Professor
M_MED-CORE-ENDO
Research Interests
Biomolecules involved in Lipid:Cardiovascular biology
Email
+1 415 476-2241
Faculty Type
Core CVRI Faculty
Research Summary:
Structure and function of lipoproteins; genetic determinants of arteriosclerosis Summary: The Kane laboratory focuses on the discovery of the native structures of lipoproteins ( proteins that carry cholesterol so that we can better understand how they are involved in the development of heart disease and stroke. We are also active in the discovery of alterations in genes that lead to heart disease and stroke.
Publications
Increased prevalence of coronary heart disease among current smokers carrying APOL1 risk variants within the African American population.
Journal of clinical lipidology
Meta-analysis of genome-wide associations and polygenic risk prediction for atrial fibrillation in more than 180,000 cases.
Nature genetics
Identification and functional analysis of novel homozygous LMF1 variants in severe hypertriglyceridemia.
Journal of clinical lipidology
Logistic Regression and Statistical Regularization Techniques for Risk Classification of Coronary Artery Disease using Cytokines transported by high density lipoproteins.
Proceedings. International Conference on Computational Science and Computational Intelligence
Optimization of Smoking Classification by Applying Neural Network with Variable Importance Using Cytokine Biomarkers.
Proceedings. International Conference on Computational Science and Computational Intelligence
Smoking Classification Using Novel Plasma Cytokines by implementing Machine Learning and Statistical Methods.
Proceedings. International Conference on Computational Science and Computational Intelligence
Trends in cannabis use in New Jersey: Effects of COVID-19 and cannabis legalization.
Journal of the American College of Emergency Physicians open
Meta-Analysis of Genome-Wide Association Studies Reveals Genetic Mechanisms of Supraventricular Arrhythmias.
Circulation. Genomic and precision medicine
APOL1 Risk Variants Associate With the Prevalence of Stroke in African American Current and Past Smokers.
Journal of the American Heart Association
APOL1 Risk Variants Associate with the Prevalence of Stroke in African American Current and Past Smokers.
medRxiv : the preprint server for health sciences
Contemporary Homozygous Familial Hypercholesterolemia in the United States: Insights From the CASCADE FH Registry.
Journal of the American Heart Association
Structural variation across 138,134 samples in the TOPMed consortium.
bioRxiv : the preprint server for biology
Elastin Degradation and Lung Function Deterioration with Remote Secondhand Tobacco Smoke Exposure in Never-smokers.
Chronic obstructive pulmonary diseases (Miami, Fla.)
Application of Machine Learning Ensemble Super Learner for analysis of the cytokines transported by high density lipoproteins (HDL) of smokers and nonsmokers.
Proceedings. International Conference on Computational Science and Computational Intelligence
Implementation of PCA enabled Support Vector Machine using cytokines to differentiate smokers versus nonsmokers.
Proceedings. International Conference on Computational Science and Computational Intelligence
Whole-exome sequencing reveals damaging gene variants associated with hypoalphalipoproteinemia.
Journal of lipid research
Dyslipidemia and diabetes mellitus: Role of lipoprotein species and interrelated pathways of lipid metabolism in diabetes mellitus.
Current opinion in pharmacology
Machine learning and statistical approaches for classification of risk of coronary artery disease using plasma cytokines.
BioData mining
Levels of Prebeta-1 High-Density Lipoprotein Are a Strong Independent Positive Risk Factor for Coronary Heart Disease and Myocardial Infarction: A Meta-Analysis.
Journal of the American Heart Association
Ancestry-specific profiles of genetic determinants of severe hypertriglyceridemia.
Journal of clinical lipidology
Loss-of-Function CREB3L3 Variants in Patients With Severe Hypertriglyceridemia.
Arteriosclerosis, thrombosis, and vascular biology
Separation of postprandial lipoproteins: improved purification of chylomicrons using an ApoB100 immunoaffinity method.
Journal of lipid research
Three patients with homozygous familial hypercholesterolemia: Genomic sequencing and kindred analysis.
Molecular genetics & genomic medicine
Cardiac 123I-MIBG normal uptake values are population-specific: Results from a cohort of controls over 60 years of age.
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
Partial LPL deletions: rare copy-number variants contributing towards severe hypertriglyceridemia.
Journal of lipid research
Emerging roles of HDL in immune function.
