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Fineman

Jeffrey Fineman, MD

Professor
Pediatrics
Address: 
Please update your Location In, Rm 001
UCSF Box 0106
' ', CA 00001
United States

Research Interests: Endothelial regulation of the pulmonary circulation during normal development and during the development of pediatric pulmonary hypertension disorders. Endothelial dysfunction in pediatric pulmonary hypertension Summary: Pulmonary hypertension, high blood pressure in the lungs, is a serious disorder in subsets of neonates, infants, and children. These include newborns with persistent pulmonary hypertension of the newborn (PPHN), children with congenital heart defects, and teenagers and young adults with primary pulmonary hypertension. The vascular endothelium (the cells that line the blood vessels in the lungs), via the production of vasoactive factors such as nitric oxide and endothelin-1, are important regulators of the tone and growth of pulmonary blood vessels. We utilize an integrated physiologic, biochemical, molecular, and anatomic approach, to study the potential role of aberrant endothelial function in the pathophysiology of pulmonary hypertensive disorders. To this end, we utilize fetal surgical techniques to create animal models of congenital heart disease, and investigate the early role of endothelial alterations in the pathophysiology of pulmonary hypertension secondary to congenital heart disease with increased pulmonary blood flow. Our clinical research interests include the use of pulmonary vasodilator therapy for pediatric pulmonary hypertension, and the use of peri-operative BNP levels as marker of outcome following repair of congenital heart disease.

Publications: 

A Multi-Chamber Pulsating-Flow Device with Optimized Spatial Shear Stress and Pressure for Endothelial-Cell Testing.

Journal of biomechanical engineering

Campos O, Garcia De Herreros A, Sánchez A, Fineman JR, Pawlak G

MicroRNA Profiling to Inform Disease Classification, Severity, and Treatment Response in Pediatric Pulmonary Hypertension.

American journal of physiology. Heart and circulatory physiology

Smith MA, Chiacchia S, Boehme J, Datar SA, Morell E, Keller RL, Romer A, Colglazier E, Parker C, Becerra J, Fineman JR

Actigraphy Study Endpoints to Reduce Sample Size and Facilitate Drug Development for Pediatric Pulmonary Arterial Hypertension.

The Journal of pediatrics

Sun H, Stockbridge N, Ivy DD, Clark J, Bates A, Handler SS, Krishnan US, Mullen MP, Yung D, Hopper RK, Varghese NP, Avitabile CM, Fineman J, Austin ED, Freire G

Innovative Dual Combination Cospray-Dried Rock Inhibitor/l-Carnitine Inhalable Dry Powder Aerosols.

ACS bio & med chem Au

Acosta MF, Encinas-Basurto D, Abrahamson MD, Eedara BB, Hayes D, Fineman JR, Black SM, Mansour HM

Perinatal Caffeine Administration Improves Outcomes in an Ovine Model of Neonatal Hypoxia-Ischemia.

Stroke

Mike JK, White Y, Ha J, Iranmahboub A, Hawkins C, Hutchings RS, Vento C, Manzoor H, Wang A, Goudy BD, Vali P, Lakshminrusimha S, Gobburu JVS, Long-Boyle J, Fineman JR, Ferriero DM, Maltepe E

Inhalable Advanced Co-Spray Dried Microparticles/Nanoparticles of a Novel RhoA/Rho Kinase Inhibitor with Lung Surfactant Biomimetic Phospholipids for Targeted Lung Delivery.

ACS pharmacology & translational science

Ruiz VH, Encinas-Basurto D, Ortega-Alarcon N, Eedara BB, Fineman JR, Black SM, Mansour HM

The mitochondrial redistribution of ENOS is regulated by AKT1 and dimer status.

Nitric oxide : biology and chemistry

Sun X, Moreno Caceres S, Yegambaram M, Lu Q, Pokharel MD, Boehme JT, Datar SA, Aggarwal S, Wang T, Fineman JR, Black SM

VIEWING PULMONARY HYPERTENSION THROUGH A PEDIATRIC LENS.

The European respiratory journal

Agarwal S, Fineman J, Cornfield DN, Alvira CM, Zamanian RT, Goss K, Yuan K, Bonnet S, Boucherat O, Pullamsetti S, Alcázar MA, Goncharova E, Kudryashova TV, Nicolls MR, de Jesús Pérez V

Defining the Typical Course of Persistent Pulmonary Hypertension of the Newborn: When to Think Beyond Reversible Causes.

The Journal of pediatrics

Tsoi SM, Steurer M, Nawaytou H, Cheung S, Keller RL, Fineman JR

Pre-eclampsia and barker's hypothesis: are we beginning to see the trees within the forest?

Pediatric research

Tsoi SM, Steurer M, Maltepe E, Fineman JR

Pulmonary hypertension in the intensive care unit after pediatric allogeneic hematopoietic stem cell transplant: incidence, risk factors, and outcomes.

Frontiers in oncology

Smith MA, Cheng G, Phelan R, Brazauskas R, Strom J, Ahn KW, Hamilton BK, Peterson A, Savani B, Schoemans H, Schoettler ML, Sorror M, Keller RL, Higham CS, Dvorak CC, Fineman JR, Zinter MS

Management of pulmonary vascular disease associated with congenital left-to-right shunts: A single-center experience.

The Journal of thoracic and cardiovascular surgery

Nawaytou H, Lakkaraju R, Stevens L, Reddy VM, Swami N, Keller RL, Teitel DF, Fineman JR

Inflammatory lung injury is associated with endothelial cell mitochondrial fission and requires the nitration of RhoA and cytoskeletal remodeling.

Free radical biology & medicine

Pokharel MD, Fu P, Garcia-Flores A, Yegambaram M, Lu Q, Sun X, Unwalla H, Aggarwal S, Fineman JR, Wang T, Black SM

OMX: A NOVEL OXYGEN DELIVERY BIOTHERAPEUTIC IMPROVES OUTCOMES IN AN OVINE MODEL OF CONTROLLED HEMORRHAGIC SHOCK.

Shock (Augusta, Ga.)

Maltepe E, Smith M, Boehme J, Datar SA, Hutchings RS, Vento CA, Manzoor H, Loucks A, Winger JA, Fineman JR

A single institution anesthetic experience with catheterization of pediatric pulmonary hypertension patients.

Pulmonary circulation

Morell E, Colglazier E, Becerra J, Stevens L, Steurer MA, Sharma A, Nguyen H, Kathiriya IS, Weston S, Teitel D, Keller R, Amin EK, Nawaytou H, Fineman JR

Actigraphy methodology in the Kids Mod PAH trial: Physical activity as a functional endpoint in pediatric clinical trials.

Pulmonary circulation

Avitabile CM, Krishnan US, Yung D, Handler SS, Varghese N, Bates A, Fineman J, Sullivan R, Friere G, Austin E, Mullen MP, Pereira C, Christensen EJ, Yenokyan G, Collaco JM, Abman SH, Romer L, Dunbar Ivy D, Rosenzweig EB

Mitochondrial network dynamics in pulmonary disease: Bridging the gap between inflammation, oxidative stress, and bioenergetics.

Redox biology

Pokharel MD, Garcia-Flores A, Marciano D, Franco MC, Fineman JR, Aggarwal S, Wang T, Black SM

Novel Relationship between Mitofusin 2-Mediated Mitochondrial Hyperfusion, Metabolic Remodeling, and Glycolysis in Pulmonary Arterial Endothelial Cells.

International journal of molecular sciences

Yegambaram M, Sun X, Flores AG, Lu Q, Soto J, Richards J, Aggarwal S, Wang T, Gu H, Fineman JR, Black SM

Simvastatin restores pulmonary endothelial function in the setting of pulmonary over-circulation.

Nitric oxide : biology and chemistry

Boehme JT, Sun X, Lu Q, Barton J, Wu X, Gong W, Raff GW, Datar SA, Wang T, Fineman JR, Black SM

Mitochondrial hyperfusion induces metabolic remodeling in lung endothelial cells by modifying the activities of electron transport chain complexes I and III.

Free radical biology & medicine

Yegambaram M, Sun X, Lu Q, Jin Y, Ornatowski W, Soto J, Aggarwal S, Wang T, Tieu K, Gu H, Fineman JR, Black SM

Prostaglandin-E1 infusion in persistent pulmonary hypertension of the newborn.

Pediatric pulmonology

Tsoi SM, Nawaytou H, Almeneisi H, Steurer M, Zhao Y, Fineman JR, Keller RL

Kids Mod PAH trial: A multicenter trial comparing mono- versus duo-therapy for initial treatment of pediatric pulmonary hypertension.

