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Brian Graham, MD

Professor
Medicine
Address: 
1001 Potrero Avenue, Rm 5J1
UCSF Box 0862
San Francisco, CA 94110
United States
Phone: 
+1 628 206-4422
Email: 
[email protected]
UCSF Profiles

Research Interests: Pulmonary hypertension and pulmonary vascular inflammation, and cardiac angiogenesis.   Summary:

Our research group investigates pulmonary hypertension, a disease of the lung blood vessels. The major focus of our research is how the immune system contributes to the disease. The goal of our work is to discover new treatment approaches to help prevent or reverse this disease.

Publications: 

Reply to the letter to the editor entitled "Bridging the species divide: The limits of rat models in capturing human PVOD mechanisms" by Perros F. et al.

Pulmonary circulation

Prabhakar A, Kumar R, Wadhwa M, Tuder RM, Morrell NW, Graham BB, Lagna G, Hata A

Activation of Platelets and the Complement System in Mice with Schistosoma-Induced Pulmonary Hypertension.

American journal of physiology. Lung cellular and molecular physiology

Mickael C, Jordan M, Posey JN, Tuder RM, Nozik E, Thurman JM, Stenmark KR, Graham BB, Delaney C

Mechanisms underlying age-associated exacerbation of pulmonary veno-occlusive disease.

JCI insight

Prabhakar A, Wadhwa M, Kumar R, Ghatpande P, Gandjeva A, Tuder RM, Graham BB, Lagna G, Hata A

Classical dendritic cells contribute to hypoxia-induced pulmonary hypertension.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Mickael C, Sanders LA, Lee MH, Kumar R, Fonseca-Balladares D, Gandjeva A, Cautivo-Reyes K, Kassa B, Kumar S, Irwin D, Swindle D, Phang T, Stearman RS, Molofsky AB, McKee AS, Stenmark KR, Graham BB, Tuder RM

Intrapulmonary T Cells Are Sufficient for Schistosoma-Induced Pulmonary Hypertension.

International journal of molecular sciences

Fonseca Balladares DC, Kassa B, Mickael C, Kumar R, Nolan K, Menezes TCF, Lee MH, Lau-Xiao AM, Molofsky AB, Wells E, Graham BB

Two hits strike out causing persistent pulmonary hypertension in mice.

American journal of physiology. Lung cellular and molecular physiology

Menezes TCF, Fonseca Balladares DC, Nolan K, Graham BB

Reversal of pulmonary veno-occlusive disease phenotypes by inhibition of the integrated stress response.

Nature Cardiovascular Research

Prabhakar A, Kumar R, Wadhwa M, Ghatpande P, Zhang J, Zhao Z, Lizama CO, Kharbikar BN, Gräf S, Treacy CM, Morrell NW, Graham BB, Lagna G, Hata A

Interstitial macrophage phenotypes in Schistosoma-induced pulmonary hypertension.

Frontiers in immunology

Kumar R, Kumar S, Mickael C, Fonseca Balladares D, Nolan K, Lee MH, Sanders L, Nilsson J, Molofsky AB, Tuder RM, Stenmark KR, Graham BB

Single cell transcriptomic analyses reveal diverse and dynamic changes of distinct populations of lung interstitial macrophages in hypoxia-induced pulmonary hypertension.

Frontiers in immunology

Kumar S, Mickael C, Kumar R, Prasad RR, Campbell NV, Zhang H, Li M, McKeon BA, Allen TE, Graham BB, Yu YA, Stenmark KR

Hypobaric hypoxia modulated structural characteristics of circulating cell free DNA in high altitude pulmonary edema.

American journal of physiology. Lung cellular and molecular physiology

Ali M, Choudhary R, Singh K, Kumari S, Kumar R, Graham BB, Pasha MAQ, Rabyang S, Thinlas T, Mishra A

Experimental Schistosoma haematobium pulmonary hypertension.

