome in Sepsis: Epidemiology, Clinical Features, and Biologic Markers.
American journal of respiratory and critical care medicine
Prognostic factors for development of acute respiratory distress syndrome following traumatic injury: a systematic review and meta-analysis.
The European respiratory journal
Aerosolized vitamin E acetate causes oxidative injury in mice and in alveolar macrophages.
American journal of physiology. Lung cellular and molecular physiology
A conserved immune trajectory of recovery in hospitalized COVID-19 patients.
bioRxiv : the preprint server for biology
Towards a biological definition of ARDS: are treatable traits the solution?
Intensive care medicine experimental
Single Nucleotide Variant in FAS Associates With Organ Failure and Soluble Fas Cell Surface Death Receptor in Critical Illness.
Critical care medicine
Reply to Kuindersma and Spronk: Time to Tailor the One-Size-Fits-All Approach?
American journal of respiratory and critical care medicine
Phenotyping in acute respiratory distress syndrome: state of the art and clinical implications.
Current opinion in critical care
Update on the Features and Measurements of Experimental Acute Lung Injury in Animals: An Official American Thoracic Society Workshop Report.
American journal of respiratory cell and molecular biology
Functional Transcriptomic Studies of Immune Responses and Endotoxin Tolerance in Early Human Sepsis.
Shock (Augusta, Ga.)
Validation and utility of ARDS subphenotypes identified by machine-learning models using clinical data: an observational, multicohort, retrospective analysis.
The Lancet. Respiratory medicine
Identification of phenotypes in paediatric patients with acute respiratory distress syndrome: a latent class analysis.
The Lancet. Respiratory medicine
Latent Class Analysis Reveals COVID-19-related Acute Respiratory Distress Syndrome Subgroups with Differential Responses to Corticosteroids.
American journal of respiratory and critical care medicine
Impaired immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19.
medRxiv : the preprint server for health sciences
Promises and challenges of personalized medicine to guide ARDS therapy.
Critical care (London, England)
Metabolic signatures of ARDS and ARDS heterogeneity.
American journal of physiology. Lung cellular and molecular physiology
A Research Agenda for Precision Medicine in Sepsis and Acute Respiratory Distress Syndrome: An Official American Thoracic Society Research Statement.
American journal of respiratory and critical care medicine
Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS.
Nature communications
Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19.
Science translational medicine
Publisher Correction: Global absence and targeting of protective immune states in severe COVID-19.
Nature
Plasma Metabolites in Early Sepsis Identify Distinct Clusters Defined by Plasma Lipids.
Critical care explorations
Advancing precision medicine for acute respiratory distress syndrome.
The Lancet. Respiratory medicine
Acute respiratory distress syndrome.
Lancet (London, England)
Mesenchymal stromal cell extracellular vesicles rescue mitochondrial dysfunction and improve barrier integrity in clinically relevant models of ARDS.
The European respiratory journal
Acute Respiratory Distress Syndrome Subphenotypes beyond the Syndrome: A Step toward Treatable Traits?
American journal of respiratory and critical care medicine
Accuracy of the Radiographic Assessment of Lung Edema Score for the Diagnosis of ARDS.
Frontiers in physiology
Immunotherapy in COVID-19: why, who, and when?
The Lancet. Respiratory medicine
Sepsis Subclasses: A Framework for Development and Interpretation.
Critical care medicine
Impaired immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19.
Research square
Longitudinal single-cell epitope and RNA-sequencing reveals the immunological impact of type 1 interferon autoantibodies in critical COVID-19: Anti-IFN antibodies in critical COVID-19 correlate with poor ISG response and upregulation of LAIR1 surface prot
bioRxiv : the preprint server for biology
Precision medicine in acute respiratory distress syndrome: workshop report and recommendations for future research.
European respiratory review : an official journal of the European Respiratory Society
Assessing the importance of interleukin-6 in COVID-19 - Authors' reply.
The Lancet. Respiratory medicine
COVID-19 ARDS is characterized by a dysregulated host response that differs from cytokine storm and is modified by dexamethasone.
Research square
The ABO histo-blood group, endothelial activation, and acute respiratory distress syndrome risk in critical illness.