Pulmonary circulation

Collaco JM, Abman SH, Austin ED, Avitabile CM, Bates A, Fineman JR, Freire GA, Handler SS, Ivy DD, Krishnan US, Mullen MP, Varghese NP, Yung D, Nies MK, Everett AD, Zimmerman KO, Simmons W, Chakraborty H, Yenokyan G, Newell-Sturdivant A, Christensen E, Eyzaguirre LM, Hanley DF, Rosenzweig EB, Romer LH

Effect of Clemastine on Neurophysiological Outcomes in an Ovine Model of Neonatal Hypoxic-Ischemic Encephalopathy.

Children (Basel, Switzerland)

Mike JK, White Y, Hutchings RS, Vento C, Ha J, Iranmahboub A, Manzoor H, Gunewardena A, Cheah C, Wang A, Goudy BD, Lakshminrusimha S, Long-Boyle J, Fineman JR, Ferriero DM, Maltepe E

Perinatal Azithromycin Provides Limited Neuroprotection in an Ovine Model of Neonatal Hypoxic-Ischemic Encephalopathy.

Stroke

Mike JK, White Y, Hutchings RS, Vento C, Ha J, Manzoor H, Lee D, Losser C, Arellano K, Vanhatalo O, Seifert E, Gunewardena A, Wen B, Wang L, Wang A, Goudy BD, Vali P, Lakshminrusimha S, Gobburu JVS, Long-Boyle J, Wu YW, Fineman JR, Ferriero DM, Maltepe E

Safety and tolerability of continuous inhaled iloprost in critically ill pediatric pulmonary hypertension patients: A retrospective case series.

Pulmonary circulation

Colglazier E, Ng AJ, Parker C, Woolsey D, Holmes R, Dsouza A, Becerra J, Stevens L, Nawaytou H, Keller RL, Fineman JR

Endothelin-1 acutely increases nitric oxide production via the calcineurin mediated dephosphorylation of Caveolin-1.

Nitric oxide : biology and chemistry

Yegambaram M, Kumar S, Wu X, Lu Q, Sun X, Garcia Flores A, Meadows ML, Barman S, Fulton D, Wang T, Fineman JR, Black SM

Associated radiation exposure from medical imaging and excess lifetime risk of developing cancer in pediatric patients with pulmonary hypertension.

Pulmonary circulation

Mahendra M, Chu P, Amin EK, Nawaytou H, Duncan JR, Fineman JR, Smith-Bindman R

Measurement of Physical Activity by Actigraphy in Infants and Young Children with Pulmonary Arterial Hypertension.

The Journal of pediatrics

Avitabile CM, Yung D, Handler S, Hopper RK, Fineman J, Freire G, Varghese N, Mullen MP, Krishnan US, Austin E, Silveira L, Ivy DD

Metabolic reprogramming, oxidative stress, and pulmonary hypertension.

Redox biology

Pokharel MD, Marciano DP, Fu P, Franco MC, Unwalla H, Tieu K, Fineman JR, Wang T, Black SM

Wnt7a deficit is associated with dysfunctional angiogenesis in pulmonary arterial hypertension.

The European respiratory journal

Chakraborty A, Nathan A, Orcholski M, Agarwal S, Shamskhou EA, Auer N, Mitra A, Guardado ES, Swaminathan G, Condon DF, Yu J, McCarra M, Juul NH, Mallory A, Guzman-Hernandez RA, Yuan K, Rojas V, Crossno JT, Yung LM, Yu PB, Spencer T, Winn RA, Frump A, Karoor V, Lahm T, Hedlin H, Fineman JR, Lafyatis R, Knutsen CNF, Alvira CM, Cornfield DN, de Jesus Perez VA

Nitration-mediated activation of the small GTPase RhoA stimulates cellular glycolysis through enhanced mitochondrial fission.

The Journal of biological chemistry

Lu Q, Sun X, Yegambaram M, Ornatowski W, Wu X, Wang H, Garcia-Flores A, Da Silva V, Zemskov EA, Tang H, Fineman JR, Tieu K, Wang T, Black SM

Hemodynamic assessment of transitioning from parenteral prostacyclin to selexipag in pediatric pulmonary hypertension.

Pulmonary circulation

Colglazier E, Stevens L, Parker C, Nawaytou HM, Amin EK, Becerra J, Steurer M, Fineman JR

Predictability and stability testing to assess clinical decision instrument performance for children after blunt torso trauma.

PLOS digital health

Kornblith AE, Singh C, Devlin G, Addo N, Streck CJ, Holmes JF, Kuppermann N, Grupp-Phelan J, Fineman J, Butte AJ, Yu B

Caveolin-1 associated with severe (pediatric-onset) presentation of pulmonary arterial hypertension.

Pulmonary circulation

Farrell R, Colglazier E, Parker C, Stevens L, Austin ED, Fineman JR

Persistence of persistent pulmonary hypertension of the newborn: A case of de novo TBX4 variant.

Pulmonary circulation

Tsoi SM, Jones K, Colglazier E, Parker C, Nawaytou H, Teitel D, Fineman JR, Keller RL

Cardiac Catheterization and Hemodynamics in a Multicenter Cohort of Children with Pulmonary Hypertension.

Annals of the American Thoracic Society

Rosenzweig EB, Bates A, Mullen MP, Abman SH, Austin ED, Everett A, Fineman J, Feinstein J, Hopper RK, Kinsella JP, Krishnan US, Lu M, Mandl KD, Raj JU, Varghese N, Yung D, Handler SS, Sleeper LA

Defining Longer-Term Outcomes in an Ovine Model of Moderate Perinatal Hypoxia-Ischemia.

Developmental neuroscience

Mike JK, Wu KY, White Y, Pathipati P, Ndjamen B, Hutchings RS, Losser C, Vento C, Arellano K, Vanhatalo O, Ostrin S, Windsor C, Ha J, Alhassen Z, Goudy BD, Vali P, Lakshminrusimha S, Gobburu JVS, Long-Boyle J, Chen P, Wu YW, Fineman JR, Ferriero DM, Maltepe E

Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension.

The Journal of clinical investigation

Bertero T, Lu Y, Annis S, Hale A, Bhat B, Saggar R, Saggar R, Wallace WD, Ross DJ, Vargas SO, Graham BB, Kumar R, Black SM, Fratz S, Fineman JR, West JD, Haley KJ, Waxman AB, Chau BN, Cottrill KA, Chan SY

Building a dedicated pediatric pulmonary hypertension program: A consensus statement from the pediatric pulmonary hypertension network.

Pulmonary circulation

Handler SS, Varghese NP, Rosenzweig EB, Yung D, Krishnan U, Whalen E, Bates A, Avitabile CM, Jackson EO, Hirsch R, Fineman J, Abman SH, Pediatric Pulmonary Hypertension Network (PPHNet)

Genetics dictating therapeutic decisions in pediatric pulmonary hypertension? A case report suggesting we are getting closer.

Pulmonary circulation

Stevens L, Colglazier E, Parker C, Amin EK, Nawaytou H, Teitel D, Reddy VM, Welch CL, Chung WK, Fineman JR

Characterisation of paediatric pulmonary hypertensive vascular disease from the PPHNet Registry.

The European respiratory journal

Abman SH, Mullen MP, Sleeper LA, Austin ED, Rosenzweig EB, Kinsella JP, Ivy D, Hopper RK, Raj JU, Fineman J, Keller RL, Bates A, Krishnan US, Avitabile CM, Davidson A, Natter MD, Mandl KD, Pediatric Pulmonary Hypertension Network

Biallelic variants of <i>ATP13A3</i> cause dose-dependent childhood-onset pulmonary arterial hypertension characterised by extreme morbidity and mortality.

Journal of medical genetics

Machado RD, Welch CL, Haimel M, Bleda M, Colglazier E, Coulson JD, Debeljak M, Ekstein J, Fineman JR, Golden WC, Griffin EL, Hadinnapola C, Harris MA, Hirsch Y, Hoover-Fong JE, Nogee L, Romer LH, Vesel S, NIHR Bioresource – Rare Diseases, Gräf S, Morrell NW, Southgate L, Chung WK

Mortality from Pulmonary Hypertension in the Pediatric Cardiac ICU.

American journal of respiratory and critical care medicine

Morell E, Gaies M, Fineman JR, Charpie J, Rao R, Sasaki J, Zhang W, Reichle G, Banerjee M, Tabbutt S

Safety and Tolerability of a Rapid Transition From Intravenous Treprostinil to Oral Selexipag in Three Adolescent Patients With Pulmonary Arterial Hypertension.