Pulmonary circulation

Kassa B, Fonseca-Balladares DC, Kumar R, Lee MH, Mickael C, Sanders L, Nolan K, Graham BB

Hypobaric hypoxia drives selection of altitude-associated adaptative alleles in the Himalayan population.

The Science of the total environment

Sharma S, Koshy R, Kumar R, Mohammad G, Thinlas T, Graham BB, Pasha Q

Dexamethasone prophylaxis protects from acute high-altitude illness by modifying the peripheral blood mononuclear cell inflammatory transcriptome.

Bioscience reports

Kumar R, Chanana N, Sharma K, Palmo T, Lee MH, Mishra A, Nolan K, Fonseca Balladares DC, Mickael C, Gupta MD, Thinlas T, Pasha Q, Graham BB

Reversal of pulmonary veno-occlusive disease phenotypes by inhibition of the integrated stress response.

bioRxiv : the preprint server for biology

Prabhakar A, Kumar R, Wadhwa M, Ghatpande P, Zhang J, Zhao Z, Lizama CO, Kharbikar BN, Gräf S, Treacy CM, Morrell NW, Graham BB, Lagna G, Hata A

Is pulmonary arterial hypertension associated with schistosomiasis distinct from pulmonary arterial hypertension associated with portal hypertension?

JHLT open

Graham BB, Hilton JF, Lee MH, Kumar R, Balladares DF, Rahaghi FN, Estépar RSJ, Mickael C, Lima RLB, Loureiro CMC, Lucena J, Oliveira RKF, Corrêa RA

PFKFB3 Inhibits Fructose Metabolism in Pulmonary Microvascular Endothelial Cells.

American journal of respiratory cell and molecular biology

Lee JY, Stevens RP, Pastukh VV, Pastukh VM, Kozhukhar N, Alexeyev MF, Reisz JA, Nerguizian D, D'Alessandro A, Koloteva A, Gwin MS, Roberts JT, Borchert GM, Wagener BM, Pittet JF, Graham BB, Stenmark KR, Stevens T

Repetitive schistosoma exposure causes perivascular lung fibrosis and persistent pulmonary hypertension.

Clinical science (London, England : 1979)

Kumar R, Lee MH, Kassa B, Fonseca Balladares DC, Mickael C, Sanders L, Andruska A, Kumar M, Spiekerkoetter E, Bandeira A, Stenmark KR, Tuder RM, Graham BB

Functional and molecular determinants of right ventricular response to severe pulmonary hypertension in a large animal model.

American journal of physiology. Heart and circulatory physiology

Brown RD, Hunter KS, Li M, Frid MG, Harral J, Krafsur GM, Holt TN, Williams J, Zhang H, Riddle SR, Edwards MG, Kumar S, Hu CJ, Graham BB, Walker LA, Garry FB, Buttrick PM, Lahm T, Kheyfets VO, Hansen KC, Stenmark KR

Potential long-term effects of SARS-CoV-2 infection on the pulmonary vasculature: Multilayered cross-talks in the setting of coinfections and comorbidities.

PLoS pathogens

Kumar R, Aktay-Cetin Ö, Craddock V, Morales-Cano D, Kosanovic D, Cogolludo A, Perez-Vizcaino F, Avdeev S, Kumar A, Ram AK, Agarwal S, Chakraborty A, Savai R, de Jesus Perez V, Graham BB, Butrous G, Dhillon NK

Exercise metabolomics in pulmonary arterial hypertension: Where pulmonary vascular metabolism meets exercise physiology.

Frontiers in physiology

Lee MH, Menezes TCF, Reisz JA, Ferreira EVM, Graham BB, Oliveira RKF

HIV and Schistosoma Co-Exposure Leads to Exacerbated Pulmonary Endothelial Remodeling and Dysfunction Associated with Altered Cytokine Landscape.

