Associate Professor
Cardiovascular Research Institute
Research Interests
Transcription regulation in energy homeostasis
Email
+1 415 502-2023
Faculty Type
Core CVRI Faculty
Research Summary:
Type II diabetes mellitus accounts for 90-95% of all cases of diabetes, and this heterogeneous disorder afflicts an estimated 6% of the adult population in Western society. Energy imbalance by high calorie intake and/or lack of physical activity can lead to obesity, which is often associated with an increased risk of developing insulin resistance followed by type II diabetes. Our research is focused on understanding how circulating hormones modulate energy balance in multiple metabolic tissues, and how disruption of these hormonal actions contributes to pathophysiology of type II diabetes.
Publications
Autoregulation of insulin receptor signaling through MFGE8 and the αvβ5 integrin.
Proceedings of the National Academy of Sciences of the United States of America
Role of mTORC2 in biphasic regulation of brown fat metabolism in response to mild and severe cold.
The Journal of biological chemistry
A thermogenic fat-epithelium cell axis regulates intestinal disease tolerance.
Proceedings of the National Academy of Sciences of the United States of America
Salt-inducible kinase 1 maintains HDAC7 stability to promote pathologic cardiac remodeling.
The Journal of clinical investigation
Adipocyte HDAC4 activation leads to beige adipocyte expansion and reduced adiposity.
The Journal of endocrinology
Sympathetic inputs regulate adaptive thermogenesis in brown adipose tissue through cAMP-Salt inducible kinase axis.
Scientific reports
Proteome Imbalance of Mitochondrial Electron Transport Chain in Brown Adipocytes Leads to Metabolic Benefits.
Cell metabolism
Address
555 & 535 Mission Bay Blvd Sou, Rm 252Y
UCSF Box 3118
San Francisco, CA 94158
United States