Current opinion in lipidology
Severe hypertriglyceridemia is primarily polygenic.
Journal of clinical lipidology
Levels of prebeta-1 high-density lipoprotein are elevated in 3 phenotypes of dyslipidemia.
Journal of clinical lipidology
Moderate statin treatment reduces prebeta-1 high-density lipoprotein levels in dyslipidemic patients.
Journal of clinical lipidology
Biochemical Analysis of the Lipoprotein Lipase Truncation Variant, LPLS447X, Reveals Increased Lipoprotein Uptake.
Biochemistry
Lipoproteins and amyloid vascular disease.
Current opinion in lipidology
Familial hypercholesterolaemia: cholesterol efflux and coronary disease.
European journal of clinical investigation
Infectious basophilia?
American journal of hematology
Emerging molecular strategies for management of dyslipidemias.
Current opinion in lipidology
Cholesterol Efflux Capacity and Pre-Beta-1 HDL Concentrations Are Increased in Dyslipidemic Patients Treated With Evacetrapib.
Journal of the American College of Cardiology
Identification and metabolic profiling of patients with lysosomal acid lipase deficiency.
Journal of clinical lipidology
HDL cholesterol efflux capacity and cardiovascular events.
The New England journal of medicine
Exome sequencing in suspected monogenic dyslipidemias.
Circulation. Cardiovascular genetics
Effects of the absence of apolipoprotein e on lipoproteins, neurocognitive function, and retinal function.
JAMA neurology
Aberrant hetero-disulfide bond formation by the hypertriglyceridemia-associated p.Gly185Cys APOA5 variant (rs2075291).
Arteriosclerosis, thrombosis, and vascular biology
Sebelipase alfa over 52 weeks reduces serum transaminases, liver volume and improves serum lipids in patients with lysosomal acid lipase deficiency.
Journal of hepatology
Association of endothelial lipase Thr111Ile polymorphism with proliferative retinopathy in type 2 diabetes patients.
Diabetes & metabolism
Lipoprotein (a), LPA Ile4399Met, and fibrin clot properties.
Thrombosis research
Impact of a 4q25 genetic variant in atrial flutter and on the risk of atrial fibrillation after cavotricuspid isthmus ablation.
Journal of cardiovascular electrophysiology
Evidence that an HMGA1 gene variant associates with type 2 diabetes, body mass index, and high-density lipoprotein cholesterol in a Hispanic-American population.
Metabolic syndrome and related disorders
Needed: a better understanding of the antiatherogenic properties of HDL.
Current opinion in lipidology
New horizons in lipid management.
Journal of the American College of Cardiology
Deficiency of TDAG51 protects against atherosclerosis by modulating apoptosis, cholesterol efflux, and peroxiredoxin-1 expression.
Journal of the American Heart Association
Clinical effect and safety profile of recombinant human lysosomal acid lipase in patients with cholesteryl ester storage disease.
Hepatology (Baltimore, Md.)
Hyperlipidemia and cardiovascular disease.
Current opinion in lipidology
Prebeta-1 HDL and coronary heart disease.
Current opinion in lipidology
New molecular insights into CETP structure and function: a review.
Journal of lipid research
Rare and common variants in CARD14, encoding an epidermal regulator of NF-kappaB, in psoriasis.
American journal of human genetics
Polymorphisms and noncardioembolic stroke in three case-control studies.
Cerebrovascular diseases (Basel, Switzerland)
Relation of increased prebeta-1 high-density lipoprotein levels to risk of coronary heart disease.
The American journal of cardiology
Evaluation of polymorphisms in EWSR1 and risk of Ewing sarcoma: a report from the Childhood Cancer Survivor Study.
Pediatric blood & cancer
Disruption of the murine procollagen C-proteinase enhancer 2 gene causes accumulation of pro-apoA-I and increased HDL levels.
Journal of lipid research
Association of endothelial lipase Thr111Ile polymorphism with lipid metabolism and microvascular complications in type 2 diabetic patients.
Diabetes & metabolism
Morphology and structure of lipoproteins revealed by an optimized negative-staining protocol of electron microscopy.
Journal of lipid research
Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?
Pharmacogenomics
Metabolic abnormalities and coronary heart disease risk in human immunodeficiency virus-infected adults.
