Home > People > Laura Koth, MD, MA

Laura Koth, MD, MA

Professor
Medicine
Address: 
505 Parnassus Avenue, Rm M1098
UCSF Box 0111
San Francisco, CA 94117
United States
Phone: 
+1 415 514-4369

Research Interests: Sarcoidosis Granulomatous Lung Diseases T cells Monocytes chemokines Summary: Dr. Koth's research program is structured around the study of samples from human research studies. With the breath of research techniques that can be applied to human samples to learn about disease, Dr. Koth is taking a direct approach in the study of lung diseases. Dr. Koth's current focus involves understanding the inflammatory disease called sarcoidosis. This is not a disease as common as asthma, but it affects both young and middle aged people and causes significant morbidity and mortality. More awareness and funds are needed if we hope to understand the complicated biology of the disease. For example, many of the main immune subsets of the body are abnormally regulated in this disease. Most research has focused on the traditional T-cell. For example, it is thought that specific T cells are very activated and making inflammatory products which are contributing to and continuing the disease. However there are other immune cells that have not been studied adequately. Dr. Koth's lab has taken an active interest in these other types of immune cells. One reason for this is that we have identified, using Genomics research, that specific transcripts in the blood actually predict whether a specific patient will have progressive disease or not. She and her lab are now pursuing a line of investigation to understand where this 'biomarker message' is coming from in order to be able to stop it. Dr. Koth's lab is also interested in using state-of-the-art technology to think about new therapies for this disease. We are looking into cutting-edge translational methods of expanding a type of immune cell responsible for down regulating the inflammatory process of the body. To perform these experiments in clinical trials will require significant financial support and we are seeking this input in order to move this very exciting potential treatment forward. The other aspect of my research program includes the development of a 'center of excellence in sarcoidosis'. This program will be designed to include both excellence in clinical care and novel clinical studies. Developing clinical care standards is an important area in managing sarcoidosis patients since sarcoidosis is a chronic disease that may be active for 10-20 years or more. Thus, a full-service clinical care program would facilitate the creation of clinical management tools and treatment regimens (developed as products from clinical trials networks) to address three arms of care in sarcoidosis: 1) organ damage, 2) symptom control, and 3) psychosocial aspects of living with the disease.

Publications: 

Trends in All-cause Mortality among U.S. Veterans with Sarcoidosis, 2004-2022.

Chest

Seedahmed MI, Albirair MT, Baugh AD, Gellad WF, Nouraie SM, Gibson KF, Whooley MA, McCulloch CE, Koth LL, Arjomandi M

Discovery of Two Novel Immunoepitopes and Development of Peptide-based Sarcoidosis Immunoassay.

American journal of respiratory and critical care medicine

Peng C, Talreja J, Steinbauer B, Shinki K, Koth LL, Samavati L

Chest computed tomography provides more information than chest X-ray alone in determining extent of physiologic impairment in pulmonary sarcoidosis.

Chest

Benn BS, Lippitt W, Cortopassi I, G K B, Barbosa EM, Drake WP, Herzog E, Gibson K, Chen ES, Koth LL, Fuhrman C, Lynch DA, Kaminski N, Wisniewski SR, Carlson NE, Maier LA

Response.

Chest

Seedahmed MI, Albirair MT, Whooley MA, Koth LL, Blanc PD, Arjomandi M

Examination of eQTL Polymorphisms Associated with Increased Risk of Progressive Complicated Sarcoidosis in European and African Descent Subjects.

European journal of respiratory medicine

Casanova NG, Camp SM, Gonzalez-Garay ML, Batai K, Garman L, Montgomery CG, Ellis N, Kittles R, Bime C, Hsu AP, Holland S, Lussier YA, Karnes J, Sweiss N, Maier LA, Koth L, Moller DR, Kaminski N, Garcia JGN

Genome-wide association study identifies multiple HLA loci for sarcoidosis susceptibility.

