
Research Interests: Summary: Lipoprotein metabolism and risk of cardiovascular disease Despite recent advances in treatment, cardiovascular disease (CVD) remains the leading cause of death in the US and will soon achieve this status globally. Our group's research is aimed at addressing three major challenges for reducing this enormous disease burden. First, standard diagnostic procedures do not identify a high proportion of children and adults who are at risk for CVD. We have developed and implemented a sophisticated new procedure that, by analyzing individual lipoprotein particles, provides more specific information than that afforded by ordinary cholesterol testing, and hence is capable of improving both the assessment and management of CVD risk. Second, dietary and lifestyle guidance has failed to substantially impact CVD risk factors, particularly those related to overweight and obesity. We have demonstrated that carbohydrate restriction can reverse the high risk lipid profile found in a high proportion of overweight and obese individuals even without weight loss, and that this effect is independent of saturated fat intake. These findings have helped support dietary guidelines that place a greater emphasis on limiting refined carbohydrates than fats. Third, despite the awareness of wide interindividual variability in response to treatments aimed at reducing CVD risk, the potential benefits of applying genomic tools for developing personalized approaches for maximizing CVD risk reduction have not been realized. A major component of our research program has been the application and development of genomic methodology for dissecting genetic influences on the therapeutic responses to statins, the most widely prescribed class of drugs for reducing CVD risk.
Publications
Dietary Management of Atherogenic Dyslipidemia.
Polygenic prediction of body mass index and obesity through the life course and across ancestries.
Uncertainty in the estimated effects of statin initiation on risk of dementia: using a multiverse analysis to assess sources of variability.
Response to "Comment on 'Independent associations of high-density lipoprotein cholesterol and triglyceride levels with Alzheimer's disease and related dementias' ".
MIR192 Upregulates GLP-1 Receptor and Improves Statin-Induced Impairment of Insulin Secretion.
Regular-fat and low-fat dairy foods and cardiovascular diseases: perspectives for future dietary recommendations.
SLCO1B1 Functional Variants, Bilirubin, Statin-Induced Myotoxicity, and Recent Sub-Saharan African Ancestry: A Precision Medicine Health Equity Study.
Sociodemographic modifiers of effects of statin initiation on dementia incidence: An emulated trial design in a large health care member population with 10+ years of follow-up.
Independent associations of high-density lipoprotein cholesterol and triglyceride levels with Alzheimer's disease and related dementias.
Effect of Hormone Therapy on Lipoprotein Subfractions in Early and Late Postmenopausal Women.
GWAS of CRP response to statins further supports the role of APOE in Statin Response: a GIST consortium study.
TOMM40 regulates hepatocellular and plasma lipid metabolism via an LXR-dependent pathway.
Participant-derived cell line transcriptomic analyses and mouse studies reveal a role for ZNF335 in plasma cholesterol statin response.
Leveraging altered lipid metabolism in treating B cell malignancies.
X chromosome dosage drives statin-induced dysglycemia and mitochondrial dysfunction.
Ketogenic Diet Intervention on Metabolic and Psychiatric Health in Bipolar and Schizophrenia: A Pilot Trial.
Changes in Soluble LDL Receptor and Lipoprotein Fractions in Response to Diet in the DIETFITS Weight Loss Study.
Identification of genetic drivers of plasma lipoprotein size in the Diversity Outbred mouse population.
Missense variants in SORT1 are associated with LDL-C in an Amish population.
TOMM40 and TOMM22 of the Translocase Outer Mitochondrial Membrane Complex rescue statin-impaired mitochondrial dynamics, morphology, and mitophagy in skeletal myotubes.
Participant-derived cell line transcriptomic analyses and mouse studies reveal a role for ZNF335 in plasma cholesterol statin response.
Author Correction: The power of genetic diversity in genome-wide association studies of lipids.
An association of CSF apolipoprotein E glycosylation and amyloid-beta 42 in individuals who carry the APOE4 allele.
Development and application of an algorithm for statin-induced myopathy based on electronic health record-derived structured elements.
VLDL receptor gene therapy for reducing atherogenic lipoproteins.
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis.
Obesity and cardiovascular disease: beyond body weight and energy balance.
Elevated LDL-cholesterol levels among lean mass hyper-responders on low-carbohydrate ketogenic diets deserve urgent clinical attention and further research.
Polygenic Risk Score and Statin Relative Risk Reduction for Primary Prevention of Myocardial Infarction in a Real-World Population.
A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids.
Competing paradigms of obesity pathogenesis: energy balance versus carbohydrate-insulin models.
Undifferentiated Induced Pluripotent Stem Cells as a Genetic Model for Nonalcoholic Fatty Liver Disease.
Modest effect of statins on fasting glucose in a longitudinal electronic health record based cohort.
Lipoprotein subfractions and subclinical vascular health in middle aged women: does menopause status matter?
Remnant lipoprotein particles and cardiovascular disease risk.
The small HDL particle hypothesis of Alzheimer's disease.
Meta-GWAS of PCSK9 levels detects two novel loci at APOB and TM6SF2.
Small dense low-density lipoprotein particles: clinically relevant?
The Clinical Pharmacogenetics Implementation Consortium Guideline for SLCO1B1, ABCG2, and CYP2C9 genotypes and Statin-Associated Musculoskeletal Symptoms.
Concerns regarding NMR lipoprotein analyses performed on the Nightingale heath platform - Focus on LDL subclasses.
Reply to A Drewnowski et al, O Devinsky, D A Booth and E L Gibson, and D J Millward.