Metabolic syndrome and related disorders
Single variants can explain the association between coronary heart disease and haplotypes in the apolipoprotein(a) locus.
Atherosclerosis
Effect of niacin on preβ-1 high-density lipoprotein levels in diabetes.
Metabolism: clinical and experimental
High-density lipoprotein metabolism and the human embryo.
Human reproduction update
Genetic variants of the ENPP1/PC-1 gene are associated with hypertriglyceridemia in male subjects.
Metabolic syndrome and related disorders
The I4399M variant of apolipoprotein(a) is associated with increased oxidized phospholipids on apolipoprotein B-100 particles.
Atherosclerosis
HDL antielastase activity prevents smooth muscle cell anoikis, a potential new antiatherogenic property.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Expression of reverse cholesterol transport proteins ATP-binding cassette A1 (ABCA1) and scavenger receptor BI (SR-BI) in the retina and retinal pigment epithelium.
The British journal of ophthalmology
Regulation of apoAI processing by procollagen C-proteinase enhancer-2 and bone morphogenetic protein-1.
Journal of lipid research
Association of functionally significant Melanocortin-4 but not Melanocortin-3 receptor mutations with severe adult obesity in a large North American case-control study.
Human molecular genetics
GOSR2 Lys67Arg is associated with hypertension in whites.
American journal of hypertension
Galanin preproprotein is associated with elevated plasma triglycerides.
Arteriosclerosis, thrombosis, and vascular biology
Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and coronary heart disease risk in familial hypercholesterolemia.
Atherosclerosis
WW-domain-containing oxidoreductase is associated with low plasma HDL-C levels.
American journal of human genetics
Replication study of 10 genetic polymorphisms associated with coronary heart disease in a specific high-risk population with familial hypercholesterolemia.
European heart journal
An apolipoprotein A-V gene SNP is associated with marked hypertriglyceridemia among Asian-American patients.
Journal of lipid research
A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci.
PLoS genetics
Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study.
Arteriosclerosis, thrombosis, and vascular biology
Five common gene variants identify elevated genetic risk for coronary heart disease.
Genetics in medicine : official journal of the American College of Medical Genetics
Apolipoprotein E e4 allele increases the risk of early postoperative delirium in older patients undergoing noncardiac surgery.
Anesthesiology
Assessment of lipoprotein profiles study (ALPS) and antioxidant activity in healthy subjects treated with AGI-1067.
Journal of clinical lipidology
A polymorphism in the protease-like domain of apolipoprotein(a) is associated with severe coronary artery disease.
Arteriosclerosis, thrombosis, and vascular biology
Prediction of coronary heart disease risk using a genetic risk score: the Atherosclerosis Risk in Communities Study.
American journal of epidemiology
The lipoprotein lipase gene in combined hyperlipidemia: evidence of a protective allele depletion.
Lipids in health and disease
Gene variants of VAMP8 and HNRPUL1 are associated with early-onset myocardial infarction.
Arteriosclerosis, thrombosis, and vascular biology
High density lipoprotein mediated lipid efflux from retinal pigment epithelial cells in culture.
The British journal of ophthalmology
Lack of support for the association between GAD2 polymorphisms and severe human obesity.
PLoS biology
Identification of four gene variants associated with myocardial infarction.
American journal of human genetics
Parotid secretory protein is an HDL-associated protein with anticandidal activity.
American journal of physiology. Regulatory, integrative and comparative physiology
Apolipoprotein L-I is positively associated with hyperglycemia and plasma triglycerides in CAD patients with low HDL.
Journal of lipid research
The primary stone event: a new hypothesis involving a vascular etiology.
The Journal of urology
Regulated expression of apolipoprotein E by human retinal pigment epithelial cells.
Journal of lipid research
Dynamic regulation of alternative ATP-binding cassette transporter A1 transcripts.
Biochemical and biophysical research communications
Apolipoprotein A-II: active or passive role in familial combined hyperlipidemia.
Circulation research
Primary hypercholesterolemia: genetic causes and treatment of five monogenic disorders.
Expert review of cardiovascular therapy
Genetic analysis of a polymorphism in the human apoA-V gene: effect on plasma lipids.
Journal of lipid research
The effects of physical exercise on plasma prebeta-1 high-density lipoprotein.
Metabolism: clinical and experimental
Human cholesterol 7alpha-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype.
