Home > People > Onur Cil, MD, PhD

Onur Cil, MD, PhD

Associate Professor
Pediatrics
Address: 
513 Parnassus Avenue, HSE, Rm 1244
UCSF Box 0521
San Francisco, CA 94143
United States
Phone: 
Email: 
[email protected]
UCSF Profiles

Dr. Onur Cil is a pediatric nephrologist and physician-scientist. Cil Lab’s research focus is small molecule drug discovery and drug repurposing for treatment of renal, gastrointestinal and cardiovascular diseases. Ultimate goal of our research is advancing our discoveries to clinical trials and establishing better and safer treatments. Our research is focused on membrane proteins including calcium-sensing receptor (CaSR), SLC26A3 (DRA), SLC26A4 (Pendrin), SLC26A6 (PAT1), CFTR, TMEM16A and urea transporters.

Publications: 

Lysophosphatidic acid receptor 3 (LPAR3) regulates ocular surface chloride transport via calcium signaling.

Experimental eye research

Lindgren ES, Yan R, Kuo YM, Gao Q, de Souza Goncalves L, Chen FY, Chan MF, Verkman AS, Cil O, Pasricha ND

Topological segregation of stress sensors along the gut crypt-villus axis.

Nature

Touhara KK, Rossen ND, Deng F, Castro J, Harrington AM, Chu T, Garcia-Caraballo S, Brizuela M, O'Donnell T, Xu J, Cil O, Brierley SM, Li Y, Julius D

High potency 3-carboxy-2-methylbenzofuran pendrin inhibitors as novel diuretics.

European journal of medicinal chemistry

Master RJ, Karmakar J, Haggie PM, Anthony-Tan J, Chu T, Verkman AS, Anderson MO, Cil O

DRA involvement in linaclotide-stimulated bicarbonate secretion during loss of CFTR function.

JCI insight

Sarthi JB, Trumbull AM, Abazari SM, van Unen V, Chan JE, Jiang Y, Gammons J, Anderson MO, Cil O, Kuo CJ, Sellers ZM

Calcium-sensing receptor (CaSR) modulates ocular surface chloride transport and its inhibition promotes ocular surface hydration.

The ocular surface

Pasricha ND, Lindgren ES, Yan R, Kuo YM, Chan M, Verkman AS, Chu T, Yottasan P, de Souza Goncalves L, Cil O

Crypt and Villus Enterochromaffin Cells are Distinct Stress Sensors in the Gut.

bioRxiv : the preprint server for biology

Touhara KK, Rossen ND, Deng F, Chu T, Cil O, Li Y, Julius D

Key role of down-regulated in adenoma (SLC26A3) chloride/bicarbonate exchanger in linaclotide-stimulated intestinal bicarbonate secretion upon loss of CFTR function.

bioRxiv : the preprint server for biology

Sarthi JB, Trumbull AM, Abazari SM, van Unen V, Chan JE, Jiang Y, Gammons J, Anderson MO, Cil O, Kuo CJ, Sellers ZM

Substituted 4-methylcoumarin inhibitors of SLC26A3 (DRA) for treatment of constipation and hyperoxaluria.

RSC medicinal chemistry

Ahmadi M, de Souza Goncalves L, Verkman AS, Cil O, Anderson MO

Incidence and Mitigation of Corneal Pseudomicrocysts Induced by Antibody-Drug Conjugates (ADCs).

Current ophthalmology reports

Lindgren ES, Yan R, Cil O, Verkman AS, Chan MF, Seitzman GD, Farooq AV, Huppert LA, Rugo HS, Pohlmann PR, Lu J, Esserman LJ, Pasricha ND

Mg2+ supplementation treats secretory diarrhea in mice by activating calcium-sensing receptor in intestinal epithelial cells.

The Journal of clinical investigation

de Souza Goncalves L, Chu T, Master R, Chhetri PD, Gao Q, Cil O

Repurposing calcium-sensing receptor activator drug cinacalcet for ADPKD treatment.

Translational research : the journal of laboratory and clinical medicine

Yottasan P, Chu T, Chhetri PD, Cil O

Repurposing calcium-sensing receptor activator drug cinacalcet for ADPKD treatment.

Translational Research

Pattareeya Yottasan, Tifany Chu, Parth D. Chhetri, Onur Cil

Selective isoxazolopyrimidine PAT1 (SLC26A6) inhibitors for therapy of intestinal disorders.

