
Research Summary:
Cardiac Electrophysiology, Arrhythmias, Mechanisms, Remodeling, Cardiac Fibrosis, Atrial Fibrillation, Cardiac Ablation, Mouse models, animal models, mouse electrophysiology, optical mapping, atrial fibrillation ablation, clinical trials. Summary: Mechanisms of arrhythmias, remodeling and cardiac fibrosis, atrial fibrillation, ventricular fibrillation, sudden death, prediction of atrial fibrillation, prediction of sudden death. Dr. Olgin's basic research lab is interested in atrial and ventricular remodeling and how these processes occur to develop a substrate for atrial fibrillation and ventricular tachycardia. His work has demonstrated the circuit for human atrial flutter and has demonstrated the importance of atrial fibrosis as a cause for atrial fibrillation. He is currently interested in how TGFß signaling is regulated in the atria to produce atrial fibrosis and atrial fibrillation. His lab is translational in that he utilizes a spectrum of techniques and studies that span from mouse, large animal physiologic models, human tissue, human biomarkers and genetic approaches to understanding the disease. He also has active studies in understanding the remodeling that occurs in the ventricle in the setting of heart failure and myocardial infarction to create the substrate for sudden death and ventricular tachycardia and fibrillation. Dr. Olgin also runs the UCSF Cardiology Clinical Coordinating Center. He is PI of the VEST study, a multi-center, international randomized study to determine whether a wearable defibrillator vest can reduce the big early sudden death rate post-MI.
Publications
New Threshold for Defining Mild Aortic Stenosis Derived From Velocity-Encoded MRI in 60,000 Individuals.
Associations between local COVID-19 policies and anxiety in the USA: a longitudinal digital cohort study.
Molecular convergence of risk variants for congenital heart defects leveraging a regulatory map of the human fetal heart.
Shorter Premature Atrial Complex Coupling Interval Leads to Mechanical Dysfunction, Fibrosis, and AF in Swine.
Atrial Flutter and Sick Sinus Syndrome.
Fear of Cancer Recurrence in Adult Survivors of Childhood Cancer.
Single-nucleus RNA/ATAC-seq in early-stage HCM models predicts SWI/SNF-activation in mutant-myocytes, and allele-specific differences in fibroblasts.
Mechanical Dispersion Discriminates Between Arrhythmic and Nonarrhythmic Sudden Death: From the POST SCD Study.
Continuous Atrial Fibrillation Monitoring From Photoplethysmography: Comparison Between Supervised Deep Learning and Heuristic Signal Processing.
Acute alcohol exposure and electrocardiographic changes: Finding from the HOLIDAY trial.
Association of nirmatrelvir for acute SARS-CoV-2 infection with subsequent Long COVID symptoms in an observational cohort study.
Email-Based Recruitment Into the Health eHeart Study: Cohort Analysis of Invited Eligible Patients.
Cholecystokinin-A signaling regulates automaticity of pacemaker cardiomyocytes.
Digital Tool-Assisted Hospitalization Detection in the Tailored Antiplatelet Initiation to Lessen Outcomes due to Decreased Clopidogrel Response After Percutaneous Coronary Intervention Study Compared to Traditional Site-Coordinator Ascertainment: Interve
Development of text messages for primary prevention of cardiovascular disease in persons with HIV.
Preceding Night Sleep Quality and Atrial Fibrillation Episodes in the I-STOP-AFIB Randomized Trial.
Cholecystokinin-A Signaling Regulates Automaticity of Pacemaker Cardiomyocytes.
CathAI: fully automated coronary angiography interpretation and stenosis estimation.
Cardiac contraction and relaxation are regulated by distinct subcellular cAMP pools.
Interindividual Variability in Self-Monitoring of Blood Pressure Using Consumer-Purchased Wireless Devices.
Automated Assessment of Cardiac Systolic Function From Coronary Angiograms With Video-Based Artificial Intelligence Algorithms.
Mechanical Dispersion Discriminates between Arrhythmic and Non-Arrhythmic Sudden Death: From the POST SCD Study.
Assessment of valvular function in over 47,000 people using deep learning-based flow measurements.
Acute Effects of Coffee Consumption on Health among Ambulatory Adults.
Deep learning augmented ECG analysis to identify biomarker-defined myocardial injury.
Factors Associated With Long COVID Symptoms in an Online Cohort Study.
Electrocardiogram Detection of Pulmonary Hypertension Using Deep Learning.