The Journal of clinical investigation
Influence of an asparagine to lysine mutation at amino acid 3516 of apolipoprotein B on low-density lipoprotein receptor binding.
Clinica chimica acta; international journal of clinical chemistry
Human retinal pigment epithelial cells express scavenger receptors BI and BII.
Biochemical and biophysical research communications
Does hypertriglyceridemia present an indication for pioglitazone therapy in diabetes?
Diabetes technology & therapeutics
Apolipoprotein L gene family: tissue-specific expression, splicing, promoter regions; discovery of a new gene.
Journal of lipid research
A risk factor for atherosclerosis: triglyceride-rich lipoproteins.
Advances in internal medicine
Elevated baseline triglyceride levels modulate effects of HMGCoA reductase inhibitors on plasma lipoproteins.
Journal of cardiovascular pharmacology and therapeutics
Haplotypes of the human renin gene associated with essential hypertension and stroke.
Journal of human hypertension
Low levels of high density lipoproteins in Turks, a population with elevated hepatic lipase. High density lipoprotein characterization and gender-specific effects of apolipoprotein e genotype.
Journal of lipid research
Plasma apolipoprotein L concentrations correlate with plasma triglycerides and cholesterol levels in normolipidemic, hyperlipidemic, and diabetic subjects.
Journal of lipid research
Analysis of hABC1 gene 5' end: additional peptide sequence, promoter region, and four polymorphisms.
Biochemical and biophysical research communications
Lack of association of lipoprotein(a) levels with coronary calcium deposits in asymptomatic postmenopausal women.
Journal of the American College of Cardiology
Human renin gene BglI dimorphism associated with hypertension in two independent populations.
Clinical genetics
Renin gene MboI dimorphism is a discriminator for hypertension in hyperlipidaemic subjects.
Hypertension research : official journal of the Japanese Society of Hypertension
Evaluation of Langerhans' cells in the cervical epithelium of women with cervical intraepithelial neoplasia.
Gynecologic oncology
The apolipoprotein B R3531C mutation. Characteristics of 24 subjects from 9 kindreds.
Journal of lipid research
A multilocus genotyping assay for cardiovascular disease.
Clinical chemistry and laboratory medicine
Prebeta-1 HDL in plasma of normolipidemic individuals: influences of plasma lipoproteins, age, and gender.
Journal of lipid research
Rationale and design of the Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering (MIRACL) study that evaluates atorvastatin in unstable angina pectoris and in non-Q-wave acute myocardial infarction.
The American journal of cardiology
Aggressive medical therapy for the prevention and treatment of coronary artery disease.
Disease-a-month : DM
Apolipoprotein L, a new human high density lipoprotein apolipoprotein expressed by the pancreas. Identification, cloning, characterization, and plasma distribution of apolipoprotein L.
The Journal of biological chemistry
Measurement of prebeta-1 HDL in human plasma by an ultrafiltration-isotope dilution technique.
Analytical biochemistry
A novel apolipoprotein C-III variant, apoC-III(Gln38-->Lys), associated with moderate hypertriglyceridemia in a large kindred of Mexican origin.
Journal of lipid research
Isolation of subpopulations of high density lipoproteins: three particle species containing apoE and two species devoid of apoE that have affinity for heparin.
Journal of lipid research
A single copy of apolipoprotein B-48 is present on the human chylomicron remnant.
Journal of lipid research
Cryo-electron microscopy of low density lipoprotein and reconstituted discoidal high density lipoprotein: imaging of the apolipoprotein moiety.
Journal of lipid research
Aggressive medical therapy for the prevention and treatment of coronary artery disease.
Advances in internal medicine
The apolipoprotein B Q3405E polymorphism has no effect on its low-density-lipoprotein receptor binding affinity.
Human genetics
Angiographically silent atherosclerosis detected by intravascular ultrasound in patients with familial hypercholesterolemia and familial combined hyperlipidemia: correlation with high density lipoproteins.
Journal of the American College of Cardiology
Triglyceride-rich lipoproteins prevent septic death in rats.
The Journal of experimental medicine
Familial ligand-defective apolipoprotein B. Identification of a new mutation that decreases LDL receptor binding affinity.
The Journal of clinical investigation
Triglyceride-rich lipoproteins isolated by selected-affinity anti-apolipoprotein B immunosorption from human atherosclerotic plaque.