A gene-diet interaction controlling relative intake of dietary carbohydrates and fats.
The Pharmacogenetics of Statin Therapy on Clinical Events: No Evidence that Genetic Variation Affects Statin Response on Myocardial Infarction.
The microbial gbu gene cluster links cardiovascular disease risk associated with red meat consumption to microbiota L-carnitine catabolism.
The carbohydrate-insulin model: a physiological perspective on the obesity pandemic.
Fecal Microbiome Composition Does Not Predict Diet-Induced TMAO Production in Healthy Adults.
Effect of SLCO1B1 T521C on Statin-Related Myotoxicity With Use of Lovastatin and Atorvastatin.
A unified framework identifies new links between plasma lipids and diseases from electronic medical records across large-scale cohorts.
Efficacy of AAV9-mediated SGPL1 gene transfer in a mouse model of S1P lyase insufficiency syndrome.
A multi-ethnic genome-wide association study implicates collagen matrix integrity and cell differentiation pathways in keratoconus.
Correction to: Impact of a 2‑year trial of nutritional ketosis on indices of cardiovascular disease risk in patients with type 2 diabetes.
Impact of a 2-year trial of nutritional ketosis on indices of cardiovascular disease risk in patients with type 2 diabetes.
Consensus Statement by the American Association of Clinical Endocrinologists and American College of Endocrinology on the Management of Dyslipidemia and Prevention of Cardiovascular Disease Algorithm - 2020 Executive Summary.
Genetic variants modulate gene expression statin response in human lymphoblastoid cell lines.
Public health guidelines should recommend reducing saturated fat consumption as much as possible: Debate Consensus.
Public health guidelines should recommend reducing saturated fat consumption as much as possible: NO.
Public health guidelines should recommend reducing saturated fat consumption as much as possible: YES.
Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel.
Saturated Fats and Health: A Reassessment and Proposal for Food-Based Recommendations: JACC State-of-the-Art Review.
Lipoprotein Particle Predictors of Arterial Stiffness after 17 Years of Follow Up: The Malmö Diet and Cancer Study.
Phosphatidylinositol-(4,5)-Bisphosphate Regulates Plasma Cholesterol Through LDL (Low-Density Lipoprotein) Receptor Lysosomal Degradation.
High-Risk Atherosclerosis and Metabolic Phenotype: The Roles of Ectopic Adiposity, Atherogenic Dyslipidemia, and Inflammation.
Comparison of nonfasting and fasting lipoprotein subfractions and size in 15,397 apparently healthy individuals: An analysis from the VITamin D and OmegA-3 TriaL.
The impact of adjusting for baseline in pharmacogenomic genome-wide association studies of quantitative change.
Role of angiopoietin-like protein 3 in sugar-induced dyslipidemia in rhesus macaques: suppression by fish oil or RNAi.
Statin-induced LDL cholesterol response and type 2 diabetes: a bidirectional two-sample Mendelian randomization study.
Expanding Precompetitive Multisector Collaborations to Advance Drug Development and Pharmacogenomics.
ATP synthase inhibitory factor 1 (IF1), a novel myokine, regulates glucose metabolism by AMPK and Akt dual pathways.
Lessons Learned from the POUNDS Lost Study: Genetic, Metabolic, and Behavioral Factors Affecting Changes in Body Weight, Body Composition, and Cardiometabolic Risk.
Lifestyle factors and high-risk atherosclerosis: Pathways and mechanisms beyond traditional risk factors.
WHO draft guidelines on dietary saturated and trans fatty acids: time for a new approach?
Effects of red meat, white meat, and nonmeat protein sources on atherogenic lipoprotein measures in the context of low compared with high saturated fat intake: a randomized controlled trial.
Dietary carbohydrate restriction improves metabolic syndrome independent of weight loss.
ApoC-III ASO promotes tissue LPL activity in the absence of apoE-mediated TRL clearance.
Low plasma adropin concentrations increase risks of weight gain and metabolic dysregulation in response to a high-sugar diet in male nonhuman primates.
A randomized, controlled trial on the effects of almonds on lipoprotein response to a higher carbohydrate, lower fat diet in men and women with abdominal adiposity.
Relationship between resolution of non-alcoholic steatohepatitis and changes in lipoprotein sub-fractions: a post-hoc analysis of the PIVENS trial.
Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women.
Fructose-induced hypertriglyceridemia in rhesus macaques is attenuated with fish oil or ApoC3 RNA interference.
Bidirectional Mendelian randomization to explore the causal relationships between body mass index and polycystic ovary syndrome.
Low-Density Lipoprotein Particle Size Subfractions and Cerebral Amyloidosis.
Single-molecule 3D imaging of human plasma intermediate-density lipoproteins reveals a polyhedral structure.
Metagenomic Insights into the Degradation of Resistant Starch by Human Gut Microbiota.
Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders.
LPA Variants Are Associated With Residual Cardiovascular Risk in Patients Receiving Statins.
Characterization of Statin Low-Density Lipoprotein Cholesterol Dose-Response Using Electronic Health Records in a Large Population-Based Cohort.
Adverse effects of statin therapy: perception vs. the evidence - focus on glucose homeostasis, cognitive, renal and hepatic function, haemorrhagic stroke and cataract.
Dietary fat and cardiometabolic health: evidence, controversies, and consensus for guidance.
Pathways and mechanisms linking dietary components to cardiometabolic disease: thinking beyond calories.