Human molecular genetics

Liao SY, Jacobson S, Hamzeh NY, Culver DA, Barkes BQ, Mroz M, Macphail K, Pacheco K, Patel DC, Wasfi YS, Koth LL, Langefeld CD, Leach SM, White E, Montgomery C, Maier LA, Fingerlin TE, GRADs Investigators

Screening for Exposure to Beryllium Among US Veterans With a Diagnosis of Sarcoidosis, 2002-2020.

Chest

Seedahmed MI, Albirair MT, Whooley MA, Koth LL, Blanc PD, Arjomandi M

Epidemiology of Sarcoidosis in U.S. Veterans from 2003 to 2019.

Annals of the American Thoracic Society

Seedahmed MI, Baugh AD, Albirair MT, Luo Y, Chen J, McCulloch CE, Whooley MA, Koth LL, Arjomandi M

Standardization of flow cytometry and cell sorting to enable a transcriptomic analysis in a multi-site sarcoidosis study.

PloS one

Magallon RE, Harmacek LD, Arger NK, Grewal P, Powers L, Werner BR, Barkes BQ, Li L, MacPhail K, Gillespie M, White EK, Collins SE, Brown T, Cardenas J, Chen ES, Maier LA, Leach SM, Hamzeh NY, Koth LL, O'Connor BP

Modulatory role of macrophage migration inhibitory factor on cytokines and clinical features of sarcoidosis.

Scientific reports

Elahi M, Talreja J, Steinbauer B, Koth LL, Samavati L

Transcriptomics of bronchoalveolar lavage cells identifies new molecular endotypes of sarcoidosis.

The European respiratory journal

Vukmirovic M, Yan X, Gibson KF, Gulati M, Schupp JC, DeIuliis G, Adams TS, Hu B, Mihaljinec A, Woolard TN, Lynn H, Emeagwali N, Herzog EL, Chen ES, Morris A, Leader JK, Zhang Y, Garcia JGN, Maier LA, Collman RG, Drake WP, Becich MJ, Hochheiser H, Wisniewski SR, Benos PV, Moller DR, Prasse A, Koth LL, Kaminski N, GRADS Investigators

Defining CD4 T helper and T regulatory cell endotypes of progressive and remitting pulmonary sarcoidosis (BRITE): protocol for a US-based, multicentre, longitudinal observational bronchoscopy study.

BMJ open

Koth LL, Harmacek LD, White EK, Arger NK, Powers L, Werner BR, Magallon RE, Grewal P, Barkes BQ, Li L, Gillespie M, Collins SE, Cardenas J, Chen ES, Maier LA, Leach SM, O'Connor BP, Hamzeh NY

Neurosarcoidosis: Pathophysiology, Diagnosis, and Treatment.

Neurology(R) neuroimmunology & neuroinflammation

Bradshaw MJ, Pawate S, Koth LL, Cho TA, Gelfand JM

Molecular profiling in sarcoidosis.

Current opinion in pulmonary medicine

Arger NK, O'Connor B, Koth LL

T-bet Expression in Peripheral Th17.0 Cells Is Associated With Pulmonary Function Changes in Sarcoidosis.

Frontiers in immunology

Arger NK, Machiraju S, Allen IE, Woodruff PG, Koth LL

Diagnosis and Detection of Sarcoidosis. An Official American Thoracic Society Clinical Practice Guideline.

American journal of respiratory and critical care medicine

Crouser ED, Maier LA, Wilson KC, Bonham CA, Morgenthau AS, Patterson KC, Abston E, Bernstein RC, Blankstein R, Chen ES, Culver DA, Drake W, Drent M, Gerke AK, Ghobrial M, Govender P, Hamzeh N, James WE, Judson MA, Kellermeyer L, Knight S, Koth LL, Poletti V, Raman SV, Tukey MH, Westney GE, Baughman RP

Long-Term Corticosteroid-Sparing Immunosuppression for Cardiac Sarcoidosis.