Arteriosclerosis and thrombosis : a journal of vascular biology
Lipopolysaccharide (LPS)-binding protein is carried on lipoproteins and acts as a cofactor in the neutralization of LPS.
The Journal of experimental medicine
The apolipoprotein C-II variant apoC-IILys19-->Thr is not associated with dyslipidemia in an affected kindred.
Clinical genetics
Medical management of hyperlipidemic states.
Advances in internal medicine
The protective effect of serum lipoproteins against bacterial lipopolysaccharide.
European heart journal
Chylomicrons enhance endotoxin excretion in bile.
Infection and immunity
Exploratory data analysis of hyperlipidemia on the Macintosh: software tools for analysis of biochemical, clinical, and genetic variables in 1677 consecutive lipid clinic patients.
Journal of medical systems
Chylomicrons alter the fate of endotoxin, decreasing tumor necrosis factor release and preventing death.
The Journal of clinical investigation
Molecular cloning and characteristics of a new apolipoprotein C-II mutant identified in three unrelated individuals with hypercholesterolemia and hypertriglyceridemia.
Human molecular genetics
Binding of transition metals by apolipoprotein A-I-containing plasma lipoproteins: inhibition of oxidation of low density lipoproteins.
Proceedings of the National Academy of Sciences of the United States of America
A polymorphic PstI site in intron 2 of the human apolipoprotein C-II gene detected by polymerase chain reaction.
Human genetics
Two apolipoprotein B gene defects in a kindred with hypobetalipoproteinemia, one of which results in a truncated variant, apoB-61, in VLDL and LDL.
Journal of lipid research
Drs malloy and kane respond.
The Western journal of medicine
Chylomicrons can inhibit endotoxin activity in vitro.
The Journal of surgical research
Molecular and metabolic basis for the metabolic disorder normotriglyceridemic abetalipoproteinemia.
The Journal of clinical investigation
Niacin--the long and the short of it.
The Western journal of medicine
Detection of endotoxin in triglyceride-rich lipoproteins in vitro.
The Journal of laboratory and clinical medicine
Differences in local conformation in human apolipoprotein B-100 of plasma low density and very low density lipoproteins as identified by cathepsin D.
The Journal of biological chemistry
Familial chylomicronemia (type I hyperlipoproteinemia) due to a single missense mutation in the lipoprotein lipase gene.
The Journal of clinical investigation
Two apolipoprotein E5 variants illustrate the importance of the position of additional positive charge on receptor-binding activity.
Journal of lipid research
Conformation of apolipoprotein B-100 in the low density lipoproteins of tangier disease. Identification of localized conformational response to triglyceride content.
The Journal of biological chemistry
Pre-beta high density lipoprotein. Unique disposition of apolipoprotein A-I increases susceptibility to proteolysis.
Arteriosclerosis (Dallas, Tex.)
Treatment of hyperlipidemia.
Annual review of medicine
Structural domains of human apolipoprotein B-100. Differential accessibility to limited proteolysis of B-100 in low density and very low density lipoproteins.
The Journal of biological chemistry
Particle size distribution of lipoproteins from human atherosclerotic plaque: a preliminary report.
Journal of vascular surgery
Neutralization of mouse xenotropic virus by lipoproteins involves binding to the virions.
The Journal of general virology
Radiation inactivation of binding sites for high-density lipoproteins in human liver membranes.
Biochimica et biophysica acta
Bsm I RFLP at the human apolipoprotein AI-CIII gene complex locus.
Nucleic Acids Research
NcoI dimorphic site located 8kb 3' to the human apolipoprotein AIV (APOA4) gene.
Nucleic Acids Research
Determinants of kallikrein proteolysis of apolipoprotein B-100 in human blood plasma.
European journal of clinical investigation
Radiation inactivation of binding sites for high density lipoproteins in human fibroblast membranes.
The Journal of biological chemistry
When to treat hyperlipidemia.
Advances in internal medicine
Carboxyl terminal analysis of human B-48 protein confirms the novel mechanism proposed for chain termination.
Biochemical and biophysical research communications
Complementarity of colestipol, niacin, and lovastatin in treatment of severe familial hypercholesterolemia.
Annals of internal medicine
Human apolipoprotein CI (apoC1) gene locus: DraI dimorphic site.
