
Professor
Medicine
Research Interests
Extracellular matrix regulation of fibrosis and whole body metabolism
Email
+1 415 514-1159
Education and Training
07/2021
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09/2021
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Research Activities And Funding
Jan 1, 2021 - Nov 30, 2024
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NIH Ro1GM137109
Role: Principal Investigator
NIH Ro1GM137109
Role: Principal Investigator
Sep 1, 2012 - July 31, 2015
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NIH Ro1GM137109
Role: Principal Investigator
NIH Ro1GM137109
Role: Principal Investigator
Websites
VCard
Faculty Type
Core CVRI Faculty
Research Summary:
The accumulation of cellular and molecular debris in the extracellular compartment must be precisely regulated to preserve tissue integrity. We are interested in discovering the pathways that regulate tissue homeostasis through the removal of matrix molecules (collagen) and cellular debris (apoptotic cells) under normal and pathological conditions.
Publications
Radial glia integrin avb8 regulates cell autonomous microglial TGFβ1 signaling that is necessary for microglial identity.
Nature communications
The American Thoracic Society Research Program (ATSRP) - Twenty Years of Driving Discovery in Respiratory Medicine.
American journal of respiratory and critical care medicine
BCL-2 Modulates IRE1α Activation to Attenuate ER Stress and Pulmonary Fibrosis.
American journal of respiratory cell and molecular biology
Genome-wide screens identify SEL1L as an intracellular rheostat controlling collagen turnover.
Nature communications
PTP1B mediates the inhibitory effect of MFGE8 on insulin signaling through the β5 integrin.
The Journal of biological chemistry
Genome-wide screens identify SEL1L as an intracellular rheostat controlling collagen turnover.
bioRxiv : the preprint server for biology
Radial glia promote microglial development through integrin αVβ8 -TGFβ1 signaling.
bioRxiv : the preprint server for biology
MFGE8 inhibits insulin signaling through PTP1B.
bioRxiv : the preprint server for biology
Tu1246 CROHN'S DISEASE STRICTURE MATRISOME ANALYSIS REVEALS THE ANTI-FIBROTIC ACTIVITY OF MILK-FAT GLOBULE-EPIDERMAL GROWTH FACTOR 8 (MFGE8).
Gastroenterology
DOP32 Crohn’s disease stricture matrisome analysis reveals the anti-fibrotic activity of milk-fat globule-epidermal growth factor 8 (MFGE8).
Journal of Crohn's and Colitis
Autoregulation of insulin receptor signaling through MFGE8 and the αvβ5 integrin.
Proceedings of the National Academy of Sciences of the United States of America
You Say You Want a Resolution (of Fibrosis).
American journal of respiratory cell and molecular biology
Fat fibrosis: friend or foe?
JCI insight
Autocrine Mfge8 Signaling Prevents Developmental Exhaustion of the Adult Neural Stem Cell Pool.
Cell stem cell
Deletion of MFGE8 Inhibits Neointima Formation upon Arterial Damage.
Thrombosis and haemostasis
Cell division cycle 7 kinase is a negative regulator of cell-mediated collagen degradation.
American journal of physiology. Lung cellular and molecular physiology
The Mfge8-α8β1-PTEN pathway regulates airway smooth muscle contraction in allergic inflammation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Extracellular matrix in lung development, homeostasis and disease.
Matrix biology : journal of the International Society for Matrix Biology
Inflammatory bone loss associated with MFG-E8 deficiency is rescued by teriparatide.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Inhibition of hepatocyte nuclear factor 1b induces hepatic steatosis through DPP4/NOX1-mediated regulation of superoxide.
Free radical biology & medicine
Cd36 knockout mice are protected against lithogenic diet-induced gallstones.
Journal of lipid research
Abstract 210: Milk Fat Globule Epidermal Growth Factor VIII Mediates Vascular Remodeling by Increasing Inflammation and Smooth Muscle Activation.
Arteriosclerosis Thrombosis and Vascular Biology
Mfge8 regulates enterocyte lipid storage by promoting enterocyte triglyceride hydrolase activity.
JCI insight
Prevention of gallbladder hypomotility via FATP2 inhibition protects from lithogenic diet-induced cholelithiasis.
American journal of physiology. Gastrointestinal and liver physiology
IQGAP1-dependent scaffold suppresses RhoA and inhibits airway smooth muscle contraction.
The Journal of clinical investigation
Polarization of prostate cancer-associated macrophages is induced by milk fat globule-EGF factor 8 (MFG-E8)-mediated efferocytosis.
The Journal of biological chemistry
Mfge8 promotes obesity by mediating the uptake of dietary fats and serum fatty acids.
Nature medicine
Functional genomic screen identifies novel mediators of collagen uptake.
Molecular biology of the cell
Always cleave up your mess: targeting collagen degradation to treat tissue fibrosis.
American journal of physiology. Lung cellular and molecular physiology
Mfge8 suppresses airway hyperresponsiveness in asthma by regulating smooth muscle contraction.
Proceedings of the National Academy of Sciences of the United States of America
IL-17A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction.
Nature medicine
Mfge8 diminishes the severity of tissue fibrosis in mice by binding and targeting collagen for uptake by macrophages.
The Journal of clinical investigation
Essential role for MFG-E8 as ligand for alphavbeta5 integrin in diurnal retinal phagocytosis.
Proceedings of the National Academy of Sciences of the United States of America
Roles of the innate immune system in mammary gland remodeling during involution.
Journal of mammary gland biology and neoplasia
Mfge8 is critical for mammary gland remodeling during involution.
Molecular biology of the cell
Keratinocyte growth factor can enhance alveolar epithelial repair by nonmitogenic mechanisms.
American journal of physiology. Lung cellular and molecular physiology
Aerosolized beta(2)-adrenergic agonists achieve therapeutic levels in the pulmonary edema fluid of ventilated patients with acute respiratory failure.
Intensive care medicine
Human eosinophils induce mucin production in airway epithelial cells via epidermal growth factor receptor activation.
Journal of immunology (Baltimore, Md. : 1950)
Pulmonary edema fluid from patients with acute lung injury augments in vitro alveolar epithelial repair by an IL-1beta-dependent mechanism.
American journal of respiratory and critical care medicine
Increased expression of CD23 (Fc(epsilon) receptor II) by peripheral blood monocytes of aids patients.
AIDS research and human retroviruses
Interleukin-1beta augments in vitro alveolar epithelial repair.
American journal of physiology. Lung cellular and molecular physiology
Address
555 Mission Bay Blvd South, Rm 001
UCSF Box 3118
San Francisco, CA 94158
United States