
Associate Professor
Pediatrics
Email
Websites
Dr. Onur Cil is a pediatric nephrologist and physician-scientist. Cil Lab’s research focus is small molecule drug discovery and drug repurposing for treatment of renal, gastrointestinal and cardiovascular diseases. Ultimate goal of our research is advancing our discoveries to clinical trials and establishing better and safer treatments. Our research is focused on membrane proteins including calcium-sensing receptor (CaSR), SLC26A3 (DRA), SLC26A4 (Pendrin), SLC26A6 (PAT1), CFTR, TMEM16A and urea transporters.
Faculty Type
Affiliate Faculty
Publications
TMEM16A in gastrointestinal and vascular smooth muscle contractility.
The Journal of physiology
Lysophosphatidic acid receptor 3 (LPAR3) regulates ocular surface chloride transport via calcium signaling.
Experimental eye research
High potency 3-carboxy-2-methylbenzofuran pendrin inhibitors as novel diuretics.
European journal of medicinal chemistry
Magnesium Supplementation Reduces Vascular Calcification by Activating Calcium-Sensing Receptor (CaSR) in Vascular Smooth Muscle Cells.
Journal of the American Society of Nephrology
Magnesium for disease treatment and prevention: emerging mechanisms and opportunities.
Trends in pharmacological sciences
DRA involvement in linaclotide-stimulated bicarbonate secretion during loss of CFTR function.
JCI insight
Calcium-sensing receptor (CaSR) modulates ocular surface chloride transport and its inhibition promotes ocular surface hydration.
The ocular surface
702 MAGNESIUM IS THE MAJOR ACTIVATOR OF CALCIUM-SENSING RECEPTOR IN THE INTESTINE AND ITS SUPPLEMENTATION CAN TREAT SECRETORY DIARRHEA.
Gastroenterology
Crypt and Villus Enterochromaffin Cells are Distinct Stress Sensors in the Gut.
bioRxiv : the preprint server for biology
Key role of down-regulated in adenoma (SLC26A3) chloride/bicarbonate exchanger in linaclotide-stimulated intestinal bicarbonate secretion upon loss of CFTR function.
bioRxiv : the preprint server for biology
Substituted 4-methylcoumarin inhibitors of SLC26A3 (DRA) for treatment of constipation and hyperoxaluria.
RSC medicinal chemistry
Incidence and Mitigation of Corneal Pseudomicrocysts Induced by Antibody-Drug Conjugates (ADCs).
Current ophthalmology reports
Mg2+ supplementation treats secretory diarrhea in mice by activating calcium-sensing receptor in intestinal epithelial cells.
The Journal of clinical investigation
Repurposing calcium-sensing receptor activator drug cinacalcet for ADPKD treatment.
Translational research : the journal of laboratory and clinical medicine
Selective isoxazolopyrimidine PAT1 (SLC26A6) inhibitors for therapy of intestinal disorders.
RSC medicinal chemistry
Calcium-sensing receptor activator cinacalcet for treatment of cyclic nucleotide-mediated secretory diarrheas.
Translational research : the journal of laboratory and clinical medicine
Structure of human NCC: insights into the inhibition mechanism of thiazides.
Signal transduction and targeted therapy
Case report: Short-term eculizumab use in atypical HUS associated with Lemierre's syndrome and post-infectious glomerulonephritis.
Frontiers in medicine
Small molecule inhibitors of intestinal epithelial anion exchanger SLC26A3 (DRA) with a luminal, extracellular site of action.
European journal of medicinal chemistry
Genetic testing in children with nephrolithiasis and nephrocalcinosis.
Pediatric nephrology (Berlin, Germany)
Repurposing Calcium-Sensing Receptor Activator Cinacalcet for Autosomal Dominant Polycystic Kidney Disease Treatment.
Journal of the American Society of Nephrology
Ocular Surface Ion Transport and Dry Eye Disease.