Nucleic Acids Research
Human apolipoprotein CI (ApoC1) gene locus: BglI dimorphic site.
Nucleic Acids Research
DraI RFLP in the human apolipoprotein AI-CIII-AIV gene complex.
Nucleic Acids Research
TaqI and XbaI RFLPs detected with a human apo IV (Apo4) cDNA probe.
Nucleic Acids Research
Metabolism of apolipoproteins B-48 and B-100 of triglyceride-rich lipoproteins in patients with familial dysbetalipoproteinemia.
The Journal of clinical investigation
Analysis of cDNA clones encoding the entire B-26 region of human apolipoprotein B.
Proceedings of the National Academy of Sciences of the United States of America
Scission of human apolipoprotein B-100 by kallikrein: characterization of the cleavage site.
Biochemical and biophysical research communications
Isolation of a cDNA clone encoding the amino-terminal region of human apolipoprotein B.
Proceedings of the National Academy of Sciences of the United States of America
A variant primary structure of apolipoprotein C-II in individuals of African descent.
The Journal of clinical investigation
Discrimination between subclasses of human high-density lipoproteins by the HDL binding sites of bovine liver.
Biochimica et biophysica acta
Speciation of HDL.
Advances in experimental medicine and biology
Treatment of hypercholesterolemia.
Annual review of medicine
Apolipoprotein A-I-containing lipoproteins with pre-beta electrophoretic mobility.
Journal of lipid research
Characteristics of human lipoproteins isolated by selected-affinity immunosorption of apolipoprotein A-I.
Proceedings of the National Academy of Sciences of the United States of America
Metabolism of apolipoproteins B-48 and B-100 of triglyceride-rich lipoproteins in normal and lipoprotein lipase-deficient humans.
Proceedings of the National Academy of Sciences of the United States of America
Sex-related differences in the concentrations of apolipoprotein E in human blood plasma and plasma lipoproteins.
Journal of lipid research
Secretion of lipoproteins from the liver of normal and Watanabe heritable hyperlipidemic rabbits.
Proceedings of the National Academy of Sciences of the United States of America
Apolipoprotein and size heterogeneity in human umbilical cord blood low density lipoproteins.
Biochimica et biophysica acta
Atypical familial dysbetalipoproteinemia associated with apolipoprotein phenotype E3/3.
The Journal of clinical investigation
Cholesterol net transport, esterification, and transfer in human hyperlipidemic plasma.
The Journal of clinical investigation
Apolipoprotein B: structural and metabolic heterogeneity.
Annual review of physiology
Remnants of lipoproteins of intestinal and hepatic origin in familial dysbetalipoproteinemia.
Arteriosclerosis (Dallas, Tex.)
Concentration and composition of lipoproteins in blood plasma of the WHHL rabbit. An animal model of human familial hypercholesterolemia.
Arteriosclerosis (Dallas, Tex.)
Factors affecting the integrity of high density lipoproteins in the ultracentrifuge.
Journal of lipid research
Serum apolipoprotein A-I levels: relationship to lipoprotein lipid levels and selected demographic variables.
American journal of epidemiology
Characterization and quantitation of apolipoproteins A-I and E of normal and cholesterol-fed guinea pigs.
Journal of lipid research
Transfer of mouse anti-xenotropic virus neutralizing factor to human lipoproteins.
Journal of virology
Hypolipidemia.
The Medical clinics of North America
Treatment of hypercholesterolemia.
The Medical clinics of North America
Apolipoprotein B (B-48) of rat chylomicrons is not a precursor of the apolipoprotein of low density lipoproteins.
Proceedings of the National Academy of Sciences of the United States of America
Therapy of hyperlipidemic states.
Annual review of medicine
Familial dysbetalipoproteinemia. Abnormal binding of mutant apoprotein E to low density lipoprotein receptors of human fibroblasts and membranes from liver and adrenal of rats, rabbits, and cows.
The Journal of clinical investigation
Normotriglyceridemic abetalipoproteinemia. absence of the B-100 apolipoprotein.
The Journal of clinical investigation
Normalization of low-density-lipoprotein levels in heterozygous familial hypercholesterolemia with a combined drug regimen.