The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG

Colglazier E, Ng AJ, Parker C, Nawaytou H, Fineman JR

Monitoring deep-tissue oxygenation with a millimeter-scale ultrasonic implant.

Nature biotechnology

Sonmezoglu S, Fineman JR, Maltepe E, Maharbiz MM

Practice patterns of pulmonary hypertension secondary to left heart disease among pediatric pulmonary hypertension providers.

Pulmonary circulation

Nawaytou H, Fineman JR, Moledina S, Ivy D, Abman SH, Cerro MJD

HIF-1α promotes cellular growth in lymphatic endothelial cells exposed to chronically elevated pulmonary lymph flow.

Scientific reports

Boehme JT, Morris CJ, Chiacchia SR, Gong W, Wu KY, Kameny RJ, Raff GW, Fineman JR, Maltepe E, Datar SA

Arginine recycling in endothelial cells is regulated BY HSP90 and the ubiquitin proteasome system.

Nitric oxide : biology and chemistry

Wu X, Sun X, Sharma S, Lu Q, Yegambaram M, Hou Y, Wang T, Fineman JR, Black SM

Novel Documentation of Onset and Rapid Advancement of Pulmonary Arterial Hypertension without Symptoms in BMPR2 Mutation Carriers: Cautionary Tales?

American journal of respiratory and critical care medicine

Amin EK, Austin ED, Parker C, Colglazier E, Nawaytou H, Leary PJ, Hemnes AR, Teitel D, Fineman JR

Inhalable Nanoparticles/Microparticles of an AMPK and Nrf2 Activator for Targeted Pulmonary Drug Delivery as Dry Powder Inhalers.

The AAPS journal

Acosta MF, Abrahamson MD, Encinas-Basurto D, Fineman JR, Black SM, Mansour HM

Activation of the mechanosensitive Ca2+ channel TRPV4 induces endothelial barrier permeability via the disruption of mitochondrial bioenergetics.

Redox biology

Lu Q, Zemskov EA, Sun X, Wang H, Yegambaram M, Wu X, Garcia-Flores A, Song S, Tang H, Kangath A, Cabanillas GZ, Yuan JX, Wang T, Fineman JR, Black SM

Complex interplay between autophagy and oxidative stress in the development of pulmonary disease.

Redox biology

Ornatowski W, Lu Q, Yegambaram M, Garcia AE, Zemskov EA, Maltepe E, Fineman JR, Wang T, Black SM

Pharmacokinetics of Oral Treprostinil in Children With Pulmonary Arterial Hypertension.

Journal of cardiovascular pharmacology

Hopper RK, Ivy DD, Yung D, Mullen MP, Hanna BD, Kirkpatrick E, Hirsch R, Austin ED, Fineman J, Solum D, Deng CQ, Feinstein JA

The many faces and outcomes of pulmonary vein stenosis in early childhood.

Pediatric pulmonology

Humpl T, Fineman J, Qureshi AM

Equipoise and Acumen in Pediatric Acute Respiratory Distress Syndrome Research.

American journal of respiratory and critical care medicine

Oishi P, Fineman JR

TGF-β1 attenuates mitochondrial bioenergetics in pulmonary arterial endothelial cells via the disruption of carnitine homeostasis.

Redox biology

Sun X, Lu Q, Yegambaram M, Kumar S, Qu N, Srivastava A, Wang T, Fineman JR, Black SM

Mechanical forces alter endothelin-1 signaling: comparative ovine models of congenital heart disease.

Pulmonary circulation

Zhu T, Chiacchia S, Kameny RJ, Garcia De Herreros A, Gong W, Raff GW, Boehme JB, Maltepe E, Lasheras JC, Black SM, Datar SA, Fineman JR

Extracorporeal Membrane Oxygenation in Pediatric Pulmonary Hypertension.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Morell E, Rajagopal SK, Oishi P, Thiagarajan RR, Fineman JR, Steurer MA

Clinical Utility of Echocardiography in Former Preterm Infants with Bronchopulmonary Dysplasia.

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography

Nawaytou H, Steurer MA, Zhao Y, Guslits E, Teitel D, Fineman JR, Keller RL

Outcomes of pulmonary vascular disease in infants conceived with non-IVF fertility treatment and assisted reproductive technologies at 1 year of age.

Pediatric pulmonology

Fineman DC, Baer RJ, Chambers CD, Rajagopal S, Maltepe E, Rinaudo PF, Fineman JR, Jelliffe-Pawlowski LL, Steurer MA

Oral treprostinil in transition or as add-on therapy in pediatric pulmonary arterial hypertension.

Pulmonary circulation

Ivy DD, Feinstein JA, Yung D, Mullen MP, Kirkpatrick EC, Hirsch R, Austin ED, Fineman J, Truong U, Solum D, Deng CQ, Hopper RK

EXPRESS: Acute Vasoreactivity Testing in Pediatric Idiopathic Pulmonary Arterial Hypertension: an international Survey on Current Practice.

Pulmonary circulation

Caicedo L, Hopper RK, Garcia H, Ivy DD, Haag D, Fineman J, Humpi T, Al-Tamimi O, Feinstein J, Berger RM, Berman-Rosenzweig E, Kashour T, Diaz GF, Mendoza A, Bobhate P, Handler S, Lopes AA, Barwad P, Kumar Rahit M, Krishnan U, Adatia ITK, Moledina S, Abman S, Cerro Marin MJD

Ovine Models of Congenital Heart Disease and the Consequences of Hemodynamic Alterations for Pulmonary Artery Remodeling.

American journal of respiratory cell and molecular biology

Johnson Kameny R, Datar SA, Boehme JB, Morris C, Zhu T, Goudy BD, Johnson EG, Galambos C, Raff GW, Sun X, Wang T, Chiacchia SR, Lu Q, Black SM, Maltepe E, Fineman JR

Pulmonary Endothelial Mechanical Sensing and Signaling, a Story of Focal Adhesions and Integrins in Ventilator Induced Lung Injury.

Frontiers in physiology

Kelly GT, Faraj R, Zhang Y, Maltepe E, Fineman JR, Black SM, Wang T

Mortality in infants with bronchopulmonary dysplasia: Data from cardiac catheterization.

Pediatric pulmonology

Steurer MA, Nawaytou H, Guslits E, Colglazier E, Teitel D, Fineman JR, Keller RL

Biomechanical Forces and Oxidative Stress: Implications for Pulmonary Vascular Disease.

Antioxidants & redox signaling

Zemskov EA, Lu Q, Ornatowski W, Klinger CN, Desai AA, Maltepe E, Yuan JX, Wang T, Fineman JR, Black SM

Correction: Preservation of myocardial contractility during acute hypoxia with OMX-CV, a novel oxygen delivery biotherapeutic.

PLoS biology

Boehme J, Le Moan N, Kameny RJ, Loucks A, Johengen MJ, Lesneski AL, Gong W, Goudy BD, Davis T, Tanaka K, Davis A, He Y, Long-Boyle J, Ivaturi V, Gobburu JVS, Winger JA, Cary SP, Datar SA, Fineman JR, Krtolica A, Maltepe E

Two patients with FOXF1 mutations with alveolar capillary dysplasia with misalignment of pulmonary veins and other malformations: Two different presentations and outcomes.

American journal of medical genetics. Part A

Abu-El-Haija A, Fineman J, Connolly AJ, Murali P, Judge LM, Slavotinek AM

Preservation of myocardial contractility during acute hypoxia with OMX-CV, a novel oxygen delivery biotherapeutic.

PLoS biology

Boehme J, Le Moan N, Kameny RJ, Loucks A, Johengen MJ, Lesneski AL, Gong W, Goudy BD, Davis T, Tanaka K, Davis A, He Y, Long-Boyle J, Ivaturi V, Gobburu JVS, Winger JA, Cary SP, Datar SA, Fineman JR, Krtolica A, Maltepe E

Intensive Care Mortality Prognostic Model for Pediatric Pulmonary Hypertension.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Balkin EM, Zinter MS, Rajagopal SK, Keller RL, Fineman JR, Steurer MA

Enhancing the Development and Retention of Physician-Scientists in Academic Pediatrics: Strategies for Success.

The Journal of pediatrics

Alvira CM, Steinhorn RH, Balistreri WF, Fineman JR, Oishi PE, Padbury JF, Kinsella JP, Abman SH

Analysis of the microRNA signature driving adaptive right ventricular hypertrophy in an ovine model of congenital heart disease.