PCSK9 deficiency reduces atherosclerosis, apolipoprotein B secretion, and endothelial dysfunction.
Assessing the mechanisms of cholesteryl ester transfer protein inhibitors.
New Pharmacogenomics Research Network: An Open Community Catalyzing Research and Translation in Precision Medicine.
Odd Chain Fatty Acids; New Insights of the Relationship Between the Gut Microbiota, Dietary Intake, Biosynthesis and Glucose Intolerance.
Epigenetic Patterns in Blood Associated With Lipid Traits Predict Incident Coronary Heart Disease Events and Are Enriched for Results From Genome-Wide Association Studies.
Changes in low-density lipoprotein size phenotypes associate with changes in apolipoprotein C-III glycoforms after dietary interventions.
Pharmacometabolomic signature links simvastatin therapy and insulin resistance.
Diets high in resistant starch increase plasma levels of trimethylamine-N-oxide, a gut microbiome metabolite associated with CVD risk.
Candidate-Gene Study of Functional Polymorphisms in SLCO1B1 and CYP3A4/5 and the Cholesterol-Lowering Response to Simvastatin.
Which cheese to choose?
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals.
Meta-analysis of genome-wide association studies of HDL cholesterol response to statins.
Polyhedral 3D structure of human plasma very low density lipoproteins by individual particle cryo-electron tomography1.
Diet, lipids, and cardiovascular disease.
The early years of lipoprotein research: from discovery to clinical application.
Trans-ethnic Meta-analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin.
Prepregnancy Adverse Lipid Profile and Subsequent Risk of Gestational Diabetes.
Association between disease occurrence and fertility of dairy cows in three geographic regions of Chile.
PharmGKB summary: very important pharmacogene information for RYR1.
Transcriptomic variation of pharmacogenes in multiple human tissues and lymphoblastoid cell lines.
Does Milk Consumption Contribute to Cardiometabolic Health and Overall Diet Quality?
Comparison of the DASH (Dietary Approaches to Stop Hypertension) diet and a higher-fat DASH diet on blood pressure and lipids and lipoproteins: a randomized controlled trial.
Vaccenic acid and trans fatty acid isomers from partially hydrogenated oil both adversely affect LDL cholesterol: a double-blind, randomized controlled trial.
In Memoriam: Alexander V. Nichols (1924 – 2015).
Association study of androgen signaling pathway genes in polycystic ovary syndrome.
Food Consumption and its Impact on Cardiovascular Disease: Importance of Solutions Focused on the Globalized Food System: A Report From the Workshop Convened by the World Heart Federation.
Endogenous Sex Steroid Hormones, Lipid Subfractions, and Ectopic Adiposity in Asian Indians.
Individual and Combined Associations of Genetic Variants in CYP3A4, CYP3A5, and SLCO1B1 With Simvastatin and Simvastatin Acid Plasma Concentrations.
Low-Density Lipoprotein Particle Number Is Associated With Cardiovascular Events Among Those Not Classified Into Statin Benefit Groups.
A multicomponent nutrient bar promotes weight loss and improves dyslipidemia and insulin resistance in the overweight/obese: chronic inflammation blunts these improvements.
Statin-associated muscle symptoms: impact on statin therapy-European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management.
Further investigation in europeans of susceptibility variants for polycystic ovary syndrome discovered in genome-wide association studies of Chinese individuals.
Saturated Fats Versus Polyunsaturated Fats Versus Carbohydrates for Cardiovascular Disease Prevention and Treatment.
Genetic variation in the UGT1A locus is associated with simvastatin efficacy in a clinical practice setting.
Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins.
Changes in LDL particle concentrations after treatment with the cholesteryl ester transfer protein inhibitor anacetrapib alone or in combination with atorvastatin.
Ancestry and other genetic associations with plasma PCSK9 response to simvastatin.
CYP3A4*22 and CYP3A5*3 are associated with increased levels of plasma simvastatin concentrations in the cholesterol and pharmacogenetics study cohort.
Prediction of LDL cholesterol response to statin using transcriptomic and genetic variation.
HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials.
Mangravite et al. reply.
Diets high in protein or saturated fat do not affect insulin sensitivity or plasma concentrations of lipids and lipoproteins in overweight and obese adults.
Transmembrane protein 55B is a novel regulator of cellular cholesterol metabolism.
Nonalcoholic steatohepatitis is associated with an atherogenic lipoprotein subfraction profile.
The clinical pharmacogenetics implementation consortium guideline for SLCO1B1 and simvastatin-induced myopathy: 2014 update.
All low-density lipoprotein particles are not created equal.
Organophosphorus flame retardants inhibit specific liver carboxylesterases and cause serum hypertriglyceridemia.
Genome-wide association and pharmacological profiling of 29 anticancer agents using lymphoblastoid cell lines.
Statin-induced changes in gene expression in EBV-transformed and native B-cells.
Common variants associated with plasma triglycerides and risk for coronary artery disease.
Discovery and refinement of loci associated with lipid levels.
Characterization of statin dose response in electronic medical records.
Pharmacometabolomics of statin response.
High-density lipoproteins: a consensus statement from the National Lipid Association.
Relationship of sex to diabetes risk in statin trials.
Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis.
Alternative splicing in the regulation of cholesterol homeostasis.
A common polymorphism in the LDL receptor gene has multiple effects on LDL receptor function.
ATHENA: a tool for meta-dimensional analysis applied to genotypes and gene expression data to predict HDL cholesterol levels.
Multivariate methods and software for association mapping in dose-response genome-wide association studies.