Premature Atrial Contraction Location and Atrial Fibrillation Inducibility.
Unreported SARS-CoV-2 Home Testing and Test Positivity.
Association of daily physical activity with brain volumes and cervical spinal cord areas in multiple sclerosis.
Factors Associated with Long Covid Symptoms in an Online Cohort Study.
Heart Failure Burden by Autopsy, Guideline-Directed Medical Therapy, and ICD Utilization Among Sudden Deaths.
Risk Factors for Arrhythmic Death, Overall Mortality, and Ventricular Tachyarrhythmias Requiring Shock After Myocardial Infarction.
A common allele of HLA mediates asymptomatic SARS-CoV-2 infection.
The U.S. COVID-19 County Policy Database: a novel resource to support pandemic-related research.
Worldwide physical activity trends since COVID-19 onset.
Patient Onboarding and Engagement to Build a Digital Study After Enrollment in a Clinical Trial (TAILOR-PCI Digital Study): Intervention Study.
Underdiagnosis and Undertreatment of Modifiable Cardiovascular Risk Factors Among Survivors of Childhood Cancer.
Making Every Step Count: Minute-by-Minute Characterization of Step Counts Augments Remote Activity Monitoring in People With Multiple Sclerosis.
Atrial Fibrillation Detection and Atrial Fibrillation Burden Estimation via Wearables.
Assessment of Disease Status and Treatment Response With Artificial Intelligence-Enhanced Electrocardiography in Obstructive Hypertrophic Cardiomyopathy.
Digital platforms for clinical trials: The Eureka experience.
Remote Assessment of Cardiovascular Risk Factors and Cognition in Middle-Aged and Older Adults: Proof-of-Concept Study.
Individualized Studies of Triggers of Paroxysmal Atrial Fibrillation: The I-STOP-AFib Randomized Clinical Trial.
Performance of a Convolutional Neural Network and Explainability Technique for 12-Lead Electrocardiogram Interpretation.
Acute Consumption of Alcohol and Discrete Atrial Fibrillation Events.
The COVID-19 Citizen Science Study: Protocol for a Longitudinal Digital Health Cohort Study.
Identifying falls remotely in people with multiple sclerosis.
Predicting Incident Heart Failure in Women With Machine Learning: The Women's Health Initiative Cohort.
Sudden Cardiac Death and Myocardial Fibrosis, Determined by Autopsy, in Persons with HIV.
Smartphone-Based VO2max Measurement With Heart Snapshot in Clinical and Real-world Settings With a Diverse Population: Validation Study.
Factors Associated With Access to and Timing of Coronavirus Testing Among US Adults After Onset of Febrile Illness.
The RADx Tech Clinical Studies Core: A Model for Academic Based Clinical Studies.
Machine learning prediction of blood alcohol concentration: a digital signature of smart-breathalyzer behavior.
Sex and Racial Differences in Autopsy-Defined Causes of Presumed Sudden Cardiac Death.
Validation of an algorithm for continuous monitoring of atrial fibrillation using a consumer smartwatch.
Characteristics and Behaviors Associated with Prevalent SARS-CoV-2 Infection.
Body Weight Changes During Pandemic-Related Shelter-in-Place in a Longitudinal Cohort Study.
Antemortem and Post-Mortem Characteristics of Lethal Mitral Valve Prolapse Among All Countywide Sudden Deaths.
Atrial Fibrillation is Associated With Greater Risk of Dementia in Older Veterans.
A Randomized, Double-Blind, Placebo-Controlled Trial of Intravenous Alcohol to Assess Changes in Atrial Electrophysiology.
Comparison of the Physical Activity Measured by a Consumer Wearable Activity Tracker and That Measured by Self-Report: Cross-Sectional Analysis of the Health eHeart Study.
Effects of Time-Restricted Eating on Weight Loss and Other Metabolic Parameters in Women and Men With Overweight and Obesity: The TREAT Randomized Clinical Trial.
Rationale and design of the TAILOR-PCI digital study: Transitioning a randomized controlled trial to a digital registry.
Dyssynchrony and Fibrosis Persist After Resolution of Cardiomyopathy in a Swine Premature Ventricular Contraction Model.
Assessment of Accelerometer-Based Physical Activity During the 2017-2018 California Wildfire Seasons.
Worldwide Effect of COVID-19 on Physical Activity: A Descriptive Study.
