
Professor
M_CMP (Cellular Molecular Pha)
Email
+1 415 476-3401
Websites
Faculty Type
Affiliate Faculty
Research Interests: Summary: Our research is focused on development of endocrine and brain regions that contribute to energy balance and reproduction. We concentrate on NR5A nuclear hormone receptors that specify cell fate in developing endocrine organs and the hypothalamus using structural biology, biochemistry and physiology.
Publications
A Cellular Basis for Heightened Gut Sensitivity in Females.
bioRxiv : the preprint server for biology
Brain-Derived CCN3 Is An Osteoanabolic Hormone That Sustains Bone in Lactating Females.
bioRxiv : the preprint server for biology
Holly Ingraham.
Neuron
An evolutionary trade-off between host immunity and metabolism drives fatty liver in male mice.
Science (New York, N.Y.)
Running the Female Power Grid Across Lifespan Through Brain Estrogen Signaling.
Annual review of physiology
Chronic Stimulation of Arcuate Kiss1 Neurons Decreases Bone Mass in Female Mice.
Journal of the Endocrine Society
SPARC - Mapping Gut-Spinal Cord Connections in Visceral Pain.
The FASEB Journal
Should We Make More Bone or Not, As Told by Kisspeptin Neurons in the Arcuate Nucleus.
Seminars in reproductive medicine
948 – Nuclear Receptor Liver Receptor Homolog-1 Promotes Intestinal Notch Signaling and Enteroendocrine Cell Development.
Gastroenterology
Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones.
Nature communications
LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival.
Nature communications
273 - Nuclear Receptor LRH-1 Mitigates Intestinal Inflammatory Disease by Promoting Stem Cell Survival and Directing Normal Epithelial Composition.
Gastroenterology
Timing of adrenal regression controlled by synergistic interaction between Sf1 SUMOylation and Dax1.
Development (Cambridge, England)
Origins and Functions of the Ventrolateral VMH: A Complex Neuronal Cluster Orchestrating Sex Differences in Metabolism and Behavior.
Advances in experimental medicine and biology
Structure of Liver Receptor Homolog-1 (NR5A2) with PIP3 hormone bound in the ligand binding pocket.
Journal of structural biology
Sex-dependent changes in metabolism and behavior, as well as reduced anxiety after eliminating ventromedial hypothalamus excitatory output.
Molecular metabolism
The Signaling Phospholipid PIP3 Functions As a Ligand Hormone For Nuclear Receptors.
The FASEB Journal
An estrogen-responsive module in the ventromedial hypothalamus selectively drives sex-specific activity in females.
Cell reports
The signaling phospholipid PIP3 creates a new interaction surface on the nuclear receptor SF-1.
Proceedings of the National Academy of Sciences of the United States of America
Genetic labeling of steroidogenic factor-1 (SF-1) neurons in mice reveals ventromedial nucleus of the hypothalamus (VMH) circuitry beginning at neurogenesis and development of a separate non-SF-1 neuronal cluster in the ventrolateral VMH.
The Journal of comparative neurology
Direct modification and activation of a nuclear receptor-PIP₂ complex by the inositol lipid kinase IPMK.
Science signaling
Science Signaling Podcast: 19 June 2012.
Science signaling
An affective disorder in zebrafish with mutation of the glucocorticoid receptor.
Molecular psychiatry
Eliminating SF-1 (NR5A1) sumoylation in vivo results in ectopic hedgehog signaling and disruption of endocrine development.
Developmental cell
Demasculinization and feminization of male gonads by atrazine: consistent effects across vertebrate classes.
The Journal of steroid biochemistry and molecular biology
Small molecule agonists of the orphan nuclear receptors steroidogenic factor-1 (SF-1, NR5A1) and liver receptor homologue-1 (LRH-1, NR5A2).
Journal of medicinal chemistry
Hypothalamic Fetal Programming of Energy Homeostasis.
Obesity Before Birth
Molecular pathways controlling development of thalamus and hypothalamus: from neural specification to circuit formation.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Regulation of C. elegans fat uptake and storage by acyl-CoA synthase-3 is dependent on NR5A family nuclear hormone receptor nhr-25.