Cells

Medrano-Garcia S, Morales-Cano D, Barreira B, Vera-Zambrano A, Kumar R, Kosanovic D, Schermuly RT, Graham BB, Perez-Vizcaino F, Mathie A, Savai R, Pullamseti S, Butrous G, Fernández-Malavé E, Cogolludo A

The role of macrophages in right ventricular remodeling in experimental pulmonary hypertension.

Pulmonary circulation

Gu S, Mickael C, Kumar R, Lee MH, Sanders L, Kassa B, Harral J, Williams J, Hansen KC, Stenmark KR, Tuder RM, Graham BB

Contribution of fatty acid oxidation to the pathogenesis of pulmonary hypertension.

American journal of physiology. Lung cellular and molecular physiology

Lee MH, Sanders L, Kumar R, Hernandez-Saavedra D, Yun X, Ford JA, Perez MJ, Mickael C, Gandjeva A, Koyanagi DE, Harral JW, Irwin DC, Kassa B, Eckel RH, Shimoda LA, Graham BB, Tuder RM

Single-cell RNA sequencing and binary hierarchical clustering define lung interstitial macrophage heterogeneity in response to hypoxia.

American journal of physiology. Lung cellular and molecular physiology

Campbell NV, Mickael C, Kumar S, Zhang H, Campbell IL, Gillen AE, Trentin CO, Diener K, Gao B, Kheyfets VO, Gu S, Kumar R, Phang T, Brown RD, Graham BB, Stenmark KR

Sexual Dimorphism of Dexamethasone as a Prophylactic Treatment in Pathologies Associated With Acute Hypobaric Hypoxia Exposure.

Frontiers in pharmacology

Chanana N, Palmo T, Sharma K, Kumar R, Shah B, Mahajan S, Palleda GM, Gupta MD, Kukreti R, Faruq M, Thinlas T, Graham BB, Pasha Q

Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension.

The Journal of clinical investigation

Bertero T, Lu Y, Annis S, Hale A, Bhat B, Saggar R, Saggar R, Wallace WD, Ross DJ, Vargas SO, Graham BB, Kumar R, Black SM, Fratz S, Fineman JR, West JD, Haley KJ, Waxman AB, Chau BN, Cottrill KA, Chan SY

Peripheral Blood Inflammation Profile of Patients with Pulmonary Arterial Hypertension Using the High-Throughput Olink Proteomics Platform.

American journal of respiratory cell and molecular biology

Mickael C, Kheyfets VO, Langouët-Astrié C, Lee MH, Sanders LA, Trentin CO, Sweatt AJ, Zamanian RT, Bull TM, Stenmark K, Graham BB, Tuder RM

Rationale and design of a screening study to detect schistosomiasis-associated pulmonary hypertension in Ethiopia and Zambia.

Pulmonary circulation

Sinkala E, Ahmed HY, Sibomana JP, Lee MH, Kassa B, Kumar R, Mazimba S, Binegdie AB, Mpisa S, Wamundila K, Graham BB, Hilton JF

Experimental Schistosoma japonicum-induced pulmonary hypertension.

PLoS neglected tropical diseases

Kassa B, Lee MH, Kumar R, Mickael C, Sanders L, Tuder RM, Mentink-Kane M, Graham BB

Double Trouble: Airflow and Pulmonary Vascular Obstruction.

American journal of respiratory and critical care medicine

Lee MH, Graham BB, Bull TM

Two Birds with One Stone: Helping the Pulmonary Arteries and the Right Ventricle by Targeting BMPR2 Signaling.

American journal of respiratory cell and molecular biology

Lee MH, Mickael C, Graham BB

Endothelial cell PHD2-HIF1α-PFKFB3 contributes to right ventricle vascular adaptation in pulmonary hypertension.

American journal of physiology. Lung cellular and molecular physiology

Kassa B, Kumar R, Mickael C, Sanders L, Vohwinkel C, Lee MH, Gu S, Poth JM, Stenmark KR, Zhao YY, Tuder RM, Graham BB

Arterial vascular volume changes with haemodynamics in schistosomiasis-associated pulmonary arterial hypertension.