EventDTW: An Improved Dynamic Time Warping Algorithm for Aligning Biomedical Signals of Nonuniform Sampling Frequencies.
Association of QT-Prolonging Medications With Risk of Autopsy-Defined Causes of Sudden Death.
Atrial fibrillation detection from raw photoplethysmography waveforms: A deep learning application.
Wearable cardioverter-defibrillators: A review of evidence and indications.
Impact of wearable cardioverter-defibrillator compliance on outcomes in the VEST trial: As-treated and per-protocol analyses.
The Rise of Open-Sourced Machine Learning in Small and Imbalanced Datasets: Predicting In-Stent Restenosis.
Differences in microRNA-29 and Pro-fibrotic Gene Expression in Mouse and Human Hypertrophic Cardiomyopathy.
Validation of a consumer-grade activity monitor for continuous daily activity monitoring in individuals with multiple sclerosis.
Comparison of On-Site Versus Remote Mobile Device Support in the Framingham Heart Study Using the Health eHeart Study for Digital Follow-up: Randomized Pilot Study Set Within an Observational Study Design.
A Cryoinjury Model to Study Myocardial Infarction in the Mouse.
Characteristics of Atrial Fibrillation Patients with a Family History of Atrial Fibrillation.
Refining the World Health Organization Definition: Predicting Autopsy-Defined Sudden Arrhythmic Deaths Among Presumed Sudden Cardiac Deaths in the POST SCD Study.
Real-world heart rate norms in the Health eHeart study.
Low Left Atrial Strain Is Associated With Adverse Outcomes in Hypertrophic Cardiomyopathy Patients.
Evidence for hormonal control of heart regenerative capacity during endothermy acquisition.
Association of Continuous Assessment of Step Count by Remote Monitoring With Disability Progression Among Adults With Multiple Sclerosis.
Identifying Ventricular Arrhythmias and Their Predictors by Applying Machine Learning Methods to Electronic Health Records in Patients With Hypertrophic Cardiomyopathy (HCM-VAr-Risk Model).
Wearable Cardioverter-Defibrillator after Myocardial Infarction.
Absence of natriuretic peptide clearance receptor attenuates TGF-β1-induced selective atrial fibrosis and atrial fibrillation.
Temporal patterns of self-weighing behavior and weight changes assessed by consumer purchased scales in the Health eHeart Study.
Hypertrophic Cardiomyopathy Patients With Paroxysmal Atrial Fibrillation Have a High Burden of Left Atrial Fibrosis by Cardiac Magnetic Resonance Imaging.
Left Ventricular Dyssynchrony Predicts the Cardiomyopathy Associated With Premature Ventricular Contractions.
Wearable Cardioverter-Defibrillator after Myocardial Infarction.
Identifying heart failure using EMR-based algorithms.
Cigarette and e-cigarette dual use and risk of cardiopulmonary symptoms in the Health eHeart Study.
Prospective Countywide Surveillance and Autopsy Characterization of Sudden Cardiac Death: POST SCD Study.
Using Digital Health Technology to Better Generate Evidence and Deliver Evidence-Based Care.
Wilson's Disease and Cardiac Myopathy.
Atrial fibrillation patients with isolated pulmonary veins: Is sinus rhythm achievable?
Primary Prevention of Sudden Cardiac Death Early Post-Myocardial Infarction: Root Cause Analysis for Implantable Cardioverter-Defibrillator Failure and Currently Available Options.
Volunteer Participation in the Health eHeart Study: A Comparison with the US Population.
Smartphone-Based Geofencing to Ascertain Hospitalizations.
Bundle Branch Re-Entrant Ventricular Tachycardia: Novel Genetic Mechanisms in a Life-Threatening Arrhythmia.
Continuous daily assessment of multiple sclerosis disability using remote step count monitoring.
The QT Interval as a Noninvasive Marker of Atrial Refractoriness.
Atrial Fibrillation Associated Genetic Variants and Left Atrial Histology: Evaluation for Molecular Sub-Phenotypes.
Genetic Investigation Into the Differential Risk of Atrial Fibrillation Among Black and White Individuals.
Access to alcohol and heart disease among patients in hospital: observational cohort study using differences in alcohol sales laws.
Predicting Persistent Left Ventricular Dysfunction Following Myocardial Infarction: The PREDICTS Study.
Impact of genetic variants on the upstream efficacy of renin-angiotensin system inhibitors for the prevention of atrial fibrillation.
