Home > People > Bruce Conklin, MD

Bruce Conklin, MD

Professor
Medicine
Address: 
35 Medical Center Way, Rm 001
UCSF Box 1230
San Francisco, CA 94143
United States
Phone: 
+1 415 734-2000
Email: 
[email protected]
UCSF Profiles

Dr. Conklin uses patient-derived induced pluripotent stem cells (iPSCs) to model potential CRISPR therapies in cardiomyocytes and neurons. Dominant mutations are particularly promising targets since precise CRISPR inactivation of disease-causing alleles could provide a cure.  Allele specific gene inactivation could be beneficial to a wide range of dominant genetic diseases.

Publications: 

Dual a-globin-truncated erythropoietin receptor knockin restores hemoglobin production in a-thalassemia-derived erythroid cells.

Cell reports

Chu SN, Soupene E, Sharma D, Sinha R, McCreary T, Hernandez B, Shen H, Wienert B, Bowman C, Yin H, Lesch BJ, Jia K, Romero KA, Kostamo Z, Zhang Y, Tran T, Cordero M, Homma S, Hampton JP, Gardner JM, Conklin BR, MacKenzie TC, Sheehan VA, Porteus MH, Cromer MK

Haplotype editing with CRISPR/Cas9 as a therapeutic approach for dominant-negative missense mutations in NEFL.

bioRxiv : the preprint server for biology

Dua PH, Simon BMJ, Marley CBE, Feliciano CM, Watry HL, Steury D, Abraham A, Gilbertson EN, Ramey GD, Capra JA, Conklin BR, Judge LM

Reversal of C9orf72 mutation-induced transcriptional dysregulation and pathology in cultured human neurons by allele-specific excision.

Alzheimer's & Dementia

Aradhana Sachdev, Kamaljot Gil, Maria Sckaff, Alisha M Birk, Olubankole Aladesuyi Arogundade, Katherine A Brown, Runvir S Chouhan, Patrick Issagholian Lewin, Esha Patel, Kathleen Keough, Bruce Conklin, Alec ST Smith, Claire Clelland

Programmable epigenome editing by transient delivery of CRISPR epigenome editor ribonucleoproteins.

bioRxiv : the preprint server for biology

Xu D, Besselink S, Ramadoss GN, Dierks PH, Lubin JP, Pattali RK, Brim JI, Christenson AE, Colias PJ, Ornelas IJ, Nguyen CD, Chasins SE, Conklin BR, Nuñez JK

Neuronal DNA repair reveals strategies to influence CRISPR editing outcomes.

bioRxiv : the preprint server for biology

Ramadoss GN, Namaganda SJ, Hamilton JR, Sharma R, Chow KG, Macklin BL, Sun M, Liu JC, Fellmann C, Watry HL, Jin J, Perez BS, Sandoval Espinoza CR, Matia MP, Lu SH, Judge LM, Nussenzweig A, Adamson B, Murthy N, Doudna JA, Kampmann M, Conklin BR

Permittivity tensor imaging: modular label-free imaging of 3D dry mass and 3D orientation at high resolution.

Nature methods

Yeh LH, Ivanov IE, Chandler T, Byrum JR, Chhun BB, Guo SM, Foltz C, Hashemi E, Perez-Bermejo JA, Wang H, Yu Y, Kazansky PG, Conklin BR, Han MH, Mehta SB

Advances and challenges in modeling inherited peripheral neuropathies using iPSCs.

Experimental & molecular medicine

Van Lent J, Prior R, PĂ©rez Siles G, Cutrupi AN, Kennerson ML, Vangansewinkel T, Wolfs E, Mukherjee-Clavin B, Nevin Z, Judge L, Conklin B, Tyynismaa H, Clark AJ, Bennett DL, Van Den Bosch L, Saporta M, Timmerman V

Dual α-globin and truncated EPO receptor knockin restores hemoglobin production in α-thalassemia-derived red blood cells.

bioRxiv : the preprint server for biology

Chu SN, Soupene E, Wienert B, Yin H, Sharma D, McCreary T, Jia K, Homma S, Hampton JP, Gardner JM, Conklin BR, MacKenzie TC, Porteus MH, Cromer MK

Reversal of C9orf72 mutation-induced transcriptional dysregulation and pathology in cultured human neurons by allele-specific excision.

Proceedings of the National Academy of Sciences of the United States of America

Sachdev A, Gill K, Sckaff M, Birk AM, Aladesuyi Arogundade O, Brown KA, Chouhan RS, Issagholian-Lewin PO, Patel E, Watry HL, Bernardi MT, Keough KC, Tsai YC, Smith AST, Conklin BR, Clelland CD

Give heart cells a beat: An interactive museum exhibit that synchronizes stem cell-derived cardiomyocytes to visitors' heartbeat.

Stem cell reports

Perez-Bermejo JA, Reisman SJ, Ma J, Carrison-Stone D, Cerrito C, Ribeiro AJS, Conklin BR, Yu K

Validated assays for the quantification of C9orf72 human pathology.

Scientific reports

Salomonsson SE, Maltos AM, Gill K, Aladesuyi Arogundade O, Brown KA, Sachdev A, Sckaff M, Lam KJK, Fisher IJ, Chouhan RS, Van Laar VS, Marley CB, McLaughlin I, Bankiewicz KS, Tsai YC, Conklin BR, Clelland CD

Dual a-Globin and Truncated EPO Receptor Knockin Restores Hemoglobin Production in a-Thalassemia-Derived Hematopoietic Stem and Progenitor Cells.

Blood

Simon N Chu, Eric Soupene, Beeke Wienert, Han Yin, Devesh Sharma, Kun Jia, Shota Homma, Jessica P Hampton, Bruce Conklin, Tippi C. MacKenzie, Matthew Porteus, Kyle Cromer

Functional analysis of a common BAG3 allele associated with protection from heart failure.

Nature Cardiovascular Research

Perez-Bermejo JA, Judge LM, Jensen CL, Wu K, Watry HL, Truong A, Ho JJ, Carter M, Runyon WV, Kaake RM, Pulido EH, Mandegar MA, Swaney DL, So PL, Krogan NJ, Conklin BR

Evaluation of CRISPR/Cas9 exon-skipping vector for choroideremia using human induced pluripotent stem cell-derived RPE.

The journal of gene medicine

Iwagawa T, Masumoto H, Tabuchi H, Tani K, Conklin BR, Watanabe S

A reference human induced pluripotent stem cell line for large-scale collaborative studies.

