Professor
Psychiatry
Email
+1 415 476-7871
Faculty Type
Affiliate Faculty
Research Interests: Subcellular organization and dynamics of receptor-mediated signaling systems in eukaryotic cells. Summary: Our laboratory studies mechanisms by which receptors that control cardiovascular biology are regulated. These receptors are important therapeutic targets and their regulation is known to be disturbed in a number of important disease states.
Publications
Profiling the proximal proteome of the activated μ-opioid receptor.
Nature chemical biology
β-Arrestin-independent endosomal cAMP signaling by a polypeptide hormone GPCR.
Nature chemical biology
Endosomal cAMP production broadly impacts the cellular phosphoproteome.
The Journal of biological chemistry
A High-throughput CRISPR Interference Screen to Dissect Functional Regulators of GPCR/cAMP Signaling.
The FASEB Journal
Subcellular Organization of GPCR Signaling.
Trends in pharmacological sciences
Retromer Endosome Exit Domains Serve Multiple Trafficking Destinations and Regulate Local G Protein Activation by GPCRs.
Current biology : CB
Endosomal Phosphatidylinositol 3-Kinase Is Essential for Canonical GPCR Signaling.
Molecular pharmacology
Effects of endocytosis on receptor-mediated signaling.
Current opinion in cell biology
G protein-coupled receptor (GPCR) signaling via heterotrimeric G proteins from endosomes.
The Journal of biological chemistry
Editorial overview: Cell regulation: The ins and outs of G protein-coupled receptors.
Current opinion in cell biology
Investigating signaling consequences of GPCR trafficking in the endocytic pathway.
Methods in enzymology
GPCR signaling along the endocytic pathway.
Current opinion in cell biology
Science Signaling Podcast: 9 August 2011.
Science signaling
Opioid Receptor Trafficking.
The Opiate Receptors
Membrane traffic in the post-genomic era.
Genome biology
Regulation of opioid receptors by endocytic membrane traffic: mechanisms and translational implications.
Drug and alcohol dependence
Chapter 27 Agonist-Induced Desensitization and Endocytosis of G-protein-Coupled Receptors.
Handbook of Cell Signaling
Signaling on the endocytic pathway.
Current opinion in cell biology
Endocytosis.
Encyclopedia of Molecular Cell Biology and Molecular Medicine
Regulated Membrane Trafficking and Proteolysis of GPCRs.
The G Protein-Coupled Receptors Handbook
Identification of Protein Interactions by Yeast Two-Hybrid Screening and Coimmunoprecipitation.
Receptor Signal Transduction Protocols
A walk on the wild side (of the synapse).
Nature cell biology
Chapter 31 Agonist-Induced Desensitization and Endocytosis of G-Protein-Coupled Receptors.
Handbook of Cell Signaling
Address
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