Measurement of brachial artery endothelial function using a standard blood pressure cuff.
Accuracy and Usability of a Self-Administered 6-Minute Walk Test Smartphone Application.
Sudden Death in Patients With Cardiac Implantable Electronic Devices.
The effects of remodeling with heart failure on mode of initiation of ventricular fibrillation and its spatiotemporal organization.
Perceptions, Information Sources, and Behavior Regarding Alcohol and Heart Health.
Immuno-modification of enhancing stem cells targeting for myocardial repair.
Targeted deep sequencing reveals no definitive evidence for somatic mosaicism in atrial fibrillation.
Telomere length and the risk of atrial fibrillation: insights into the role of biological versus chronological aging.
Atrial fibrillation therapy now and in the future: drugs, biologicals, and ablation.
Coupling interval dispersion and body mass index are independent predictors of idiopathic premature ventricular complex-induced cardiomyopathy.
Safety of new oral anticoagulants for patients undergoing atrial fibrillation ablation.
Impact of a 4q25 genetic variant in atrial flutter and on the risk of atrial fibrillation after cavotricuspid isthmus ablation.
Randomized trial of conventional transseptal needle versus radiofrequency energy needle puncture for left atrial access (the TRAVERSE-LA study).
Molecular basis of selective atrial fibrosis due to overexpression of transforming growth factor-β1.
Asymptomatic Left Bundle Branch Block Predicts New-Onset Congestive Heart Failure and Death From Cardiovascular Diseases.
Diagnosis and ablation of multiform fascicular tachycardia.
Alcohol and vagal tone as triggers for paroxysmal atrial fibrillation.
Predictors of axillary vein location for vascular access during pacemaker and defibrillator lead implantation.
GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease.
Predictors of unusual ECG characteristics in cavotricuspid isthmus-dependent atrial flutter ablation.
Frequency of atrial flutter after adult lung transplantation.
Approach to the Patient with Suspected Arrhythmias
Wenckebach during supraventricular tachycardia.
Prospective observations in the clinical and electrophysiological characteristics of intra-isthmus reentry.
Cardiac conduction is required to preserve cardiac chamber morphology.
Pirfenidone mitigates left ventricular fibrosis and dysfunction after myocardial infarction and reduces arrhythmias.
Racial differences in atrial fibrillation prevalence and left atrial size.
High-resolution optical mapping of ventricular tachycardia in rats with chronic myocardial infarction.
Atrial Fibrillation Substrates and Mechanisms. In Cardiac Electrophysiology. 5th Ed. Edited by Zipes and Jalife
Specific Arrhythmias: Diagnosis and Treatment. In: Heart Disease: A Textbook of Cardiovascular Medicine. 9th Ed. Edited by Braunwald, Zipes, Libby
Association of TGFBR2 polymorphism with risk of sudden cardiac arrest in patients with coronary artery disease.
Test characteristics of neck fullness and witnessed neck pulsations in the diagnosis of typical AV nodal reentrant tachycardia.
Prevention of atrial fibrillation: report from a national heart, lung, and blood institute workshop.
Atrial Tachycardias. In Cardiac Mapping. Edited by Shenasa and Bogreffe
Impact of remote magnetic catheter navigation on ablation fluoroscopy and procedure time.
Rates and severity of perforation from implantable cardioverter-defibrillator leads: a 4-year study.
Impact of advanced age on survival in patients with implantable cardioverter defibrillators.
Safety profiles and lesion size of different radiofrequency ablation technologies: a comparison of large tip, open and closed irrigation catheters.
Protracted CRP elevation after atrial fibrillation ablation.
Alcohol intake is significantly associated with atrial flutter in patients under 60 years of age and a shorter right atrial effective refractory period.
Phase angle shift is a better determinant for catheter electrode contact with tissue compared to a catheter sensed electrogram.
Interleukin-6 and atrial fibrillation in patients with coronary artery disease: data from the Heart and Soul Study.
Effects of atrial fibrillation substrate and spatiotemporal organization on atrial defibrillation thresholds.
Impact of renal function on survival in patients with implantable cardioverter-defibrillators.
Repeat transseptal catheterization after ablation for atrial fibrillation.
Structural atrial remodeling alters the substrate and spatiotemporal organization of atrial fibrillation: a comparison in canine models of structural and electrical atrial remodeling.