The Journal of clinical investigation
Practitioner's Guide to Latent Class Analysis: Methodological Considerations and Common Pitfalls.
Critical care medicine
Severe COVID-19 Infections-Knowledge Gained and Remaining Questions.
JAMA internal medicine
A neutrophil subset defined by intracellular olfactomedin 4 is associated with mortality in sepsis.
American journal of physiology. Lung cellular and molecular physiology
A manifesto for the future of ICU trials.
Critical care (London, England)
Dose-Dependent Pulmonary Toxicity of Aerosolized Vitamin E Acetate.
American journal of respiratory cell and molecular biology
Alternative Tobacco Product Use in Critically Ill Patients.
International journal of environmental research and public health
Twenty-Four-Hour Cardiovascular Effects of Electronic Cigarettes Compared With Cigarette Smoking in Dual Users.
Journal of the American Heart Association
Phenotypes and personalized medicine in the acute respiratory distress syndrome.
Intensive care medicine
Upper airway gene expression reveals suppressed immune responses to SARS-CoV-2 compared with other respiratory viruses.
Nature communications
Fluid administration and monitoring in ARDS: which management?
Intensive care medicine
Prone Positioning in Awake, Nonintubated Patients With COVID-19: Necessity Is the Mother of Invention.
JAMA internal medicine
Global Absence and Targeting of Protective Immune States in Severe COVID-19.
bioRxiv : the preprint server for biology
Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes.
The Lancet. Respiratory medicine
Using best subset regression to identify clinical characteristics and biomarkers associated with sepsis-associated acute kidney injury.
American journal of physiology. Renal physiology
Machine Learning Classifier Models Can Identify Acute Respiratory Distress Syndrome Phenotypes Using Readily Available Clinical Data.
American journal of respiratory and critical care medicine
E-Cigarette or Vaping Product Use-associated Lung Injury: Developing a Research Agenda. An NIH Workshop Report.
American journal of respiratory and critical care medicine
A living WHO guideline on drugs for covid-19
BMJ (Clinical research ed.)
Is a "Cytokine Storm" Relevant to COVID-19?
JAMA internal medicine
Prevalence of phenotypes of acute respiratory distress syndrome in critically ill patients with COVID-19: a prospective observational study.
The Lancet. Respiratory medicine
Identifying Clinical Research Priorities in Adult Pulmonary and Critical Care. NHLBI Working Group Report.
American journal of respiratory and critical care medicine
Sonographic B-Lines, Fluid Resuscitation, and Hypoxemia in Malawian Patients with Suspected Sepsis.
American journal of respiratory and critical care medicine
COVID-19-associated acute respiratory distress syndrome: is a different approach to management warranted?
The Lancet. Respiratory medicine
Clinician Recognition of the Acute Respiratory Distress Syndrome: Risk Factors for Under-Recognition and Trends Over Time.
Critical care medicine
Subphenotypes in critical care: translation into clinical practice.
The Lancet. Respiratory medicine
The attributable mortality of acute respiratory distress syndrome.
Intensive care medicine
Upper airway gene expression differentiates COVID-19 from other acute respiratory illnesses and reveals suppression of innate immune responses by SARS-CoV-2.
medRxiv : the preprint server for health sciences
Long-term ozone exposure is positively associated with telomere length in critically ill patients.
Environment international
Acute respiratory distress syndrome subphenotypes and therapy responsive traits among preclinical models: protocol for a systematic review and meta-analysis.
Respiratory research
Gender Differences in Authorship of Critical Care Literature.
American journal of respiratory and critical care medicine
ARDS Subphenotypes: Understanding a Heterogeneous Syndrome.
Critical care (London, England)
Acute respiratory distress syndrome-attributable mortality in critically ill patients with sepsis.
Intensive care medicine
Detection of Pneumonia Pathogens from Plasma Cell-Free DNA.
American journal of respiratory and critical care medicine
Peripheral blood leukocyte telomere length is associated with survival of sepsis patients.
The European respiratory journal
Development and validation of parsimonious algorithms to classify acute respiratory distress syndrome phenotypes: a secondary analysis of randomised controlled trials.