RSC medicinal chemistry

Chu T, Karmakar J, Haggie PM, Tan JA, Master R, Ramaswamy K, Verkman AS, Anderson MO, Cil O

Calcium-sensing receptor activator cinacalcet for treatment of cyclic nucleotide-mediated secretory diarrheas.

Translational research : the journal of laboratory and clinical medicine

Chu T, Yottasan P, Goncalves LS, Oak AA, Lin R, Tse M, Donowitz M, Cil O

Structure of human NCC: insights into the inhibition mechanism of thiazides.

Signal transduction and targeted therapy

de Souza Goncalves L, Yottasan P, Cil O

Small molecule inhibitors of intestinal epithelial anion exchanger SLC26A3 (DRA) with a luminal, extracellular site of action.

European journal of medicinal chemistry

Cil O, Anderson MO, de Souza Goncalves L, Tan JA, Haggie PM, Verkman AS

Genetic testing in children with nephrolithiasis and nephrocalcinosis.

Pediatric nephrology (Berlin, Germany)

Gefen AM, Sethna CB, Cil O, Perwad F, Schoettler M, Michael M, Angelo JR, Safdar A, Amlie-Wolf L, Hunley TE, Ellison JS, Feig D, Zaritsky J

Selective isoxazolopyrimidine PAT1 (SLC26A6) inhibitors for therapy of intestinal disorders.

RSC medicinal chemistry

Tifany Chu, Joy Karmakar, Peter M. Haggie, Joseph-Anthony Tan, Riya Master, Keerthana Ramaswamy, Alan S. Verkman, Marc O. Anderson, Onur Cil

Repurposing Calcium-Sensing Receptor Activator Cinacalcet for Autosomal Dominant Polycystic Kidney Disease Treatment.

Journal of the American Society of Nephrology

Pattareeya Yottasan, Qi Tifany Chu, Onur Cil

Ocular Surface Ion Transport and Dry Eye Disease.

Current ophthalmology reports

Lindgren ES, Cil O, Verkman AS, Pasricha ND

Cystinuria: An Overview of Diagnosis and Medical Management.

Turkish archives of pediatrics

Sadiq S, Cil O

A small molecule inhibitor of the chloride channel TMEM16A blocks vascular smooth muscle contraction and lowers blood pressure in spontaneously hypertensive rats.

Kidney international

Cil O, Chen X, Askew Page HR, Baldwin SN, Jordan MC, Myat Thwe P, Anderson MO, Haggie PM, Greenwood IA, Roos KP, Verkman AS

Small Molecule Inhibitor of TMEM16A Chloride Channel Blocks Vascular Smooth Muscle Contraction and Lowers Blood Pressure in Spontaneously Hypertensive Rats.

Journal of the American Society of Nephrology

Onur Cil, Xiaolan Chen, Henry Askew Page, Maria C. Jordan, Pyone Myat Thwe, Samuel N. Baldwin, Marc O. Anderson, Iain A. Greenwood, Kenneth P. Roos, Alan S. Verkman

Slowed gastric emptying and improved oral glucose tolerance produced by a nanomolar-potency inhibitor of calcium-activated chloride channel TMEM16A.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Cil O, Anderson MO, Yen R, Kelleher B, Huynh TL, Seo Y, Nilsen SP, Turner JR, Verkman AS

Inhibition of CFTR-mediated intestinal chloride secretion as potential therapy for bile acid diarrhea.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Duan T, Cil O, Tse CM, Sarker R, Lin R, Donowitz M, Verkman AS

SLC26A3 inhibitor identified in small molecule screen blocks colonic fluid absorption and reduces constipation.

JCI insight

Haggie PM, Cil O, Lee S, Tan JA, Rivera AA, Phuan PW, Verkman AS

Nanomolar-Potency 1,2,4-Triazoloquinoxaline Inhibitors of the Kidney Urea Transporter UT-A1.

Journal of medicinal chemistry

Lee S, Cil O, Diez-Cecilia E, Anderson MO, Verkman AS

Monogenic Causes of Proteinuria in Children.

Frontiers in medicine

Cil O, Perwad F

Substituted 2-Acylaminocycloalkylthiophene-3-carboxylic Acid Arylamides as Inhibitors of the Calcium-Activated Chloride Channel Transmembrane Protein 16A (TMEM16A).

Journal of medicinal chemistry

Truong EC, Phuan PW, Reggi AL, Ferrera L, Galietta LJV, Levy SE, Moises AC, Cil O, Diez-Cecilia E, Lee S, Verkman AS, Anderson MO

High-Potency Phenylquinoxalinone Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activators.