A genome-wide association analysis of temozolomide response using lymphoblastoid cell lines shows a clinically relevant association with MGMT.
Effects of dietary saturated fat on LDL subclasses and apolipoprotein CIII in men.
Metabolomics reveals amino acids contribute to variation in response to simvastatin treatment.
Steroidogenic regulatory factor FOS is underexpressed in polycystic ovary syndrome (PCOS) adipose tissue and genetically associated with PCOS susceptibility.
The clinical pharmacogenomics implementation consortium: CPIC guideline for SLCO1B1 and simvastatin-induced myopathy.
A nutrient-dense, high-fiber, fruit-based supplement bar increases HDL cholesterol, particularly large HDL, lowers homocysteine, and raises glutathione in a 2-wk trial.
Genetic variation in PNPLA3 but not APOC3 influences liver fat in non-alcoholic fatty liver disease.
Impact of mifepristone, a glucocorticoid/progesterone antagonist, on HDL cholesterol, HDL particle concentration, and HDL function.
Structural basis of transfer between lipoproteins by cholesteryl ester transfer protein.
Changes in lipoprotein subfraction concentration and composition in healthy individuals treated with the CETP inhibitor anacetrapib.
Replication of association of DENND1A and THADA variants with polycystic ovary syndrome in European cohorts.
Changes in atherogenic dyslipidemia induced by carbohydrate restriction in men are dependent on dietary protein source.
High disaccharide intake associates with atherogenic lipoprotein profile.
Cardiovascular pharmacogenomics.
MBX-8025, a novel peroxisome proliferator receptor-delta agonist: lipid and other metabolic effects in dyslipidemic overweight patients treated with and without atorvastatin.
Energy substrate partitioning and efficiency in individuals with atherogenic lipoprotein phenotype.
The role of reducing intakes of saturated fat in the prevention of cardiovascular disease: where does the evidence stand in 2010?
HDL measures, particle heterogeneity, proposed nomenclature, and relation to atherosclerotic cardiovascular events.
The emerging role of electronic medical records in pharmacogenomics.
Saturated fatty acids and risk of coronary heart disease: modulation by replacement nutrients.
Changes in lipoprotein(a), oxidized phospholipids, and LDL subclasses with a low-fat high-carbohydrate diet.
Lipoprotein subfractions and cardiovascular disease risk.
Phospholipid transfer protein and atherosclerosis: genetic studies take aim at a moving target.
Reversal of small, dense LDL subclass phenotype by weight loss is associated with impaired fat oxidation.
VLDL hydrolysis by LPL activates PPAR-alpha through generation of unbound fatty acids.
Combined influence of LDLR and HMGCR sequence variation on lipid-lowering response to simvastatin.
Lipidomic analysis of variation in response to simvastatin in the Cholesterol and Pharmacogenetics Study.
Genome-wide association of lipid-lowering response to statins in combined study populations.
Plasma triglyceride concentrations are rapidly reduced following individual bouts of endurance exercise in women.
Saturated fat, carbohydrate, and cardiovascular disease.
Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease.
A gene score of nine LDL and HDL regulating genes is associated with fluvastatin-induced cholesterol changes in women.
Ion mobility analysis of lipoprotein subfractions identifies three independent axes of cardiovascular risk.
The role of HMGCR alternative splicing in statin efficacy.
Reversal of small, dense LDL subclass phenotype by normalization of adiposity.
Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans.
Hepatic nuclear factor 1-alpha: inflammation, genetics, and atherosclerosis.
A reappraisal of the impact of dairy foods and milk fat on cardiovascular disease risk.
Population analysis of large copy number variants and hotspots of human genetic disease.
Use of an electronic medical record to characterize cases of intermediate statin-induced muscle toxicity.
Pharmacogenomics of statin response.
Consumption of fructose-sweetened beverages for 10 weeks increases postprandial triacylglycerol and apolipoprotein-B concentrations in overweight and obese women.
Characterization of low-density lipoprotein cholesterol-lowering efficacy for atorvastatin in a population-based DNA biorepository.
Genetic loci associated with plasma concentration of low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, apolipoprotein A1, and Apolipoprotein B among 6382 white women in genome-wide analysis with replication.
Overactive endocannabinoid signaling impairs apolipoprotein E-mediated clearance of triglyceride-rich lipoproteins.
Interview.
Tracing sub-structure in the European American population with PCA-informative markers.
A novel function of lipoprotein [a] as a preferential carrier of oxidized phospholipids in human plasma.
Direct determination of lipoprotein particle sizes and concentrations by ion mobility analysis.
Protein in optimal health: heart disease and type 2 diabetes.
Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein.
Lipid metabolism in children and adolescents: Impact on vascular biology.
The editor's roundtable: expanded versus standard lipid panels in assessing and managing cardiovascular risk.
Analysis of polymorphisms in the 3' untranslated region of the LDL receptor gene and their effect on plasma cholesterol levels and drug response.
What can the genome tell us about LDL cholesterol?
Low-fat dietary pattern and risk of cardiovascular disease in the Women's Health Initiative Randomized Controlled Dietary Modification Trial.
Atherogenic lipid phenotype in a general group of subjects.
Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges.
Fatty acid desaturase regulation in adipose tissue by dietary composition is independent of weight loss and is correlated with the plasma triacylglycerol response.
Estrogen receptor genotypes, menopausal status, and the lipid effects of tamoxifen.
Differential effects of ramipril on ambulatory blood pressure in African Americans and Caucasians.