American journal of physiology. Heart and circulatory physiology

Kameny RJ, He Y, Zhu T, Gong W, Raff GW, Chapin CJ, Datar SA, Boehme JT, Hata A, Fineman JR

KLF2-mediated disruption of PPAR-γ signaling in lymphatic endothelial cells exposed to chronically increased pulmonary lymph flow.

American journal of physiology. Heart and circulatory physiology

Morris CJ, Kameny RJ, Boehme J, Gong W, He Y, Zhu T, Maltepe E, Raff GW, Fineman JR, Datar SA

The Left Ventricle in Congenital Diaphragmatic Hernia: Implications for the Management of Pulmonary Hypertension.

The Journal of pediatrics

Kinsella JP, Steinhorn RH, Mullen MP, Hopper RK, Keller RL, Ivy DD, Austin ED, Krishnan US, Rosenzweig EB, Fineman JR, Everett AD, Hanna BD, Humpl T, Raj JU, Abman SH, Pediatric Pulmonary Hypertension Network (PPHNet)

Safety, efficacy and Management of subcutaneous treprostinil infusions in the treatment of severe pediatric pulmonary hypertension.

International journal of cardiology

Levy M, Del Cerro MJ, Nadaud S, Vadlamudi K, Colgazier E, Fineman J, Bonnet D, Adatia I

Multicenter mortality and morbidity associated with pulmonary hypertension in the pediatric intensive care unit.

Pulmonary circulation

Balkin EM, Steurer MA, Delagnes EA, Zinter MS, Rajagopal S, Keller RL, Fineman JR

Altered Carnitine Homeostasis in Children With Increased Pulmonary Blood Flow Due to Ventricular Septal Defects.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Black SM, Field-Ridley A, Sharma S, Kumar S, Keller RL, Kameny R, Maltepe E, Datar SA, Fineman JR

Pulmonary veno-occlusive disease in a pediatric hematopoietic stem cell transplant patient: a cautionary tale.

Leukemia & lymphoma

Zinter MS, Melton A, Sabnis AJ, Dvorak CC, Elicker BM, Nawaytou HM, Kameny RJ, Fineman JR

Pushing the envelope: a treat and repair strategy for patients with advanced pulmonary hypertension associated with congenital heart disease.

Pulmonary circulation

Kameny RJ, Colglazier E, Nawaytou H, Moore P, Reddy VM, Teitel D, Fineman JR

Evaluation and Management of Pulmonary Hypertension in Children with Bronchopulmonary Dysplasia.

The Journal of pediatrics

Krishnan U, Feinstein JA, Adatia I, Austin ED, Mullen MP, Hopper RK, Hanna B, Romer L, Keller RL, Fineman J, Steinhorn R, Kinsella JP, Ivy DD, Rosenzweig EB, Raj U, Humpl T, Abman SH, Pediatric Pulmonary Hypertension Network (PPHNet)

Pulmonary vein stenosis of ex-premature infants with pulmonary hypertension and bronchopulmonary dysplasia, epidemiology, and survival from a multicenter cohort.

Pediatric pulmonology

Mahgoub L, Kaddoura T, Kameny AR, Lopez Ortego P, Vanderlaan RD, Kakadekar A, Dicke F, Rebeyka I, Calderone CA, Redington A, Del Cerro MJ, Fineman J, Adatia I

The Prescient Prognosticator? Hepatoma-derived Growth Factor in Pulmonary Hypertension.

American journal of respiratory and critical care medicine

Kameny RJ, Fineman JR

Pulmonary artery smooth muscle cell hyperproliferation and metabolic shift triggered by pulmonary overcirculation.

American journal of physiology. Heart and circulatory physiology

Boehme J, Sun X, Tormos KV, Gong W, Kellner M, Datar SA, Kameny RJ, Yuan JX, Raff GW, Fineman JR, Black SM, Maltepe E

Bosentan as Adjunctive Therapy for Persistent Pulmonary Hypertension of the Newborn: Results of the Randomized Multicenter Placebo-Controlled Exploratory Trial.

The Journal of pediatrics

Steinhorn RH, Fineman J, Kusic-Pajic A, Cornelisse P, Gehin M, Nowbakht P, Pierce CM, Beghetti M, FUTURE-4 study investigators

Asymmetric Dimethylarginine Stimulates Akt1 Phosphorylation via Heat Shock Protein 70-Facilitated Carboxyl-Terminal Modulator Protein Degradation in Pulmonary Arterial Endothelial Cells.

American journal of respiratory cell and molecular biology

Sun X, Kellner M, Desai AA, Wang T, Lu Q, Kangath A, Qu N, Klinger C, Fratz S, Yuan JX, Jacobson JR, Garcia JG, Rafikov R, Fineman JR, Black SM

Pulmonary Hypertension.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Oishi P, Fineman JR

Disrupted NOS signaling in lymphatic endothelial cells exposed to chronically increased pulmonary lymph flow.

American journal of physiology. Heart and circulatory physiology

Datar SA, Gong W, He Y, Johengen M, Kameny RJ, Raff GW, Maltepe E, Oishi PE, Fineman JR

Metabolic Changes Precede the Development of Pulmonary Hypertension in the Monocrotaline Exposed Rat Lung.

PloS one

Rafikova O, Meadows ML, Kinchen JM, Mohney RP, Maltepe E, Desai AA, Yuan JX, Garcia JG, Fineman JR, Rafikov R, Black SM

Change in Pediatric Functional Classification During Treatment and Morbidity and Mortality in Children with Pulmonary Hypertension.

Pediatric cardiology

Balkin EM, Olson ED, Robertson L, Adatia I, Fineman JR, Keller RL

Overexpression of Nitric Oxide Synthase Restores Circulating Angiogenic Cell Function in Patients With Coronary Artery Disease: Implications for Autologous Cell Therapy for Myocardial Infarction.

Journal of the American Heart Association

Chen Q, Varga M, Wang X, Haddad DJ, An S, Medzikovic L, Derakhshandeh R, Kostyushev DS, Zhang Y, Clifford BT, Luu E, Danforth OM, Rafikov R, Gong W, Black SM, Suchkov SV, Fineman JR, Heiss C, Aschbacher K, Yeghiazarians Y, Springer ML

Recommendations for the Use of Inhaled Nitric Oxide Therapy in Premature Newborns with Severe Pulmonary Hypertension.

The Journal of pediatrics

Kinsella JP, Steinhorn RH, Krishnan US, Feinstein JA, Adatia I, Austin ED, Rosenzweig EB, Everett AD, Fineman JR, Hanna BD, Hopper RK, Humpl T, Ivy DD, Keller RL, Mullen MP, Raj JU, Wessel DL, Abman SH

Pediatric Pulmonary Hypertension: Guidelines From the American Heart Association and American Thoracic Society.

Circulation

Abman SH, Hansmann G, Archer SL, Ivy DD, Adatia I, Chung WK, Hanna BD, Rosenzweig EB, Raj JU, Cornfield D, Stenmark KR, Steinhorn R, Thébaud B, Fineman JR, Kuehne T, Feinstein JA, Friedberg MK, Earing M, Barst RJ, Keller RL, Kinsella JP, Mullen M, Deterding R, Kulik T, Mallory G, Humpl T, Wessel DL, American Heart Association Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitatio

Matrix Remodeling Promotes Pulmonary Hypertension through Feedback Mechanoactivation of the YAP/TAZ-miR-130/301 Circuit.

Cell reports

Bertero T, Cottrill KA, Lu Y, Haeger CM, Dieffenbach P, Annis S, Hale A, Bhat B, Kaimal V, Zhang YY, Graham BB, Kumar R, Saggar R, Saggar R, Wallace WD, Ross DJ, Black SM, Fratz S, Fineman JR, Vargas SO, Haley KJ, Waxman AB, Chau BN, Fredenburgh LE, Chan SY

Complex I dysfunction underlies the glycolytic switch in pulmonary hypertensive smooth muscle cells.

Redox biology

Rafikov R, Sun X, Rafikova O, Louise Meadows M, Desai AA, Khalpey Z, Yuan JX, Fineman JR, Black SM

Short-Term Treprostinil Use in Infants with Congenital Diaphragmatic Hernia following Repair.

The Journal of pediatrics

Olson E, Lusk LA, Fineman JR, Robertson L, Keller RL

Right ventricular nitric oxide signaling in an ovine model of congenital heart disease: a preserved fetal phenotype.

