Tien Peng, MD

Associate Professor

Medicine

Address:

513 Parnassus Avenue, HSE, Rm 1312

UCSF Box 0130

San Francisco, CA 94143

United States

Email:

[email protected]

UCSF Profiles

Developmental pathways in the maintenance of adult tissue homeostasis Our laboratory is interested in studying how key developmental pathways continue to persist in adulthood to maintain normal homeostatic organ function. We are particularly focused on the mesenchymal cell types (e.g. fibroblasts, pericytes, and etc.) that are poorly understood and lack precise anatomical definition, but are integral to the structural integrity and function of adult organs such as the lung.

Publications:

Identification of Meibomian gland stem cell populations and mechanisms of aging.

Nature communications

Zhu X, Xu M, Portal C, Lin Y, Ferdinand A, Peng T, Morrisey EE, Dlugosz AA, Castellano JM, Lee V, Seykora JT, Wong SY, Iomini C, Millar SE

Convergent evolution of senescent fibroblasts in fibrosis and cancer with aging.

Seminars in cancer biology

Lee JY, Peng T

Identification of Meibomian gland stem cell populations and mechanisms of aging.

bioRxiv : the preprint server for biology

Zhu X, Xu M, Portal C, Lin Y, Ferdinand A, Peng T, Morrisey EE, Dlugosz AA, Castellano JM, Lee V, Seykora JT, Iomini C, Millar SE

Senescent fibroblasts in the tumor stroma rewire lung cancer metabolism and plasticity.

bioRxiv : the preprint server for biology

Lee JY, Reyes N, Woo SH, Goel S, Stratton F, Kuang C, Mansfield AS, LaFave LM, Peng T

An in vivo screening platform identifies senolytic compounds that target p16INK4a+ fibroblasts in lung fibrosis.

The Journal of clinical investigation

Lee JY, Reyes NS, Ravishankar S, Zhou M, Krasilnikov M, Ringler C, Pohan G, Wilson C, Ang KK, Wolters PJ, Tsukui T, Sheppard D, Arkin MR, Peng T

In vivo protein turnover rates in varying oxygen tensions nominate MYBBP1A as a mediator of the hyperoxia response.

Science advances

Chen X, Haribowo AG, Baik AH, Fossati A, Stevenson E, Chen YR, Reyes NS, Peng T, Matthay MA, Traglia M, Pico AR, Jarosz DF, Buchwalter A, Ghaemmaghami S, Swaney DL, Jain IH

Bad Neighbors or Bad Neighborhoods: Pathogenic Residency of T Cells in Chronic Obstructive Pulmonary Disease.

American journal of respiratory and critical care medicine

Peng T

Single-nuclei characterization of pervasive transcriptional signatures across organs in response to COVID-19.

eLife

COVID Tissue Atlas Consortium, Granados AA, Bucher S, Song H, Agrawal A, Chen AT, Peng T, Neff N, Pisco AO, Huang F, Wang B

Group 2 innate lymphoid cells constrain type 3/17 lymphocytes in shared stromal niches to restrict liver fibrosis.

bioRxiv : the preprint server for biology

Sbierski-Kind J, Cautivo KM, Wagner JC, Dahlgren MW, Nilsson J, Krasilnikov M, Mroz NM, Lizama CO, Gan AL, Matatia PR, Taruselli MT, Chang AA, Caryotakis S, O'Leary CE, Kotas M, Mattis AN, Peng T, Locksley RM, Molofsky AB

Dysregulated lung stroma drives emphysema exacerbation by potentiating resident lymphocytes to suppress an epithelial stem cell reservoir.

Immunity

Wang C, Hyams B, Allen NC, Cautivo K, Monahan K, Zhou M, Dahlgren MW, Lizama CO, Matthay M, Wolters P, Molofsky AB, Peng T

Sentinel p16INK4a+ cells in the basement membrane form a reparative niche in the lung.

Science (New York, N.Y.)

Reyes NS, Krasilnikov M, Allen NC, Lee JY, Hyams B, Zhou M, Ravishankar S, Cassandras M, Wang C, Khan I, Matatia P, Johmura Y, Molofsky A, Matthay M, Nakanishi M, Sheppard D, Campisi J, Peng T

Intersection of Inflammation and Senescence in the Aging Lung Stem Cell Niche.

Frontiers in cell and developmental biology

Allen NC, Reyes NS, Lee JY, Peng T

Human alveolar type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells.

Nature cell biology

Kathiriya JJ, Wang C, Zhou M, Brumwell A, Cassandras M, Le Saux CJ, Cohen M, Alysandratos KD, Wang B, Wolters P, Matthay M, Kotton DN, Chapman HA, Peng T

An inflammatory switch for stem cell plasticity.

Nature cell biology

Kathiriya JJ, Peng T

Gli1+ mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung.

Nature cell biology

Cassandras M, Wang C, Kathiriya J, Tsukui T, Matatia P, Matthay M, Wolters P, Molofsky A, Sheppard D, Chapman H, Peng T

The Role of Hedgehog Signaling in Adult Lung Regeneration and Maintenance.

Journal of developmental biology

Wang C, Cassandras M, Peng T

Adventitial Stromal Cells Define Group 2 Innate Lymphoid Cell Tissue Niches.