Cell stem cell

Pantazis CB, Yang A, Lara E, McDonough JA, Blauwendraat C, Peng L, Oguro H, Kanaujiya J, Zou J, Sebesta D, Pratt G, Cross E, Blockwick J, Buxton P, Kinner-Bibeau L, Medura C, Tompkins C, Hughes S, Santiana M, Faghri F, Nalls MA, Vitale D, Ballard S, Qi YA, Ramos DM, Anderson KM, Stadler J, Narayan P, Papademetriou J, Reilly L, Nelson MP, Aggarwal S, Rosen LU, Kirwan P, Pisupati V, Coon SL, Scholz SW, Priebe T, Ă–ttl M, Dong J, Meijer M, Janssen LJM, Lourenco VS, van der Kant R, Crusius D, Paquet D, Raulin AC, Bu G, Held A, Wainger BJ, Gabriele RMC, Casey JM, Wray S, Abu-Bonsrah D, Parish CL, Beccari MS, Cleveland DW, Li E, Rose IVL, Kampmann M, Calatayud Aristoy C, Verstreken P, Heinrich L, Chen MY, SchĂ¼le B, Dou D, Holzbaur ELF, Zanellati MC, Basundra R, Deshmukh M, Cohen S, Khanna R, Raman M, Nevin ZS, Matia M, Van Lent J, Timmerman V, Conklin BR, Johnson Chase K, Zhang K, Funes S, Bosco DA, Erlebach L, Welzer M, Kronenberg-Versteeg D, Lyu G, Arenas E, Coccia E, Sarrafha L, Ahfeldt T, Marioni JC, Skarnes WC, Cookson MR, Ward ME, Merkle FT

Transcription Factor GATA4 Regulates Cell Type-Specific Splicing Through Direct Interaction With RNA in Human Induced Pluripotent Stem Cell-Derived Cardiac Progenitors.

Circulation

Zhu L, Choudhary K, Gonzalez-Teran B, Ang YS, Thomas R, Stone NR, Liu L, Zhou P, Zhu C, Ruan H, Huang Y, Jin S, Pelonero A, Koback F, Padmanabhan A, Sadagopan N, Hsu A, Costa MW, Gifford CA, van Bemmel JG, HĂ¼ttenhain R, Vedantham V, Conklin BR, Black BL, Bruneau BG, Steinmetz L, Krogan NJ, Pollard KS, Srivastava D

Transcription factor protein interactomes reveal genetic determinants in heart disease.

Cell

Gonzalez-Teran B, Pittman M, Felix F, Thomas R, Richmond-Buccola D, HĂ¼ttenhain R, Choudhary K, Moroni E, Costa MW, Huang Y, Padmanabhan A, Alexanian M, Lee CY, Maven BEJ, Samse-Knapp K, Morton SU, McGregor M, Gifford CA, Seidman JG, Seidman CE, Gelb BD, Colombo G, Conklin BR, Black BL, Bruneau BG, Krogan NJ, Pollard KS, Srivastava D

BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2.

Nature cell biology

Samelson AJ, Tran QD, Robinot R, Carrau L, Rezelj VV, Kain AM, Chen M, Ramadoss GN, Guo X, Lim SA, Lui I, Nuñez JK, Rockwood SJ, Wang J, Liu N, Carlson-Stevermer J, Oki J, Maures T, Holden K, Weissman JS, Wells JA, Conklin BR, TenOever BR, Chakrabarti LA, Vignuzzi M, Tian R, Kampmann M

Abstract 11332: Integration of Protein Interactome Networks with Congenital Heart Disease Variants Reveals Candidate Disease Genes.

Circulation

Barbara Gonzalez Teran, Maureen Pittman, Reuben Thomas, Franco Felix, Desmond Richmond-Buccola, Krishna Choudhary, Elisabetta Moroni, Colombo Giorgio, Arun Padmanabhan, Mauro Costa, Yu Huang, Michael Alexanian, Clara Lee, Bonie Cole, Kaitlen Samse-Knapp, Michael McGregor, Casey Gifford, Ruth Huttenhain, Bruce Gelb, Bruce Conklin, Brian L Black, Benoit Bruneau, Nevan Krogan, Katherine Pollard, Deepak Srivastava

Gain-of-function cardiomyopathic mutations in RBM20 rewire splicing regulation and re-distribute ribonucleoprotein granules within processing bodies.

Nature communications

Fenix AM, Miyaoka Y, Bertero A, Blue SM, Spindler MJ, Tan KKB, Perez-Bermejo JA, Chan AH, Mayerl SJ, Nguyen TD, Russell CR, Lizarraga PP, Truong A, So PL, Kulkarni A, Chetal K, Sathe S, Sniadecki NJ, Yeo GW, Murry CE, Conklin BR, Salomonis N

BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2.

bioRxiv : the preprint server for biology

Samelson AJ, Tran QD, Robinot R, Carrau L, Rezelj VV, Mac Kain A, Chen M, Ramadoss GN, Guo X, Lim SA, Lui I, Nunez J, Rockwood SJ, Wang J, Liu N, Carlson-Stevermer J, Oki J, Maures T, Holden K, Weissman JS, Wells JA, Conklin BR, TenOever BR, Chakrabarti LA, Vignuzzi M, Tian R, Kampmann M

Allele-Specific Gene Editing Rescues Pathology in a Human Model of Charcot-Marie-Tooth Disease Type 2E.

Frontiers in cell and developmental biology

Feliciano CM, Wu K, Watry HL, Marley CBE, Ramadoss GN, Ghanim HY, Liu AZ, Zholudeva LV, McDevitt TC, Saporta MA, Conklin BR, Judge LM

Bioengineered optogenetic model of human neuromuscular junction.

Biomaterials

Vila OF, Chavez M, Ma SP, Yeager K, Zholudeva LV, ColĂ³n-Mercado JM, Qu Y, Nash TR, Lai C, Feliciano CM, Carter M, Kamm RD, Judge LM, Conklin BR, Ward ME, McDevitt TC, Vunjak-Novakovic G

SARS-CoV-2 infection of human iPSC-derived cardiac cells reflects cytopathic features in hearts of patients with COVID-19.

Science translational medicine

Perez-Bermejo JA, Kang S, Rockwood SJ, Simoneau CR, Joy DA, Silva AC, Ramadoss GN, Flanigan WR, Fozouni P, Li H, Chen PY, Nakamura K, Whitman JD, Hanson PJ, McManus BM, Ott M, Conklin BR, McDevitt TC

Investigating Zeta Globin Gene Expression to Develop a Potential Therapy for Alpha Thalassemia Major.