American journal of physiology. Heart and circulatory physiology

Kameny RJ, He Y, Morris C, Sun C, Johengen M, Gong W, Raff GW, Datar SA, Oishi PE, Fineman JR

Longitudinal development of obesity in the post-Fontan population.

European journal of clinical nutrition

Wellnitz K, Harris IS, Sapru A, Fineman JR, Radman M

Sox18 preserves the pulmonary endothelial barrier under conditions of increased shear stress.

Journal of cellular physiology

Gross CM, Aggarwal S, Kumar S, Tian J, Kasa A, Bogatcheva N, Datar SA, Verin AD, Fineman JR, Black SM

B-type natriuretic peptide: prognostic marker in congenital diaphragmatic hernia.

Pediatric research

Steurer MA, Moon-Grady AJ, Fineman JR, Sun CE, Lusk LA, Wai KC, Keller RL

Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension.

The Journal of clinical investigation

Bertero T, Lu Y, Annis S, Hale A, Bhat B, Saggar R, Saggar R, Wallace WD, Ross DJ, Vargas SO, Graham BB, Kumar R, Black SM, Fratz S, Fineman JR, West JD, Haley KJ, Waxman AB, Chau BN, Cottrill KA, Chan SY

Endothelin-1 induces a glycolytic switch in pulmonary arterial endothelial cells via the mitochondrial translocation of endothelial nitric oxide synthase.

American journal of respiratory cell and molecular biology

Sun X, Kumar S, Sharma S, Aggarwal S, Lu Q, Gross C, Rafikova O, Lee SG, Dasarathy S, Hou Y, Meadows ML, Han W, Su Y, Fineman JR, Black SM

Adaptive right ventricular performance in response to acutely increased afterload in a lamb model of congenital heart disease: evidence for enhanced Anrep effect.

American journal of physiology. Heart and circulatory physiology

Johnson RC, Datar SA, Oishi PE, Bennett S, Maki J, Sun C, Johengen M, He Y, Raff GW, Redington AN, Fineman JR

Altered reactivity and nitric oxide signaling in the isolated thoracic duct from an ovine model of congenital heart disease with increased pulmonary blood flow.

American journal of physiology. Heart and circulatory physiology

Datar SA, Oishi PE, Gong W, Bennett SH, Sun CE, Johengen M, Maki J, Johnson RC, Raff GW, Fineman JR

Nitration of tyrosine 247 inhibits protein kinase G-1α activity by attenuating cyclic guanosine monophosphate binding.

The Journal of biological chemistry

Aggarwal S, Gross CM, Rafikov R, Kumar S, Fineman JR, Ludewig B, Jonigk D, Black SM

Endothelin-1 stimulates catalase activity through the PKCδ-mediated phosphorylation of serine 167.

Free radical biology & medicine

Rafikov R, Kumar S, Aggarwal S, Hou Y, Kangath A, Pardo D, Fineman JR, Black SM

Antenatal maternally-administered phosphodiesterase type 5 inhibitors normalize eNOS expression in the fetal lamb model of congenital diaphragmatic hernia.

Journal of pediatric surgery

Shue EH, Schecter SC, Gong W, Etemadi M, Johengen M, Iqbal C, Derderian SC, Oishi P, Fineman JR, Miniati D

Preoperative B-type natriuretic peptide levels are associated with outcome after total cavopulmonary connection (Fontan).

The Journal of thoracic and cardiovascular surgery

Radman M, Keller RL, Oishi P, Datar SA, Wellnitz K, Azakie A, Hanley F, Char D, Hsu JH, Amrinovin R, Adatia I, Fineman JR

Reactive oxygen species in pulmonary vascular remodeling.

Comprehensive Physiology

Aggarwal S, Gross CM, Sharma S, Fineman JR, Black SM

Reply to the editor.

The Journal of thoracic and cardiovascular surgery

Amirnovin R, Oishi P, Fineman JR, Keller RL

L-carnitine preserves endothelial function in a lamb model of increased pulmonary blood flow.

Pediatric research

Sharma S, Aramburo A, Rafikov R, Sun X, Kumar S, Oishi PE, Datar SA, Raff G, Xoinis K, Kalkan G, Fratz S, Fineman JR, Black SM

The effect of preoperative nutritional status on postoperative outcomes in children undergoing surgery for congenital heart defects in San Francisco (UCSF) and Guatemala City (UNICAR).

The Journal of thoracic and cardiovascular surgery

Radman M, Mack R, Barnoya J, Castañeda A, Rosales M, Azakie A, Mehta N, Keller R, Datar S, Oishi P, Fineman J

Disruption of endothelial cell mitochondrial bioenergetics in lambs with increased pulmonary blood flow.

Antioxidants & redox signaling

Sun X, Sharma S, Fratz S, Kumar S, Rafikov R, Aggarwal S, Rafikova O, Lu Q, Burns T, Dasarathy S, Wright J, Schreiber C, Radman M, Fineman JR, Black SM

Tezosentan increases nitric oxide signaling via enhanced hydrogen peroxide generation in lambs with surgically induced acute increases in pulmonary blood flow.

Journal of cellular biochemistry

Kumar S, Oishi PE, Rafikov R, Aggarwal S, Hou Y, Datar SA, Sharma S, Azakie A, Fineman JR, Black SM

Chronic inhibition of PPAR-γ signaling induces endothelial dysfunction in the juvenile lamb.

Pulmonary pharmacology & therapeutics

Sharma S, Barton J, Rafikov R, Aggarwal S, Kuo HC, Oishi PE, Datar SA, Fineman JR, Black SM

Implications of the U.S. Food and Drug Administration warning against the use of sildenafil for the treatment of pediatric pulmonary hypertension.

American journal of respiratory and critical care medicine

Abman SH, Kinsella JP, Rosenzweig EB, Krishnan U, Kulik T, Mullen M, Wessel DL, Steinhorn R, Adatia I, Hanna B, Feinstein J, Fineman J, Raj U, Humpl T, Pediatric Pulmonary Hypertension Network (PPHNet)

Rosiglitazone preserves pulmonary vascular function in lambs with increased pulmonary blood flow.

Pediatric research

Oishi PE, Sharma S, Datar SA, Kumar S, Aggarwal S, Lu Q, Raff G, Azakie A, Hsu JH, Sajti E, Fratz S, Black SM, Fineman JR

Endostatin, an inhibitor of angiogenesis, decreases after bidirectional superior cavopulmonary anastamosis.

Pediatric cardiology

Field-Ridley A, Heljasvaara R, Pihlajaniemi T, Adatia I, Sun C, Keller RL, Gong WH, Datar S, Oishi P, Fineman JR

PPAR-γ regulates carnitine homeostasis and mitochondrial function in a lamb model of increased pulmonary blood flow.

PloS one

Sharma S, Sun X, Rafikov R, Kumar S, Hou Y, Oishi PE, Datar SA, Raff G, Fineman JR, Black SM

B-type natriuretic peptide levels predict outcomes in infants undergoing cardiac surgery in a lesion-dependent fashion.

The Journal of thoracic and cardiovascular surgery

Amirnovin R, Keller RL, Herrera C, Hsu JH, Datar S, Karl TR, Adatia I, Oishi P, Fineman JR

Pulmonary interstitial glycogenosis: an unrecognized etiology of persistent pulmonary hypertension of the newborn in congenital heart disease?

Pediatric cardiology

Radman MR, Goldhoff P, Jones KD, Azakie A, Datar S, Adatia I, Oishi PE, Fineman JR

Preserving mitochondrial function prevents the proteasomal degradation of GTP cyclohydrolase I.

Free radical biology & medicine

Sharma S, Sun X, Kumar S, Rafikov R, Aramburo A, Kalkan G, Tian J, Rehmani I, Kallarackal S, Fineman JR, Black SM

Racial disparities in congenital heart disease: beyond red and blue.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Soskolne G, Collins JW, Fineman JR, Fuentes-Afflick E

Altered lymphatics in an ovine model of congenital heart disease with increased pulmonary blood flow.

American journal of physiology. Lung cellular and molecular physiology

Datar SA, Johnson EG, Oishi PE, Johengen M, Tang E, Aramburo A, Barton J, Kuo HC, Bennett S, Xoinis K, Reel B, Kalkan G, Sajti E, Osorio O, Raff GW, Matthay MA, Fineman JR

Usefulness of B-type natriuretic peptide and N-terminal pro-B-type natriuretic peptide as biomarkers for heart failure in young children with single ventricle congenital heart disease.