Immunity

Dahlgren MW, Jones SW, Cautivo KM, Dubinin A, Ortiz-Carpena JF, Farhat S, Yu KS, Lee K, Wang C, Molofsky AV, Tward AD, Krummel MF, Peng T, Molofsky AB

Endothelial toll-like receptor 4 maintains lung integrity via epigenetic suppression of p16INK4a.

Aging cell

Kim SJ, Shan P, Hwangbo C, Zhang Y, Min JN, Zhang X, Ardito T, Li A, Peng T, Sauler M, Lee PJ

Expansion of hedgehog disrupts mesenchymal identity and induces emphysema phenotype.

The Journal of clinical investigation

Wang C, de Mochel NSR, Christenson SA, Cassandras M, Moon R, Brumwell AN, Byrnes LE, Li A, Yokosaki Y, Shan P, Sneddon JB, Jablons D, Lee PJ, Matthay MA, Chapman HA, Peng T

Emergence of a Wave of Wnt Signaling that Regulates Lung Alveologenesis by Controlling Epithelial Self-Renewal and Differentiation.

Cell reports

Frank DB, Peng T, Zepp JA, Snitow M, Vincent TL, Penkala IJ, Cui Z, Herriges MJ, Morley MP, Zhou S, Lu MM, Morrisey EE

Hedgehog actively maintains adult lung quiescence and regulates repair and regeneration.

Nature

Peng T, Frank DB, Kadzik RS, Morley MP, Rathi KS, Wang T, Zhou S, Cheng L, Lu MM, Morrisey EE

Long noncoding RNAs are spatially correlated with transcription factors and regulate lung development.

Genes & development

Herriges MJ, Swarr DT, Morley MP, Rathi KS, Peng T, Stewart KM, Morrisey EE

Distinct functions for Wnt/β-catenin in hair follicle stem cell proliferation and survival and interfollicular epidermal homeostasis.

Cell stem cell

Choi YS, Zhang Y, Xu M, Yang Y, Ito M, Peng T, Cui Z, Nagy A, Hadjantonakis AK, Lang RA, Cotsarelis G, Andl T, Morrisey EE, Millar SE

Lentiviral vectors with two independent internal promoters transfer high-level expression of multiple transgenes to human hematopoietic stem-progenitor cells.

Molecular therapy : the journal of the American Society of Gene Therapy

Yu X, Zhan X, D'Costa J, Tanavde VM, Ye Z, Peng T, Malehorn MT, Yang X, Civin CI, Cheng L

Websites:

https://penglab.squarespace.com/

Faculty Type:

Parnassus Pulmonary Research Faculty

Tien Peng, MD

Identification of Meibomian gland stem cell populations and mechanisms of aging.

Convergent evolution of senescent fibroblasts in fibrosis and cancer with aging.

Identification of Meibomian gland stem cell populations and mechanisms of aging.

Senescent fibroblasts in the tumor stroma rewire lung cancer metabolism and plasticity.

An in vivo screening platform identifies senolytic compounds that target p16INK4a+ fibroblasts in lung fibrosis.

In vivo protein turnover rates in varying oxygen tensions nominate MYBBP1A as a mediator of the hyperoxia response.

Bad Neighbors or Bad Neighborhoods: Pathogenic Residency of T Cells in Chronic Obstructive Pulmonary Disease.

Single-nuclei characterization of pervasive transcriptional signatures across organs in response to COVID-19.

Group 2 innate lymphoid cells constrain type 3/17 lymphocytes in shared stromal niches to restrict liver fibrosis.

Dysregulated lung stroma drives emphysema exacerbation by potentiating resident lymphocytes to suppress an epithelial stem cell reservoir.

Sentinel p16INK4a+ cells in the basement membrane form a reparative niche in the lung.

Intersection of Inflammation and Senescence in the Aging Lung Stem Cell Niche.

Human alveolar type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells.

An inflammatory switch for stem cell plasticity.

Gli1+ mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung.

The Role of Hedgehog Signaling in Adult Lung Regeneration and Maintenance.

Adventitial Stromal Cells Define Group 2 Innate Lymphoid Cell Tissue Niches.

Endothelial toll-like receptor 4 maintains lung integrity via epigenetic suppression of p16INK4a.

Expansion of hedgehog disrupts mesenchymal identity and induces emphysema phenotype.

Emergence of a Wave of Wnt Signaling that Regulates Lung Alveologenesis by Controlling Epithelial Self-Renewal and Differentiation.

Hedgehog actively maintains adult lung quiescence and regulates repair and regeneration.

Long noncoding RNAs are spatially correlated with transcription factors and regulate lung development.

Distinct functions for Wnt/β-catenin in hair follicle stem cell proliferation and survival and interfollicular epidermal homeostasis.

Coordination of heart and lung co-development by a multipotent cardiopulmonary progenitor.

Development of the pulmonary vasculature: Current understanding and concepts for the future.

Plasma levels of S100A4 in portopulmonary hypertension.

Herpes simplex encephalitis in a patient with recurrent pituitary adenoma receiving radiation therapy.

The 1p-encoded protein stathmin and resistance of malignant gliomas to nitrosoureas.

Short hairpin RNA loop design for the facilitation of sequence verification.

Lentiviral vectors with two independent internal promoters transfer high-level expression of multiple transgenes to human hematopoietic stem-progenitor cells.

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Tien Peng, MD