Journal of the American Heart Association

Rosenthal DG, Parwani P, Murray TO, Petek BJ, Benn BS, De Marco T, Gerstenfeld EP, Janmohamed M, Klein L, Lee BK, Moss JD, Scheinman MM, Hsia HH, Selby V, Koth LL, Pampaloni MH, Zikherman J, Vedantham V

Serum CXCL11 correlates with pulmonary outcomes and disease burden in sarcoidosis.

Respiratory medicine

Arger NK, Ho M, Woodruff PG, Koth LL

Elastin-Specific Autoimmunity in Smokers With Thoracic Aortic Aneurysm and Dissection is Independent of Chronic Obstructive Pulmonary Disease.

Journal of the American Heart Association

Gu BH, Choi JC, Shen YH, Song LZ, Scheurer ME, Luong A, Rodriguez A, Woodruff P, Koth L, Corry DB, Kheradmand F, LeMaire SA

Tissue Isn't the Issue.

Journal of hospital medicine

Santhosh L, Koth L, Baudendistel TE, Sharpe B, Monash B

Migraine is common in patients with sarcoidosis.

Cephalalgia : an international journal of headache

Gelfand JM, Gelfand AA, Goadsby PJ, Benn BS, Koth LL

Sleep disturbance and symptom burden in sarcoidosis.

Respiratory medicine

Benn BS, Lehman Z, Kidd SA, Miaskowski C, Sunwoo BY, Ho M, Sun S, Ramstein J, Gelfand JM, Koth LL

Increased T-helper 17.1 cells in sarcoidosis mediastinal lymph nodes.

The European respiratory journal

Broos CE, Koth LL, van Nimwegen M, In 't Veen JCCM, Paulissen SMJ, van Hamburg JP, Annema JT, Heller-Baan R, Kleinjan A, Hoogsteden HC, Wijsenbeek MS, Hendriks RW, van den Blink B, Kool M

Disease Burden and Variability in Sarcoidosis.

Annals of the American Thoracic Society

Gerke AK, Judson MA, Cozier YC, Culver DA, Koth LL

Infliximab for the treatment of CNS sarcoidosis: A multi-institutional series.

Neurology

Gelfand JM, Bradshaw MJ, Stern BJ, Clifford DB, Wang Y, Cho TA, Koth LL, Hauser SL, Dierkhising J, Vu N, Sriram S, Moses H, Bagnato F, Kaufmann JA, Ammah DJ, Yohannes TH, Hamblin MJ, Venna N, Green AJ, Pawate S

Clinical and Biological Insights from the University of California San Francisco Prospective and Longitudinal Cohort.

Lung

Benn BS, Lehman Z, Kidd SA, Ho M, Sun S, Ramstein J, Arger NK, Nguyen CP, Su R, Gomez A, Gelfand JM, Koth LL

Pathologic Findings and Prognosis in a Large Prospective Cohort of Chronic Hypersensitivity Pneumonitis.

Chest

Wang P, Jones KD, Urisman A, Elicker BM, Urbania T, Johannson KA, Assayag D, Lee J, Wolters PJ, Collard HR, Koth LL

IFN-γ-Producing T-Helper 17.1 Cells Are Increased in Sarcoidosis and Are More Prevalent than T-Helper Type 1 Cells.

American journal of respiratory and critical care medicine

Ramstein J, Broos CE, Simpson LJ, Ansel KM, Sun SA, Ho ME, Woodruff PG, Bhakta NR, Christian L, Nguyen CP, Antalek BJ, Benn BS, Hendriks RW, van den Blink B, Kool M, Koth LL

A diagnostic model for chronic hypersensitivity pneumonitis.

Thorax

Johannson KA, Elicker BM, Vittinghoff E, Assayag D, de Boer K, Golden JA, Jones KD, King TE, Koth LL, Lee JS, Ley B, Wolters PJ, Collard HR

Rationale and Design of the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis (GRADS) Study. Sarcoidosis Protocol.