The American journal of cardiology

Lowenthal A, Camacho BV, Lowenthal S, Natal-Hernandez L, Liszewski W, Hills NK, Fineman JR, Bernstein HS

Attenuated vasodilatation in lambs with endogenous and exogenous activation of cGMP signaling: role of protein kinase G nitration.

Journal of cellular physiology

Aggarwal S, Gross CM, Kumar S, Datar S, Oishi P, Kalkan G, Schreiber C, Fratz S, Fineman JR, Black SM

Advances in the management of pediatric pulmonary hypertension.

Respiratory care

Oishi P, Datar SA, Fineman JR

Pediatric pulmonary arterial hypertension: current and emerging therapeutic options.

Expert opinion on pharmacotherapy

Oishi P, Datar SA, Fineman JR

Early determinants of pulmonary vascular remodeling in animal models of complex congenital heart disease.

Circulation

Fratz S, Fineman JR, Görlach A, Sharma S, Oishi P, Schreiber C, Kietzmann T, Adatia I, Hess J, Black SM

Delineating the angiogenic gene expression profile before pulmonary vascular remodeling in a lamb model of congenital heart disease.

Physiological genomics

Tian J, Fratz S, Hou Y, Lu Q, Görlach A, Hess J, Schreiber C, Datar SA, Oishi P, Nechtman J, Podolsky R, She JX, Fineman JR, Black SM

Reciprocal regulation of Rac1 and PAK-1 by HIF-1alpha: a positive-feedback loop promoting pulmonary vascular remodeling.

Antioxidants & redox signaling

Diebold I, Petry A, Djordjevic T, Belaiba RS, Fineman J, Black S, Schreiber C, Fratz S, Hess J, Kietzmann T, Görlach A

Congenital diaphragmatic hernia: endothelin-1, pulmonary hypertension, and disease severity.

American journal of respiratory and critical care medicine

Keller RL, Tacy TA, Hendricks-Munoz K, Xu J, Moon-Grady AJ, Neuhaus J, Moore P, Nobuhara KK, Hawgood S, Fineman JR

Nitric oxide alterations following acute ductal constriction in the fetal lamb: a role for superoxide.

American journal of physiology. Lung cellular and molecular physiology

Hsu JH, Oishi P, Wiseman DA, Hou Y, Chikovani O, Datar S, Sajti E, Johengen MJ, Harmon C, Black SM, Fineman JR

Perinatal changes in superoxide generation in the ovine lung: Alterations associated with increased pulmonary blood flow.

Vascular pharmacology

Sharma S, Kumar S, Wiseman DA, Kallarackal S, Ponnala S, Elgaish M, Tian J, Fineman JR, Black SM

Early elevations in B-type natriuretic peptide levels are associated with poor clinical outcomes in pediatric acute lung injury.

Pediatric pulmonology

Reel B, Oishi PE, Hsu JH, Gildengorin G, Matthay MA, Fineman JR, Flori H

Usefulness of various plasma biomarkers for diagnosis of heart failure in children with single ventricle physiology.

The American journal of cardiology

Shah A, Feraco AM, Harmon C, Tacy T, Fineman JR, Bernstein HS

Effect of PPARgamma inhibition on pulmonary endothelial cell gene expression: gene profiling in pulmonary hypertension.

Physiological genomics

Tian J, Smith A, Nechtman J, Podolsky R, Aggarwal S, Snead C, Kumar S, Elgaish M, Oishi P, Göerlach A, Fratz S, Hess J, Catravas JD, Verin AD, Fineman JR, She JX, Black SM

Alterations in lung arginine metabolism in lambs with pulmonary hypertension associated with increased pulmonary blood flow.

Vascular pharmacology

Sharma S, Kumar S, Sud N, Wiseman DA, Tian J, Rehmani I, Datar S, Oishi P, Fratz S, Venema RC, Fineman JR, Black SM

Peripheral arterial function in infants and young children with one-ventricle physiology and hypoxemia.

The American journal of cardiology

Natarajan S, Heiss C, Yeghiazarians Y, Fineman JR, Teitel DF, Tacy TA

Progressive dysfunction of nitric oxide synthase in a lamb model of chronically increased pulmonary blood flow: a role for oxidative stress.

American journal of physiology. Lung cellular and molecular physiology

Oishi PE, Wiseman DA, Sharma S, Kumar S, Hou Y, Datar SA, Azakie A, Johengen MJ, Harmon C, Fratz S, Fineman JR, Black SM

Perioperative B-type natriuretic peptide levels predict outcome after bidirectional cavopulmonary anastomosis and total cavopulmonary connection.

The Journal of thoracic and cardiovascular surgery

Hsu JH, Oishi PE, Keller RL, Chikovani O, Karl TR, Azakie A, Adatia I, Fineman JR

Altered carnitine homeostasis is associated with decreased mitochondrial function and altered nitric oxide signaling in lambs with pulmonary hypertension.

American journal of physiology. Lung cellular and molecular physiology

Sharma S, Sud N, Wiseman DA, Carter AL, Kumar S, Hou Y, Rau T, Wilham J, Harmon C, Oishi P, Fineman JR, Black SM

Alterations in cGMP, soluble guanylate cyclase, phosphodiesterase 5, and B-type natriuretic peptide induced by chronic increased pulmonary blood flow in lambs.

Pediatric pulmonology

Oishi P, Sharma S, Grobe A, Azakie A, Harmon C, Johengen MJ, Hsu JH, Fratz S, Black SM, Fineman JR

B-type natriuretic peptide levels predict outcomes for children on extracorporeal life support after cardiac surgery.

The Journal of thoracic and cardiovascular surgery

Chikovani O, Hsu JH, Keller R, Karl TR, Azakie A, Adatia I, Oishi P, Fineman JR

B-type natriuretic peptide levels predict outcome after neonatal cardiac surgery.

The Journal of thoracic and cardiovascular surgery

Hsu JH, Keller RL, Chikovani O, Cheng H, Hollander SA, Karl TR, Azakie A, Adatia I, Oishi P, Fineman JR

Nitric oxide and superoxide generation from endothelial NOS: modulation by HSP90.

American journal of physiology. Lung cellular and molecular physiology

Sud N, Sharma S, Wiseman DA, Harmon C, Kumar S, Venema RC, Fineman JR, Black SM

Lung antioxidant enzymes are regulated by development and increased pulmonary blood flow.

American journal of physiology. Lung cellular and molecular physiology

Sharma S, Grobe AC, Wiseman DA, Kumar S, Englaish M, Najwer I, Benavidez E, Oishi P, Azakie A, Fineman JR, Black SM

The role of nitric oxide synthase-derived reactive oxygen species in the altered relaxation of pulmonary arteries from lambs with increased pulmonary blood flow.

American journal of physiology. Heart and circulatory physiology

Lakshminrusimha S, Wiseman D, Black SM, Russell JA, Gugino SF, Oishi P, Steinhorn RH, Fineman JR

Fibroblast growth factor-2 expression is altered in lambs with increased pulmonary blood flow and pulmonary hypertension.

Pediatric research

Wedgwood S, Devol JM, Grobe A, Benavidez E, Azakie A, Fineman JR, Black SM

Pediatric pulmonary hypertension: Roles of endothelin-1 and nitric oxide.

Clinical hemorheology and microcirculation

Black SM, Kumar S, Wiseman D, Ravi K, Wedgwood S, Ryzhov V, Fineman JR

Abnormal vascular tone in infants and children with lung hypoplasia: Findings from cardiac catheterization and the response to chronic therapy.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Keller RL, Moore P, Teitel D, Hawgood S, McQuitty J, Fineman JR

Myocardial transcription factors are modulated during pathologic cardiac hypertrophy in vivo.

The Journal of thoracic and cardiovascular surgery

Azakie A, Fineman JR, He Y

Nesiritide acutely increases pulmonary and systemic levels of nitric oxide in patients with pulmonary hypertension.

Journal of Cardiac Failure

Khush KK, De Marco T, Vakharia KT, Harmon C, Fineman JR, Chatterjee K, Michaels AD

BNP for pediatrics--not quite ready for primetime.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Oishi PE, Fineman JR

Increased oxidative stress in lambs with increased pulmonary blood flow and pulmonary hypertension: role of NADPH oxidase and endothelial NO synthase.

American journal of physiology. Lung cellular and molecular physiology

Grobe AC, Wells SM, Benavidez E, Oishi P, Azakie A, Fineman JR, Black SM

Alterations in plasma B-type natriuretic peptide levels after repair of congenital heart defects: a potential perioperative marker.