The New England journal of medicine
Levels and interrelationships of serum and lipoprotein cholesterol and triglycerides. Association with adiposity and the consumption of ethanol, tobacco, and beverages containing caffeine.
Arteriosclerosis (Dallas, Tex.)
Human apolipoprotein C-I: concentration in blood serum and lipoproteins.
Biochemical medicine
Radioimmunoassay of human arginine-rich apolipoprotein, apoprotein E. Concentration in blood plasma and lipoproteins as affected by apoprotein E-3 deficiency.
The Journal of clinical investigation
Pancreatic alpha and beta cell function in familial dysbetalipoproteinemia.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
Heterogeneity of apolipoprotein B: isolation of a new species from human chylomicrons.
Proceedings of the National Academy of Sciences of the United States of America
Apolipoprotein is responsible for neutralization of xenotropic type C virus by mouse serum.
Proceedings of the National Academy of Sciences of the United States of America
Secondary structure in very low density and intermediate density lipoproteins of human serum.
Journal of lipid research
Isoelectric heterogeneity of the cofactor protein for lipoprotein lipase in human blood plasma.
Biochemical medicine
Normocholesterolemic dysbetalipoproteinemia with xanthomatosis.
Metabolism: clinical and experimental
Heterogeneity of hemoglobin gamma chains in normal newborns and in cases of alpha and beta thalassemia.
American journal of hematology
Molecular weight distributions of polydisperse systems: application to very low density lipoproteins.
Biochemistry
Bladder cancer and squamous metaplasia in spinal cord injury patients.
The Journal of urology
Characterization of human very low density lipoproteins containing two electrophoretic populations: double pre-beta lipoproteinemia and primary dysbetalipoproteinemia.
Journal of lipid research
Hb Leiden-beta (0) thalassemia in a Chinese with severe hemolytic anemia.
American journal of hematology
New protein in human blood plasma, rich in proline, with lipid-binding properties.
Proceedings of the National Academy of Sciences of the United States of America
Effects of a 3-day fast and of ethanol on splanchnic metabolism of FFA, amino acids, and carbohydrates in healthy young men.
The Journal of clinical investigation
Apoprotein composition of very low density lipoproteins of human serum.
The Journal of clinical investigation
Metabolism of apoprotein B of plasma very low density lipoproteins in the rat.
The Journal of clinical investigation
Quantification of triglyceride transport in blood plasma: a critical analysis.
Federation proceedings
Stability of the apoprotein of human serum low density lipoprotein: absence of endogenous endopeptidase activity.
Biochemical and biophysical research communications
The complement system in cryoglobulinaemia. Interaction with immunoglobulins and lipoproteins.
Clinical and experimental immunology
Temperature dependence of the optical activity of human serum low density lipoprotein. The role of lipids.
Biochemistry
Editorial: Early prevention of atherosclerosis.
The Western journal of medicine
Contribution of carotenoids to the optical activity of human serum low-density lipoprotein.
Biochemistry
Mechanism of the hypolipemic effect of clofibrate in postabsorptive man.
The Journal of clinical investigation
Primary dysbetalipoproteinemia: predominance of a specific apoprotein species in triglyceride-rich lipoproteins.
Proceedings of the National Academy of Sciences of the United States of America
A rapid electrophoretic technique for identification of subunit species of apoproteins in serum lipoproteins.
Analytical biochemistry
Drugs and lipid metabolism.
Annual review of pharmacology
Interchange of apolipoproteins between chylomicrons and high density lipoproteins during alimentary lipemia in man.
The Journal of clinical investigation
Cholestasis: lamellar structure of the abnormal human serum lipoprotein.
Science (New York, N.Y.)
Splanchnic metabolism of free fatty acids and production of triglycerides of very low density lipoproteins in normotriglyceridemic and hypertriglyceridemic humans.
The Journal of clinical investigation
Subunit heterogeneity in human serum beta lipoprotein.
Proceedings of the National Academy of Sciences of the United States of America
Splanchnic metabolism in von Gierke's disease (glycogenosis type I).
Transactions of the Association of American Physicians
STUDIES OF CARBOHYDRATE METABOLISM IN IDIOPATHIC HYPERTRIGLYCERIDEMIA.
Metabolism: clinical and experimental
Sterol biosynthesis under the influence of a thyroxine analog (3,5-diiodothyroacetic acid).
Metabolism: clinical and experimental
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