Blood

Georgia L. Gregory, Beeke Wienert, Marisa Schwab, Billie Rachael Lianoglou, Roger P. Hollis, Donald B. Kohn, Bruce R. Conklin, Tippi C. MacKenzie

SARS-CoV-2 infection of human iPSC-derived cardiac cells predicts novel cytopathic features in hearts of COVID-19 patients.

bioRxiv : the preprint server for biology

PĂ©rez-Bermejo JA, Kang S, Rockwood SJ, Simoneau CR, Joy DA, Ramadoss GN, Silva AC, Flanigan WR, Li H, Nakamura K, Whitman JD, Ott M, Conklin BR, McDevitt TC

Rapid, precise quantification of large DNA excisions and inversions by ddPCR.

Scientific reports

Watry HL, Feliciano CM, Gjoni K, Takahashi G, Miyaoka Y, Conklin BR, Judge LM

Critical Roles of Translation Initiation and RNA Uridylation in Endogenous Retroviral Expression and Neural Differentiation in Pluripotent Stem Cells.

Cell reports

Takahashi K, Jeong D, Wang S, Narita M, Jin X, Iwasaki M, Perli SD, Conklin BR, Yamanaka S

Timed inhibition of CDC7 increases CRISPR-Cas9 mediated templated repair.

Nature communications

Wienert B, Nguyen DN, Guenther A, Feng SJ, Locke MN, Wyman SK, Shin J, Kazane KR, Gregory GL, Carter MAM, Wright F, Conklin BR, Marson A, Richardson CD, Corn JE

CRISPR off-target detection with DISCOVER-seq.

Nature protocols

Wienert B, Wyman SK, Yeh CD, Conklin BR, Corn JE

Cardiac Microtissues: Maladaptive Contractility of 3D Human Cardiac Microtissues to Mechanical Nonuniformity (Adv. Healthcare Mater. 8/2020).

Advanced Healthcare Materials

Chenyan Wang, Sangmo Koo, Minok Park, Zacharias Vangelatos, Plansky Hoang, Bruce R. Conklin, Costas P. Grigoropoulos, Kevin E. Healy, Zhen Ma

Maladaptive Contractility of 3D Human Cardiac Microtissues to Mechanical Nonuniformity.

Advanced Healthcare Materials

Wang C, Koo S, Park M, Vangelatos Z, Hoang P, Conklin BR, Grigoropoulos CP, Healy KE, Ma Z

Automated Design of Pluripotent Stem Cell Self-Organization.

Cell systems

Libby ARG, Briers D, Haghighi I, Joy DA, Conklin BR, Belta C, McDevitt TC

AlleleAnalyzer: a tool for personalized and allele-specific sgRNA design.

Genome biology

Keough KC, Lyalina S, Olvera MP, Whalen S, Conklin BR, Pollard KS

Abstract 934: Physical and Genetic Interaction Analyses in Human Pluripotent Stem Cell-Derived Cardiomyocytes to Study Protein Quality Control Disease in the Heart.

Circulation research

Juan A Perez-Bermejo, Luke M Judge, Kenneth Wu, Christina L Jensen, Robyn M Kaake, Danielle Swaney, Po-Lin So, Nevan J Krogan, Bruce R Conklin

Phenotype-Based High-Throughput Classification of Long QT Syndrome Subtypes Using Human Induced Pluripotent Stem Cells.

Stem cell reports

Yoshinaga D, Baba S, Makiyama T, Shibata H, Hirata T, Akagi K, Matsuda K, Kohjitani H, Wuriyanghai Y, Umeda K, Yamamoto Y, Conklin BR, Horie M, Takita J, Heike T

Mapping cis-regulatory chromatin contacts in neural cells links neuropsychiatric disorder risk variants to target genes.

Nature genetics

Song M, Yang X, Ren X, Maliskova L, Li B, Jones IR, Wang C, Jacob F, Wu K, Traglia M, Tam TW, Jamieson K, Lu SY, Ming GL, Li Y, Yao J, Weiss LA, Dixon JR, Judge LM, Conklin BR, Song H, Gan L, Shen Y

A NOVEL ROLE FOR THE FTD-CAUSING PROTEIN PROGRANULIN IN APOPTOSIS SIGNALING.

Alzheimer's & Dementia

Claire Clelland, J. Iker Etchegaray, Lay Kodama, Faten Sayed, Aradhana Sachdev, Yaqiao Li, David Le, Lihong Zhan, Yungui Zhou, Duc Duong, Nicholas T. Seyfried, Thomas G. Kukar, Li Xuan Tan, Aparna Lakkaraju, Bruce Conklin, Li Gan

Unbiased detection of CRISPR off-targets in vivo using DISCOVER-Seq.

Science (New York, N.Y.)

Wienert B, Wyman SK, Richardson CD, Yeh CD, Akcakaya P, Porritt MJ, Morlock M, Vu JT, Kazane KR, Watry HL, Judge LM, Conklin BR, Maresca M, Corn JE

MESP1 knock-down in human iPSC attenuates early vascular progenitor cell differentiation after completed primitive streak specification.

Developmental biology

Eskildsen TV, Ayoubi S, Thomassen M, Burton M, Mandegar MA, Conklin BR, Jensen CH, Andersen DC, Sheikh SP

Spatiotemporal mosaic self-patterning of pluripotent stem cells using CRISPR interference.

eLife

Libby AR, Joy DA, So PL, Mandegar MA, Muncie JM, Mendoza-Camacho FN, Weaver VM, Conklin BR, McDevitt TC

Contractile deficits in engineered cardiac microtissues as a result of MYBPC3 deficiency and mechanical overload.

Nature biomedical engineering

Ma Z, Huebsch N, Koo S, Mandegar MA, Siemons B, Boggess S, Conklin BR, Grigoropoulos CP, Healy KE

Quantitatively characterizing drug-induced arrhythmic contractile motions of human stem cell-derived cardiomyocytes.

Biotechnology and bioengineering

Hoang P, Huebsch N, Bang SH, Siemons BA, Conklin BR, Healy KE, Ma Z, Jacquir S

Quantitatively Characterizing Drug-Induced Arrhythmic Contractile Motions of Human Stem Cell-Derived Cardiomyocytes.