Pharmacogenomics of statin response.
Increased plasma concentrations of lipoprotein(a) during a low-fat, high-carbohydrate diet are associated with increased plasma concentrations of apolipoprotein C-III bound to apolipoprotein B-containing lipoproteins.
Genetic nondiscrimination legislation: a critical prerequisite for pharmacogenomics data sharing.
When good drugs go bad.
The pharmacogenetics research network: from SNP discovery to clinical drug response.
Pharmacogenomics: challenges and opportunities.
Endurance training has little effect on active muscle free fatty acid, lipoprotein cholesterol, or triglyceride net balances.
Separate effects of reduced carbohydrate intake and weight loss on atherogenic dyslipidemia.
Clinical implications of pharmacogenomics of statin treatment.
Apo B versus cholesterol in estimating cardiovascular risk and in guiding therapy: report of the thirty-person/ten-country panel.
Phenotypic predictors of response to simvastatin therapy among African-Americans and Caucasians: the Cholesterol and Pharmacogenetics (CAP) Study.
Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute scientific statement.
Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute scientific statement: Executive Summary.
Diagnosis and management of the metabolic syndrome. An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Executive summary.
Influence of dietary carbohydrate and fat on LDL and HDL particle distributions.
The case for strategic international alliances to harness nutritional genomics for public and personal health.
Dietary and genetic probes of atherogenic dyslipidemia.
Is there a simple way to identify insulin-resistant individuals at increased risk of cardiovascular disease?
Concordant lipoprotein and weight responses to dietary fat change in identical twins with divergent exercise levels 1.
Role of CYP27A in cholesterol and bile acid metabolism.
Low-density lipoprotein particle size loci in familial combined hyperlipidemia: evidence for multiple loci from a genome scan.
Dyslipidemia in type 2 diabetes.
Metabolic abnormalities: triglyceride and low-density lipoprotein.
Hold the antioxidants and improve plasma lipids?
Plasma clearance of human low-density lipoprotein in human apolipoprotein B transgenic mice is related to particle diameter.
Haplotypes in the APOA1-C3-A4-A5 gene cluster affect plasma lipids in both humans and baboons.
Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults.
Association of the APOLIPOPROTEIN A1/C3/A4/A5 gene cluster with triglyceride levels and LDL particle size in familial combined hyperlipidemia.
Obesity in BSB mice is correlated with expression of genes for iron homeostasis and leptin.
Subclasses of low-density lipoprotein and very low-density lipoprotein in familial combined hyperlipidemia: relationship to multiple lipoprotein phenotype.
Effects on lipoprotein subclasses of combined expression of human hepatic lipase and human apoB in transgenic rabbits.
Insulin resistance syndrome and dyslipidemia.
Determination and use of haplotypes: ethnic comparison and association of the lipoprotein lipase gene and coronary artery disease in Mexican-Americans.
American College of Endocrinology position statement on the insulin resistance syndrome.
Smallest LDL particles are most strongly related to coronary disease progression in men.
Effects of simvastatin, an HMG-CoA reductase inhibitor, in patients with hypertriglyceridemia.
Two independent apolipoprotein A5 haplotypes influence human plasma triglyceride levels.
ApoC-III content of apoB-containing lipoproteins is associated with binding to the vascular proteoglycan biglycan.
Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia.
Metabolic origins and clinical significance of LDL heterogeneity.
Metabolic effects of nandrolone decanoate and resistance training in men with HIV.
Analysis and quantitation of biotinylated apoB-containing lipoproteins with streptavidin-Cy3.
Individualized hormone-replacement therapy?
Altered activities of anti-atherogenic enzymes LCAT, paraoxonase, and platelet-activating factor acetylhydrolase in atherosclerosis-susceptible mice.
Properties of triglyceride-rich and cholesterol-rich lipoproteins in the remnant-like particle fraction of human blood plasma.
Is the size of low-density lipoprotein particles related to the risk of coronary heart disease?
AHA/ACC Guidelines for Preventing Heart Attack and Death in Patients With Atherosclerotic Cardiovascular Disease: 2001 update. A statement for healthcare professionals from the American Heart Association and the American College of Cardiology.
An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing.
Molecular signal transduction by conformational transmission: use of tetrasubstituted perhydroanthracenes as transducers.
AHA scientific statement: summary of the Scientific Conference on Dietary Fatty Acids and Cardiovascular Health. Conference summary from the Nutrition Committee of the American Heart Association.
Familial factors in the antihypertensive response to lisinopril.
Atherogenic lipoprotein phenotype and diet-gene interactions.
Enhanced oxidative susceptibility and reduced antioxidant content of metabolic precursors of small, dense low-density lipoproteins.
Lipoprotein candidate genes for multivariate factors of the insulin resistance syndrome: a sib-pair linkage analysis in women twins.
Dietary and genetic effects on LDL heterogeneity.
Dietary and genetic effects on low-density lipoprotein heterogeneity.
Revision 2000: a statement for healthcare professionals from the Nutrition Committee of the American Heart Association.
Increased low density lipoprotein degradation in aorta of irradiated mice is inhibited by preenrichment of low density lipoprotein with alpha-tocopherol.
Induction and maintenance of the neuronal cholinergic phenotype in the central nervous system by BMP-9.
Cardiovascular fitness, body composition, and lipoprotein lipid metabolism in older men.
Reduced LDL particle size in children consuming a very-low-fat diet is related to parental LDL-subclass patterns.
Genetic recipes for heart-healthy diets.
