Jeffrey Bush, PhD

Professor, Cell and Tissue Biology

Research Interests: Signaling control of mammalian morphogenesis and congenital disease

Our lab studies basic mechaniss by which signaling between cells coordinates mammalian morphogenesis. Understanding this control has significance beyond its fundamental importance in development since birth defects are the leading cause of death for infants during the first year of life. We utilize multiple approaches based in mouse genetics to understand fundamental signaling processes as they relate to development and disease with particular foci in the craniofacial and respiratory systems. In addition to mouse genetics approaches, we utilize human ES/IPSCs, biophysical approaches, multiomics, and live imaging to understand the cellular and molecular control of morphogenesis.

Address: 
513 Parnassus Avenue, HSE, Rm 1502
San Francisco, CA 94143
United States
Phone: 
+1 415 476-9459
Faculty Type: 
Affiliate Faculty
Publications: 

Eed controls craniofacial osteoblast differentiation and mesenchymal proliferation from the neural crest.(link is external)

bioRxiv : the preprint server for biology

Casey-Clyde T, Liu SJ, Serrano JAC, Teng C, Jang YG, Vasudevan HN, Bush JO, Raleigh DR

A Suite of Mouse Reagents for Studying Amelogenesis.(link is external)

bioRxiv : the preprint server for biology

Wald T, Verma A, Cooley V, Marangoni P, Cazares O, Sharir A, Sandoval EJ, Sung D, Najibi H, Drennon TY, Bush JO, Joester D, Klein OD

Exome sequencing efficacy and phenotypic expansions involving esophageal atresia/tracheoesophageal fistula plus.(link is external)

American journal of medical genetics. Part A

Sy MR, Chauhan J, Prescott K, Imam A, Kraus A, Beleza A, Salkeld L, Hosdurga S, Parker M, Vasudevan P, Islam L, Goel H, Bain N, Park SM, Mohammed S, Dieterich K, Coutton C, Satre V, Vieville G, Donaldson A, Beneteau C, Ghoumid J, Van Den Bogaert K, Boogaerts A, Boudry E, Vanlerberghe C, Petit F, Bernardini L, Torres B, Mattina T, Carli D, Mandrile G, Pinelli M, Brunetti-Pierri N, Neas K, Beddow R, Tørring PM, Faletra F, Spedicati B, Gasparini P, Mussa A, Ferrero GB, Lampe A, Lam W, Bi W, Bacino CA, Kuwahara A, Bush JO, Zhao X, Luna PN, Shaw CA, Rosenfeld JA, Scott DA

Investigating Cell Fate Specification upon Nkx2-1Loss.

The FASEB Journal

Marisol A. O'Neill, Jeffrey O. Bush

Investigating the effects of compound paralogous EPHB receptor mutations on mouse facial development.(link is external)

Developmental dynamics : an official publication of the American Association of Anatomists

Mincer ST, Niethamer TK, Teng T, Bush JO, Percival CJ

EPH/EPHRIN regulates cellular organization by actomyosin contractility effects on cell contacts.(link is external)

The Journal of Cell Biology

Kindberg AA, Srivastava V, Muncie JM, Weaver VM, Gartner ZJ, Bush JO

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