The European respiratory journal

Rahaghi FN, Hilton JF, Corrêa RA, Loureiro C, Ota-Arakaki JS, Verrastro CGY, Lee MH, Mickael C, Nardelli P, Systrom DA, Waxman AB, Washko GR, San José Estépar R, Graham BB, Oliveira RKF

Interleukin-6 mediates neutrophil mobilization from bone marrow in pulmonary hypertension.

Cellular & molecular immunology

Florentin J, Zhao J, Tai YY, Vasamsetti SB, O'Neil SP, Kumar R, Arunkumar A, Watson A, Sembrat J, Bullock GC, Sanders L, Kassa B, Rojas M, Graham BB, Chan SY, Dutta P

Schistosomiasis Pulmonary Arterial Hypertension.

Frontiers in immunology

Sibomana JP, Campeche A, Carvalho-Filho RJ, Correa RA, Duani H, Pacheco Guimaraes V, Hilton JF, Kassa B, Kumar R, Lee MH, Loureiro CMC, Mazimba S, Mickael C, Oliveira RKF, Ota-Arakaki JS, Rezende CF, Silva LCS, Sinkala E, Ahmed HY, Graham BB

Pathophysiology and potential future therapeutic targets using preclinical models of COVID-19.

ERJ open research

Kumar R, Lee MH, Mickael C, Kassa B, Pasha Q, Tuder R, Graham B

Interstitial macrophage-derived thrombospondin-1 contributes to hypoxia-induced pulmonary hypertension.

Cardiovascular research

Kumar R, Mickael C, Kassa B, Sanders L, Hernandez-Saavedra D, Koyanagi DE, Kumar S, Pugliese SC, Thomas S, McClendon J, Maloney JP, Janssen WJ, Stenmark KR, Tuder RM, Graham BB

Exploring New Therapeutic Pathways in Pulmonary Hypertension. Metabolism, Proliferation, and Personalized Medicine.

American journal of respiratory cell and molecular biology

George MP, Gladwin MT, Graham BB

Sex-derived attributes contributing to SARS-CoV-2 mortality.

American journal of physiology. Endocrinology and metabolism

Chanana N, Palmo T, Sharma K, Kumar R, Graham BB, Pasha Q

Publisher Correction: Stable isotope metabolomics of pulmonary artery smooth muscle and endothelial cells in pulmonary hypertension and with TGF-beta treatment.

Scientific reports

Hernandez-Saavedra D, Sanders L, Freeman S, Reisz JA, Lee MH, Mickael C, Kumar R, Kassa B, Gu S, D' Alessandro A, Stenmark KR, Tuder RM, Graham BB

Stable isotope metabolomics of pulmonary artery smooth muscle and endothelial cells in pulmonary hypertension and with TGF-beta treatment.

Scientific reports

Hernandez-Saavedra D, Sanders L, Freeman S, Reisz JA, Lee MH, Mickael C, Kumar R, Kassa B, Gu S, D' Alessandro A, Stenmark KR, Tuder RM, Graham BB

Suppression of HIF2 signalling attenuates the initiation of hypoxia-induced pulmonary hypertension.

The European respiratory journal

Hu CJ, Poth JM, Zhang H, Flockton A, Laux A, Kumar S, McKeon B, Mouradian G, Li M, Riddle S, Pugliese SC, Brown RD, Wallace EM, Graham BB, Frid MG, Stenmark KR

Th2 CD4+ T Cells Are Necessary and Sufficient for Schistosoma-Pulmonary Hypertension.

Journal of the American Heart Association

Kumar R, Mickael C, Kassa B, Sanders L, Koyanagi D, Hernandez-Saavedra D, Freeman S, Morales-Cano D, Cogolludo A, McKee AS, Fontenot AP, Butrous G, Tuder RM, Graham BB

A retrospective study of schistosomiasis-associated pulmonary hypertension from an endemic area in Brazil.