Journal of medicinal chemistry

Son JH, Zhu JS, Phuan PW, Cil O, Teuthorn AP, Ku CK, Lee S, Verkman AS, Kurth MJ

Benzopyrimido-pyrrolo-oxazine-dione CFTR inhibitor (R)-BPO-27 for antisecretory therapy of diarrheas caused by bacterial enterotoxins.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Cil O, Phuan PW, Gillespie AM, Lee S, Tradtrantip L, Yin J, Tse M, Zachos NC, Lin R, Donowitz M, Verkman AS

Phenylquinoxalinone CFTR activator as potential prosecretory therapy for constipation.

Translational research : the journal of laboratory and clinical medicine

Cil O, Phuan PW, Son JH, Zhu JS, Ku CK, Tabib NA, Teuthorn AP, Ferrera L, Zachos NC, Lin R, Galietta LJV, Donowitz M, Kurth MJ, Verkman AS

Small-Molecule Inhibitors of Pendrin Potentiate the Diuretic Action of Furosemide.

Journal of the American Society of Nephrology : JASN

Cil O, Haggie PM, Phuan PW, Tan JA, Verkman AS

CFTR activator increases intestinal fluid secretion and normalizes stool output in a mouse model of constipation.

Cellular and molecular gastroenterology and hepatology

Cil O, Phuan PW, Lee S, Tan J, Haggie PM, Levin MH, Sun L, Thiagarajah JR, Ma T, Verkman AS

A Turkish BCS1L mutation causes GRACILE-like disorder.

The Turkish journal of pediatrics

Serdaroglu E, Takci S, Kotarsky H, Çil O, Utine E, Yigit S, Fellman V

MCP1 2518 A/G polymorphism affects progression of childhood focal segmental glomerulosclerosis.

Renal failure

Besbas N, Kalyoncu M, Cil O, Ozgul RK, Bakkaloglu A, Ozaltin F

Salt-sparing diuretic action of a water-soluble urea analog inhibitor of urea transporters UT-A and UT-B in rats.

Kidney international

Cil O, Esteva-Font C, Tas ST, Su T, Lee S, Anderson MO, Ertunc M, Verkman AS

Genetic abnormalities and prognosis in patients with congenital and infantile nephrotic syndrome.

Pediatric nephrology (Berlin, Germany)

Cil O, Besbas N, Duzova A, Topaloglu R, Peco-Antic A, Korkmaz E, Ozaltin F

Diuresis and reduced urinary osmolality in rats produced by small-molecule UT-A-selective urea transport inhibitors.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Esteva-Font C, Cil O, Phuan PW, Su T, Lee S, Anderson MO, Verkman AS

Small-molecule inhibitors of urea transporters.

Sub-cellular biochemistry

Verkman AS, Esteva-Font C, Cil O, Anderson MO, Li F, Li M, Lei T, Ren H, Yang B

A novel mutation in protein C gene (PROC) causing severe phenotype in neonatal period.

Pediatric blood & cancer

Unal S, Gumruk F, Yigit S, Tuncer M, Tavil B, Cil O, Takci S, Urata M, Hotta T, Kang D, Cetin M

Protective effect of coenzyme Q10 in paclitaxel-induced peripheral neuropathy in rats.

Neurosciences (Riyadh, Saudi Arabia)

Celebi N, Cil H, Cil O, Canbay O, Onur R, Aypar U

Role of CXCR1 (CKR-1) in inflammation of experimental mesangioproliferative glomerulonephritis.

Renal failure

Ozaltin F, Besbas N, Iskit AB, Cil O, Akcoren Z, Kale G, Bakkaloglu A

The diuretic effect of urea analog dimethylthiourea in female Wistar rats.

Human & experimental toxicology

Cil O, Ertunc M, Onur R

Family history of renal disease severity predicts the mutated gene in ADPKD.

Journal of the American Society of Nephrology : JASN

Barua M, Cil O, Paterson AD, Wang K, He N, Dicks E, Parfrey P, Pei Y

Evidence for pathogenicity of atypical splice mutations in autosomal dominant polycystic kidney disease.

Clinical journal of the American Society of Nephrology : CJASN

Wang K, Zhao X, Chan S, Cil O, He N, Song X, Paterson AD, Pei Y

Websites: 
https://cillab.ucsf.edu/
Faculty Type: 
Affiliate Faculty