Biotechnology and bioengineering

Plansky Hoang, Nathaniel Huebsch, Shin Hyuk Bang, Brian A. Siemons, Bruce R. Conklin, Kevin E. Healy, Zhen Ma, Sabir Jacquir

Detection and Quantification of HDR and NHEJ Induced by Genome Editing at Endogenous Gene Loci Using Droplet Digital PCR.

Methods in molecular biology (Clifton, N.J.)

Miyaoka Y, Mayerl SJ, Chan AH, Conklin BR

TMOD-09. HUMAN PLURIPOTENT STEM CELL-BASED MODELS OF NEUROBLASTOMA.

Neuro-Oncology

Miller Huang, Tina Zheng, Jeffrey Guo, Colin Sperring, Matthew Miller, Lauren McHenry, Qiqi Zhen, Branden Moriarity, Marianne Bronner, Bruce Conklin, David Largaespada, John Maris, Katherine Matthay, William Weiss

A BAG3 chaperone complex maintains cardiomyocyte function during proteotoxic stress.

JCI insight

Judge LM, Perez-Bermejo JA, Truong A, Ribeiro AJ, Yoo JC, Jensen CL, Mandegar MA, Huebsch N, Kaake RM, So PL, Srivastava D, Pruitt BL, Krogan NJ, Conklin BR

Multi-Imaging Method to Assay the Contractile Mechanical Output of Micropatterned Human iPSC-Derived Cardiac Myocytes.

Circulation research

Ribeiro AJS, Schwab O, Mandegar MA, Ang YS, Conklin BR, Srivastava D, Pruitt BL

CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells.

Science (New York, N.Y.)

Liu SJ, Horlbeck MA, Cho SW, Birk HS, Malatesta M, He D, Attenello FJ, Villalta JE, Cho MY, Chen Y, Mandegar MA, Olvera MP, Gilbert LA, Conklin BR, Chang HY, Weissman JS, Lim DA

Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system.

Nature medicine

Workman MJ, Mahe MM, Trisno S, Poling HM, Watson CL, Sundaram N, Chang CF, Schiesser J, Aubert P, Stanley EG, Elefanty AG, Miyaoka Y, Mandegar MA, Conklin BR, Neunlist M, Brugmann SA, Helmrath MA, Wells JM

GENT-49. SYSTEMATIC IDENTIFICATION OF ESSENTIAL LONG NON-CODING RNA GENES IN GLIOBLASTOMA.

Neuro-Oncology

Siyuan Liu, Max Horlbeck, Seung Woo Cho, Harjus Birk, Martina Malatesta, Daniel He, Jacqueline Villalta, Min Cho, Yuwen Chen, Mohammad Mandegar, Michael Olvera, Bruce Conklin, Howard Chang, Jonathan Weissman, Daniel Lim

BMP-SMAD-ID promotes reprogramming to pluripotency by inhibiting p16/INK4A-dependent senescence.

Proceedings of the National Academy of Sciences of the United States of America

Hayashi Y, Hsiao EC, Sami S, Lancero M, Schlieve CR, Nguyen T, Yano K, Nagahashi A, Ikeya M, Matsumoto Y, Nishimura K, Fukuda A, Hisatake K, Tomoda K, Asaka I, Toguchida J, Conklin BR, Yamanaka S

Organs-on-a-chip – Microphysiological platforms as in vitro models of cardiac and adipose tissue.

Toxicology Letters

P. Loskill, A. Mathur, B.R. Conklin, A. Stahl, L.P. Lee, K.E. Healy

Detecting Single-Nucleotide Substitutions Induced by Genome Editing.

Cold Spring Harbor protocols

Miyaoka Y, Chan AH, Conklin BR

Ligand-binding domains of nuclear receptors facilitate tight control of split CRISPR activity.

Nature communications

Nguyen DP, Miyaoka Y, Gilbert LA, Mayerl SJ, Lee BH, Weissman JS, Conklin BR, Wells JA

Miniaturized iPS-Cell-Derived Cardiac Muscles for Physiologically Relevant Drug Response Analyses.

Scientific reports

Huebsch N, Loskill P, Deveshwar N, Spencer CI, Judge LM, Mandegar MA, Fox CB, Mohamed TM, Ma Z, Mathur A, Sheehan AM, Truong A, Saxton M, Yoo J, Srivastava D, Desai TA, So PL, Healy KE, Conklin BR

Systematic quantification of HDR and NHEJ reveals effects of locus, nuclease, and cell type on genome-editing.

Scientific reports

Miyaoka Y, Berman JR, Cooper SB, Mayerl SJ, Chan AH, Zhang B, Karlin-Neumann GA, Conklin BR

CRISPR Interference Efficiently Induces Specific and Reversible Gene Silencing in Human iPSCs.

Cell stem cell

Mandegar MA, Huebsch N, Frolov EB, Shin E, Truong A, Olvera MP, Chan AH, Miyaoka Y, Holmes K, Spencer CI, Judge LM, Gordon DE, Eskildsen TV, Villalta JE, Horlbeck MA, Gilbert LA, Krogan NJ, Sheikh SP, Weissman JS, Qi LS, So PL, Conklin BR

Generating trunk neural crest from human pluripotent stem cells.

Scientific reports

Huang M, Miller ML, McHenry LK, Zheng T, Zhen Q, Ilkhanizadeh S, Conklin BR, Bronner ME, Weiss WA

Efficient CRISPR/Cas9-Based Genome Engineering in Human Pluripotent Stem Cells.

Current protocols in human genetics

Kime C, Mandegar MA, Srivastava D, Yamanaka S, Conklin BR, Rand TA

Abstract 3230: Human stem cell-based model of MYCN-driven neuroblastoma.

Tumor Biology

Miller Huang, Lauren K. McHenry, Matthew L. Miller, Grace E. Kim, Branden S. Moriarity, Yuichiro Miyaoka, Marianne E. Bronner, David A. Largaespada, Bruce R. Conklin, Hanlee P. Ji, John M. Maris, Katherine K. Matthay, William A. Weiss

Self-organizing human cardiac microchambers mediated by geometric confinement.

Nature communications

Ma Z, Wang J, Loskill P, Huebsch N, Koo S, Svedlund FL, Marks NC, Hua EW, Grigoropoulos CP, Conklin BR, Healy KE

Dysregulation of locus coeruleus development in congenital central hypoventilation syndrome.