The Lancet. Respiratory medicine
Plasma sRAGE Acts as a Genetically Regulated Causal Intermediate in Sepsis-associated Acute Respiratory Distress Syndrome.
American journal of respiratory and critical care medicine
Plasma sTNFR1 and IL8 for prognostic enrichment in sepsis trials: a prospective cohort study.
Critical care (London, England)
Estimated dead space fraction and the ventilatory ratio are associated with mortality in early ARDS.
Annals of intensive care
Biomarkers and Precision Medicine: State of the Art.
Critical care clinics
Clinically relevant model of pneumococcal pneumonia, ARDS, and nonpulmonary organ dysfunction in mice.
American journal of physiology. Lung cellular and molecular physiology
FLASH: a next-generation CRISPR diagnostic for multiplexed detection of antimicrobial resistance sequences.
Nucleic Acids Research
A new frontier in ARDS trials: phenotyping before randomisation.
The Lancet. Respiratory medicine
Inflammasomes Assemble: Cytoplasmic Guardians or Fallen Heroes?
Critical care medicine
Predictors of postinjury acute respiratory distress syndrome: Lung injury persists in the era of hemostatic resuscitation.
The journal of trauma and acute care surgery
Peeking under the Hood of Acute Respiratory Distress Syndrome Phenotypes: Deeper Insights into Biological Heterogeneity.
American journal of respiratory and critical care medicine
Pulmonary Dead Space Monitoring: Identifying Subjects With ARDS at Risk of Developing Right Ventricular Dysfunction.
Respiratory care
Acute Respiratory Distress Syndrome Phenotypes.
Seminars in respiratory and critical care medicine
Identification of Acute Kidney Injury Subphenotypes with Differing Molecular Signatures and Responses to Vasopressin Therapy.
American journal of respiratory and critical care medicine
Positive Cumulative Fluid Balance Is Associated With Mortality in Pediatric Acute Respiratory Distress Syndrome in the Setting of Acute Kidney Injury.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Precision medicine for cell therapy in acute respiratory distress syndrome - Authors' reply.
The Lancet. Respiratory medicine
The authors reply.
Critical care medicine
The authors reply.
Critical care medicine
Acute respiratory distress syndrome.
Nature reviews. Disease primers
Prospective Assessment of the Feasibility of a Trial of Low-Tidal Volume Ventilation for Patients with Acute Respiratory Failure.
Annals of the American Thoracic Society
Phenotypes in acute respiratory distress syndrome: moving towards precision medicine.
Current opinion in critical care
Physiologic Analysis and Clinical Performance of the Ventilatory Ratio in Acute Respiratory Distress Syndrome.
American journal of respiratory and critical care medicine
Metagenomic comparison of tracheal aspirate and mini-bronchial alveolar lavage for assessment of respiratory microbiota.
American journal of physiology. Lung cellular and molecular physiology
Early Plasma Matrix Metalloproteinase Profiles. A Novel Pathway in Pediatric Acute Respiratory Distress Syndrome.
American journal of respiratory and critical care medicine
Low to Moderate Air Pollutant Exposure and Acute Respiratory Distress Syndrome after Severe Trauma.
American journal of respiratory and critical care medicine
Integrating host response and unbiased microbe detection for lower respiratory tract infection diagnosis in critically ill adults.
Proceedings of the National Academy of Sciences of the United States of America
Treatment with allogeneic mesenchymal stromal cells for moderate to severe acute respiratory distress syndrome (START study): a randomised phase 2a safety trial.
The Lancet. Respiratory medicine
Beyond Low Tidal Volume Ventilation: Treatment Adjuncts for Severe Respiratory Failure in Acute Respiratory Distress Syndrome.
Critical care medicine
Perhaps it's not the platelet: Ristocetin uncovers the potential role of von Willebrand factor in impaired platelet aggregation following traumatic brain injury.
The journal of trauma and acute care surgery
Plasma angiopoietin-2 as a potential causal marker in sepsis-associated ARDS development: evidence from Mendelian randomization and mediation analysis.