Cell metabolism
Neuroendocrine transcriptional programs adapt dynamically to the supply and demand for neuropeptides as revealed in NSF mutant zebrafish.
Neural development
Stimulating the GPR30 estrogen receptor with a novel tamoxifen analogue activates SF-1 and promotes endometrial cell proliferation.
Cancer research
The structure of corepressor Dax-1 bound to its target nuclear receptor LRH-1.
Proceedings of the National Academy of Sciences of the United States of America
Structure of SF-1 bound by different phospholipids: evidence for regulatory ligands.
Molecular endocrinology (Baltimore, Md.)
Decreased recognition of SUMO-sensitive target genes following modification of SF-1 (NR5A1).
Molecular and Cellular Biology
Nuclear Receptors, Chemistry of.
Wiley Encyclopedia of Chemical Biology
The neonatal ventromedial hypothalamus transcriptome reveals novel markers with spatially distinct patterning.
The Journal of neuroscience : the official journal of the Society for Neuroscience
International Union of Pharmacology. LXVI. Orphan nuclear receptors.
Pharmacological reviews
Diminished hypothalamic bdnf expression and impaired VMH function are associated with reduced SF-1 gene dosage.
The Journal of comparative neurology
Orphan nuclear receptors adopted by crystallography.
Current opinion in structural biology
The DEAD-box protein DP103 (Ddx20 or Gemin-3) represses orphan nuclear receptor activity via SUMO modification.
Molecular and Cellular Biology
Differential requirement for steroidogenic factor-1 gene dosage in adrenal development versus endocrine function.
Molecular endocrinology (Baltimore, Md.)
128 UPREGULATION OF WNT4 DISRUPTS TESTICULAR VASCULOGENESIS AND INHIBITS TESTOSTERONE SYNTHESIS.
Journal of Investigative Medicine
UPREGULATION OF WNT4 DISRUPTS TESTICULAR VASCULOGENESIS AND INHIBITS TESTOSTERONE SYNTHESIS.: 128.
Journal of Investigative Medicine
Wnt4 overexpression disrupts normal testicular vasculature and inhibits testosterone synthesis by repressing steroidogenic factor 1/beta-catenin synergy.
Proceedings of the National Academy of Sciences of the United States of America
Steroidogenic factor-1 and the gonadotrope-specific element enhance basal and pituitary adenylate cyclase-activating polypeptide-stimulated transcription of the human glycoprotein hormone alpha-subunit gene in gonadotropes.
Molecular endocrinology (Baltimore, Md.)
Structural basis for ligand-independent activation of the orphan nuclear receptor LRH-1.
Molecular cell
Tissue growth and remodeling of the embryonic and adult adrenal gland.
Annals of the New York Academy of Sciences
Requirement of the orphan nuclear receptor SF-1 in terminal differentiation of ventromedial hypothalamic neurons.
Molecular and cellular neurosciences
Thyroid hormone receptor-beta mutations conferring hormone resistance and reduced corepressor release exhibit decreased stability in the N-terminal ligand-binding domain.
Molecular endocrinology (Baltimore, Md.)
Phosphorylation and intramolecular stabilization of the ligand binding domain in the nuclear receptor steroidogenic factor 1.
Molecular and Cellular Biology
Anti-Müllerian Hormone Inhibits Initiation of Primordial Follicle Growth in the Mouse Ovary.
Endocrinology
Anti-Müllerian hormone inhibits initiation of primordial follicle growth in the mouse ovary.
Endocrinology
Involvement of a matrix metalloproteinase in MIS-induced cell death during urogenital development.
Development (Cambridge, England)
Regulation of the orphan nuclear receptor steroidogenic factor 1 by Sox proteins.
Molecular endocrinology (Baltimore, Md.)
The serine/threonine transmembrane receptor ALK2 mediates Müllerian inhibiting substance signaling.
Molecular endocrinology (Baltimore, Md.)
Müllerian inhibitory substance induces growth of rat preantral ovarian follicles.
Biology of reproduction
Upregulation of Wnt4 Disrupts Testicular Vasculogenesis and Inhibits Testosterone Synthesis.
Journal of Investigative Medicine
Haploinsufficiency of steroidogenic factor-1 in mice disrupts adrenal development leading to an impaired stress response.