Contribution of the hepatic lipase gene to the atherogenic lipoprotein phenotype in familial combined hyperlipidemia.
Garlic powder, effect on plasma lipids, postprandial lipemia, low-density lipoprotein particle size, high-density lipoprotein subclass distribution and lipoprotein(a).
Genomic interval engineering of mice identifies a novel modulator of triglyceride production.
Alterations in low-density lipoprotein and high-density lipoprotein subclasses among Hispanic women with polycystic ovary syndrome: influence of insulin and genetic factors.
Low-fat diets, lipoprotein subclasses, and heart disease risk.
Effects of a low-fat, high-carbohydrate diet on VLDL-triglyceride assembly, production, and clearance.
Structural heterogeneity of apoB-containing serum lipoproteins visualized using cryo-electron microscopy.
Pathophysiology of triglyceride-rich lipoproteins in atherothrombosis: clinical aspects.
A very low-fat diet is not associated with improved lipoprotein profiles in men with a predominance of large, low-density lipoproteins.
Overexpression of human hepatic lipase and ApoE in transgenic rabbits attenuates response to dietary cholesterol and alters lipoprotein subclass distributions.
Dissociable and nondissociable forms of platelet-activating factor acetylhydrolase in human plasma LDL: implications for LDL oxidative susceptibility.
Lamellar lipoproteins uniquely contribute to hyperlipidemia in mice doubly deficient in apolipoprotein E and hepatic lipase.
Obesity: impact of cardiovascular disease.
Acceptability of a substitution of estrogen replacement therapy to women enrolled in a health maintenance organization.
Relationships between insulin resistance and lipoproteins in nondiabetic African Americans, Hispanics, and non-Hispanic whites: the Insulin Resistance Atherosclerosis Study.
Families with familial combined hyperlipidemia and families enriched for coronary artery disease share genetic determinants for the atherogenic lipoprotein phenotype.
Metabolism of lipoproteins containing apolipoprotein B in hepatic lipase-deficient mice.
The American College of Physicians guidelines for screening blood cholesterol levels: a commentary.
Triglycerides and atherogenic lipoproteins: rationale for lipid management.
Sulfur K-edge x-ray absorption spectroscopy: a spectroscopic tool to examine the redox state of S-containing metabolites in vivo.
Change in dietary saturated fat intake is correlated with change in mass of large low-density-lipoprotein particles in men.
The obesity problem.
Influence of apoE content on receptor binding of large, bouyant LDL in subjects with different LDL subclass phenotypes.
Atherogenicity of triglyceride-rich lipoproteins.
Candidate-gene studies of the atherogenic lipoprotein phenotype: a sib-pair linkage analysis of DZ women twins.
Quantification of HDL2 and HDL3 cholesterol by the Vertical Auto Profile-II (VAP-II) methodology.
Relation of LDL size to the insulin resistance syndrome and coronary heart disease in American Indians. The Strong Heart Study.
Diet-gene interactions in human lipoprotein metabolism.
Effect of fluvastatin on low-density lipoprotein peak particle diameter.
Associations of age, adiposity, menopause, and alcohol intake with low-density lipoprotein subclasses.
Intermediate-density lipoproteins and progression of carotid arterial wall intima-media thickness.
Charge properties of low density lipoprotein subclasses.
Cryo-electron microscopy of low density lipoprotein and reconstituted discoidal high density lipoprotein: imaging of the apolipoprotein moiety.
LDL subclass patterns and lipoprotein response to a low-fat, high-carbohydrate diet in women.
The atherogenic lipoprotein phenotype is not caused by a mutation in the coding region of the low density lipoprotein receptor gene.
Variability of plasma HDL subclass concentrations in men and women over time.
Understanding the basis for variation in response to cholesterol-lowering diets.
Genetic, metabolic, and dietary influences on the atherogenic lipoprotein phenotype.
Heritability of factors of the insulin resistance syndrome in women twins.
Selective resistance of LDL core lipids to iron-mediated oxidation. Implications for the biological properties of iron-oxidized LDL.
Preventing heart attack and death in patients with coronary disease. Endorsed by the board of trustees of the American College of Cardiology.
Differences in receptor binding of LDL subfractions.
Lipoprotein subclasses in the Monitored Atherosclerosis Regression Study (MARS). Treatment effects and relation to coronary angiographic progression.
Hormone replacement therapy, hormone levels, and lipoprotein cholesterol concentrations in elderly women.
Multilocus genetic determinants of LDL particle size in coronary artery disease families.
Soy protein and serum lipids.
Differing alpha-tocopherol oxidative lability and ascorbic acid sparing effects in buoyant and dense LDL.
Overexpression of human apolipoprotein B-100 in transgenic rabbits results in increased levels of LDL and decreased levels of HDL.
Low-density-lipoprotein subclasses and response to a low-fat diet in healthy men.
Predominance of large LDL and reduced HDL2 cholesterol in normolipidemic men with coronary artery disease.
Effects of dietary fat on high-density-lipoprotein subclasses are influenced by both apolipoprotein E isoforms and low-density-lipoprotein subclass patterns.
Solvent drag of LDL across mammalian endothelial barriers with increased permeability.
Greater oxidative susceptibility of the surface monolayer in small dense LDL may contribute to differences in copper-induced oxidation among LDL density subfractions.
LDL physical and chemical properties in familial combined hyperlipidemia.
Associations of hepatic and lipoprotein lipase activities with changes in dietary composition and low density lipoprotein subclasses.