Acta neuropathologica

Nobuta H, Cilio MR, Danhaive O, Tsai HH, Tupal S, Chang SM, Murnen A, Kreitzer F, Bravo V, Czeisler C, Gokozan HN, Gygli P, Bush S, Weese-Mayer DE, Conklin B, Yee SP, Huang EJ, Gray PA, Rowitch D, Otero JJ

Loss of Gi G-Protein-Coupled Receptor Signaling in Osteoblasts Accelerates Bone Fracture Healing.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Wang L, Hsiao EC, Lieu S, Scott M, O'Carroll D, Urrutia A, Conklin BR, Colnot C, Nissenson RA

Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells.

Proceedings of the National Academy of Sciences of the United States of America

Hayashi Y, Caboni L, Das D, Yumoto F, Clayton T, Deller MC, Nguyen P, Farr CL, Chiu HJ, Miller MD, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Tomoda K, Conklin BR, Wilson IA, Yamanaka S, Fletterick RJ

A non-invasive platform for functional characterization of stem-cell-derived cardiomyocytes with applications in cardiotoxicity testing.

Stem cell reports

Maddah M, Heidmann JD, Mandegar MA, Walker CD, Bolouki S, Conklin BR, Loewke KE

Human iPSC-based cardiac microphysiological system for drug screening applications.

Scientific reports

Mathur A, Loskill P, Shao K, Huebsch N, Hong S, Marcus SG, Marks N, Mandegar M, Conklin BR, Lee LP, Healy KE

Assessing the osteoblast transcriptome in a model of enhanced bone formation due to constitutive Gs-G protein signaling in osteoblasts.

Experimental cell research

Wattanachanya L, Wang L, Millard SM, Lu WD, O'Carroll D, Hsiao EC, Conklin BR, Nissenson RA

Gαi/o-coupled receptor signaling restricts pancreatic β-cell expansion.

Proceedings of the National Academy of Sciences of the United States of America

Berger M, Scheel DW, Macias H, Miyatsuka T, Kim H, Hoang P, Ku GM, Honig G, Liou A, Tang Y, Regard JB, Sharifnia P, Yu L, Wang J, Coughlin SR, Conklin BR, Deneris ES, Tecott LH, German MS

Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory.

Nature neuroscience

Orr AG, Hsiao EC, Wang MM, Ho K, Kim DH, Wang X, Guo W, Kang J, Yu GQ, Adame A, Devidze N, Dubal DB, Masliah E, Conklin BR, Mucke L

Automated Video-Based Analysis of Contractility and Calcium Flux in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Cultured over Different Spatial Scales.

Tissue engineering. Part C, Methods

Huebsch N, Loskill P, Mandegar MA, Marks NC, Sheehan AS, Ma Z, Mathur A, Nguyen TN, Yoo JC, Judge LM, Spencer CI, Chukka AC, Russell CR, So PL, Conklin BR, Healy KE

Calcium transients closely reflect prolonged action potentials in iPSC models of inherited cardiac arrhythmia.

Stem cell reports

Spencer CI, Baba S, Nakamura K, Hua EA, Sears MA, Fu CC, Zhang J, Balijepalli S, Tomoda K, Hayashi Y, Lizarraga P, Wojciak J, Scheinman MM, Aalto-Setälä K, Makielski JC, January CT, Healy KE, Kamp TJ, Yamanaka S, Conklin BR

Synthetic control of mammalian-cell motility by engineering chemotaxis to an orthogonal bioinert chemical signal.

Proceedings of the National Academy of Sciences of the United States of America

Park JS, Rhau B, Hermann A, McNally KA, Zhou C, Gong D, Weiner OD, Conklin BR, Onuffer J, Lim WA

Isolation of single-base genome-edited human iPS cells without antibiotic selection.

Nature methods

Miyaoka Y, Chan AH, Judge LM, Yoo J, Huang M, Nguyen TD, Lizarraga PP, So PL, Conklin BR

Human induced pluripotent stem cell-based microphysiological tissue models of myocardium and liver for drug development.

Stem cell research & therapy

Mathur A, Loskill P, Hong S, Lee J, Marcus SG, Dumont L, Conklin BR, Willenbring H, Lee LP, Healy KE

Induced pluripotent stem cells from patients with human fibrodysplasia ossificans progressiva show increased mineralization and cartilage formation.

Orphanet journal of rare diseases

Matsumoto Y, Hayashi Y, Schlieve CR, Ikeya M, Kim H, Nguyen TD, Sami S, Baba S, Barruet E, Nasu A, Asaka I, Otsuka T, Yamanaka S, Conklin BR, Toguchida J, Hsiao EC

Three-dimensional filamentous human diseased cardiac tissue model.

Biomaterials

Ma Z, Koo S, Finnegan MA, Loskill P, Huebsch N, Marks NC, Conklin BR, Grigoropoulos CP, Healy KE

The C-terminus of the long AKAP13 isoform (AKAP-Lbc) is critical for development of compensatory cardiac hypertrophy.

Journal of molecular and cellular cardiology

Taglieri DM, Johnson KR, Burmeister BT, Monasky MM, Spindler MJ, DeSantiago J, Banach K, Conklin BR, Carnegie GK

A robust method to derive functional neural crest cells from human pluripotent stem cells.

American journal of stem cells

Kreitzer FR, Salomonis N, Sheehan A, Huang M, Park JS, Spindler MJ, Lizarraga P, Weiss WA, So PL, Conklin BR

AKAP13 Rho-GEF and PKD-binding domain deficient mice develop normally but have an abnormal response to β-adrenergic-induced cardiac hypertrophy.

PloS one

Spindler MJ, Burmeister BT, Huang Y, Hsiao EC, Salomonis N, Scott MJ, Srivastava D, Carnegie GK, Conklin BR

Structure of a novel winged-helix like domain from human NFRKB protein.

PloS one

Kumar A, Möcklinghoff S, Yumoto F, Jaroszewski L, Farr CL, Grzechnik A, Nguyen P, Weichenberger CX, Chiu HJ, Klock HE, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Conklin BR, Fletterick RJ, Wilson IA

Derivation conditions impact X-inactivation status in female human induced pluripotent stem cells.

Cell stem cell

Tomoda K, Takahashi K, Leung K, Okada A, Narita M, Yamada NA, Eilertson KE, Tsang P, Baba S, White MP, Sami S, Srivastava D, Conklin BR, Panning B, Yamanaka S

GO-Elite: a flexible solution for pathway and ontology over-representation.

Bioinformatics (Oxford, England)

Zambon AC, Gaj S, Ho I, Hanspers K, Vranizan K, Evelo CT, Conklin BR, Pico AR, Salomonis N

WikiPathways: building research communities on biological pathways.