Intensive care medicine
Latent class analysis of ARDS subphenotypes: a secondary analysis of the statins for acutely injured lungs from sepsis (SAILS) study.
Intensive care medicine
Association between pre-operative biological phenotypes and postoperative pulmonary complications: An unbiased cluster analysis.
European journal of anaesthesiology
Possible hepatotoxicity of IQOS.
Tobacco control
Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial.
The Lancet. Respiratory medicine
Plasma sRAGE is independently associated with increased mortality in ARDS: a meta-analysis of individual patient data.
Intensive care medicine
Human pulmonary endothelial cell permeability after exposure to LPS-stimulated leukocyte supernatants derived from patients with early sepsis.
American journal of physiology. Lung cellular and molecular physiology
Health care utilization and the cost of posttraumatic acute respiratory distress syndrome care.
The journal of trauma and acute care surgery
Elevated plasma levels of TIMP-3 are associated with a higher risk of acute respiratory distress syndrome and death following severe isolated traumatic brain injury.
Trauma surgery & acute care open
Cigarette smoke exposure worsens acute lung injury in antibiotic-treated bacterial pneumonia in mice.
American journal of physiology. Lung cellular and molecular physiology
Lung Microbiota Is Related to Smoking Status and to Development of Acute Respiratory Distress Syndrome in Critically Ill Trauma Patients.
American journal of respiratory and critical care medicine
Platelet aggregation after blunt trauma is associated with the acute respiratory distress syndrome and altered by cigarette smoke exposure.
The journal of trauma and acute care surgery
Exposing the bidirectional effects of alcohol on coagulation in trauma: Impaired clot formation and decreased fibrinolysis in rotational thromboelastometry.
The journal of trauma and acute care surgery
Reply to "Letter to the Editor: Pulmonary toxicity of electronic cigarettes: more doubts than certainties".
American journal of physiology. Lung cellular and molecular physiology
Characterizing the gut microbiome in trauma: significant changes in microbial diversity occur early after severe injury.
Trauma surgery & acute care open
Reply: Next Step to Understanding Subphenotypes of Acute Respiratory Distress Syndrome.
American journal of respiratory and critical care medicine
Cigarette Smoke Exposure Worsens Endotoxin-Induced Lung Injury and Pulmonary Edema in Mice.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
Derivation and validation of a two-biomarker panel for diagnosis of ARDS in patients with severe traumatic injuries.
Trauma surgery & acute care open
Gender Parity in Critical Care Medicine.
American journal of respiratory and critical care medicine
External validation of a biomarker and clinical prediction model for hospital mortality in acute respiratory distress syndrome.
Intensive care medicine
Characterization of distinct coagulopathic phenotypes in injury: Pathway-specific drivers and implications for individualized treatment.
The journal of trauma and acute care surgery
Novel translational approaches to the search for precision therapies for acute respiratory distress syndrome.
The Lancet. Respiratory medicine
Pulmonary toxicity of e-cigarettes.
American journal of physiology. Lung cellular and molecular physiology
Incorporating Inflammation into Mortality Risk in Pediatric Acute Respiratory Distress Syndrome.
Critical care medicine
The Canary in the Coal Mine Is Coughing: Electronic Cigarettes and Respiratory Symptoms in Adolescents.
American journal of respiratory and critical care medicine
Higher mini-BAL total protein concentration in early ARDS predicts faster resolution of lung injury measured by more ventilator-free days.
American journal of physiology. Lung cellular and molecular physiology
Acute Respiratory Distress Syndrome Subphenotypes Respond Differently to Randomized Fluid Management Strategy.
American journal of respiratory and critical care medicine
Acute kidney injury subphenotypes based on creatinine trajectory identifies patients at increased risk of death.
Critical care (London, England)
A Simple and Robust Bedside Model for Mortality Risk in Pediatric Patients With Acute Respiratory Distress Syndrome.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
The authors reply.
Critical care medicine
The authors reply.
Critical care medicine
Opening the Debate on the New Sepsis Definition. Precision Medicine: An Opportunity to Improve Outcomes of Patients with Sepsis.
