Michael Matthay, MD

Professor, Medicine

Research Interests: Alveolar epithelial transport under normal and pathologic conditions. Resolution of pulmonary edema Mechanisms of Acute Lung Injury Summary: My research program is focused on identifying mechanisms responsible for fluid transport across the alveolar epithelium using cell, molecular, and in vivo models. In addition, our group is focused on understanding the mechanisms responsible for the development and resolution of pulmonary edema and acute lung injury in critically ill patients with acute respiratory failure. The studies include experimental and human-based studies designed to understand the pathogenesis of acute respiratory failure and to test potential new therapies. The work is supported primarily by grants from the National Heart, Lung, and Blood Institute.

Address: 
513 Parnassus Avenue, HSE, Rm 760
UCSF Box 0624
San Francisco, CA 94143
United States
Phone: 
+1 415 819-2807
Faculty Type: 
Parnassus Pulmonary Research Faculty
Publications: 

Plasma Soluble Intercellular Adhesion Molecule-1 Has a Central Role in Biomarker Network Analysis and Is Associated With Poor Outcomes in Two Distinct Pediatric Cohorts of Acute Respiratory Distress Syndrome and Acute Respiratory Failure.(link is external)

Critical care medicine

Lim MJ, Whitney JE, Sallee CJ, Markovic D, Bera A, Sinha P, Zeigler A, Chen L, Zinter MS, Ali A, Matthay MA, Schwingshackl A, Agus MSD, Sapru A, Pediatric Acute Lung Injury (PALI) and Coagulation and Fibrinolysis in Pediatric Insulin Titration T

Elastance May Determine the Neuromuscular Blockade Effect on Mortality in Acute Respiratory Distress Syndrome.(link is external)

American journal of respiratory and critical care medicine

Zalucky AA, Dianti J, Neyton LPA, Sinha P, Liu KD, Matthay MA, Thompson BT, Goligher EC, Calfee CS

Awake Prone Positioning in COVID-19-Is There a New Standard of Care?(link is external)

JAMA internal medicine

Matthay MA, Wick KD, Alipanah-Lechner N

Beyond immunosuppression: decoding systemic immune dysregulation in ICU-acquired pneumonia.(link is external)

The European respiratory journal

Neyton LPA, Matthay MA, Dela Cruz CS, Rizzo AN

A randomized trial of open lung protective ventilation compared to conventional mechanical ventilation in deceased organ donors.(link is external)

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

Ware LB, Koyama T, Shaver CM, Swain S, Nguyen J, Salehi A, Dhillon G, Wickersham N, Maheshwari J, Singer JP, Weigt SS, Kukreja J, Matthay MA

Endothelial ENaC-α Restrains Oxidative Stress in Lung Capillaries in Murine Pneumococcal Pneumonia-associated Acute Lung Injury.(link is external)

American journal of respiratory cell and molecular biology

Romero MJ, Yue Q, Ahn WM, Hamacher J, Zaidi Y, Haigh S, Sridhar S, Gonzales J, Hudel M, Huo Y, Verin AD, Pace BS, Stansfield BK, Maishan M, Neptune ER, Enkhbaatar P, Su Y, Chakraborty T, Gonsalvez G, Hummler E, Davis WB, Bogdanov VY, Fulton DJR, Csanyi G, Matthay MA, Eaton DC, Lucas R

Gut bacterial lactate stimulates lung epithelial mitochondria and exacerbates acute lung injury.(link is external)

bioRxiv : the preprint server for biology

Upadhyay V, Ortega EF, Ramirez Hernandez LA, Alexander M, Kaur G, Trepka K, Rock RR, Shima RT, Cheshire WC, Alipanah-Lechner N, Calfee CS, Matthay MA, Lee JV, Goga A, Jain IH, Turnbaugh PJ

Agreement Between Sepsis-2 and Sepsis-3 Definitions Among Patients Admitted to the Intensive Care Unit.(link is external)

Annals of the American Thoracic Society

Zalucky AA, Evrard B, Delucchi K, Zhuo H, Wu N, Liu KD, Hendrickson CM, Matthay MA, Kangelaris KN, Calfee CS

Temporal Transitions of the Hyperinflammatory and Hypoinflammatory Phenotypes in Critical Illness.(link is external)

American journal of respiratory and critical care medicine

van Amstel RBE, Bartek B, Vlaar APJ, Gay E, van Vught LA, Cremer OL, Van der Poll T, Shapiro NI, Matthay MA, Calfee CS, Sinha P, Bos LDJ

Unlocking the Therapeutic Code of Mesenchymal Stromal Cells.(link is external)

American journal of respiratory and critical care medicine

Lingappan K, Matthay MA

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