Nucleic Acids Research

Kelder T, van Iersel MP, Hanspers K, Kutmon M, Conklin BR, Evelo CT, Pico AR

Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture.

Disease models & mechanisms

Lahti AL, Kujala VJ, Chapman H, Koivisto AP, Pekkanen-Mattila M, Kerkelä E, Hyttinen J, Kontula K, Swan H, Conklin BR, Yamanaka S, Silvennoinen O, Aalto-Setälä K

Mineral composition is altered by osteoblast expression of an engineered G(s)-coupled receptor.

Calcified tissue international

Kazakia GJ, Speer D, Shanbhag S, Majumdar S, Conklin BR, Nissenson RA, Hsiao EC

Blockade of receptor-activated G(i) signaling in osteoblasts in vivo leads to site-specific increases in cortical and cancellous bone formation.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Millard SM, Louie AM, Wattanachanya L, Wronski TJ, Conklin BR, Nissenson RA

Constitutive Gs activation using a single-construct tetracycline-inducible expression system in embryonic stem cells and mice.

Stem cell research & therapy

Hsiao EC, Nguyen TD, Ng JK, Scott MJ, Chang WC, Zahed H, Conklin BR

Stem cell pluripotency: alternative modes of transcription regulation.

Cell cycle (Georgetown, Tex.)

Salomonis N, Conklin BR

AltAnalyze and DomainGraph: analyzing and visualizing exon expression data.

Nucleic Acids Research

Emig D, Salomonis N, Baumbach J, Lengauer T, Conklin BR, Albrecht M

Alternative splicing regulates mouse embryonic stem cell pluripotency and differentiation.

Proceedings of the National Academy of Sciences of the United States of America

Salomonis N, Schlieve CR, Pereira L, Wahlquist C, Colas A, Zambon AC, Vranizan K, Spindler MJ, Pico AR, Cline MS, Clark TA, Williams A, Blume JE, Samal E, Mercola M, Merrill BJ, Conklin BR

Gs G protein-coupled receptor signaling in osteoblasts elicits age-dependent effects on bone formation.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Hsiao EC, Boudignon BM, Halloran BP, Nissenson RA, Conklin BR

Ligand-mediated activation of an engineered gs g protein-coupled receptor in osteoblasts increases trabecular bone formation.

Molecular endocrinology (Baltimore, Md.)

Hsiao EC, Millard SM, Louie A, Huang Y, Conklin BR, Nissenson RA

Cloning mice and men: prohibiting the use of iPS cells for human reproductive cloning.

Cell stem cell

Lo B, Parham L, Alvarez-Buylla A, Cedars M, Conklin B, Fisher S, Gates E, Giudice L, Halme DG, Hershon W, Kriegstein A, Kwok PY, Wagner R

The BridgeDb framework: standardized access to gene, protein and metabolite identifier mapping services.

BMC bioinformatics

van Iersel MP, Pico AR, Kelder T, Gao J, Ho I, Hanspers K, Conklin BR, Evelo CT

G(i)-coupled GPCR signaling controls the formation and organization of human pluripotent colonies.

PloS one

Nakamura K, Salomonis N, Tomoda K, Yamanaka S, Conklin BR

Alternative splicing in the differentiation of human embryonic stem cells into cardiac precursors.

PLoS computational biology

Salomonis N, Nelson B, Vranizan K, Pico AR, Hanspers K, Kuchinsky A, Ta L, Mercola M, Conklin BR

Mining biological pathways using WikiPathways web services.

PloS one

Kelder T, Pico AR, Hanspers K, van Iersel MP, Evelo C, Conklin BR

AKAP10 (I646V) functional polymorphism predicts heart rate and heart rate variability in apparently healthy, middle-aged European-Americans.

Psychophysiology

Neumann SA, Tingley WG, Conklin BR, Shrader CJ, Peet E, Muldoon MF, Jennings JR, Ferrell RE, Manuck SB

Endogenous Gi signaling in osteoblasts participates in sexually dimorphic regulation of cancellous bone structure.

Bone

S. Millard, A. Louie, C. Manalac, W. Lu, N. Cotte, T.J. Wronski, B. Conklin, R.A. Nissenson

Lentiviral vectors and protocols for creation of stable hESC lines for fluorescent tracking and drug resistance selection of cardiomyocytes.

PloS one

Kita-Matsuo H, Barcova M, Prigozhina N, Salomonis N, Wei K, Jacot JG, Nelson B, Spiering S, Haverslag R, Kim C, Talantova M, Bajpai R, Calzolari D, Terskikh A, McCulloch AD, Price JH, Conklin BR, Chen HS, Mercola M

SNPLogic: an interactive single nucleotide polymorphism selection, annotation, and prioritization system.

Nucleic Acids Research

Pico AR, Smirnov IV, Chang JS, Yeh RF, Wiemels JL, Wiencke JK, Tihan T, Conklin BR, Wrensch M

Presenting and exploring biological pathways with PathVisio.

BMC bioinformatics

van Iersel MP, Kelder T, Pico AR, Hanspers K, Coort S, Conklin BR, Evelo C

Engineering GPCR signaling pathways with RASSLs.

Nature methods

Conklin BR, Hsiao EC, Claeysen S, Dumuis A, Srinivasan S, Forsayeth JR, Guettier JM, Chang WC, Pei Y, McCarthy KD, Nissenson RA, Wess J, Bockaert J, Roth BL

WikiPathways: pathway editing for the people.

PLoS biology

Pico AR, Kelder T, van Iersel MP, Hanspers K, Conklin BR, Evelo C

Marking embryonic stem cells with a 2A self-cleaving peptide: a NKX2-5 emerald GFP BAC reporter.

PloS one

Hsiao EC, Yoshinaga Y, Nguyen TD, Musone SL, Kim JE, Swinton P, Espineda I, Manalac C, deJong PJ, Conklin BR

An Introduction to Pathway Analysis with GenMAPP.

NCI Nature Pathway Interaction Database

Kristina Hanspers, Alexander R. Pico, Nathan Salomonis, Alexander C. Zambon, Karen Vranizan, Steven C. Lawlor, Kam D. Dahlquist, Scott W. Doniger, Bruce R. Conklin

MicroRNA regulation of cell lineages in mouse and human embryonic stem cells.