The Journal of thoracic and cardiovascular surgery

Shih CY, Sapru A, Oishi P, Azakie A, Karl TR, Harmon C, Asija R, Adatia I, Fineman JR

Nitric oxide-endothelin-1 interactions after surgically induced acute increases in pulmonary blood flow in intact lambs.

American journal of physiology. Heart and circulatory physiology

Oishi P, Azakie A, Harmon C, Fitzgerald RK, Grobe A, Xu J, Hendricks-Munoz K, Black SM, Fineman JR

Inhaled nitric oxide induced NOS inhibition and rebound pulmonary hypertension: a role for superoxide and peroxynitrite in the intact lamb.

American journal of physiology. Lung cellular and molecular physiology

Oishi P, Grobe A, Benavidez E, Ovadia B, Harmon C, Ross GA, Hendricks-Munoz K, Xu J, Black SM, Fineman JR

Divergent transcriptional enhancer factor-1 regulates the cardiac troponin T promoter.

American journal of physiology. Cell physiology

Azakie A, Lamont L, Fineman JR, He Y

Endothelin-1 in congenital heart disease.

Pediatric research

Beghetti M, Black SM, Fineman JR

Nitric oxide decreases surfactant protein gene expression in primary cultures of type II pneumocytes.

American journal of physiology. Lung cellular and molecular physiology

Lee JW, Gonzalez RF, Chapin CJ, Busch J, Fineman JR, Gutierrez JA

Tezosentan, a combined parenteral endothelin receptor antagonist, produces pulmonary vasodilation in lambs with acute and chronic pulmonary hypertension.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Fitzgerald RK, Oishi P, Ovadia B, Ross GA, Reinhartz O, Johengen MJ, Fineman JR

Endothelial alterations during inhaled NO in lambs with pulmonary hypertension: implications for rebound hypertension.

American journal of physiology. Lung cellular and molecular physiology

Ross GA, Oishi P, Azakie A, Fratz S, Fitzgerald RK, Johengen MJ, Harmon C, Hendricks-Munoz K, Xu J, Black SM, Fineman JR

Chronic endothelin A receptor blockade in lambs with increased pulmonary blood flow and pressure.

American journal of physiology. Lung cellular and molecular physiology

Fratz S, Meyrick B, Ovadia B, Johengen MJ, Reinhartz O, Azakie A, Ross G, Fitzgerald R, Oishi P, Hess J, Black SM, Fineman JR

Impact of right ventricle to pulmonary artery conduit on outcome of the modified Norwood procedure.

The Annals of thoracic surgery

Azakie A, Martinez D, Sapru A, Fineman J, Teitel D, Karl TR

Inhaled nitric oxide decreases pulmonary soluble guanylate cyclase protein levels in 1-month-old lambs.

The Journal of thoracic and cardiovascular surgery

Thelitz S, Bekker JM, Ovadia B, Stuart RB, Johengen MJ, Black SM, Fineman JR

Phosphodiesterase-3 inhibition prevents the increase in pulmonary vascular resistance following inhaled nitric oxide withdrawal in lambs.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Thelitz S, Oishi P, Sanchez LS, Bekker JM, Ovadia B, Johengen MJ, Black SM, Fineman JR

Treatment of rebound and chronic pulmonary hypertension with oral sildenafil in an infant with congenital diaphragmatic hernia.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Keller RL, Hamrick SE, Kitterman JA, Fineman JR, Hawgood S

Increased pulmonary blood flow does not alter surfactant protein gene expression in lambs within the first week of life.

American journal of physiology. Lung cellular and molecular physiology

Lee JW, Ovadia B, Azakie A, Salas S, Goerke J, Fineman JR, Gutierrez JA

Pharmacologic therapy for persistent pulmonary hypertension of the newborn: as "poly" as the disease itself.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Oishi P, Fineman JR

Emergence of smooth muscle cell endothelin B-mediated vasoconstriction in lambs with experimental congenital heart disease and increased pulmonary blood flow.

Circulation

Black SM, Mata-Greenwood E, Dettman RW, Ovadia B, Fitzgerald RK, Reinhartz O, Thelitz S, Steinhorn RH, Gerrets R, Hendricks-Munoz K, Ross GA, Bekker JM, Johengen MJ, Fineman JR

Inhaled nitric oxide increases surfactant protein gene expression in the intact lamb.

American journal of physiology. Lung cellular and molecular physiology

Stuart RB, Ovadia B, Suzara VV, Ross PA, Thelitz S, Fineman JR, Gutierrez JA

Alterations in TGF-beta1 expression in lambs with increased pulmonary blood flow and pulmonary hypertension.

American journal of physiology. Lung cellular and molecular physiology

Mata-Greenwood E, Meyrick B, Steinhorn RH, Fineman JR, Black SM

Expression of VEGF and its receptors Flt-1 and Flk-1/KDR is altered in lambs with increased pulmonary blood flow and pulmonary hypertension.

American journal of physiology. Lung cellular and molecular physiology

Mata-Greenwood E, Meyrick B, Soifer SJ, Fineman JR, Black SM

Developmental differences in the shear stress-induced expression of endothelial NO synthase: changing role of AP-1.

American journal of physiology. Lung cellular and molecular physiology

Wedgwood S, Mitchell CJ, Fineman JR, Black SM

Alterations in ET-1, not nitric oxide, in 1-week-old lambs with increased pulmonary blood flow.

American journal of physiology. Heart and circulatory physiology

Ovadia B, Reinhartz O, Fitzgerald R, Bekker JM, Johengen MJ, Azakie A, Thelitz S, Black SM, Fineman JR

Pulmonary vascular K+ channel expression and vasoreactivity in a model of congenital heart disease.

American journal of physiology. Lung cellular and molecular physiology

Cornfield DN, Resnik ER, Herron JM, Reinhartz O, Fineman JR

Alterations in nitric oxide production in 8-week-old lambs with increased pulmonary blood flow.

Pediatric research

Black SM, Bekker JM, McMullan DM, Parry AJ, Ovadia B, Reinhartz O, Lakshminrushimha S, Mata-Greenwood E, Steinhorn RH, Fineman JR

Nitric oxide-endothelin-1 interactions after acute ductal constriction in fetal lambs.

American journal of physiology. Heart and circulatory physiology

Ovadia B, Bekker JM, Fitzgerald RK, Kon A, Thelitz S, Johengen MJ, Hendricks-Munoz K, Gerrets R, Black SM, Fineman JR

Decreased surfactant proteins in lambs with pulmonary hypertension secondary to increased blood flow.

American journal of physiology. Lung cellular and molecular physiology

Gutierrez JA, Parry AJ, McMullan DM, Chapin CJ, Fineman JR

sGC and PDE5 are elevated in lambs with increased pulmonary blood flow and pulmonary hypertension.

American journal of physiology. Lung cellular and molecular physiology

Black SM, Sanchez LS, Mata-Greenwood E, Bekker JM, Steinhorn RH, Fineman JR

Inhaled nitric oxide-induced rebound pulmonary hypertension: role for endothelin-1.

American journal of physiology. Heart and circulatory physiology

McMullan DM, Bekker JM, Johengen MJ, Hendricks-Munoz K, Gerrets R, Black SM, Fineman JR

Inhaled nitric oxide in neonates with persistent pulmonary hypertension.

Lancet (London, England)

Tworetzky W, Bristow J, Moore P, Brook MM, Segal MR, Brasch RC, Hawgood S, Fineman JR

Altered endothelium-dependent relaxations in lambs with high pulmonary blood flow and pulmonary hypertension.

American journal of physiology. Heart and circulatory physiology

Steinhorn RH, Russell JA, Lakshminrusimha S, Gugino SF, Black SM, Fineman JR

Alterations in endogenous nitric oxide production after cardiopulmonary bypass in lambs with normal and increased pulmonary blood flow.

Circulation

McMullan DM, Bekker JM, Parry AJ, Johengen MJ, Kon A, Heidersbach RS, Black SM, Fineman JR

Management and outcomes of delayed sternal closure after cardiac surgery in neonates and infants.

Critical care medicine

McElhinney DB, Reddy VM, Parry AJ, Johnson L, Fineman JR, Hanley FL

Pulmonary blood flow alters nitric oxide production in patients undergoing device closure of atrial septal defects.

Journal of the American College of Cardiology

Tworetzky W, Moore P, Bekker JM, Bristow J, Black SM, Fineman JR

Altered regulation of the ET-1 cascade in lambs with increased pulmonary blood flow and pulmonary hypertension.