International journal of cardiology. Heart & vasculature

Botoni FA, Marinho CC, Carvalho VT, Mickael CS, Graham BB

IL-6Ra in Smooth Muscle Cells Protects against Schistosoma- and Hypoxia-induced Pulmonary Hypertension.

American journal of respiratory cell and molecular biology

Mickael C, Kumar R, Hernandez-Saavedra D, Kassa B, Sanders L, Koyanagi D, Gu S, Lee MH, Tuder RM, Graham BB

Systems Analysis of the Human Pulmonary Arterial Hypertension Lung Transcriptome.

American journal of respiratory cell and molecular biology

Stearman RS, Bui QM, Speyer G, Handen A, Cornelius AR, Graham BB, Kim S, Mickler EA, Tuder RM, Chan SY, Geraci MW

BOLA (BolA Family Member 3) Deficiency Controls Endothelial Metabolism and Glycine Homeostasis in Pulmonary Hypertension.

Circulation

Yu Q, Tai YY, Tang Y, Zhao J, Negi V, Culley MK, Pilli J, Sun W, Brugger K, Mayr J, Saggar R, Saggar R, Wallace WD, Ross DJ, Waxman AB, Wendell SG, Mullett SJ, Sembrat J, Rojas M, Khan OF, Dahlman JE, Sugahara M, Kagiyama N, Satoh T, Zhang M, Feng N, Gorcsan J, Vargas SO, Haley KJ, Kumar R, Graham BB, Langer R, Anderson DG, Wang B, Shiva S, Bertero T, Chan SY

Common genetic variants in pulmonary arterial hypertension.

The Lancet. Respiratory medicine

Gu S, Kumar R, Lee MH, Mickael C, Graham BB

Paclitaxel blocks Th2-mediated TGF-β activation in Schistosoma mansoni-induced pulmonary hypertension.

Pulmonary circulation

Kassa B, Mickael C, Kumar R, Sanders L, Koyanagi D, Hernandez-Saavedra D, Tuder RM, Graham BB

Vascular Adaptation of the Right Ventricle in Experimental Pulmonary Hypertension.

American journal of respiratory cell and molecular biology

Graham BB, Kumar R, Mickael C, Kassa B, Koyanagi D, Sanders L, Zhang L, Perez M, Hernandez-Saavedra D, Valencia C, Dixon K, Harral J, Loomis Z, Irwin D, Nemkov T, D'Alessandro A, Stenmark KR, Tuder RM

NEDD9 targets COL3A1 to promote endothelial fibrosis and pulmonary arterial hypertension.

Science translational medicine

Samokhin AO, Stephens T, Wertheim BM, Wang RS, Vargas SO, Yung LM, Cao M, Brown M, Arons E, Dieffenbach PB, Fewell JG, Matar M, Bowman FP, Haley KJ, Alba GA, Marino SM, Kumar R, Rosas IO, Waxman AB, Oldham WM, Khanna D, Graham BB, Seo S, Gladyshev VN, Yu PB, Fredenburgh LE, Loscalzo J, Leopold JA, Maron BA

Dominant Role for Regulatory T Cells in Protecting Females Against Pulmonary Hypertension.

Circulation research

Tamosiuniene R, Manouvakhova O, Mesange P, Saito T, Qian J, Sanyal M, Lin YC, Nguyen LP, Luria A, Tu AB, Sante JM, Rabinovitch M, Fitzgerald DJ, Graham BB, Habtezion A, Voelkel NF, Aurelian L, Nicolls MR

Right Ventricle Vasculature in Human Pulmonary Hypertension Assessed by Stereology.

