Jeffrey Fineman, MD

Professor, Pediatrics

Research Interests: Endothelial regulation of the pulmonary circulation during normal development and during the development of pediatric pulmonary hypertension disorders. Endothelial dysfunction in pediatric pulmonary hypertension Summary: Pulmonary hypertension, high blood pressure in the lungs, is a serious disorder in subsets of neonates, infants, and children. These include newborns with persistent pulmonary hypertension of the newborn (PPHN), children with congenital heart defects, and teenagers and young adults with primary pulmonary hypertension. The vascular endothelium (the cells that line the blood vessels in the lungs), via the production of vasoactive factors such as nitric oxide and endothelin-1, are important regulators of the tone and growth of pulmonary blood vessels. We utilize an integrated physiologic, biochemical, molecular, and anatomic approach, to study the potential role of aberrant endothelial function in the pathophysiology of pulmonary hypertensive disorders. To this end, we utilize fetal surgical techniques to create animal models of congenital heart disease, and investigate the early role of endothelial alterations in the pathophysiology of pulmonary hypertension secondary to congenital heart disease with increased pulmonary blood flow. Our clinical research interests include the use of pulmonary vasodilator therapy for pediatric pulmonary hypertension, and the use of peri-operative BNP levels as marker of outcome following repair of congenital heart disease.

Address: 
550 16th Street, Rm 5563
UCSF Box 0106
San Francisco, CA 94158
United States
Faculty Type: 
Affiliate Faculty
Publications: 

Mechanotransductive stabilization of HIF-1α is inhibited by mitochondrial antioxidant therapy in the setting of pulmonary overcirculation.(link is external)

Scientific reports

Boehme JT, Datar SA, Sun X, Gong W, Lu Q, Soto J, Smith MA, Garcia-Flores AE, Raff GW, Wang T, Maltepe E, Black SM, Fineman JR

Chloroquine Restores eNOS Signaling in Shunt Endothelial Cells via Inhibiting eNOS Uncoupling.(link is external)

International journal of molecular sciences

Liang Y, Ornatowski W, Lu Q, Sun X, Yegambaram M, Feng A, Dong Y, Aggarwal S, Unwalla HJ, Fineman JR, Black SM, Wang T

Mitochondrial fission produces a Warburg effect via the oxidative inhibition of prolyl hydroxylase domain-2.(link is external)

Redox biology

Sun X, Yegambaram M, Lu Q, Garcia Flores AE, Pokharel MD, Soto J, Aggarwal S, Wang T, Fineman JR, Black SM

A Multi-Chamber Pulsating-Flow Device with Optimized Spatial Shear Stress and Pressure for Endothelial-Cell Testing.(link is external)

Journal of biomechanical engineering

Campos O, Garcia De Herreros A, Sánchez A, Fineman JR, Pawlak G

MicroRNA Profiling to Inform Disease Classification, Severity, and Treatment Response in Pediatric Pulmonary Hypertension.(link is external)

American journal of physiology. Heart and circulatory physiology

Smith MA, Chiacchia S, Boehme J, Datar SA, Morell E, Keller RL, Romer A, Colglazier E, Parker C, Becerra J, Fineman JR

Actigraphy Study Endpoints to Reduce Sample Size and Facilitate Drug Development for Pediatric Pulmonary Arterial Hypertension.(link is external)

The Journal of pediatrics

Sun H, Stockbridge N, Ivy DD, Clark J, Bates A, Handler SS, Krishnan US, Mullen MP, Yung D, Hopper RK, Varghese NP, Avitabile CM, Fineman J, Austin ED, Freire G

Innovative Dual Combination Cospray-Dried Rock Inhibitor/l-Carnitine Inhalable Dry Powder Aerosols.(link is external)

ACS bio & med chem Au

Acosta MF, Encinas-Basurto D, Abrahamson MD, Eedara BB, Hayes D, Fineman JR, Black SM, Mansour HM

Perinatal Caffeine Administration Improves Outcomes in an Ovine Model of Neonatal Hypoxia-Ischemia.(link is external)

Stroke

Mike JK, White Y, Ha J, Iranmahboub A, Hawkins C, Hutchings RS, Vento C, Manzoor H, Wang A, Goudy BD, Vali P, Lakshminrusimha S, Gobburu JVS, Long-Boyle J, Fineman JR, Ferriero DM, Maltepe E

Inhalable Advanced Co-Spray Dried Microparticles/Nanoparticles of a Novel RhoA/Rho Kinase Inhibitor with Lung Surfactant Biomimetic Phospholipids for Targeted Lung Delivery.(link is external)

ACS pharmacology & translational science

Ruiz VH, Encinas-Basurto D, Ortega-Alarcon N, Eedara BB, Fineman JR, Black SM, Mansour HM

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