Annals of the American Thoracic Society

Moller DR, Koth LL, Maier LA, Morris A, Drake W, Rossman M, Leader JK, Collman RG, Hamzeh N, Sweiss NJ, Zhang Y, O'Neal S, Senior RM, Becich M, Hochheiser HS, Kaminski N, Wisniewski SR, Gibson KF, GRADS Sarcoidosis Study Group

Survival in interstitial pneumonia with features of autoimmune disease: a comparison of proposed criteria.

Respiratory medicine

Assayag D, Kim EJ, Elicker BM, Jones KD, Golden JA, King TE, Koth LL, Shum AK, Wolters PJ, Collard HR, Lee JS

The effect of bronchodilators on forced vital capacity measurement in patients with idiopathic pulmonary fibrosis.

Respiratory medicine

Assayag D, Vittinghoff E, Ryerson CJ, Cocconcelli E, Tonelli R, Hu X, Elicker BM, Golden JA, Jones KD, King TE, Koth LL, Lee JS, Ley B, Shum AK, Wolters PJ, Ryu JH, Collard HR

Lung transplantation for hypersensitivity pneumonitis.

Chest

Kern RM, Singer JP, Koth L, Mooney J, Golden J, Hays S, Greenland J, Wolters P, Ghio E, Jones KD, Leard L, Kukreja J, Blanc PD

Longitudinal analysis of sarcoidosis blood transcriptomic signatures and disease outcomes.

The European respiratory journal

Su R, Li MM, Bhakta NR, Solberg OD, Darnell EP, Ramstein J, Garudadri S, Ho M, Woodruff PG, Koth LL

The WASOG Sarcoidosis Organ Assessment Instrument: An update of a previous clinical tool.

Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG

Judson MA, Costabel U, Drent M, Wells A, Maier L, Koth L, Shigemitsu H, Culver DA, Gelfand J, Valeyre D, Sweiss N, Crouser E, Morgenthau AS, Lower EE, Azuma A, Ishihara M, Morimoto S, Tetsuo Yamaguchi T, Shijubo N, Grutters JC, Rosenbach M, Li HP, Rottoli P, Inoue Y, Prasse A, Baughman RP, Organ Assessment Instrument Investigators TW

Predicting survival across chronic interstitial lung disease: the ILD-GAP model.

Chest

Ryerson CJ, Vittinghoff E, Ley B, Lee JS, Mooney JJ, Jones KD, Elicker BM, Wolters PJ, Koth LL, King TE, Collard HR

Surgical lung biopsy over bronchoalveolar lavage in chronic hypersensitivity pneumonitis.

American journal of respiratory and critical care medicine

Mooney JJ, Koth LL

Interferon-inducible chemokines reflect severity and progression in sarcoidosis.

Respiratory research

Su R, Nguyen ML, Agarwal MR, Kirby C, Nguyen CP, Ramstein J, Darnell EP, Gomez AD, Ho M, Woodruff PG, Koth LL

Radiographic fibrosis score predicts survival in hypersensitivity pneumonitis.

Chest

Mooney JJ, Elicker BM, Urbania TH, Agarwal MR, Ryerson CJ, Nguyen MLT, Woodruff PG, Jones KD, Collard HR, King TE, Koth LL

Invariant natural killer T (iNKT) cell exhaustion in sarcoidosis.

European journal of immunology

Snyder-Cappione JE, Nixon DF, Chi JC, Nguyen ML, Kirby CK, Milush JM, Koth LL

Prevalence and prognosis of unclassifiable interstitial lung disease.

The European respiratory journal

Ryerson CJ, Urbania TH, Richeldi L, Mooney JJ, Lee JS, Jones KD, Elicker BM, Koth LL, King TE, Wolters PJ, Collard HR

Relative versus absolute change in forced vital capacity in idiopathic pulmonary fibrosis.