Cell stem cell

Ivey KN, Muth A, Arnold J, King FW, Yeh RF, Fish JE, Hsiao EC, Schwartz RJ, Conklin BR, Bernstein HS, Srivastava D

Comparative analysis of wild-type and cAMP-deathless S49 lymphoma cells identifies genes and pathways of cAMP/PKA-promoted apoptosis.

The FASEB Journal

Lingzhi Zhang, Alexander C Zambon, Karen Vranizan, Kanishka Pothula, Bruce R Conklin, Paul A Insel

Osteoblast expression of an engineered Gs-coupled receptor dramatically increases bone mass.

Proceedings of the National Academy of Sciences of the United States of America

Hsiao EC, Boudignon BM, Chang WC, Bencsik M, Peng J, Nguyen TD, Manalac C, Halloran BP, Conklin BR, Nissenson RA

Modifying ligand-induced and constitutive signaling of the human 5-HT4 receptor.

PloS one

Chang WC, Ng JK, Nguyen T, Pellissier L, Claeysen S, Hsiao EC, Conklin BR

Conditional expression of a Gi-coupled receptor in osteoblasts results in trabecular osteopenia.

Endocrinology

Peng J, Bencsik M, Louie A, Lu W, Millard S, Nguyen P, Burghardt A, Majumdar S, Wronski TJ, Halloran B, Conklin BR, Nissenson RA

Modeling insertional mutagenesis using gene length and expression in murine embryonic stem cells.

PloS one

Nord AS, Vranizan K, Tingley W, Zambon AC, Hanspers K, Fong LG, Hu Y, Bacchetti P, Ferrin TE, Babbitt PC, Doniger SW, Skarnes WC, Young SG, Conklin BR

GenMAPP 2: new features and resources for pathway analysis.

BMC bioinformatics

Salomonis N, Hanspers K, Zambon AC, Vranizan K, Lawlor SC, Dahlquist KD, Doniger SW, Stuart J, Conklin BR, Pico AR

Canonical Wnt signaling is a positive regulator of mammalian cardiac progenitors.

Proceedings of the National Academy of Sciences of the United States of America

Kwon C, Arnold J, Hsiao EC, Taketo MM, Conklin BR, Srivastava D

Interfacing silicon nanowires with mammalian cells.

Journal of the American Chemical Society

Kim W, Ng JK, Kunitake ME, Conklin BR, Yang P

Gene-trapped mouse embryonic stem cell-derived cardiac myocytes and human genetics implicate AKAP10 in heart rhythm regulation.

Proceedings of the National Academy of Sciences of the United States of America

Tingley WG, Pawlikowska L, Zaroff JG, Kim T, Nguyen T, Young SG, Vranizan K, Kwok PY, Whooley MA, Conklin BR

New tools to build synthetic hormonal pathways.

Proceedings of the National Academy of Sciences of the United States of America

Conklin BR

Development of hydrocephalus in mice expressing the G(i)-coupled GPCR Ro1 RASSL receptor in astrocytes.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Sweger EJ, Casper KB, Scearce-Levie K, Conklin BR, McCarthy KD

Integration of biological networks and gene expression data using Cytoscape.

Nature protocols

Cline MS, Smoot M, Cerami E, Kuchinsky A, Landys N, Workman C, Christmas R, Avila-Campilo I, Creech M, Gross B, Hanspers K, Isserlin R, Kelley R, Killcoyne S, Lotia S, Maere S, Morris J, Ono K, Pavlovic V, Pico AR, Vailaya A, Wang PL, Adler A, Conklin BR, Hood L, Kuiper M, Sander C, Schmulevich I, Schwikowski B, Warner GJ, Ideker T, Bader GD

mGluR2 acts through inhibitory Galpha subunits to regulate transmission and long-term plasticity at hippocampal mossy fiber-CA3 synapses.

Proceedings of the National Academy of Sciences of the United States of America

Nicholls RE, Zhang XL, Bailey CP, Conklin BR, Kandel ER, Stanton PK

A Series of RASSLs Activated by a Single Agonist.

The FASEB Journal

Peter Chang, Edward Hsiao, Alex C Zambon, Bruce R Conklin

The International Gene Trap Consortium Website: a portal to all publicly available gene trap cell lines in mouse.

Nucleic Acids Research

Nord AS, Chang PJ, Conklin BR, Cox AV, Harper CA, Hicks GG, Huang CC, Johns SJ, Kawamoto M, Liu S, Meng EC, Morris JH, Rossant J, Ruiz P, Skarnes WC, Soriano P, Stanford WL, Stryke D, von Melchner H, Wurst W, Yamamura K, Young SG, Babbitt PC, Ferrin TE

Sustained preconditioning induced by cardiac transgenesis with the tetracycline transactivator.

American journal of physiology. Heart and circulatory physiology

Turnbull L, Zhou HZ, Swigart PM, Turcato S, Karliner JS, Conklin BR, Simpson PC, Baker AJ

Gene expression patterns define key transcriptional events in cell-cycle regulation by cAMP and protein kinase A.

Proceedings of the National Academy of Sciences of the United States of America

Zambon AC, Zhang L, Minovitsky S, Kanter JR, Prabhakar S, Salomonis N, Vranizan K, Dubchak I, Conklin BR, Insel PA

Cardiac transgenesis with the tetracycline transactivator changes myocardial function and gene expression.

Physiological genomics

McCloskey DT, Turnbull L, Swigart PM, Zambon AC, Turcato S, Joho S, Grossman W, Conklin BR, Simpson PC, Baker AJ

Identifying genetic networks underlying myometrial transition to labor.

Genome biology

Salomonis N, Cotte N, Zambon AC, Pollard KS, Vranizan K, Doniger SW, Dolganov G, Conklin BR

Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans.

The Journal of clinical investigation

Srinivasan S, Lubrano-Berthelier C, Govaerts C, Picard F, Santiago P, Conklin BR, Vaisse C

A public gene trap resource for mouse functional genomics.

Nature genetics

Skarnes WC, von Melchner H, Wurst W, Hicks G, Nord AS, Cox T, Young SG, Ruiz P, Soriano P, Tessier-Lavigne M, Conklin BR, Stanford WL, Rossant J, International Gene Trap Consortium

Time- and exercise-dependent gene regulation in human skeletal muscle.

Genome biology

Zambon AC, McDearmon EL, Salomonis N, Vranizan KM, Johansen KL, Adey D, Takahashi JS, Schambelan M, Conklin BR

Engineering the melanocortin-4 receptor to control G(s) signaling in vivo.