Persistence of low HDL-C levels after weight reduction in older men with small LDL particles.
Dense low density lipoproteins and coronary artery disease.
Apolipoprotein E isoform phenotype and LDL subclass response to a reduced-fat diet.
The associations of high-density lipoprotein subclasses with insulin and glucose levels, physical activity, resting heart rate, and regional adiposity in men with coronary artery disease: the Stanford Coronary Risk Intervention Project baseline survey.
Multivariate analysis of the insulin resistance syndrome in women.
Genetic predictors of FCHL in four large pedigrees. Influence of ApoB level major locus predicted genotype and LDL subclass phenotype.
Variations in high-density lipoprotein subclasses during the menstrual cycle.
Heterogeneity of plasma low-density lipoproteins and atherosclerosis risk.
Cardiovascular disease and hyperlipidaemia.
Isolation of allele-specific, receptor-binding-defective low density lipoproteins from familial defective apolipoprotein B-100 subjects.
Relations of plasma TG and HDL-C concentrations to body composition and plasma insulin levels are altered in men with small LDL particles.
Effects of low-fat diet, calorie restriction, and running on lipoprotein subfraction concentrations in moderately overweight men.
Modification of LCAT activity and HDL structure. New links between cigarette smoke and coronary heart disease risk.
Oxidative susceptibility of low density lipoprotein subfractions is related to their ubiquinol-10 and alpha-tocopherol content.
Reduced adipose tissue lipoprotein lipase responses, postprandial lipemia, and low high-density lipoprotein-2 subspecies levels in older athletes with silent myocardial ischemia.
Low-density lipoprotein subclass patterns and lipoprotein response to a reduced-fat diet in men.
Associations of age, adiposity, alcohol intake, menstrual status, and estrogen therapy with high-density lipoprotein subclasses.
Differential effects of estrogen on low-density lipoprotein subclasses in healthy postmenopausal women.
Insulin resistance and hyperinsulinemia in individuals with small, dense low density lipoprotein particles.
The hypertriglyceridemia of acquired immunodeficiency syndrome is associated with an increased prevalence of low density lipoprotein subclass pattern B.
Genetics of LDL subclass phenotypes in women twins. Concordance, heritability, and commingling analysis.
Susceptibility of small, dense, low-density lipoproteins to oxidative modification in subjects with the atherogenic lipoprotein phenotype, pattern B.
HDL and coronary artery disease.
Lipoprotein subclasses in genetic studies: the Berkeley data set.
Familial correlations of HDL subclasses based on gradient gel electrophoresis.
LDL subclass phenotypes and triglyceride metabolism in non-insulin-dependent diabetes.
Production of polyacrylamide gradient gels for the electrophoretic resolution of lipoproteins.
Epidermal growth factor receptor in synaptic fractions of the rat central nervous system.
Lipoprotein(a) in women twins: heritability and relationship to apolipoprotein(a) phenotypes.
The metabolic impact of oral contraceptives.
Differential effects of nicotinic acid in subjects with different LDL subclass patterns.
Reduced HDL2 cholesterol subspecies and elevated postheparin hepatic lipase activity in older men with abdominal obesity and asymptomatic myocardial ischemia.
Correlations of plasma lipoproteins with LDL subfractions by particle size in men and women.
Effects of weight-loss by exercise and by diet on apolipoproteins A-I and A-II and the particle-size distribution of high-density lipoproteins in men.
Variations in oxidative susceptibility among six low density lipoprotein subfractions of differing density and particle size.
Associations of lipoproteins and apolipoproteins with gradient gel electrophoresis estimates of high density lipoprotein subfractions in men and women.
Linkage of atherogenic lipoprotein phenotype to the low density lipoprotein receptor locus on the short arm of chromosome 19.
Association of a genetic polymorphism in human apolipoprotein B-100 with intermediate density lipoprotein concentrations.
Pathophysiology of triglyceride-rich particles. A. Metabolism of triglyceride-rich particles.
Dissociation of high density lipoprotein precursors from apolipoprotein B-containing lipoproteins in the presence of unesterified fatty acids and a source of apolipoprotein A-I.
Size transformations of intermediate and low density lipoproteins induced by unesterified fatty acids.
The tangled web of coronary risk factors.
Expression of human apolipoprotein A-I in transgenic mice results in reduced plasma levels of murine apolipoprotein A-I and the appearance of two new high density lipoprotein size subclasses.
Lack of evidence for linkage between low-density lipoprotein subclass phenotypes and the apolipoprotein B locus in familial combined hyperlipidemia.
Linkage analysis of low-density lipoprotein subclass phenotypes and the apolipoprotein B gene.
Increased immunoreactivity of apolipoprotein B epitopes during prolonged storage of low density lipoproteins.
Unique structural properties of apolipoprotein B in low-density lipoproteins produced by several human hepatoma-derived cell lines.
Differences in carbohydrate content of low density lipoproteins associated with low density lipoprotein subclass patterns.
Tumor necrosis factor acutely increases plasma levels of very low density lipoproteins of normal size and composition.
Atherogenic lipoprotein phenotype. A proposed genetic marker for coronary heart disease risk.
Familial defective apolipoprotein B-100: a mutation of apolipoprotein B that causes hypercholesterolemia.
Inheritance of low density lipoprotein subclass patterns in familial combined hyperlipidemia.
Identifying the predominant peak diameter of high-density and low-density lipoproteins by electrophoresis.