American journal of respiratory and critical care medicine
Toward Smarter Lumping and Smarter Splitting: Rethinking Strategies for Sepsis and Acute Respiratory Distress Syndrome Clinical Trial Design.
American journal of respiratory and critical care medicine
The acute respiratory distress syndrome following isolated severe traumatic brain injury.
The journal of trauma and acute care surgery
Association of common genetic variation in the protein C pathway genes with clinical outcomes in acute respiratory distress syndrome.
Critical care (London, England)
Long-Term Ozone Exposure Increases the Risk of Developing the Acute Respiratory Distress Syndrome.
American journal of respiratory and critical care medicine
Personalized medicine for ARDS: the 2035 research agenda.
Intensive care medicine
Diagnostic workup for ARDS patients.
Intensive care medicine
Focusing on the alveolar epithelium: Alveolar fluid clearance in diffuse versus focal acute respiratory distress syndrome.
Anaesthesia, critical care & pain medicine
The relationship between plasma lipid peroxidation products and primary graft dysfunction after lung transplantation is modified by donor smoking and reperfusion hyperoxia.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
Timing of Intubation and Clinical Outcomes in Adults With Acute Respiratory Distress Syndrome.
Critical care medicine
Elevated soluble thrombomodulin is associated with organ failure and mortality in children with acute respiratory distress syndrome (ARDS): a prospective observational cohort study.
Critical care (London, England)
Plasma angiopoietin-2 outperforms other markers of endothelial injury in prognosticating pediatric ARDS mortality.
American journal of physiology. Lung cellular and molecular physiology
ARDS in 2015: new clinical directions, new biological insights.
The Lancet. Respiratory medicine
Cigarette Smoke Exposure and the Acute Respiratory Distress Syndrome.
Critical care medicine
Misclassification of acute respiratory distress syndrome after traumatic injury: The cost of less rigorous approaches.
The journal of trauma and acute care surgery
Biomarkers of ARDS: what's new?
Intensive care medicine
Distinct molecular phenotypes of direct vs indirect ARDS in single-center and multicenter studies.
Chest
Differences in degree, differences in kind: characterizing lung injury in trauma.
The journal of trauma and acute care surgery
Increased expression of neutrophil-related genes in patients with early sepsis-induced ARDS.
American journal of physiology. Lung cellular and molecular physiology
Erratum to: plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome.
Intensive care medicine
Plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome.
Intensive care medicine
Clearing the air. Smoking and incident asthma in adults.
American journal of respiratory and critical care medicine
Mesenchymal stem (stromal) cells for treatment of ARDS: a phase 1 clinical trial.
The Lancet. Respiratory medicine
ARDS: new mechanistic insights, new therapeutic directions.
Clinics in chest medicine
Environmental risk factors for acute respiratory distress syndrome.
Clinics in chest medicine
Prevalence and impact of active and passive cigarette smoking in acute respiratory distress syndrome.
Critical care medicine
Donor smoking is associated with pulmonary edema, inflammation and epithelial dysfunction in ex vivo human donor lungs.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Silencing Bruton's tyrosine kinase in alveolar neutrophils protects mice from LPS/immune complex-induced acute lung injury.
American journal of physiology. Lung cellular and molecular physiology
Design and implementation of the START (STem cells for ARDS Treatment) trial, a phase 1/2 trial of human mesenchymal stem/stromal cells for the treatment of moderate-severe acute respiratory distress syndrome.
Annals of intensive care
Intensive care unit scoring systems outperform emergency department scoring systems for mortality prediction in critically ill patients: a prospective cohort study.
Journal of intensive care
Keratinocyte growth factor promotes epithelial survival and resolution in a human model of lung injury.
American journal of respiratory and critical care medicine
Subphenotypes in acute respiratory distress syndrome: latent class analysis of data from two randomised controlled trials.
The Lancet. Respiratory medicine
Performance of interleukin-27 as a sepsis diagnostic biomarker in critically ill adults.
Journal of critical care
Is there still a role for the lung injury score in the era of the Berlin definition ARDS?
Annals of intensive care
Fibrinogen and platelet contributions to clot formation: implications for trauma resuscitation and thromboprophylaxis.