Pediatric research

Black SM, Bekker JM, Johengen MJ, Parry AJ, Soifer SJ, Fineman JR

Inhaled nitric oxide inhibits NOS activity in lambs: potential mechanism for rebound pulmonary hypertension.

The American journal of physiology

Black SM, Heidersbach RS, McMullan DM, Bekker JM, Johengen MJ, Fineman JR

Alveolar capillary dysplasia: diagnostic potential for cardiac catheterization.

Journal of perinatology : official journal of the California Perinatal Association

Hintz SR, Vincent JA, Pitlick PT, Fineman JR, Steinhorn RH, Kim GE, Benitz WE

Altered endothelial function in lambs with pulmonary hypertension and acute lung injury.

Pediatric pulmonology

Fineman JR, Wong J, Mikhailov T, Vanderford PA, Jerome HE, Soifer SJ

Endothelin receptor blockade prevents the rise in pulmonary vascular resistance after cardiopulmonary bypass in lambs with increased pulmonary blood flow.

The Journal of thoracic and cardiovascular surgery

Petrossian E, Parry AJ, Reddy VM, Akkersdijk GP, McMullan DM, Thompson L, Hendricks-Munoz KD, Hallak H, Hanley FL, Fineman JR

Role of the endothelium in placental dysfunction after fetal cardiac bypass.

The Journal of thoracic and cardiovascular surgery

Reddy VM, McElhinney DB, Rajasinghe HA, Liddicoat JR, Hendricks-Munoz K, Fineman JR, Hanley FL

Endothelin-receptor blockade does not alter closure of the ductus arteriosus.

The American journal of physiology

Fineman JR, Takahashi Y, Roman C, Clyman RI

Increased endothelial NOS in lambs with increased pulmonary blood flow and pulmonary hypertension.

The American journal of physiology

Black SM, Fineman JR, Steinhorn RH, Bristow J, Soifer SJ

The effects of inhaled nitric oxide on postoperative pulmonary hypertension in infants and children undergoing surgical repair of congenital heart disease.

Anesthesia and analgesia

Russell IA, Zwass MS, Fineman JR, Balea M, Rouine-Rapp K, Brook M, Hanley FL, Silverman NH, Cahalan MK

Inhaled nitric oxide enhances oxygenation but not survival in infants with alveolar capillary dysplasia.

The Journal of pediatrics

Steinhorn RH, Cox PN, Fineman JR, Finer NN, Rosenberg EM, Silver MM, Tyebkhan J, Zwass MS, Morin FC

Inhaled nitric oxide and persistent pulmonary hypertension of the newborn. The Inhaled Nitric Oxide Study Group.

The New England journal of medicine

Roberts JD, Fineman JR, Morin FC, Shaul PW, Rimar S, Schreiber MD, Polin RA, Zwass MS, Zayek MM, Gross I, Heymann MA, Zapol WM

Post-cardiopulmonary bypass pulmonary hypertension in lambs with increased pulmonary blood flow. A role for endothelin 1.

Circulation

Reddy VM, Hendricks-Munoz KD, Rajasinghe HA, Petrossian E, Hanley FL, Fineman JR

Hemodynamic effects of epinephrine, bicarbonate and calcium in the early postnatal period in a lamb model of single-ventricle physiology created in utero.

Journal of the American College of Cardiology

Reddy VM, Liddicoat JR, McElhinney DB, Fineman JR, Klein JR, Chang R, Hanley FL

Altered endothelium-dependent responses in lambs with pulmonary hypertension and increased pulmonary blood flow.

The American journal of physiology

Reddy VM, Wong J, Liddicoat JR, Johengen M, Chang R, Fineman JR

Exogenous endothelin-1 causes renal vasodilation in the fetal lamb.

The Journal of urology

Bogaert GA, Kogan BA, Mevorach RA, Wong J, Gluckman GR, Fineman JR, Heymann MA

Fetal model of single ventricle physiology: hemodynamic effects of oxygen, nitric oxide, carbon dioxide, and hypoxia in the early postnatal period.

The Journal of thoracic and cardiovascular surgery

Reddy VM, Liddicoat JR, Fineman JR, McElhinney DB, Klein JR, Hanley FL

Endothelin receptor blockade does not alter the increase in pulmonary blood flow due to oxygen ventilation in fetal lambs.

Pediatric research

Winters JW, Wong J, Van Dyke D, Johengen M, Heymann MA, Fineman JR

Endothelin-1 vasoactive responses in lambs with pulmonary hypertension and increased pulmonary blood flow.

The American journal of physiology

Wong J, Reddy VM, Hendricks-Munoz K, Liddicoat JR, Gerrets R, Fineman JR

Inhaled nitric oxide therapy for persistent pulmonary hypertension of the newborn.

Acta paediatrica Japonica : Overseas edition

Fineman JR, Zwass MS

Endothelinb receptor agonists produce pulmonary vasodilation in intact newborn lambs with pulmonary hypertension.

Journal of cardiovascular pharmacology

Wong J, Vanderford PA, Winters J, Soifer SJ, Fineman JR

Regulation of pulmonary vascular tone in the perinatal period.

Annual review of physiology

Fineman JR, Soifer SJ, Heymann MA

Inhaled nitric oxide in congenital hypoplasia of the lungs due to diaphragmatic hernia or oligohydramnios.

Pediatrics

Karamanoukian HL, Glick PL, Zayek M, Steinhorn RH, Zwass MS, Fineman JR, Morin FC

Developmental effects of endothelin-1 on the pulmonary circulation in sheep.

Pediatric research

Wong J, Vanderford PA, Fineman JR, Soifer SJ

Chronic nitric oxide inhibition in utero produces persistent pulmonary hypertension in newborn lambs.

The Journal of clinical investigation

Fineman JR, Wong J, Morin FC, Wild LM, Soifer SJ

HA1004, an intracellular calcium antagonist, selectively attenuates pulmonary hypertension in newborn lambs.

Journal of cardiovascular pharmacology

Crowley MR, Fineman JR, Soifer SJ

Diethylamine/nitric oxide (NO) adduct, an NO donor, produces potent pulmonary and systemic vasodilation in intact newborn lambs.

Journal of cardiovascular pharmacology

Vanderford PA, Wong J, Chang R, Keefer LK, Soifer SJ, Fineman JR

Endothelin-1 produces pulmonary vasodilation in the intact newborn lamb.

The American journal of physiology

Wong J, Vanderford PA, Fineman JR, Chang R, Soifer SJ

Endothelin-1 does not mediate acute hypoxic pulmonary vasoconstriction in the intact newborn lamb.

Journal of cardiovascular pharmacology

Wong J, Vanderford PA, Winters JW, Chang R, Soifer SJ, Fineman JR

M&B 22948, a cGMP phosphodiesterase inhibitor, is a pulmonary vasodilator in lambs.

The American journal of physiology

Braner DA, Fineman JR, Chang R, Soifer SJ

EDRF inhibition attenuates the increase in pulmonary blood flow due to oxygen ventilation in fetal lambs.

Journal of applied physiology (Bethesda, Md. : 1985)

Moore P, Velvis H, Fineman JR, Soifer SJ, Heymann MA

K+ channel pulmonary vasodilation in fetal lambs: role of endothelium-derived nitric oxide.

Journal of applied physiology (Bethesda, Md. : 1985)

Chang JK, Moore P, Fineman JR, Soifer SJ, Heymann MA

EDRF inhibition augments pulmonary hypertension in intact newborn lambs.

The American journal of physiology

Fineman JR, Chang R, Soifer SJ

L-Arginine, a precursor of EDRF in vitro, produces pulmonary vasodilation in lambs.

The American journal of physiology

Fineman JR, Chang R, Soifer SJ

In vivo attenuation of endothelium-dependent pulmonary vasodilation by methylene blue.

Journal of applied physiology (Bethesda, Md. : 1985)

Fineman JR, Crowley MR, Heymann MA, Soifer SJ

N omega-nitro-L-arginine attenuates endothelium-dependent pulmonary vasodilation in lambs.

The American journal of physiology

Fineman JR, Heymann MA, Soifer SJ

The role of pulmonary vascular endothelium in perinatal pulmonary circulatory regulation.

Seminars in perinatology

Fineman JR, Soifer SJ, Heymann MA

Selective pulmonary vasodilation with ATP-MgCl2 during pulmonary hypertension in lambs.

Journal of applied physiology (Bethesda, Md. : 1985)

Fineman JR, Crowley MR, Soifer SJ

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Affiliate Faculty