American journal of respiratory and critical care medicine

Graham BB, Koyanagi D, Kandasamy B, Tuder RM

TGF-β activation by bone marrow-derived thrombospondin-1 causes Schistosoma- and hypoxia-induced pulmonary hypertension.

Nature communications

Kumar R, Mickael C, Kassa B, Gebreab L, Robinson JC, Koyanagi DE, Sanders L, Barthel L, Meadows C, Fox D, Irwin D, Li M, McKeon BA, Riddle S, Dale Brown R, Morgan LE, Evans CM, Hernandez-Saavedra D, Bandeira A, Maloney JP, Bull TM, Janssen WJ, Stenmark KR, Tuder RM, Graham BB

A Time- and Compartment-Specific Activation of Lung Macrophages in Hypoxic Pulmonary Hypertension.

Journal of immunology (Baltimore, Md. : 1950)

Pugliese SC, Kumar S, Janssen WJ, Graham BB, Frid MG, Riddle SR, El Kasmi KC, Stenmark KR

Enhanced inflammatory cell profiles in schistosomiasis-induced pulmonary vascular remodeling.

Pulmonary circulation

Ali Z, Kosanovic D, Kolosionek E, Schermuly RT, Graham BB, Mathie A, Butrous G

Fatty Acid Metabolism, Bone Morphogenetic Protein Receptor Type 2, and the Right Ventricle.

American journal of respiratory and critical care medicine

Graham BB, Robinson JC, Tuder RM

Increased mitochondrial arginine metabolism supports bioenergetics in asthma.

The Journal of clinical investigation

Xu W, Ghosh S, Comhair SA, Asosingh K, Janocha AJ, Mavrakis DA, Bennett CD, Gruca LL, Graham BB, Queisser KA, Kao CC, Wedes SH, Petrich JM, Tuder RM, Kalhan SC, Erzurum SC

Matrix Remodeling Promotes Pulmonary Hypertension through Feedback Mechanoactivation of the YAP/TAZ-miR-130/301 Circuit.

Cell reports

Bertero T, Cottrill KA, Lu Y, Haeger CM, Dieffenbach P, Annis S, Hale A, Bhat B, Kaimal V, Zhang YY, Graham BB, Kumar R, Saggar R, Saggar R, Wallace WD, Ross DJ, Black SM, Fratz S, Fineman JR, Vargas SO, Haley KJ, Waxman AB, Chau BN, Fredenburgh LE, Chan SY

The Causal Role of IL-4 and IL-13 in Schistosoma mansoni Pulmonary Hypertension.

American journal of respiratory and critical care medicine

Kumar R, Mickael C, Chabon J, Gebreab L, Rutebemberwa A, Garcia AR, Koyanagi DE, Sanders L, Gandjeva A, Kearns MT, Barthel L, Janssen WJ, Mauad T, Bandeira A, Schmidt E, Tuder RM, Graham BB

Severe pulmonary hypertension is associated with altered right ventricle metabolic substrate uptake.

American journal of physiology. Lung cellular and molecular physiology

Graham BB, Kumar R, Mickael C, Sanders L, Gebreab L, Huber KM, Perez M, Smith-Jones P, Serkova NJ, Tuder RM

Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron-sulfur deficiency and pulmonary hypertension.

EMBO molecular medicine

White K, Lu Y, Annis S, Hale AE, Chau BN, Dahlman JE, Hemann C, Opotowsky AR, Vargas SO, Rosas I, Perrella MA, Osorio JC, Haley KJ, Graham BB, Kumar R, Saggar R, Saggar R, Wallace WD, Ross DJ, Khan OF, Bader A, Gochuico BR, Matar M, Polach K, Johannessen NM, Prosser HM, Anderson DG, Langer R, Zweier JL, Bindoff LA, Systrom D, Waxman AB, Jin RC, Chan SY

The crossroads of iron with hypoxia and cellular metabolism. Implications in the pathobiology of pulmonary hypertension.