The journal of trauma and acute care surgery
One-year mortality and predictors of death among hospital survivors of acute respiratory distress syndrome.
Intensive care medicine
Effect of simvastatin on physiological and biological outcomes in patients undergoing esophagectomy: a randomized placebo-controlled trial.
Annals of surgery
The association between physiologic dead-space fraction and mortality in subjects with ARDS enrolled in a prospective multi-center clinical trial.
Respiratory care
Biomarkers of lung epithelial injury and inflammation distinguish severe sepsis patients with acute respiratory distress syndrome.
Critical care (London, England)
Comparison of thermodilution measured extravascular lung water with chest radiographic assessment of pulmonary oedema in patients with acute lung injury.
Annals of intensive care
Early acute lung injury: criteria for identifying lung injury prior to the need for positive pressure ventilation*.
Critical care medicine
Plasma angiopoietin-2 predicts the onset of acute lung injury in critically ill patients.
American journal of respiratory and critical care medicine
Fixing the leak: targeting the vascular endothelium in sepsis.
Critical care (London, England)
The search for diagnostic markers in sepsis: many miles yet to go.
American journal of respiratory and critical care medicine
Clinical evidence of early acute lung injury often precedes the diagnosis of ALI.
Journal of intensive care medicine
Plasma angiopoietin-2 in clinical acute lung injury: prognostic and pathogenetic significance.
Critical care medicine
Comparison of chest radiograph scoring to lung weight as a quantitative index of pulmonary edema in organ donors.
Clinical transplantation
Critical role of activated protein C in early coagulopathy and later organ failure, infection and death in trauma patients.
Annals of surgery
A simple classification model for hospital mortality in patients with acute lung injury managed with lung protective ventilation.
Critical care medicine
FGF-23 and PTH levels in patients with acute kidney injury: A cross-sectional case series study.
Annals of intensive care
Use of risk reclassification with multiple biomarkers improves mortality prediction in acute lung injury.
Critical care medicine
Active and passive cigarette smoking and acute lung injury after severe blunt trauma.
American journal of respiratory and critical care medicine
ANGPT2 genetic variant is associated with trauma-associated acute lung injury and altered plasma angiopoietin-2 isoform ratio.
American journal of respiratory and critical care medicine
Biomarkers increase detection of active smoking and secondhand smoke exposure in critically ill patients.
Critical care medicine
Therapeutic strategies for severe acute lung injury.
Critical care medicine
Early release of soluble receptor for advanced glycation endproducts after severe trauma in humans.
The Journal of trauma
Plasma interleukin-8 is not an effective risk stratification tool for adults with vasopressor-dependent septic shock.
Critical care medicine
Acute lung injury in patients with traumatic injuries: utility of a panel of biomarkers for diagnosis and pathogenesis.
The Journal of trauma
Plasma biomarker profiles in acute exacerbation of idiopathic pulmonary fibrosis.
American journal of physiology. Lung cellular and molecular physiology
Early release of high mobility group box nuclear protein 1 after severe trauma in humans: role of injury severity and tissue hypoperfusion.
Critical care (London, England)
Determining the aetiology of pulmonary oedema by the oedema fluid-to-plasma protein ratio.
The European respiratory journal
Plasma granulocyte colony-stimulating factor levels correlate with clinical outcomes in patients with acute lung injury.
Critical care medicine
Soluble intercellular adhesion molecule-1 and clinical outcomes in patients with acute lung injury.
Intensive care medicine
Plasma receptor for advanced glycation end products and clinical outcomes in acute lung injury.
Thorax
Trauma-associated lung injury differs clinically and biologically from acute lung injury due to other clinical disorders.
Critical care medicine
Biomarkers of lung injury in primary graft dysfunction following lung transplantation.
Biomarkers in medicine
Plasma receptor for advanced glycation end-products predicts duration of ICU stay and mechanical ventilation in patients after lung transplantation.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
Clinical problem-solving. Anchors away.
The New England journal of medicine
Recent advances in mechanical ventilation.
The American journal of medicine
Address
505 Parnassus Avenue, Rm M1088A
UCSF Box 0111
San Francisco, CA 94117
United States