Thorax

Richeldi L, Ryerson CJ, Lee JS, Wolters PJ, Koth LL, Ley B, Elicker BM, Jones KD, King TE, Ryu JH, Collard HR

Sarcoidosis blood transcriptome reflects lung inflammation and overlaps with tuberculosis.

American journal of respiratory and critical care medicine

Koth LL, Solberg OD, Peng JC, Bhakta NR, Nguyen CP, Woodruff PG

A comprehensive ex vivo functional analysis of human NKT cells reveals production of MIP1-α and MIP1-β, a lack of IL-17, and a Th1-bias in males.

PloS one

Snyder-Cappione JE, Tincati C, Eccles-James IG, Cappione AJ, Ndhlovu LC, Koth LL, Nixon DF

DAP12 is required for macrophage recruitment to the lung in response to cigarette smoke and chemotaxis toward CCL2.

Journal of immunology (Baltimore, Md. : 1950)

Koth LL, Cambier CJ, Ellwanger A, Solon M, Hou L, Lanier LL, Abram CL, Hamerman JA, Woodruff PG

Undifferentiated connective tissue disease-associated interstitial lung disease: changes in lung function.

Lung

Kinder BW, Shariat C, Collard HR, Koth LL, Wolters PJ, Golden JA, Panos RJ, King TE

T-helper type 2-driven inflammation defines major subphenotypes of asthma.

American journal of respiratory and critical care medicine

Woodruff PG, Modrek B, Choy DF, Jia G, Abbas AR, Ellwanger A, Koth LL, Arron JR, Fahy JV

Alveolar macrophage recruitment and activation by chronic second hand smoke exposure in mice.

COPD

Woodruff PG, Ellwanger A, Solon M, Cambier CJ, Pinkerton KE, Koth LL

Integrin beta6 mediates phospholipid and collectin homeostasis by activation of latent TGF-beta1.

American journal of respiratory cell and molecular biology

Koth LL, Alex B, Hawgood S, Nead MA, Sheppard D, Erle DJ, Morris DG

Idiopathic nonspecific interstitial pneumonia: lung manifestation of undifferentiated connective tissue disease?

American journal of respiratory and critical care medicine

Kinder BW, Collard HR, Koth L, Daikh DI, Wolters PJ, Elicker B, Jones KD, King TE

A distinctive alveolar macrophage activation state induced by cigarette smoking.

American journal of respiratory and critical care medicine

Woodruff PG, Koth LL, Yang YH, Rodriguez MW, Favoreto S, Dolganov GM, Paquet AC, Erle DJ

Hypersensitivity pneumonitis reaction to Mycobacterium avium in household water.

Chest

Marras TK, Wallace RJ, Koth LL, Stulbarg MS, Cowl CT, Daley CL

Aspergillus antigen induces robust Th2 cytokine production, inflammation, airway hyperreactivity and fibrosis in the absence of MCP-1 or CCR2.

Respiratory research

Koth LL, Rodriguez MW, Bernstein XL, Chan S, Huang X, Charo IF, Rollins BJ, Erle DJ

Spotted long oligonucleotide arrays for human gene expression analysis.

Genome research

Barczak A, Rodriguez MW, Hanspers K, Koth LL, Tai YC, Bolstad BM, Speed TP, Erle DJ

Hard metal interstitial lung disease: high-resolution computed tomography appearance.

Journal of thoracic imaging

Gotway MB, Golden JA, Warnock M, Koth LL, Webb R, Reddy GP, Balmes JR

Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma.

Nature medicine

Kuperman DA, Huang X, Koth LL, Chang GH, Dolganov GM, Zhu Z, Elias JA, Sheppard D, Erle DJ

Interleukin-13 induces dramatically different transcriptional programs in three human airway cell types.

American journal of respiratory cell and molecular biology

Lee JH, Kaminski N, Dolganov G, Grunig G, Koth L, Solomon C, Erle DJ, Sheppard D

Faculty Type: 
Affiliate Faculty