This NIH T32 funded training program is exclusively postdoctoral. To maximize the impact of this T32 and the number of trainees exposed to its rigorous standards and activities, 8 trainees will be appointed each year for a single year of T32 funding, then rotate off to support provided by individual fellowship grants, grants on which the mentor is PI or other laboratory funds. All trainees will hold PhD, MD, or MD/PhD degrees. Two T32-funded positions will be dedicated to MD or MD/PhD Cardiology fellows (or occasionally other clinical fellows in disciplines relevant to cardiovascular biology and disease) seeking rigorous training in patient-based research through UCSF's TICR program. The remaining trainees will be a mix of PhD, MD, and MD/PhD trainees recruited into CVRI laboratories by individual mentors.
All trainees appointed to the T32 are required to take the Responsible Conduct of Research course. In addition, MD-trained program trainees engaged in clinical research have the option to take formal coursework for training or advanced training in clinical research. Partial tuition for TICR-based trainees will be covered by the program. Opportunities for Laboratory-based Research Track appointees are also available – the trainee will discuss possible coursework opportunities with the Advisor and primary mentor in their initial meeting. Trainees will be encouraged to take the graduate school course(s) relevant to their areas of interest if they have not had similar courses in their prior training.
Although coursework is available, the heart of this training program is formulation and execution of a substantial research project relevant to cardiovascular biology and disease (broadly defined) and development of professional skills under the guidance of a faculty mentor. This core research training is supplemented by co-, group- and peer-mentoring, and by coursework tailored to a trainee’s specific needs. Coursework is particularly intensive for the TICR track, which grounds MD-trained appointees in clinical research. In the laboratory-based research track, trainees have usually selected a primary mentor and apply to the program with support from that investigator. Entering Cardiology fellows who apply to the laboratory-based research track or TICR tracks will be aided in their selection of a primary mentor by Dr. Javid Moslehi. When the primary mentor is a junior faculty member, an advisory committee of co-mentors is provided. Otherwise, the primary mentor and trainee select co-mentors as appropriate for complementary knowledge and skills that support the project. Group and peer mentoring will occur in CVRIPS at which trainees present ongoing work to the entire community, laboratory group meetings, thematic research-in-progress groups, daily interactions in the laboratory, and other venues to facilitate formal and informal scientific interaction.
To apply for a position on the CVRI’s T32, please send by email a cover letter including a brief statement of your research interests and accomplishments with your curriculum vitae directly to the Program Faculty Member/s of interest to you. Applications to the NIH T32 training grant will be made jointly with the faculty member. Program faculty members are listed below.
Christopher Allen
Mechanisms of allergic lung inflammation
Kaveh Ashrafi
Metabolic regulation of neural functions during aging
Kamran Atabai
Limiting fibrosis through cell-mediated collagen turnover
Brian Black
Gene Regulatory Networks in cardiovascular development and regeneration
Benoit Bruneau
Heart development/congenital heart disease
Abigail Buchwalter
Function and dynamic regulation of the nuclear lamina
Daniele Canzio
Regulation of clustered Protocadherins;neuronal cell-surface diversity
John Chorba
Chemical Biology of Cardiometabolic Disease
Jan Christoph
Computational cardiology, cardiac arrhythmia mechanisms and imaging
Pao-Tien Chuang
The mechanisms of lung branching and alveolar formation
William Degrado
Protein Design, Drug Design, Integrin structure/function, Fibrosis
John Fahy
Airway biology and molecular phenotypes of airway diseases
Trevor Fidler
Macrophages and atherosclerosis
Jeffrey R. Fineman
Pediatric Pulmonary Vascular Disorders
Edward Gerstenfeld
Mechanism of ectopy induced remodeling in cardiac arrhythmias
Douglas Gould
Biological functions and pathogenic contributions of extracellular matrix
Michael Grabe
Computational approaches to structure/function of membrane proteins
Akiko Hata
Pathogenesis of vascular disease and deregulation of TGFbeta signaling
Robert A. Hiatt
Epidemiology; cancer; social determinants; health disparities
Guo Huang
Heart regeneration
Roshanak Irannejad
Subcellular GPCR signaling in the cardiovascular system
Isha Jain
Oxygen and vitamin metabolism and treatment
Lily Jan
Studies of calcium-activated ion channels and lipid scramblases
David Julius
Molecular biology of somatosensation and pain
Natalia Jura
Regulation of growth factor signaling by ubiquitination
Tom Kornberg
Organogenesis and patterning during Drosophila development
Mark Looney
Immunobiology of the normal and injured lung
Dengke Ma
Molecular genetic basis of physiological resilience in animals
Takashi Mikawa
Developmental regulation of organogenesis
Daniel Minor
Structure, function, and pharmacology of ion channels
Javid J. Moslehi
Cardiovascular complications of novel targeted cancer therapies
Maxence V. Nachury
Quality control of the primary cilium proteome
Jose Angel Nicolas-Avila
Macrophages and cardiovascular quality control
Elphege P. Nora
Chromosome biology and genomics
Jeffrey Olgin
Mechanisms of arrhythmias
Akinyemi Oni-Orisan
Pharmaco-genomics
Jeremy Reiter
Signaling at the primary cilium, the cell's antenna
Dean Sheppard
In vivo biology of integrins
Kevan M. Shokat
Chemical approaches to deciphering and controlling signal transduction
Xiaokun Shu
Protein engineering; Fluorescence reporters; biomolecular condensates
Anthony K. Shum
Study of the intersection of autoimmunity with cardiopulmonary disease
Deepak Srivastava
Molecular and genetic dissection of cardiogenesis
Christina V. Theodoris
Gene Regulatory Networks in Cardiovascular Disease
Geoffrey H. Tison
Cardiovascular disease phenotyping and prediction, machine learning
Zian Tseng
Heart rhythm
Vasanth Vedantham
Heart rhythm
Biao Wang
Energy metabolism in adipocytes
Lei Wang
Genetically encoding unnatural amino acids and biotherapeutics
Rong Wang
Molecular programming of the vasculature in development/disease
Orion Weiner
Cell polarity
Balyn W. Zaro
Innate immunity in human disease, therapeutic development