American journal of respiratory cell and molecular biology

Robinson JC, Graham BB, Rouault TC, Tuder RM

Rtp801 suppression of epithelial mTORC1 augments endotoxin-induced lung inflammation.

The American journal of pathology

Nadon AM, Perez MJ, Hernandez-Saavedra D, Smith LP, Yang Y, Sanders LA, Gandjeva A, Chabon J, Koyanagi DE, Graham BB, Tuder RM, Schmidt EP

Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension.

The Journal of clinical investigation

Bertero T, Lu Y, Annis S, Hale A, Bhat B, Saggar R, Saggar R, Wallace WD, Ross DJ, Vargas SO, Graham BB, Kumar R, Black SM, Fratz S, Fineman JR, West JD, Haley KJ, Waxman AB, Chau BN, Cottrill KA, Chan SY

Adventitial fibroblasts induce a distinct proinflammatory/profibrotic macrophage phenotype in pulmonary hypertension.

Journal of immunology (Baltimore, Md. : 1950)

El Kasmi KC, Pugliese SC, Riddle SR, Poth JM, Anderson AL, Frid MG, Li M, Pullamsetti SS, Savai R, Nagel MA, Fini MA, Graham BB, Tuder RM, Friedman JE, Eltzschig HK, Sokol RJ, Stenmark KR

Role of vascular endothelial growth factor signaling in Schistosoma-induced experimental pulmonary hypertension.

Pulmonary circulation

Chabon JJ, Gebreab L, Kumar R, Debella E, Tanaka T, Koyanagi D, Rodriguez Garcia A, Sanders L, Perez M, Tuder RM, Graham BB

Functional prostacyclin synthase promoter polymorphisms. Impact in pulmonary arterial hypertension.

American journal of respiratory and critical care medicine

Stearman RS, Cornelius AR, Lu X, Conklin DS, Del Rosario MJ, Lowe AM, Elos MT, Fettig LM, Wong RE, Hara N, Cogan JD, Phillips JA, Taylor MR, Graham BB, Tuder RM, Loyd JE, Geraci MW

Fat and cardiotoxicity in hereditary pulmonary hypertension.

American journal of respiratory and critical care medicine

Tuder RM, Robinson JC, Graham BB

Protective role of IL-6 in vascular remodeling in Schistosoma pulmonary hypertension.

American journal of respiratory cell and molecular biology

Graham BB, Chabon J, Kumar R, Kolosionek E, Gebreab L, Debella E, Edwards M, Diener K, Shade T, Bifeng G, Bandeira A, Butrous G, Jones K, Geraci M, Tuder RM

Updated approach for the assessment of ventilator-associated pneumonia.

Critical care medicine

Macht M, Robinson JC, Graham BB

Pathology of pulmonary hypertension.

Clinics in chest medicine

Tuder RM, Stacher E, Robinson J, Kumar R, Graham BB

Pulmonary veins in the normal lung and pulmonary hypertension due to left heart disease.

American journal of physiology. Lung cellular and molecular physiology

Hunt JM, Bethea B, Liu X, Gandjeva A, Mammen PP, Stacher E, Gandjeva MR, Parish E, Perez M, Smith L, Graham BB, Kuebler WM, Tuder RM

Transforming growth factor-β signaling promotes pulmonary hypertension caused by Schistosoma mansoni.

Circulation

Graham BB, Chabon J, Gebreab L, Poole J, Debella E, Davis L, Tanaka T, Sanders L, Dropcho N, Bandeira A, Vandivier RW, Champion HC, Butrous G, Wang XJ, Wynn TA, Tuder RM

A sinus venosus atrial septal defect is diagnosed by echocardiography with an unusual bubble study.

Echocardiography (Mount Kisco, N.Y.)

Dorosz JL, Fonseca BM, Kay JD, Graham BB, Salcedo EE, Quaife RA

Schistosomiasis causes remodeling of pulmonary vessels in the lung in a heterogeneous localized manner: Detailed study.