Proceedings of the National Academy of Sciences of the United States of America
Gene dosage effects of steroidogenic factor 1 (SF-1) in adrenal development and the stress.
Endocrine research
SF-1 and DAX-1: A Dynamic Duo in Endocrine Development Mark W. Nachtigal,.
Gene Engineering in Endocrinology
Autocrine and paracrine Müllerian inhibiting substance hormone signaling in reproduction.
Recent progress in hormone research
SF-1 and DAX-1.
Gene Engineering in Endocrinology
New solutions to an ancient riddle: defining the differences between Adam and Eve.
American journal of human genetics
Steroidogenic factor-1: its role in endocrine organ development and differentiation.
Frontiers in neuroendocrinology
Paracrine-mediated apoptosis in reproductive tract development.
Developmental biology
Neuronal expression of the 5HT3 serotonin receptor gene requires nuclear factor 1 complexes.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Wilms' tumor 1 and Dax-1 modulate the orphan nuclear receptor SF-1 in sex-specific gene expression.
Cell
The nuclear receptor SF-1 mediates sexually dimorphic expression of Mullerian Inhibiting Substance, in vivo.
Development (Cambridge, England)
Bioactivation of Müllerian inhibiting substance during gonadal development by a kex2/subtilisin-like endoprotease.
Proceedings of the National Academy of Sciences of the United States of America
Molecular biology of pituitary development and disease.
Hormone research
The nuclear receptor steroidogenic factor 1 acts at multiple levels of the reproductive axis.
Genes & development
Developmental expression of mouse steroidogenic factor-1, an essential regulator of the steroid hydroxylases.
Molecular endocrinology (Baltimore, Md.)
PIT-1 AND ITS NATURALLY OCCURRING GENETIC MUTATIONS; ANSWERS AND QUESTIONS ABOUT THE MOLECULAR BIOLOGY OF PITUITARY DEVELOPMENT AND DISEASE.
Pediatric research
Mutation of the POU-specific domain of Pit-1 and hypopituitarism without pituitary hypoplasia.
Science (New York, N.Y.)
Structural analysis of the transmembrane domain of the epidermal growth factor receptor.
The Journal of biological chemistry
Mutational removal of the Thr669 and Ser671 phosphorylation sites alters substrate specificity and ligand-induced internalization of the epidermal growth factor receptor.
The Journal of biological chemistry
Pituitary cell phenotypes involve cell-specific Pit-1 mRNA translation and synergistic interactions with other classes of transcription factors.
Genes & development
A family of POU-domain and Pit-1 tissue-specific transcription factors in pituitary and neuroendocrine development.
Annual review of physiology
A pituitary POU domain protein, Pit-1, activates both growth hormone and prolactin promoters transcriptionally.
Genes & development
The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products.
Genes & development
A tissue-specific transcription factor containing a homeodomain specifies a pituitary phenotype.
Cell
Role of intrinsic protein tyrosine kinase in function and metabolism of the epidermal growth factor receptor.
Cold Spring Harbor symposia on quantitative biology
Characterization of Two Atypical Promoters and Alternate mRNA Processing in the Mouse Thy-1.2 Glycoprotein Gene.
Molecular and Cellular Biology
Characterization of two atypical promoters and alternate mRNA processing in the mouse Thy-1.2 glycoprotein gene.
Molecular and Cellular Biology
The mouse Thy-1.2 glycoprotein gene: complete sequence and identification of an unusual promoter.
Journal of immunology (Baltimore, Md. : 1950)
Mechanism of thymineless death.
Advances in experimental medicine and biology
MECHANISM OF THYMINELESS DEATH: 73.
Pediatric research
Expression of the Thy-1 glycoprotein gene by DNA-mediated gene transfer.
Proceedings of the National Academy of Sciences of the United States of America
Molecular cloning of the acetylcholine receptor.
Cold Spring Harbor symposia on quantitative biology
Mechanism for exclusion of 5-fluorouracil from DNA.
Cancer research
Characterization of Sialyltransferase in Noncancerous and Neoplastic Human Liver Tissue2.
Journal of the National Cancer Institute
Characterization of the association of specific proteins with messenger ribonucleic acid.
Biochemistry
Isolation of messenger-like ribonucleoproteins.
Biochemistry
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