Pravastatin therapy in primary moderate hypercholesterolaemia: changes in metabolism of apolipoprotein B-containing lipoproteins.
Effects of exercise-induced weight loss on low density lipoprotein subfractions in healthy men.
Lipoproteins and coronary heart disease.
Effect of alpha- and selective beta-blockade for hypertension control on plasma lipoproteins, apoproteins, lipoprotein subclasses, and postprandial lipemia.
Regional adiposity patterns in relation to lipids, lipoprotein cholesterol, and lipoprotein subfraction mass in men.
Familial defective apolipoprotein B-100: enhanced binding of monoclonal antibody MB47 to abnormal low density lipoproteins.
Inheritance of low-density lipoprotein subclass patterns: results of complex segregation analysis.
Effects of estrogen dose and smoking on lipid and lipoprotein levels in postmenopausal women.
Defective catabolism and abnormal composition of low-density lipoproteins from mutant pigs with hypercholesterolemia.
Coordinate changes in levels of human serum low and high density lipoprotein subclasses in healthy men.
Interactions of high density lipoproteins with very low and low density lipoproteins during lipolysis.
Lipoprotein metabolism during acute inhibition of lipoprotein lipase in the cynomolgus monkey.
Lipoprotein subspecies and risk of coronary disease.
The effects of oral contraceptives on plasma lipids and lipoproteins.
Familial defective apolipoprotein B-100: low density lipoproteins with abnormal receptor binding.
Intermediate-density lipoproteins and progression of coronary artery disease in hypercholesterolaemic men.
Metabolism of human intermediate and very low density lipoprotein subfractions from normal and dysbetalipoproteinemic plasma. In vivo studies in rat.
Lipolysis products promote the formation of complexes of very-low-density and low-density lipoproteins.
Relationships of plasma estradiol, testosterone, and sex hormone-binding globulin with lipoproteins, apolipoproteins, and high density lipoprotein subfractions in men.
Relationship of intermediate and low-density lipoprotein subspecies to risk of coronary artery disease.
Relationship of dietary fat, protein, cholesterol, and fiber intake to atherogenic lipoproteins in men.
Genetic control of low-density-lipoprotein subclasses.
Effects of oral contraceptives on lipid metabolism.
Lipoprotein subfractions of runners and sedentary men.
Metabolic interrelationships of HDL subclasses.
Nondenaturing polyacrylamide gradient gel electrophoresis.
Presence of multiple subpopulations of lipoproteins of intermediate density in normal subjects.
Single vertical spin density gradient ultracentrifugation.
Associations of diet and alcohol intake with high-density lipoprotein subclasses.
Modulation of apolipoprotein B antigenic determinants in human low density lipoprotein subclasses.
Associations of resting heart rate with concentrations of lipoprotein subfractions in sedentary men.
Familial apolipoprotein AI and apolipoprotein CIII deficiency. Subclass distribution, composition, and morphology of lipoproteins in a disorder associated with premature atherosclerosis.
The effect of cessation and resumption of moderate alcohol intake on serum high-density-lipoprotein subfractions. A controlled study.
Composition and distribution of low density lipoprotein fractions in hyperapobetalipoproteinemia, normolipidemia, and familial hypercholesterolemia.
Apolipoprotein and size heterogeneity in human umbilical cord blood low density lipoproteins.
Does weight loss cause the exercise-induced increase in plasma high density lipoproteins?
Effects of two low-dose oral contraceptives on serum lipids and lipoproteins: differential changes in high-density lipoprotein subclasses.
Increased exercise level and plasma lipoprotein concentrations: a one-year, randomized, controlled study in sedentary, middle-aged men.
Effects of progestational agents on serum lipids and lipoproteins.
Regulation of high density lipoprotein levels.
Identification of multiple subclasses of plasma low density lipoproteins in normal humans.
X-linked ichthyosis: increased blood cholesterol sulfate and electrophoretic mobility of low-density lipoprotein.
The effect on lipids and lipoproteins of a contraceptive vaginal ring containing levonorgestrel and estradiol.
Heterogeneity of serum low density lipoproteins in normal human subjects.
Subdermal estradiol pellets following hysterectomy and oophorectomy. Effect upon serum estrone, estradiol, luteinizing hormone, follicle-stimulating hormone, corticosteroid binding globulin-binding capacity, testosterone-estradiol binding globulin-binding
Interrelationships among subgroups of serum lipoproteins in normal human subjects.
Changes in plasma lipoprotein distribution and formation of two unusual particles after heparin-induced lipolysis in hypertriglyceridemic subjects.
Serum high-density-lipoprotein cholesterol in women using oral contraceptives, estrogens and progestins.
Infertility in male pesticide workers.
Changes in serum high density lipoproteins in women on oral contraceptive drugs.
Subclinical chronic pancreatitis in type I hyperlipoproteinemia.
Therapeutic failure in familial type II hyperlipoproteinemia.
Selective measurement of two lipase activities in postheparin plasma from normal subjects and patients with hyperlipoproteinemia.
Positional specificity of triglyceride lipases in post-heparin plasma.
Further observations on the activation and inhibition of lipoprotein lipase by apolipoproteins.
Response of plasma histaminase activity to small doses of heparin in normal subjects and patients with hyperlipoproteinemia.
Selective measurement of two different triglyceride lipase activities in rat postheparin plasma.
Characterization, subcellular localization, and partial purification of a heparin-released triglyceride lipase from rat liver.
A biochemical and morphologic study of very low density lipoproteins in carbohydrate-induced hypertriglyceridemia.
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