Current ophthalmology reports
Cystinuria: An Overview of Diagnosis and Medical Management.
Turkish archives of pediatrics
Lubiprostone is non-selective activator of cAMP-gated ion channels and Clc-2 has a minor role in its prosecretory effect in intestinal epithelial cells.
Molecular pharmacology
A small molecule inhibitor of the chloride channel TMEM16A blocks vascular smooth muscle contraction and lowers blood pressure in spontaneously hypertensive rats.
Kidney international
Repurposing calcium-sensing receptor agonist cinacalcet for treatment of CFTR-mediated secretory diarrheas.
JCI insight
Small Molecule Inhibitor of TMEM16A Chloride Channel Blocks Vascular Smooth Muscle Contraction and Lowers Blood Pressure in Spontaneously Hypertensive Rats.
Journal of the American Society of Nephrology
4,8-Dimethylcoumarin Inhibitors of Intestinal Anion Exchanger slc26a3 (Downregulated in Adenoma) for Anti-Absorptive Therapy of Constipation.
Journal of medicinal chemistry
Slowed gastric emptying and improved oral glucose tolerance produced by a nanomolar-potency inhibitor of calcium-activated chloride channel TMEM16A.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Inhibition of CFTR-mediated intestinal chloride secretion as potential therapy for bile acid diarrhea.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Nanomolar-Potency 1,2,4-Triazoloquinoxaline Inhibitors of the Kidney Urea Transporter UT-A1.
Journal of medicinal chemistry
Monogenic Causes of Proteinuria in Children.
Frontiers in medicine
Substituted 2-Acylaminocycloalkylthiophene-3-carboxylic Acid Arylamides as Inhibitors of the Calcium-Activated Chloride Channel Transmembrane Protein 16A (TMEM16A).
Journal of medicinal chemistry
High-Potency Phenylquinoxalinone Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activators.
Journal of medicinal chemistry
Benzopyrimido-pyrrolo-oxazine-dione CFTR inhibitor (R)-BPO-27 for antisecretory therapy of diarrheas caused by bacterial enterotoxins.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Phenylquinoxalinone CFTR activator as potential prosecretory therapy for constipation.
Translational research : the journal of laboratory and clinical medicine
Small-Molecule Inhibitors of Pendrin Potentiate the Diuretic Action of Furosemide.
Journal of the American Society of Nephrology : JASN
CFTR activator increases intestinal fluid secretion and normalizes stool output in a mouse model of constipation.
Cellular and molecular gastroenterology and hepatology
A Turkish BCS1L mutation causes GRACILE-like disorder.
The Turkish journal of pediatrics
MCP1 2518 A/G polymorphism affects progression of childhood focal segmental glomerulosclerosis.
Renal failure
Salt-sparing diuretic action of a water-soluble urea analog inhibitor of urea transporters UT-A and UT-B in rats.
Kidney international
Genetic abnormalities and prognosis in patients with congenital and infantile nephrotic syndrome.
Pediatric nephrology (Berlin, Germany)
Diuresis and reduced urinary osmolality in rats produced by small-molecule UT-A-selective urea transport inhibitors.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Small-molecule inhibitors of urea transporters.
Sub-cellular biochemistry
A novel mutation in protein C gene (PROC) causing severe phenotype in neonatal period.
Pediatric blood & cancer
Protective effect of coenzyme Q10 in paclitaxel-induced peripheral neuropathy in rats.
Neurosciences (Riyadh, Saudi Arabia)
Role of CXCR1 (CKR-1) in inflammation of experimental mesangioproliferative glomerulonephritis.
Renal failure
The diuretic effect of urea analog dimethylthiourea in female Wistar rats.
Human & experimental toxicology
Family history of renal disease severity predicts the mutated gene in ADPKD.
Journal of the American Society of Nephrology : JASN
Evidence for pathogenicity of atypical splice mutations in autosomal dominant polycystic kidney disease.
Clinical journal of the American Society of Nephrology : CJASN
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