Annals of the New York Academy of Sciences

Srinivasan S, Vaisse C, Conklin BR

MAPPFinder: using Gene Ontology and GenMAPP to create a global gene-expression profile from microarray data.

Genome biology

Doniger SW, Salomonis N, Dahlquist KD, Vranizan K, Lawlor SC, Conklin BR

Regression approaches for microarray data analysis.

Journal of computational biology : a journal of computational molecular cell biology

Segal MR, Dahlquist KD, Conklin BR

GenMAPP, a new tool for viewing and analyzing microarray data on biological pathways.

Nature genetics

Dahlquist KD, Salomonis N, Vranizan K, Lawlor SC, Conklin BR

Tools for dissecting signaling pathways in vivo: receptors activated solely by synthetic ligands.

Methods in enzymology

Scearce-Levie K, Coward P, Redfern CH, Conklin BR

Engineering receptors activated solely by synthetic ligands (RASSLs).

Trends in pharmacological sciences

Scearce-Levie K, Coward P, Redfern CH, Conklin BR

Abnormal contraction caused by expression of G(i)-coupled receptor in transgenic model of dilated cardiomyopathy.

American journal of physiology. Heart and circulatory physiology

Baker AJ, Redfern CH, Harwood MD, Simpson PC, Conklin BR

Tetracycline-inducible system for photoreceptor-specific gene expression.

Investigative ophthalmology & visual science

Chang MA, Horner JW, Conklin BR, DePinho RA, Bok D, Zack DJ

Conditional expression of a Gi-coupled receptor causes ventricular conduction delay and a lethal cardiomyopathy.

Proceedings of the National Academy of Sciences of the United States of America

Redfern CH, Degtyarev MY, Kwa AT, Salomonis N, Cotte N, Nanevicz T, Fidelman N, Desai K, Vranizan K, Lee EK, Coward P, Shah N, Warrington JA, Fishman GI, Bernstein D, Baker AJ, Conklin BR

A critical period of vulnerability to hyperactive Gq signaling revealed by inducible and heart-specific expression of Gq* in transgenic mice.

Journal of Cardiac Failure

Nathalie Cotte, Charles H. Redfern, Peter Mikus, Nathan Salomonis, Michael Y. Degtyarev, Peter S. Coward, Andrew Kwa, Tetsuo Shioi, Nila Shah, Tim McKinsey, Eric Olson, Seigo Izumo, Janet Warrington, Anthony J. Baker, Bruce R. Conklin

Genomic analysis of an inducible and reversible model of dilated cardiomyopathy.

Journal of Cardiac Failure

Charles H. Redfern, Michael Y. Degtyarev, Kavin Desai, Andrew Kwa, Glenn I. Fishman, Daniel Bernstein, Anthony J. Baker, Bruce R. Conklin

Chimeric G proteins allow a high-throughput signaling assay of Gi-coupled receptors.

Analytical biochemistry

Coward P, Chan SD, Wada HG, Humphries GM, Conklin BR

Conditional expression and signaling of a specifically designed Gi-coupled receptor in transgenic mice.

Nature biotechnology

Redfern CH, Coward P, Degtyarev MY, Lee EK, Kwa AT, Hennighausen L, Bujard H, Fishman GI, Conklin BR

Controlling signaling with a specifically designed Gi-coupled receptor.

Proceedings of the National Academy of Sciences of the United States of America

Coward P, Wada HG, Falk MS, Chan SD, Meng F, Akil H, Conklin BR

The N-terminal extension of Galphaq is critical for constraining the selectivity of receptor coupling.

The Journal of biological chemistry

Kostenis E, Degtyarev MY, Conklin BR, Wess J

Interactions of muscarinic receptors with the heterotrimeric G proteins Gq and G12: transduction of proliferative signals.

Journal of neurochemistry

Burstein ES, Bräuner-Osborne H, Spalding TA, Conklin BR, Brann MR

Carboxyl-terminal mutations of Gq alpha and Gs alpha that alter the fidelity of receptor activation.

Molecular pharmacology

Conklin BR, Herzmark P, Ishida S, Voyno-Yasenetskaya TA, Sun Y, Farfel Z, Bourne HR

Identification of a receptor/G-protein contact site critical for signaling specificity and G-protein activation.

Proceedings of the National Academy of Sciences of the United States of America

Liu J, Conklin BR, Blin N, Yun J, Wess J

G alpha 13 stimulates Na-H exchange.

The Journal of biological chemistry

Voyno-Yasenetskaya T, Conklin BR, Gilbert RL, Hooley R, Bourne HR, Barber DL

Mouse coat colour reconsidered.

Nature

Conklin BR, Bourne HR

Type II adenylylcyclase integrates coincident signals from Gs, Gi, and Gq.

The Journal of biological chemistry

Lustig KD, Conklin BR, Herzmark P, Taussig R, Bourne HR

A recombinant calcitonin receptor independently stimulates 3',5'-cyclic adenosine monophosphate and Ca2+/inositol phosphate signaling pathways.

Molecular endocrinology (Baltimore, Md.)

Chabre O, Conklin BR, Lin HY, Lodish HF, Wilson E, Ives HE, Catanzariti L, Hemmings BA, Bourne HR

Hormonal stimulation of adenylyl cyclase through Gi-protein beta gamma subunits.

Nature

Federman AD, Conklin BR, Schrader KA, Reed RR, Bourne HR

Gz-mediated hormonal inhibition of cyclic AMP accumulation.

Science (New York, N.Y.)

Wong YH, Conklin BR, Bourne HR

Recombinant Gq alpha. Mutational activation and coupling to receptors and phospholipase C.

The Journal of biological chemistry

Conklin BR, Chabre O, Wong YH, Federman AD, Bourne HR

Detection of coincident signals by G proteins and adenylyl cyclase.

Cold Spring Harbor symposia on quantitative biology

Bourne HR, Lustig KD, Wong YH, Conklin BR

Stimulation of arachidonic acid release and inhibition of mitogenesis by cloned genes for muscarinic receptor subtypes stably expressed in A9 L cells.

Proceedings of the National Academy of Sciences of the United States of America

Conklin BR, Brann MR, Buckley NJ, Ma AL, Bonner TI, Axelrod J

Distinct bradykinin receptors mediate stimulation of prostaglandin synthesis by endothelial cells and fibroblasts.

The Journal of pharmacology and experimental therapeutics

Conklin BR, Burch RM, Steranka LR, Axelrod J

Faculty Type: 
Affiliate Faculty