Pulmonary circulation

Kolosionek E, King J, Rollinson D, Schermuly RT, Grimminger F, Graham BB, Morrell N, Butrous G

Deletion of iron regulatory protein 1 causes polycythemia and pulmonary hypertension in mice through translational derepression of HIF2α.

Cell metabolism

Ghosh MC, Zhang DL, Jeong SY, Kovtunovych G, Ollivierre-Wilson H, Noguchi A, Tu T, Senecal T, Robinson G, Crooks DR, Tong WH, Ramaswamy K, Singh A, Graham BB, Tuder RM, Yu ZX, Eckhaus M, Lee J, Springer DA, Rouault TA

Fasting 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography to detect metabolic changes in pulmonary arterial hypertension hearts over 1 year.

Annals of the American Thoracic Society

Lundgrin EL, Park MM, Sharp J, Tang WH, Thomas JD, Asosingh K, Comhair SA, DiFilippo FP, Neumann DR, Davis L, Graham BB, Tuder RM, Dostanic I, Erzurum SC

Modern age pathology of pulmonary arterial hypertension.

American journal of respiratory and critical care medicine

Stacher E, Graham BB, Hunt JM, Gandjeva A, Groshong SD, McLaughlin VV, Jessup M, Grizzle WE, Aldred MA, Cool CD, Tuder RM

Targeting energetic metabolism: a new frontier in the pathogenesis and treatment of pulmonary hypertension.

American journal of respiratory and critical care medicine

Tuder RM, Davis LA, Graham BB

Significant intrapulmonary Schistosoma egg antigens are not present in schistosomiasis-associated pulmonary hypertension.

Pulmonary circulation

Graham BB, Chabon J, Bandeira A, Espinheira L, Butrous G, Tuder RM

Schistosomiasis-induced experimental pulmonary hypertension: role of interleukin-13 signaling.

The American journal of pathology

Graham BB, Mentink-Kane MM, El-Haddad H, Purnell S, Zhang L, Zaiman A, Redente EF, Riches DW, Hassoun PM, Bandeira A, Champion HC, Butrous G, Wynn TA, Tuder RM

Tracheal Basal cells: a facultative progenitor cell pool.

The American journal of pathology

Cole BB, Smith RW, Jenkins KM, Graham BB, Reynolds PR, Reynolds SD

Diabetes mellitus does not adversely affect outcomes from a critical illness.

Critical care medicine

Graham BB, Keniston A, Gajic O, Trillo Alvarez CA, Medvedev S, Douglas IS

[Pathogenesis of pulmonary hypertension].

Zhonghua yi xue za zhi

Graham BB, Tuder RM

TNFalpha inhibits apoptotic cell clearance in the lung, exacerbating acute inflammation.

American journal of physiology. Lung cellular and molecular physiology

Borges VM, Vandivier RW, McPhillips KA, Kench JA, Morimoto K, Groshong SD, Richens TR, Graham BB, Muldrow AM, Van Heule L, Henson PM, Janssen WJ

Clinical problem-solving. Kiss of death.

The New England journal of medicine

Graham BB, Kaul DR, Saint S, Janssen WJ

Dyspnea, chest pain, and altered mental status in a 33-year-old carpenter.

Chest

Graham BB, Burnham EL, Janssen JS, Janssen WJ

Cigarette smoke triggers code red: p21CIP1/WAF1/SDI1 switches on danger responses in the lung.

American journal of respiratory cell and molecular biology

Tuder RM, Yun JH, Graham BB

Primary pulmonary lymphoma.

The Annals of thoracic surgery

Graham BB, Mathisen DJ, Mark EJ, Takvorian RW

Pediatric tracheal surgery.

The Annals of thoracic surgery

Wright CD, Graham BB, Grillo HC, Wain JC, Mathisen DJ

Faculty Type: 
Affiliate Faculty