A unique method by which to quantitate synchrony with equilibrium radionuclide angiography.
Inhibition of angiotensin II signaling and recurrence of atrial fibrillation in AFFIRM.
Increased vulnerability to atrial fibrillation in transgenic mice with selective atrial fibrosis caused by overexpression of TGF-beta1.
Direction-dependent conduction abnormalities in a canine model of atrial fibrillation due to chronic atrial dilatation.
Left atrial dilatation resulting from chronic mitral regurgitation decreases spatiotemporal organization of atrial fibrillation in left atrium.
Basic mechanisms of atrial fibrillation.
Feature extraction of the atrial fibrillation signal using the continuous wavelet transform.
Atrial fibrillation: what are the targets for intervention?
Arrhythmogenic substrate of the pulmonary veins assessed by high-resolution optical mapping.
Tissue structure and connexin expression of canine pulmonary veins.
A changing tachycardia that did not change.
Biphasic versus monophasic shock waveform for conversion of atrial fibrillation: the results of an international randomized, double-blind multicenter trial.
Short-term rapid atrial pacing produces electrical remodeling of sinus node function in humans.
Effects of thoracic spinal cord stimulation on cardiac autonomic regulation of the sinus and atrioventricular nodes.
Transgenic and knockout mouse models of atrial arrhythmias.
Treatable causes of sudden death: not really "treatable" or not really the cause?
Localization of the origin of arrhythmias for ablation: from Electrocardiography to advanced endocardial mapping systems.
Mechanisms underlying the reentrant circuit of atrioventricular nodal reentrant tachycardia in isolated canine atrioventricular nodal preparation using optical mapping.
Is the coronary sinus really reflective of left atrial activation?
Termination of reentrant atrial tachycardia by a nonpropagated extrastimulus.
Differences in organization between acute and chronic atrial fibrillation in dogs.
A high-temporal resolution algorithm for quantifying organization during atrial fibrillation.
Management of intermittent atrial fibrillation: drugs to maintain sinus rhythm.
Optimal management of the patient with chronic atrial fibrillation: whom to cardiovert?
Radiofrequency catheter ablation for postinfarct ventricular tachycardia.
Atrial macroreentry involving the myocardium of the coronary sinus: a unique mechanism for atypical flutter.
"Cristal tachycardias": origin of right atrial tachycardias from the crista terminalis identified by intracardiac echocardiography.
Acute effects of intraoperative multisite ventricular pacing on left ventricular function and activation/contraction sequence in patients with depressed ventricular function.
Electrical mapping in combination with intracardiac ultrasound for electrical-anatomic correlation.
Ablation of atrial fibrillation.
The laboratory evaluation and role of catheter ablation for patients with atrial flutter.
Electrophysiological effects of long, linear atrial lesions placed under intracardiac ultrasound guidance.
Use of intracardiac echocardiography in interventional electrophysiology.
Electrocardiographic and electrophysiologic characterization of atypical atrial flutter in man: use of activation and entrainment mapping and implications for catheter ablation.
Mechanism of initiation of atrial flutter in humans: site of unidirectional block and direction of rotation.
The treatment of atrial fibrillation: pharmacologic and nonpharmacologic strategies.
Biophysical characteristics of radiofrequency lesion formation in vivo: dynamics of catheter tip-tissue contact evaluated by intracardiac echocardiography.
Postextrasystolic U wave augmentation, a new marker of increased arrhythmic risk in patients without the long QT syndrome.
Conduction barriers in human atrial flutter: correlation of electrophysiology and anatomy.
Regional entrainment of atrial fibrillation in man.
Pathological findings following slow pathway ablation for AV nodal reentrant tachycardia.
Results of radiofrequency catheter ablation for atrial flutter.
New approaches to treatment of atrial flutter and tachycardia.
The role of atrial anatomy in clinical atrial arrhythmias.
Radiofrequency catheter modification of the sinus node for "inappropriate" sinus tachycardia.
Comparison of high energy direct current and radiofrequency catheter ablation of the atrioventricular junction.
A blinded comparison of noninvasive, in vivo phosphorus nuclear magnetic resonance spectroscopy and the in vitro halothane/caffeine contracture test in the evaluation of malignant hyperthermia susceptibility.
Non-invasive evaluation of malignant hyperthermia susceptibility with phosphorus nuclear magnetic resonance spectroscopy.
Mitochondrial redox changes during rest-work transition in dog gracilis muscle.
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